Вариабельность артериального давления у пациентов на программном гемодиализе: прогностическая значимость и возможности медикаментозной коррекции

1. US Renal Data System. USRDS 2018 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. 2018;2:228.
2. Albeshri MA, Alsallum MS, Sindi S, et al. Hospitalization rate and outcomes in patients with left ventricular dysfunction receiving hemodialysis. Int J Gen Med. 2018;11:463-72. doi: 10.2147/IJGM.S179206
3. Mavrakanas TA, Charytan DM. Cardiovascular complications in chronic dialysis patients. Curr Opin Nephrol Hypertens. 2016;25(6):536-44. doi: 10.1097/MNH.0000000000000280
4. Quarles LD. Reducing cardiovascular mortality in chronic kidney disease: something borrowed, something new. J Clin Invest. 2013;123(2):542-3. doi: 10.1172/JCI67203
5. Горбунов В.М. Современные представления о вариабельности артериального давления. Рациональная фармакотерапия в кардиологии. 2012;8(6):810-8 [Gorbunov VM. Modern views on the variability of blood pressure. Rational Pharmacotherapy in Cardiology. 2012;8(6): 810-8 (In Russ.)]. doi: 10.20996/1819-6446-2012-8-6-810-818
6. Остроумова О.Д., Борисова Е.В., Павлеева Е.Е. Вариабельность артериального давления. Межвизитная вариабельность артериального давления. Кардиология. 2017;57(11):68-75. [Ostroumova OD, Borisova EV, Pavleeva EE. Blood Pressure Variability. Visit-to-Visit Blood Pressure Variability. Kardiologiia. 2017;57(11):68-75 (In Russ.)] doi: 10087/cardio.2017.11.10056
7. Троицкая Е.А., Котовская Ю.В., Кобалава Ж.Д. Эволюция представлений о значении вариабельности артериального давления. Артериальная гипертензия. 2013;19(1):6-17 [Troitskaya EA., Kotovskaya YV, Kobalava ZD. Evolution of the views on importance of blood pressure variability. Arterial’naya Gipertenziya. 2013;19(1):6-17 
(In Russ.)]. doi: 10.18705/1607-419X-2013-19-1-6-17
8. Flythe JE, Brunelli SM. Blood pressure variability among chronic dialysis patients: recent advances in knowledge. Curr Opin Nephrol Hypertens. 2015;24(2):163-9. doi: 10.1097/MNH.0000000000000107
9. Rothwell PM. Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension. Lancet. 2010;375(9718):938-48. doi: 10.1016/S0140-6736(10)60309-1
10. Kramer A, Pippias M, Noordzij M, et al. The European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) Registry Annual Report 2016: a summary. Clin Kidney J. 2019;12(5):702-20. doi: 10.1093/ckj/sfz011
11. Rubinger D, Backenroth R, Sapoznikov D. Sympathetic Nervous System Function and Dysfunction in Chronic Hemodialysis Patients. Semin Dial. 2013;26(3):333-43. doi: 10.1111/sdi.12093
12. Gutiérrez-Adrianzén OA, Moraes ME, Almeida AP, et al. Pathophysiological, cardiovascular and neuroendocrine changes in hypertensive patients during the hemodialysis session. J Hum Hypertens. 2015;29(6):366-72. doi: 10.1038/jhh.2014.93
13. Karpetas A, Loutradis C, Bikos A, et al. Blood pressure variability is increasing from the first to the second day of the interdialytic interval in hemodialysis patients. J Hypertens. 2017;35(12):2517-26. doi: 10.1097/HJH.0000000000001478
14. Wang JG, Yan P, Jeffers BW. Effects of amlodipine and other classes of antihypertensive drugs on long-term blood pressure variability: evidence from randomized controlled trials. J Am Soc Hypertens. 2014;8(5):340-9. doi: 10.1016/j.jash.2014.02.004
15. Rossignol P, Cridlig J, Lehert P, et al. Visit-to-visit blood pressure variability is a strong predictor of cardiovascular events in hemodialysis: insights from FOSIDIAL. Hypertension. 2012;60(2):339-46. doi: 10.1161/HYPERTENSIONAHA.111.190397
16. Juhanoja EP, Niiranen TJ, Johansson JK, et al. Outcome-Driven Thresholds for Increased Home Blood Pressure Variability. Hypertension. 2017;69(4):599-607. doi: 10.1161/HYPERTENSIONAHA.116.08603
17. Stevens SL, Wood S, Koshiaris C, et al. Blood pressure variability and cardiovascular disease: systematic review and meta-analysis. BMJ. 2016;354:i4098. doi: 10.1136/bmj.i4098
18. Feng Y, Li Z, Liu J, et al. Association of short-term blood pressure variability with cardiovascular mortality among incident hemodialysis patients. Ren Fail. 2018;40(1):259-64. doi: 10.1080/0886022X.
2018.1456456
19. Liao R, Li J, Xiong Y, et al. Association of Peridialysis Blood Pressure and Its Variability with Cardiovascular Events in Hemodialysis Patients. Kidney Blood Press Res. 2018;43(4):1352-62. doi: 10.1159/000492595
20. Selvarajah V, Pasea L, Ojha S, et al. Pre-Dialysis Systolic Blood Pressure-Variability Is Independently Associated with All-Cause Mortality in Incident Haemodialysis Patients. PLoS One. 2014;9(1):e86514. doi: 10.1371/journal.pone.0086514
21. Norioka N, Iwata S, Yanagi S, et al. Higher visit-to-visit intra-dialytic blood pressure is associated with the progression of aortic valve stenosis in chronic hemodialysis patients. Heart Vessels. 2016;31(9):1491-6. doi: 10.1007/s00380-015-0756-z
22. Cheng Y, Zhang F, Zhu J, et al. Influence of blood pressure variability on the life of arteriovenous fistulae in maintenance hemodialysis patients. Clin Hemorheol Microcirc. 2016;62(2):129-37. doi: 10.3233/CH-151959
23. Flythe JE, Brunelli SM. Blood pressure variability and dialysis: variability may not always be the spice of life. J Am Soc Nephrol. 2014;25(4):650-3. doi: 10.1681/ASN.2013111237
24. Shafi T, Sozio SM, Bandeen-Roche K, et al. DEcIDE Network Patient Outcomes in End Stage Renal Disease Study Investigators. Predialysis Systolic BP Variability and Outcomes in Hemodialysis Patients. J Am Soc Nephrol. 2014;25(4):799-809. doi: 10.1681/ASN.2013060667
25. Umemoto S, Ogihara T, Matsuzaki M, et al. Effects of calcium channel blocker-based combinations on intra-individual blood pressure variability: post hoc analysis of the COPE trial. Hypertens Res. 2016;39(1):46-53. doi: 10.1038/hr.2015.104
26. Loutradis C, Bikos A, Raptis V, et al. Nebivolol reduces short-term blood pressure variability more potently than irbesartan in patients with intradialytic hypertension. Hypertens Res. 2019;42(7):1001-10. doi: 10.1038/s41440-018-0194-2
27. Chang TI, Flythe JE, Brunelli SM, et al. Visit-to-visit systolic blood pressure variability and outcomes in hemodialysis. J Hum Hypertens. 2014;28(1):18-24. doi: 10.1038/jhh.2013.49
28. Wang Y, Qin Y, Fan X, et al. Variability in Predialysis Systolic Blood Pressure and Long-Term Outcomes in Hemodialysis Patients. Kidney Blood Press Res. 2018;43(1):115-24. doi: 10.1159/000487111

