1. Uchida M, Tabusa F, Komatsu M, et al. Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. 2-(4-chlorobenzoylamino)-3-[2(1H)quinolinon-4-yl] propionic acid related compounds. Chem Pharm Bull. 1985;33(9):3775-86.
2. Uchida M, Tabusa F, Komatsu M, et al. Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. Synthesis and antiulcer activity of the metabolites of 2-(4-chlorobenzoylamino)-3-[2(1H)quinolinon-4-yl] propionic acid. Chem Pharm Bull. 1986;34(9):4821-4. doi: 10.1248/cpb.34.4821
3. Uchida M, Tabusa F, Komatsu M, et al. Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. Synthesis and antiulcer activity of optically active A-amino acid derivatives of 2(1H) quinolinone and oxindole. Chem Pharm Bull. 1987;35(2):853-6. doi: 10,1248/cpb.35.853
4. Takano H, Uchida S, Kashiwagura Y, et al. Preparation of Cocoa Powder-Containing Orally Disintegrating Tablets of Rebamipide (Rebamipide Chocolet) and Evaluation of Their Clinical Palatability. Chem Pharm Bull. 2019;67(2):112-9. doi: 10.1248/cpb.c18-00629
5. Kim KT, Lee JY, Park JH, et al. Capmul MCM/Solutol HS15-Based Microemulsion for Enhanced Oral Bioavailability of Rebamipide. J Nanosci Nanotechnol. 2017 Apr;17(4):2340-344. doi:10.1166/ jnn.2017.13314
6. Hasegawa S, Sekino H, Matsuoka O, et al. Bioequivalence of rebamipide granules and tablets in healthy adult male volunteers. Clin Drug Investig. 2003;23:771-9. doi: 10.2165/00044011-200323120-00002
7. Naito Y, Yoshikawa T. Rebamipide: A gastrointestinal protective drug with pleiotropic activities. Expert Rev Gastroenterol Hepatol. 2010;4(3):261-70. doi: 10.1586/egh.10.25
8. Shioya Y, Shimizu T. High-performance liquid chromatographic procedure for the determination of a new anti-gastric ulcer agent, 2-(4-chlorobenzoylamino)-3[2(1H)-quinolinon-4-yl]propionic acid, in human plasma and urine. J Chromatogr. 1988;434(1):283-7. doi: 10.1016/ 0378-4347(88)80089-6
9. Koyama H, Sasabe G, Miyamoto G. Involvement of cytochrome P450 in the metabolism of rebamipide by the human liver. Xenobiotica. 2002;32:573-86. doi: 10.1080/00498250210130591
10. Arakawa T, Kobayashi K, Yoshikawa T. Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing. Dig Dis Sci. 1998;43(9):5-13.
11. Nishizawa T, Suzuki H, Nakagawa I, et al. Rebamipide-promoted restoration of gastric mucosal sonic hedgehog expression after early Helicobacter pylori eradication. Digestion. 2009;79(4):259-62. doi: 10,1159/000213241
12. Suzuki T, Yoshida N, Nakabe N, et al. Prophylactic effect of rebamipide on aspirin-induced gastric lesions and disruption of tight junctional protein zonula occludens-1 distribution. J Pharmacol Sci. 2008;106(3):469-77. doi: 10.1254/jphs.FP0071422
13. Hashimoto K, Oshima T, Tomita T, et al. Oxidative stress induces gastric epithelial permeability through claudin-3. Biochem Biophys Res Commun. 2008;376(1):154-7. doi: 10.1016/j.bbrc.2008.08.140
14. Gweon T, Park J, Kim B, et al; Western Kyonggi Gastrointestinal Study Group. Additive effects of Rebamipide plus proton pump inhibitors on the expression of tight junction proteins in a rat model of gastro-esophageal reflux disease. Gut Liver. 2018;12(1):46-50. doi: 10.5009/gnl17078
15. Tarnawski A, Chai J, Pai R, et al. Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action? Dig Dis Sci. 2004;49(2):202-9. doi: 10.1023/b:ddas.0000017439.60943.5c
16. Matsuda T, Ohno S, Hirohata S, et al. Efficacy of Rebamipide as Adjunctive Therapy in the Treatment of Recurrent Oral Aphthous Ulcers in Patients with Behçet's Disease: A Randomised, Double-Blind, Placebo-Controlled Study. Drugs R & D. 2003;4(1):19-28. doi: 10.2165/00126839-200304010-00002
17. Masanobu T, Tomoya T, Asano R, et al. Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins. Toxicology in Vitro. 2018;46:284-93. doi: 10.1016/j.tiv.2017.10.019
18. Karrasch T, Steinbrecher KA, Allard B, et al. Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytes. J Cell Physiol. 2006;207:809-15. doi: 10.1002/jcp.20626
