Клиническая характеристика и оценка качества лечения больных с хронической сердечной недостаточностью и сахарным диабетом - Журнал Терапевтический архив №4 Вопросы диагностики внутренних болезней 2020
Клиническая характеристика и оценка качества лечения больных с хронической сердечной недостаточностью и сахарным диабетом
Лазарева Н.В., Ощепкова Е.В., Орловский А.А., Терещенко С.Н. Клиническая характеристика и оценка качества лечения больных с хронической сердечной недостаточностью и сахарным диабетом. Терапевтический архив. 2020; 92 (4): 37–44. DOI: 10.26442/00403660.2020.04.000474
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Аннотация
Цель. Изучение клинико-инструментальной характеристики и качества лечения больных с хронической сердечной недостаточностью (ХСН) и сахарным диабетом (СД).
Материалы и методы. Исследование проводилось методом регистра ХСН, который представляет собой компьютерную программу с удаленным доступом, позволяющую в режиме онлайн осуществлять сбор данных о больных, прошедших обследование и лечение в первичном звене здравоохранения и в стационарах. В исследование включены 8272 больных с ХСН II–IV функционального класса (Нью-Йоркская кардиологическая ассоциация – NYHA), из них 62% больных лечились в стационаре.
Результаты. Исследование показало, что частота СД составила 21%. Ведущими причинами развития ХСН у больных СД являются ишемическая болезнь сердца, инфаркт миокарда (в анамнезе) и артериальная гипертония. У этих больных чаще диагностированы III и IV функциональный класс ХСН (по NYHA) и сохранная фракция выброса (ФВ) левого желудочка. Сниженная ФВ наблюдалась в 6,8% случаев, а частота «промежуточной» ФВ левого желудочка была достоверно больше, чем среди больных с ХСН и СД, и составила 18,9%. У больных с ХСН и СД в сравнении с больными с ХСН без СД достоверно чаще наблюдались атеросклероз периферических артерий, инсульт (в анамнезе) и хроническая болезнь почек III и IV стадий.
Заключение. На фоне проводимого лечения у больных с ХСН и СД регистрируются более высокие уровни систолического артериального давления, липидов и глюкозы плазмы крови, что свидетельствует о недостаточном качестве лечения и, соответственно, неоптимальном выполнении врачами клинических рекомендаций по лечению этой категории больных.
Ключевые слова: хроническая сердечная недостаточность, сахарный диабет, регистр больных с хронической сердечной недостаточностью, диагностика, лечение.
Materials and methods. The study was conducted by using the CHF register method, which is a computer program with remote access, which allows on-line data collection on patients who have been examined and treated in primary care and in hospitals. The study included 8272 patients with CHF II–IV FC (functional class) (New York Heart Association – NYHA); among them 62% of patients were treated in hospital.
Results. The study showed that the frequency of diabetes was 21%. The main causes of CHF in diabetic patients are coronary artery disease, myocardial infarction (in anamnesis) and hypertension. These patients are more often diagnosed with III and IV CHF FC according to (NYHA) and retained LV (left ventricular) ejection fraction. The reduced ejection fraction was observed in 6.8% of cases, and the frequency of the “intermediate” LV was significantly higher than among patients with CHF and with diabetes and accounted for 18.9%. At patients with CHF with diabetes in comparison with patients with CHF without diabetes, atherosclerosis of the peripheral arteries, stroke (in anamnesis) and chronic kidney disease of stage III and IV were significantly more common.
Conclusion.Under the treatment, patients with CHF with diabetes have higher levels of SBP (systolic blood pressure), lipids and glucose in the blood plasma, indicating a lack of quality of treatment and, accordingly, the doctors are not optimally performing the clinical guidelines on treating this category of patients.
Keywords: heart failure, diabetes mellitus, register heart failure, diagnostics, treatment.
Материалы и методы. Исследование проводилось методом регистра ХСН, который представляет собой компьютерную программу с удаленным доступом, позволяющую в режиме онлайн осуществлять сбор данных о больных, прошедших обследование и лечение в первичном звене здравоохранения и в стационарах. В исследование включены 8272 больных с ХСН II–IV функционального класса (Нью-Йоркская кардиологическая ассоциация – NYHA), из них 62% больных лечились в стационаре.