19. Murata H, Yabe Y, Tsuji S, et al. Gastro-protective agent rebamipide induces cyclooxygenease-2 (COX-2) in gastric epithelial cells. Dig Dis Sci. 2005;50:S70-S75. doi: 10,1007/s10620-005-2809-0
20. Santos MF, McCormack SA, Guo Z, et al. Rho proteins play a critical role in cell migration during the early phase of mucosal restitution. J Clin Invest. 1997;100:216-25. doi: 10,1172/JCI119515
21. Rao JN, Guo X, Liu L, et al. Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution. Am J Physiol Cell Physiol. 2003;284:848-59. doi: 10.1152/ajpcell.00371.2002
22. Takagi T, Naito Y, Uchiyama K, et al. Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution. World J Gastroenterol. 2011;17(33):3802-9. doi: 10.3748/wjg.v17.i33.3802
23. Talley NJ, Riff DS, Schwartz H, et al. Double-blind placebocontrolled multicentre studies of rebamipide, a gastroprotective drug, in the treatment of functional dyspepsia with or without Helicobacter pylori infection. Aliment Pharmacol Ther. 2001;15(10):1603-11. doi: 10.1046/j.1365-2036.2001.01074.x
24. Miwa H, Osada T, Nagahara A, et al. Effect of a gastro-protective agent, rebamipide, on symptom improvement in patients with functional dyspepsia: a double-blind placebo-controlled study in Japan. J Gastroenterol Hepatol. 2006;21(12):1826-31. doi: 10.1111/j.1440-1746.2006.04446.x
25. Chitapanarux T, Praisontarangkul OA, Lertprasertsuke N. An open-labeled study of rebamipide treatment in chronic gastritis patients with dyspeptic symptoms refractory to proton pump inhibitors. Dig Dis Sci. 2008;53(11):2896-903. doi: 10,1007 / s10620-008-0255-5
26. Du Y, Li Z, Zhan X, et al. Antiinflammatory effects of rebamipide according to Helicobacter pylori status in patients with chronic erosive gastritis: a randomized sucralfate-controlled multicenter trial in China-STARS study. Dig Dis Sci. 2008;53(11):2886-95. doi: 10,1007 / s10620-007-0180-г
27. Андреев Д.Н., Дичева Д.Т., Маев И.В. Возможности оптимизации эрадикационной терапии инфекции Helicobacter pylori в современной клинической практике. Терапевтический архив. 2017;89(2):84-90 [Andreev DN, Dicheva DT, Maev IV. Possibilities for optimization of eradication therapy for Helicobacter pylori infection in modern clinical practice. Therapeutic Archive. 2017;89(2):84-90 (In Russ.)]. doi: 10.17116/terarkh201789284-90
28. Андреев Д.Н., Маев И.В., Дичева Д.Т., Самсонов А.А., Парцваниа-Виноградова Е.В. Эффективность и безопасность применения ребамипида в схеме тройной эрадикационной терапии инфекции Helicobacter pylori: проспективное рандомизированное сравнительное исследование. Терапевтический архив. 2018;90(8):27-32 [Andreev DN, Maev IV, Dicheva DT, Samsonov AA, Partzvania-Vinogradova EV. Efficacy and safety of the use of rebamipide in the scheme of triple eradication therapy of Helicobacter pylori infection: a prospective randomized comparative study. Therapeutic Archive. 2018;90(8):27-32 (In Russ.)]. doi: 10.26442/terarkh201890827-32
29. Terano A, Arakawa T, Sugiyama T, et al. Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial. J Gastroenterol. 2007;42(8):690-3. doi: 10.1007/s00535-007-2076-2
30. Kim T, Kim E. Effectiveness of acid suppressants and other mucoprotective agents in reducing the risk of occult gastrointestinal bleeding in nonsteroidal anti-inflammatory drug users. Sci Rep. 2019;9:11696. doi: 10.1038/s41598-019-48173-6
31. Zhang S, Qing Q, Bai Y, et al. Rebamipide helps defend against nonsteroidal anti-inflammatory drugs induced gastroenteropathy: a systematic review and meta-analysis. Dig Dis Sci. 2013;58(7):1991-2000. doi: 10.1007/s10620-013-2606-0
32. Seo GH, Lee H. Chemopreventive Effect of Rebamipide against Gastric Cancer in Patients who undergo Endoscopic Resection for Early Gastric Neoplasms: A Nationwide Claims Study. Digestion. 2019;100(4):221-8. doi: 10.1159/000495288
33. Парфенов А.И., Белостоцкий Н.И., Хомерики С.Г. и др. Ребамипид повышает активность дисахаридаз у больных энтеропатией с нарушением мембранного пищеварения. Пилотное исследование. Терапевтический архив. 2019;91(2):25-31 [Parfenov AI, Belostotsky NI, Khomeriki SG, et al. Rebamipide increases the disaccharidases activity in patients with enteropathy with impaired membrane digestion. Pilot study. Therapeutic Archive. 2019;91(2):25-31 (In Russ.)]. doi: 10.26442/00403660.2019.02.000123
34. Fujimoto A, Uraoka T, Nishizawa T, et al. Rebamipide solution: a novel submucosal injection material to promote healing speed and healing quality of ulcers induced by endoscopic submucosal dissection. Gastrointest Endosc. 2018;87(4):1114-20. doi: 10.1016/j.gie.2017.09.040
35. Watanabe T, Takeuchi T, Handa O, et al. A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of High-Dose Rebamipide Treatment for Low-Dose Aspirin-Induced Moderate-to-Severe Small Intestinal Damage. PLoS One. 2015;10(4):e0122330. doi: 10.1371/journal.pone.0122330
36. Tanigawa T, Watanabe T, Otani K, et al. Rebamipide inhibits indomethacin-induced small intestinal injury: Possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5. Eur J Pharmacol. 2013;704:64-9. doi: 10.1016/j.ejphar.2013.02.010
37. Хатьков И.Е., Парфенов А.И., Князев О.В., Ручкина И.Н., Атрощенко А.О., Михайлянц Г.С. Воспалительные заболевания кишечника в прарктике терапевта и хирурга. М.: ВИТА-ПРЕСС, 2017. 120 с. [Khatkov IE, Parfenov AI, Knyazev OV, Ruchkina IN, Atroshchenko AO, Mikhailiants GS. Inflammatory bowel diseases in the practice of the therapist and surgeon: monograph. Series "Library of the doctor". Moscow: VITA-PRESS; 2017. 120 p. (In Russ.)].
38. Makiyama K, Takeshima F, Kawasaki H, Zea-Iriarte WL. Anti-inflammatory effect of rebamipide enema on proctitis type ulcerative colitis: a novel therapeutic alternative. Am J Gastroenterol. 2000;95:1838-9. doi: 10,1111/j.1572-0241.2000.02154.x
39. Miyata M, Kasugai K. Rebamipide enemas-new effective treatment for patients with corticosteroid dependent or resistant ulcerative colitis. Dig Dis Sci. 2005;50 Suppl 1:S119-23. doi: 10.1007/s10620-005-2816-1
40. Furuta R, Ando T, Watanabe O, et al. Rebamipide enema therapy as a treatment for patients with active distal ulcerative colitis. J Gastroenterol Hepatol. 2007;22(2):261-7. doi: 10.1111/j.1440-1746.2006.04399.x
41. Miyata M, Konagaya T, Kakumu S, et al. Successful treatment of severe pouchitis with rebamipide refractory to antibiotics and corticosteroids: A case report. World J Gastroenterol. 2006;12(4):656-8. doi: 10.3748/wjg.v12.i4.656
42. Matsumoto S, Tsuji K, Shirahama S. Rebamipide enema therapy for left-sided ischemic colitis patients accompanied by ulcers: Open label study. World J Gastroenterol. 2008;14(25):4059-64. doi: 10.3748/wjg.14.4059
43. Jang H, Park S, Lee J. Rebamipide alleviates radiation-induced colitis through improvement of goblet cell differentiation in mice. J Gastroenterol Hepatol. 2018;33(4):878-86. doi: 10.1111/jgh.14021
44. Saad S, Tawfeg A. The effect of rebamipide on cisplatin-induced nephrotoxicity in rats. J  Pharmacological Research. 2000;42(1):81-6. doi: 10.1006/phrs.2000.0662
45. Min H, Kim J. Rebamipide prevents peripheral arthritis and intestinal inflammation by reciprocally regulating Th17/Treg cell imbalance in mice with curdlan-induced spondyloarthritis. J Transl Med. 2016;14:190. doi: 10.1186/s12967-016-0942-5
46. Sakane Y, Yamaguchi M. Retrospective Observational Study on Rebamipide Ophthalmic Suspension on Quality of Life of Dry Eye Disease Patients. J Ophthalmol. 2019;Article ID 8145731, 8 p. doi: 10.1155/2019/8145731

________________________________________________

1. Uchida M, Tabusa F, Komatsu M, et al. Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. 2-(4-chlorobenzoylamino)-3-[2(1H)quinolinon-4-yl] propionic acid related compounds. Chem Pharm Bull. 1985;33(9):3775-86.