Результаты. Исследование показало, что частота СД составила 21%. Ведущими причинами развития ХСН у больных СД являются ишемическая болезнь сердца, инфаркт миокарда (в анамнезе) и артериальная гипертония. У этих больных чаще диагностированы III и IV функциональный класс ХСН (по NYHA) и сохранная фракция выброса (ФВ) левого желудочка. Сниженная ФВ наблюдалась в 6,8% случаев, а частота «промежуточной» ФВ левого желудочка была достоверно больше, чем среди больных с ХСН и СД, и составила 18,9%. У больных с ХСН и СД в сравнении с больными с ХСН без СД достоверно чаще наблюдались атеросклероз периферических артерий, инсульт (в анамнезе) и хроническая болезнь почек III и IV стадий.
Заключение. На фоне проводимого лечения у больных с ХСН и СД регистрируются более высокие уровни систолического артериального давления, липидов и глюкозы плазмы крови, что свидетельствует о недостаточном качестве лечения и, соответственно, неоптимальном выполнении врачами клинических рекомендаций по лечению этой категории больных.
Ключевые слова: хроническая сердечная недостаточность, сахарный диабет, регистр больных с хронической сердечной недостаточностью, диагностика, лечение.
________________________________________________
Materials and methods. The study was conducted by using the CHF register method, which is a computer program with remote access, which allows on-line data collection on patients who have been examined and treated in primary care and in hospitals. The study included 8272 patients with CHF II–IV FC (functional class) (New York Heart Association – NYHA); among them 62% of patients were treated in hospital.
Results. The study showed that the frequency of diabetes was 21%. The main causes of CHF in diabetic patients are coronary artery disease, myocardial infarction (in anamnesis) and hypertension. These patients are more often diagnosed with III and IV CHF FC according to (NYHA) and retained LV (left ventricular) ejection fraction. The reduced ejection fraction was observed in 6.8% of cases, and the frequency of the “intermediate” LV was significantly higher than among patients with CHF and with diabetes and accounted for 18.9%. At patients with CHF with diabetes in comparison with patients with CHF without diabetes, atherosclerosis of the peripheral arteries, stroke (in anamnesis) and chronic kidney disease of stage III and IV were significantly more common.
Conclusion.Under the treatment, patients with CHF with diabetes have higher levels of SBP (systolic blood pressure), lipids and glucose in the blood plasma, indicating a lack of quality of treatment and, accordingly, the doctors are not optimally performing the clinical guidelines on treating this category of patients.
Keywords: heart failure, diabetes mellitus, register heart failure, diagnostics, treatment.
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5. Herlitz J, Maimberg K, Karlson BW, et al. Mortability and morbidity during a five-year follow-up of diabetics with myocardial infarction. Acta Med Scand. 1988;224(1):31-8.
6. Ostgren CJ, Merlo J, Råstam L, et al. Atrial fibrillation and its association with type 2 diabetes and hypertension in a Swedish community.
Diabetes Obes Metab. 2004;6(5):367-74.
7. Cavender MA, Steg PG, Smith SCJr, et al. Impact of diabetes mellitus on hospitalization for heart failure, cardiovascular events, and death: outcomes at 4 years from the Reduction of Atherothrombosis for Continued Health (REACH) registry. Circulation. 2015:8;132(10):923-31. doi: 10.1161/CIRCULATIONAHA.114.014796
8. McAllister DA, Read S, Kerssens J, et al. Incidence of hospitalisation for heart failure and case-fatality among 3.25 million people with and without diabetes. Circulation. 2018;138(24):2774-86. doi: 10.1161/ CIRCULATIONAHA.118.034986
9. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes d2019. Diabetes Care. 2019;42(Suppl.1):S103-S123. doi: 10.2337/dc19S010
10. Chernikov AA, Severina AS, Shamkhalova MS, Shestakova MV. The role of “metabolic memory” mechanisms in the development and progression of vascular complications of diabetes mellitus. Diabetes mellitus. 2017;20(2):126-34 (In Russ.) doi: 10.14341/7674
11. Iribarren C, Karter AJ, Go AS, et al. Glycemic Control and Heart Failure Among Adult Patients With Diabetes. Circulation. 2001;103:2668-73. doi: 10.1161/01.CIR.103.22.2668
12. Battiprolu PK, Gillette TG, Wang ZV, et al. Diabetic cardiomyopathy: mechanisms and therapeutic targets. Drug Discov Today Dis Mech. 2010;7(2):135-43. doi: 10.1016/j.ddmec.2010.08.001
13. Lawson CA, Jones PW, Teece L, et al. Association Between Type 2 Diabetes and All-Cause Hospitalization and Mortality in the UK General Heart Failure Population: Stratification by Diabetic Glycemic Control and Medication Intensification. JACC Heart Fail. 2018;6(1):18-26. doi: 10.1016/j.jchf.2017.08.020
14. Bjorck LM, Lanitis M, Lappas G, et al. Mortality Trends 1987 to 2004 in 404,480 Hospitalized Heart Failure Patients with and without Diabetes. Circulation. 2012;125:AP208 (Abstract).