2. Uchida M, Tabusa F, Komatsu M, et al. Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. Synthesis and antiulcer activity of the metabolites of 2-(4-chlorobenzoylamino)-3-[2(1H)quinolinon-4-yl] propionic acid. Chem Pharm Bull. 1986;34(9):4821-4. doi: 10.1248/cpb.34.4821
3. Uchida M, Tabusa F, Komatsu M, et al. Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. Synthesis and antiulcer activity of optically active A-amino acid derivatives of 2(1H) quinolinone and oxindole. Chem Pharm Bull. 1987;35(2):853-6. doi: 10,1248/cpb.35.853
4. Takano H, Uchida S, Kashiwagura Y, et al. Preparation of Cocoa Powder-Containing Orally Disintegrating Tablets of Rebamipide (Rebamipide Chocolet) and Evaluation of Their Clinical Palatability. Chem Pharm Bull. 2019;67(2):112-9. doi: 10.1248/cpb.c18-00629
5. Kim KT, Lee JY, Park JH, et al. Capmul MCM/Solutol HS15-Based Microemulsion for Enhanced Oral Bioavailability of Rebamipide. J Nanosci Nanotechnol. 2017 Apr;17(4):2340-344. doi:10.1166/ jnn.2017.13314
6. Hasegawa S, Sekino H, Matsuoka O, et al. Bioequivalence of rebamipide granules and tablets in healthy adult male volunteers. Clin Drug Investig. 2003;23:771-9. doi: 10.2165/00044011-200323120-00002
7. Naito Y, Yoshikawa T. Rebamipide: A gastrointestinal protective drug with pleiotropic activities. Expert Rev Gastroenterol Hepatol. 2010;4(3):261-70. doi: 10.1586/egh.10.25
8. Shioya Y, Shimizu T. High-performance liquid chromatographic procedure for the determination of a new anti-gastric ulcer agent, 2-(4-chlorobenzoylamino)-3[2(1H)-quinolinon-4-yl]propionic acid, in human plasma and urine. J Chromatogr. 1988;434(1):283-7. doi: 10.1016/ 0378-4347(88)80089-6
9. Koyama H, Sasabe G, Miyamoto G. Involvement of cytochrome P450 in the metabolism of rebamipide by the human liver. Xenobiotica. 2002;32:573-86. doi: 10.1080/00498250210130591
10. Arakawa T, Kobayashi K, Yoshikawa T. Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing. Dig Dis Sci. 1998;43(9):5-13.
11. Nishizawa T, Suzuki H, Nakagawa I, et al. Rebamipide-promoted restoration of gastric mucosal sonic hedgehog expression after early Helicobacter pylori eradication. Digestion. 2009;79(4):259-62. doi: 10,1159/000213241
12. Suzuki T, Yoshida N, Nakabe N, et al. Prophylactic effect of rebamipide on aspirin-induced gastric lesions and disruption of tight junctional protein zonula occludens-1 distribution. J Pharmacol Sci. 2008;106(3):469-77. doi: 10.1254/jphs.FP0071422
13. Hashimoto K, Oshima T, Tomita T, et al. Oxidative stress induces gastric epithelial permeability through claudin-3. Biochem Biophys Res Commun. 2008;376(1):154-7. doi: 10.1016/j.bbrc.2008.08.140
14. Gweon T, Park J, Kim B, et al; Western Kyonggi Gastrointestinal Study Group. Additive effects of Rebamipide plus proton pump inhibitors on the expression of tight junction proteins in a rat model of gastro-esophageal reflux disease. Gut Liver. 2018;12(1):46-50. doi: 10.5009/gnl17078
15. Tarnawski A, Chai J, Pai R, et al. Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action? Dig Dis Sci. 2004;49(2):202-9. doi: 10.1023/b:ddas.0000017439.60943.5c
16. Matsuda T, Ohno S, Hirohata S, et al. Efficacy of Rebamipide as Adjunctive Therapy in the Treatment of Recurrent Oral Aphthous Ulcers in Patients with Behçet's Disease: A Randomised, Double-Blind, Placebo-Controlled Study. Drugs R & D. 2003;4(1):19-28. doi: 10.2165/00126839-200304010-00002
17. Masanobu T, Tomoya T, Asano R, et al. Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins. Toxicology in Vitro. 2018;46:284-93. doi: 10.1016/j.tiv.2017.10.019