15. Vaur L, Gueret P, Lievre M, et al. Development of congestive heart failure in type 2 diabetic patients with microalbuminuria or proteinuria: observations from the DIABHYCAR (type 2 DIABetes, Hypertension, Cardiovascular Events and Ramipril) study. Diabetes Care. 2003;26:855-60. doi: 10.2337/diacare.26.3.855
16. Oshchepkova EV, Lazareva NV, Satlykova DF, Tereshchenko SN. The First Results of the Russian Register of Chronic Heart Failure. Kardiologiya. 2015;5:22-8 (In Russ.)
17. Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37(27):2129–200. doi: 10.1093/eurheartj/ehw128
18. Mareev VY, Fomin IV, Ageev FT, et al. Russian Heart Failure Society, Russian Society of Cardiology. Russian Scientific Medical Society of Internal Medicine Guidelines for Heart failure: chronic (CHF) and acute decompensated (ADHF). Diagnosis, prevention and treatment. Kardiologiia. 2018;58(6S):8-158 (In Russ.) doi: 10.18087/cardio.2475
19. Chazova IE, Oshchepkova EV, Zhernakova IuV. Klinicheskie rekomendatsii "Diagnostika i lechenie arterial'noi gipertonii". Kardiologicheskii vestn. 2015;1:5-30 (In Russ.)
20. MacDonald MR, Petrie MC, Hawkins NM, et al. Diabetes, left ventricular systolic dysfunction, and chronic heart failure. Eur Heart J. 2008;29(10):1224-40. doi: 10.1093/eurheartj/ehn156
21. Thrainsdottir IS, Aspelund T, Thorgeirsson G, et al. The association between glucose abnormalities and heart failure in the population-based Reykjavik study. Diabetes Care. 2005;28(3):612-6. doi: 10.2337/
diacare.28.3.612
22. Win TT, Davis HT, Laskey WK. Mortality among patients hospitalized with heart failure and diabetes mellitus: results from the National Inpatient Sample 2000 to 2010. Circ Heart Fail. 2016;9(5):e003023. doi: 10.1161/CIRCHEARTFAILURE.115.003023
23. Johansson I, Dahlstrom U, Edner M, et al. Risk factors, treatment and prognosis in men and women with heart failure with and without diabetes. Heart. 2015;101(14):1139-48. doi: 10.1136/heartjnl-2014-307131
24. Nichols GA, Hillier TA, Erbey JR, Brown JB. Congestive heart failure in type 2 diabetes: prevalence, incidence, and risk factors. Diabetes Care. 2001;24(9):1614-9.
25. Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321:405-12.
26. Spinar J, Parenica J. Baseline characteristics and hospital mortality in the Acute Heart Failure Database (AHEAD) Main registry. Crit Care. 2011;15(6):291-304. doi: 10.1186/cc10584
27. Hamaguchi S, Kinugawa S. Characteristics, management, and outcomes for patients during hospitalization due to worsening heart failure-A report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-Card). Cardiology. 2013;62(2):95-101. doi: 10.1016/j.jjcc. 2013.03.009
28. Sato N, Kajimoto K, et al. Acute demopensated heart failure syndromes (ATTEND) registry. A prospective observational multicenter cohort study: Rationale, desing, and preliminary data. Am Heart J. 2010;159(6):949-56. doi: 10.1016/j.ahj.2010.03.019
29. Adams Jr KF, Fonarow CC, et al. Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J. 2005;149(2):209-16.
30. Abraham WT, Fonarow GC, et al. Predictor of in-hospital mortality in patients hospitalized for heart failure: insights from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF). J Am Coll Cardiol. 2008;52(5):347-56. doi: 10.1016/j.jacc.2008.04.028
31. Jonsson A, Edner M, Alehagen U, et al. Heart failure register: a valuable tool for improving the management of patients with heart failure. Eur
J Heart Fail. 2010;12:25-31. doi: 10.1093/eurjhf/hfp175
32. Ruiz-Laiglesia FJ, Sanchez-Marteles M, Perez-Calvo JI, et al. Comorbidity in heart failure. Results of the Spanish RICA Register. QJM. 2014;107(12):989-94. doi: 10.1093/qjmed/hcu127
33. Lauthavorn P, Hengrussamee K. Thai acute decompensated heart failure registry (Thai ADHERE). J CVD Prevention Control. 2010;5:89-95. doi: 10.1016/j.cvdpc.2010.06.001
34. Kannel WB, Abbott RD, Savage DD, McNamara PM. Coronary heart disease and atrial fibrillation: The Framingham Study. Am Heart J. 1983;106:389-96. doi: 10.1016/0002-8703(83)90208-9
35. Engstrom CP, Persson LO, Larsson S, Sullivan M. Health-related quality of life in COPD: why both disease-specific and generic measures should be used. Eur Respir J. 2001;18(1):69-76.
36. García-Olmos L, Alberquilla A, Ayala V, et al. Comorbidity in patients with chronic obstructive pulmonary disease in family practice: a cross sectional study. BMC Fam Pract. 2013;14-1. doi: 10.1186/1471-2296-14-11
37. Preobrazhenskiy DV, Vorobev PA, Nekrasova NI, et al. Anemiya u bolnykh s khronicheskoy serdechnoy nedostatochnostyu: rasprostranennost i klinicheskoe znachenie. Klinicheskaya gerontologiya. 2005;10:40-3 (In Russ.)
38. Hatamizadeh P, Fonarow GC, Budoff MJ, et al. Cardiorenal syndrome: pathophysiology and potential targets for clinical management. Nat Rev Nephrol. 2013;9(2):99-111. doi: 10.1038/nrneph.2012.279
39. Khan SS, Xue JL, Kazmi WH, et al. Does predialysis nephrology care influence patient survival after initiation of dialysis? Kidney Int. 2005;67(3):1038-46.
40. Anand I, McMurray J, Whitmore J, et al. Anemia and its relationship to clinical outcome in heart failure. Circulation. 2004;110(2):149-54. doi: 10.1161/01.CIR.0000134279.79571.73
41. Maggioni A, Opasich C, Anand I, et al. Anemia in patients with heart failure: prevalence and prognostic role in a controlled trial and in clinical practice. J Card Fail. 2005;2(11):91-8.
42. Cruz DN, Gheorghiade M, Palazzuoli A, et al. Epidemiology and outcome of the cardio-renal syndrome. Heart Fail Rev. 2011;16(6):531-42. doi: 10.1007/s10741-010-9223-1
43. Giamouzis G, Kalogeropoulos A, Georgiopoulou V, et al. Hospitalization epidemic in patients with heart failure: risk factors, risk prediction, knowledge gaps, and future directions. J Card Fail. 2011;17(1):54-75. doi: 10.1016/j.cardfail.2010.08.010
44. Go AS, Yang J, Ackerson LM, et al. Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: the Anemia in Chronic Heart Failure: Outcomes and Resource Utilization (ANCHOR) Study. Circulation. 2006;113(23):2713-23. doi: 10.1161/CIRCULATIONAHA.105.577577
45. Fonarow GC, Abraham WT, Albert NM, et al. Factors identified as precipitating hospital admissions for heart failure and clinical outcomes: findings from OPTIMIZE-HF. Arch Intern Med. 2008;168:847-54. doi: 10.1001/archinte.168.8.847
46. Steinberg BA, Zhao X, Heidenreich PA, et al. Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes. Circulation. 2012;126(1):65-75. doi: 10.1161/CIRCULATIONAHA.111.080770
47. Casado J, Montero M, Formiga F, et al. Función renal en pacientes con insuficiencia cardiaca:valor pronóstico. Rev Clin Esp. 2012;212(3):119-26.