18. Karrasch T, Steinbrecher KA, Allard B, et al. Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytes. J Cell Physiol. 2006;207:809-15. doi: 10.1002/jcp.20626
19. Murata H, Yabe Y, Tsuji S, et al. Gastro-protective agent rebamipide induces cyclooxygenease-2 (COX-2) in gastric epithelial cells. Dig Dis Sci. 2005;50:S70-S75. doi: 10,1007/s10620-005-2809-0
20. Santos MF, McCormack SA, Guo Z, et al. Rho proteins play a critical role in cell migration during the early phase of mucosal restitution. J Clin Invest. 1997;100:216-25. doi: 10,1172/JCI119515
21. Rao JN, Guo X, Liu L, et al. Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution. Am J Physiol Cell Physiol. 2003;284:848-59. doi: 10.1152/ajpcell.00371.2002
22. Takagi T, Naito Y, Uchiyama K, et al. Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution. World J Gastroenterol. 2011;17(33):3802-9. doi: 10.3748/wjg.v17.i33.3802
23. Talley NJ, Riff DS, Schwartz H, et al. Double-blind placebocontrolled multicentre studies of rebamipide, a gastroprotective drug, in the treatment of functional dyspepsia with or without Helicobacter pylori infection. Aliment Pharmacol Ther. 2001;15(10):1603-11. doi: 10.1046/j.1365-2036.2001.01074.x
24. Miwa H, Osada T, Nagahara A, et al. Effect of a gastro-protective agent, rebamipide, on symptom improvement in patients with functional dyspepsia: a double-blind placebo-controlled study in Japan. J Gastroenterol Hepatol. 2006;21(12):1826-31. doi: 10.1111/j.1440-1746.2006.04446.x
25. Chitapanarux T, Praisontarangkul OA, Lertprasertsuke N. An open-labeled study of rebamipide treatment in chronic gastritis patients with dyspeptic symptoms refractory to proton pump inhibitors. Dig Dis Sci. 2008;53(11):2896-903. doi: 10,1007 / s10620-008-0255-5
26. Du Y, Li Z, Zhan X, et al. Antiinflammatory effects of rebamipide according to Helicobacter pylori status in patients with chronic erosive gastritis: a randomized sucralfate-controlled multicenter trial in China-STARS study. Dig Dis Sci. 2008;53(11):2886-95. doi: 10,1007 / s10620-007-0180-г
27. Andreev DN, Dicheva DT, Maev IV. Possibilities for optimization of eradication therapy for Helicobacter pylori infection in modern clinical practice. Therapeutic Archive. 2017;89(2):84-90 (In Russ.) doi: 10.17116/terarkh201789284-90
28. Andreev DN, Maev IV, Dicheva DT, Samsonov AA, Partzvania-Vinogradova EV. Efficacy and safety of the use of rebamipide in the scheme of triple eradication therapy of Helicobacter pylori infection: a prospective randomized comparative study. Therapeutic Archive. 2018;90(8):27-32 (In Russ.) doi: 10.26442/terarkh201890827-32
29. Terano A, Arakawa T, Sugiyama T, et al. Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial. J Gastroenterol. 2007;42(8):690-3. doi: 10.1007/s00535-007-2076-2
30. Kim T, Kim E. Effectiveness of acid suppressants and other mucoprotective agents in reducing the risk of occult gastrointestinal bleeding in nonsteroidal anti-inflammatory drug users. Sci Rep. 2019;9:11696. doi: 10.1038/s41598-019-48173-6
31. Zhang S, Qing Q, Bai Y, et al. Rebamipide helps defend against nonsteroidal anti-inflammatory drugs induced gastroenteropathy: a systematic review and meta-analysis. Dig Dis Sci. 2013;58(7):1991-2000. doi: 10.1007/s10620-013-2606-0
32. Seo GH, Lee H. Chemopreventive Effect of Rebamipide against Gastric Cancer in Patients who undergo Endoscopic Resection for Early Gastric Neoplasms: A Nationwide Claims Study. Digestion. 2019;100(4):221-8. doi: 10.1159/000495288