48. Damman K, Navis G, Voors AA. Worsening renal function and prognosis in heart failure: systematic review and meta-analysis. J Card Fail. 2007;13(8):599608. doi: 10.1016/j.cardfail.2007.04.008
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2. Дедов И.И., Шестакова М.В., Майорова А.Ю. Клинические рекомендации «Алгоритмы специализированной медицинской помощи больным сахарным диабетом». Сахарный диабет. 2019;22(S1). [Dedov II, Shestakova MV, Mayorov AYu. Standards of specialized diabetes. Diabetes mellitus. 2019;22(S1) (In Russ.)]. doi: 10.14341/DM20171S8/
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5. Herlitz J, Maimberg K, Karlson BW, et al. Mortability and morbidity during a five-year follow-up of diabetics with myocardial infarction. Acta Med Scand. 1988;224(1):31-8.
6. Ostgren CJ, Merlo J, Råstam L, et al. Atrial fibrillation and its association with type 2 diabetes and hypertension in a Swedish community.
Diabetes Obes Metab. 2004;6(5):367-74.
7. Cavender MA, Steg PG, Smith SCJr, et al. Impact of diabetes mellitus on hospitalization for heart failure, cardiovascular events, and death: outcomes at 4 years from the Reduction of Atherothrombosis for Continued Health (REACH) registry. Circulation. 2015:8;132(10):923-31. doi: 10.1161/CIRCULATIONAHA.114.014796
8. McAllister DA, Read S, Kerssens J, et al. Incidence of hospitalisation for heart failure and case-fatality among 3.25 million people with and without diabetes. Circulation. 2018;138(24):2774-86. doi: 10.1161/ CIRCULATIONAHA.118.034986
9. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes d2019. Diabetes Care. 2019;42(Suppl.1):S103-S123. doi: 10.2337/dc19S010
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12. Battiprolu PK, Gillette TG, Wang ZV, et al. Diabetic cardiomyopathy: mechanisms and therapeutic targets. Drug Discov Today Dis Mech. 2010;7(2):135-43. doi: 10.1016/j.ddmec.2010.08.001
13. Lawson CA, Jones PW, Teece L, et al. Association Between Type 2 Diabetes and All-Cause Hospitalization and Mortality in the UK General Heart Failure Population: Stratification by Diabetic Glycemic Control and Medication Intensification. JACC Heart Fail. 2018;6(1):18-26. doi: 10.1016/j.jchf.2017.08.020
14. Bjorck LM, Lanitis M, Lappas G, et al. Mortality Trends 1987 to 2004 in 404,480 Hospitalized Heart Failure Patients with and without Diabetes. Circulation. 2012;125:AP208 (Abstract).
15. Vaur L, Gueret P, Lievre M, et al. Development of congestive heart failure in type 2 diabetic patients with microalbuminuria or proteinuria: observations from the DIABHYCAR (type 2 DIABetes, Hypertension, Cardiovascular Events and Ramipril) study. Diabetes Care. 2003;26:855-60. doi: 10.2337/diacare.26.3.855
16. Ощепкова Е.В., Лазарева Н.В., Сатлыкова Д.Ф., Терещенко С.Н. Первые результаты Российского регистра хронической сердечной недостаточности. Кардиология. 2015;5:22-8 [Oshchepkova EV, Lazareva NV, Satlykova DF, Tereshchenko SN. The First Results of the Russian Register of Chronic Heart Failure. Kardiologiya. 2015;5:22-8 (In Russ.)].
17. Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37(27):2129–200. doi: 10.1093/eurheartj/ehw128
18. Мареев В.Ю., Фомин И.В., Агеев Ф.Т. и др. Клинические рекомендации ОССН – РКО – РНМОТ. Сердечная недостаточность: хроническая (ХСН) и острая декомпенсированная (ОДСН). Диагностика, профилактика и лечение. Кардиология. 2018;58(S6) [Mareev VY, Fomin IV, Ageev FT, et al. Russian Heart Failure Society, Russian Society of Cardiology. Russian Scientific Medical Society of Internal Medicine Guidelines for Heart failure: chronic (CHF) and acute decompensated (ADHF). Diagnosis, prevention and treatment. Kardiologiia. 2018;58(6S):8-158 (In Russ.)]. doi: 10.18087/cardio.2475
19. Чазова И.Е., Ощепкова Е.В., Жернакова Ю.В. Клинические рекомендации «Диагностика и лечение артериальной гипертонии». Кардиологический вестн. 2015;1:5-30 [Chazova IE, Oshchepkova EV, Zhernakova IuV. Klinicheskie rekomendatsii "Diagnostika i lechenie arterial'noi gipertonii". Kardiologicheskii vestn. 2015;1:5-30 (In Russ.)].
20. MacDonald MR, Petrie MC, Hawkins NM, et al. Diabetes, left ventricular systolic dysfunction, and chronic heart failure. Eur Heart J. 2008;29(10):1224-40. doi: 10.1093/eurheartj/ehn156
21. Thrainsdottir IS, Aspelund T, Thorgeirsson G, et al. The association between glucose abnormalities and heart failure in the population-based Reykjavik study. Diabetes Care. 2005;28(3):612-6. doi: 10.2337/
diacare.28.3.612
22. Win TT, Davis HT, Laskey WK. Mortality among patients hospitalized with heart failure and diabetes mellitus: results from the National Inpatient Sample 2000 to 2010. Circ Heart Fail. 2016;9(5):e003023. doi: 10.1161/CIRCHEARTFAILURE.115.003023
23. Johansson I, Dahlstrom U, Edner M, et al. Risk factors, treatment and prognosis in men and women with heart failure with and without diabetes. Heart. 2015;101(14):1139-48. doi: 10.1136/heartjnl-2014-307131
24. Nichols GA, Hillier TA, Erbey JR, Brown JB. Congestive heart failure in type 2 diabetes: prevalence, incidence, and risk factors. Diabetes Care. 2001;24(9):1614-9.
25. Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321:405-12.
26. Spinar J, Parenica J. Baseline characteristics and hospital mortality in the Acute Heart Failure Database (AHEAD) Main registry. Crit Care. 2011;15(6):291-304. doi: 10.1186/cc10584
27. Hamaguchi S, Kinugawa S. Characteristics, management, and outcomes for patients during hospitalization due to worsening heart failure-A report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-Card). Cardiology. 2013;62(2):95-101. doi: 10.1016/j.jjcc. 2013.03.009
28. Sato N, Kajimoto K, et al. Acute demopensated heart failure syndromes (ATTEND) registry. A prospective observational multicenter cohort study: Rationale, desing, and preliminary data. Am Heart J. 2010;159(6):949-56. doi: 10.1016/j.ahj.2010.03.019
29. Adams Jr KF, Fonarow CC, et al. Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J. 2005;149(2):209-16.
30. Abraham WT, Fonarow GC, et al. Predictor of in-hospital mortality in patients hospitalized for heart failure: insights from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF). J Am Coll Cardiol. 2008;52(5):347-56. doi: 10.1016/j.jacc.2008.04.028
31. Jonsson A, Edner M, Alehagen U, et al. Heart failure register: a valuable tool for improving the management of patients with heart failure. Eur
J Heart Fail. 2010;12:25-31. doi: 10.1093/eurjhf/hfp175
32. Ruiz-Laiglesia FJ, Sanchez-Marteles M, Perez-Calvo JI, et al. Comorbidity in heart failure. Results of the Spanish RICA Register. QJM. 2014;107(12):989-94. doi: 10.1093/qjmed/hcu127
33. Lauthavorn P, Hengrussamee K. Thai acute decompensated heart failure registry (Thai ADHERE). J CVD Prevention Control. 2010;5:89-95. doi: 10.1016/j.cvdpc.2010.06.001
34. Kannel WB, Abbott RD, Savage DD, McNamara PM. Coronary heart disease and atrial fibrillation: The Framingham Study. Am Heart J. 1983;106:389-96. doi: 10.1016/0002-8703(83)90208-9
35. Engstrom CP, Persson LO, Larsson S, Sullivan M. Health-related quality of life in COPD: why both disease-specific and generic measures should be used. Eur Respir J. 2001;18(1):69-76.
36. García-Olmos L, Alberquilla A, Ayala V, et al. Comorbidity in patients with chronic obstructive pulmonary disease in family practice: a cross sectional study. BMC Fam Pract. 2013;14-1. doi: 10.1186/1471-2296-14-11
37. Преображенский Д.В., Воробьев П.А., Некрасова Н.И. и др. Анемия у больных с хронической сердечной недостаточностью: распространенность и клиническое значение. Клиническая геронтология. 2005;10:40-3 [Preobrazhenskiy DV, Vorobev PA, Nekrasova NI, et al. Anemiya u bolnykh s khronicheskoy serdechnoy nedostatochnostyu: rasprostranennost i klinicheskoe znachenie. Klinicheskaya gerontologiya. 2005;10:40-3 (In Russ.)].
38. Hatamizadeh P, Fonarow GC, Budoff MJ, et al. Cardiorenal syndrome: pathophysiology and potential targets for clinical management. Nat Rev Nephrol. 2013;9(2):99-111. doi: 10.1038/nrneph.2012.279
39. Khan SS, Xue JL, Kazmi WH, et al. Does predialysis nephrology care influence patient survival after initiation of dialysis? Kidney Int. 2005;67(3):1038-46.
40. Anand I, McMurray J, Whitmore J, et al. Anemia and its relationship to clinical outcome in heart failure. Circulation. 2004;110(2):149-54. doi: 10.1161/01.CIR.0000134279.79571.73
41. Maggioni A, Opasich C, Anand I, et al. Anemia in patients with heart failure: prevalence and prognostic role in a controlled trial and in clinical practice. J Card Fail. 2005;2(11):91-8.
42. Cruz DN, Gheorghiade M, Palazzuoli A, et al. Epidemiology and outcome of the cardio-renal syndrome. Heart Fail Rev. 2011;16(6):531-42. doi: 10.1007/s10741-010-9223-1
43. Giamouzis G, Kalogeropoulos A, Georgiopoulou V, et al. Hospitalization epidemic in patients with heart failure: risk factors, risk prediction, knowledge gaps, and future directions. J Card Fail. 2011;17(1):54-75. doi: 10.1016/j.cardfail.2010.08.010
44. Go AS, Yang J, Ackerson LM, et al. Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: the Anemia in Chronic Heart Failure: Outcomes and Resource Utilization (ANCHOR) Study. Circulation. 2006;113(23):2713-23. doi: 10.1161/CIRCULATIONAHA.105.577577
45. Fonarow GC, Abraham WT, Albert NM, et al. Factors identified as precipitating hospital admissions for heart failure and clinical outcomes: findings from OPTIMIZE-HF. Arch Intern Med. 2008;168:847-54. doi: 10.1001/archinte.168.8.847
46. Steinberg BA, Zhao X, Heidenreich PA, et al. Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes. Circulation. 2012;126(1):65-75. doi: 10.1161/CIRCULATIONAHA.111.080770
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60. McGuire DK, Van de Werf F, Armstrong PW, et al. Association Between Sitagliptin Use and Heart Failure Hospitalization and Related Outcomes in Type 2 Diabetes Mellitus: Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. 2016;1(2):126-35. doi: 10.1001/jamacardio. 2016.0103
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62. Mahaffey KW, Neal B, Perkovic V, et al. Canagliflozin for Primary and Secondary Prevention of Cardiovascular Events: Results From the CANVAS Program (Canagliflozin Cardiovascular Assessment Study). Circulation. 2018;137(4):323-34. doi: 10.1161/CIRCULATIONAHA. 117.032038
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Авторы
Н.В. Лазарева, Е.В. Ощепкова, А.А. Орловский, С.Н. Терещенко
ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России, Москва, Россия
National Medical Research Center for Cardiology, Moscow, Russia
ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России, Москва, Россия
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National Medical Research Center for Cardiology, Moscow, Russia
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