33. Parfenov AI, Belostotsky NI, Khomeriki SG, et al. Rebamipide increases the disaccharidases activity in patients with enteropathy with impaired membrane digestion. Pilot study. Therapeutic Archive. 2019;91(2):25-31 (In Russ.) doi: 10.26442/00403660.2019.02.000123
34. Fujimoto A, Uraoka T, Nishizawa T, et al. Rebamipide solution: a novel submucosal injection material to promote healing speed and healing quality of ulcers induced by endoscopic submucosal dissection. Gastrointest Endosc. 2018;87(4):1114-20. doi: 10.1016/j.gie.2017.09.040
35. Watanabe T, Takeuchi T, Handa O, et al. A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of High-Dose Rebamipide Treatment for Low-Dose Aspirin-Induced Moderate-to-Severe Small Intestinal Damage. PLoS One. 2015;10(4):e0122330. doi: 10.1371/journal.pone.0122330
36. Tanigawa T, Watanabe T, Otani K, et al. Rebamipide inhibits indomethacin-induced small intestinal injury: Possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5. Eur J Pharmacol. 2013;704:64-9. doi: 10.1016/j.ejphar.2013.02.010
37. Khatkov IE, Parfenov AI, Knyazev OV, Ruchkina IN, Atroshchenko AO, Mikhailiants GS. Inflammatory bowel diseases in the practice of the therapist and surgeon: monograph. Series "Library of the doctor". Moscow: VITA-PRESS; 2017. 120 p. (In Russ.)
38. Makiyama K, Takeshima F, Kawasaki H, Zea-Iriarte WL. Anti-inflammatory effect of rebamipide enema on proctitis type ulcerative colitis: a novel therapeutic alternative. Am J Gastroenterol. 2000;95:1838-9. doi: 10,1111/j.1572-0241.2000.02154.x
39. Miyata M, Kasugai K. Rebamipide enemas-new effective treatment for patients with corticosteroid dependent or resistant ulcerative colitis. Dig Dis Sci. 2005;50 Suppl 1:S119-23. doi: 10.1007/s10620-005-2816-1
40. Furuta R, Ando T, Watanabe O, et al. Rebamipide enema therapy as a treatment for patients with active distal ulcerative colitis. J Gastroenterol Hepatol. 2007;22(2):261-7. doi: 10.1111/j.1440-1746.2006.04399.x
41. Miyata M, Konagaya T, Kakumu S, et al. Successful treatment of severe pouchitis with rebamipide refractory to antibiotics and corticosteroids: A case report. World J Gastroenterol. 2006;12(4):656-8. doi: 10.3748/wjg.v12.i4.656
42. Matsumoto S, Tsuji K, Shirahama S. Rebamipide enema therapy for left-sided ischemic colitis patients accompanied by ulcers: Open label study. World J Gastroenterol. 2008;14(25):4059-64. doi: 10.3748/wjg.14.4059
43. Jang H, Park S, Lee J. Rebamipide alleviates radiation-induced colitis through improvement of goblet cell differentiation in mice. J Gastroenterol Hepatol. 2018;33(4):878-86. doi: 10.1111/jgh.14021
44. Saad S, Tawfeg A. The effect of rebamipide on cisplatin-induced nephrotoxicity in rats. J  Pharmacological Research. 2000;42(1):81-6. doi: 10.1006/phrs.2000.0662
45. Min H, Kim J. Rebamipide prevents peripheral arthritis and intestinal inflammation by reciprocally regulating Th17/Treg cell imbalance in mice with curdlan-induced spondyloarthritis. J Transl Med. 2016;14:190. doi: 10.1186/s12967-016-0942-5
46. Sakane Y, Yamaguchi M. Retrospective Observational Study on Rebamipide Ophthalmic Suspension on Quality of Life of Dry Eye Disease Patients. J Ophthalmol. 2019;Article ID 8145731, 8 p. doi: 10.1155/2019/8145731

М.Ю. Звяглова, О.В. Князев, А.И. Парфенов 

ГБУЗ «Московский клинический научно-практический центр им. А.С. Логинова» Департамента здравоохранения г. Москвы, Москва, Россия

________________________________________________

M.Yu. Zvyaglova, O.V. Knyazev, A.I. Parfenov 

Loginov Moscow Clinical Research Center, Moscow, Russia