________________________________________________

1. US Renal Data System. USRDS 2018 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. 2018;2:228.
2. Albeshri MA, Alsallum MS, Sindi S, et al. Hospitalization rate and outcomes in patients with left ventricular dysfunction receiving hemodialysis. Int J Gen Med. 2018;11:463-72. doi: 10.2147/IJGM.S179206
3. Mavrakanas TA, Charytan DM. Cardiovascular complications in chronic dialysis patients. Curr Opin Nephrol Hypertens. 2016;25(6):536-44. doi: 10.1097/MNH.0000000000000280
4. Quarles LD. Reducing cardiovascular mortality in chronic kidney disease: something borrowed, something new. J Clin Invest. 2013;123(2):542-3. doi: 10.1172/JCI67203
5. Gorbunov VM. Modern views on the variability of blood pressure. Rational Pharmacotherapy in Cardiology. 2012;8(6): 810-8 (In Russ.) doi: 10.20996/1819-6446-2012-8-6-810-818
6. Ostroumova OD, Borisova EV, Pavleeva EE. Blood Pressure Variability. Visit-to-Visit Blood Pressure Variability. Kardiologiia. 2017;57(11):68-75 (In Russ.) doi: 10087/cardio.2017.11.10056
7. Troitskaya EA., Kotovskaya YV, Kobalava ZD. Evolution of the views on importance of blood pressure variability. Arterial’naya Gipertenziya. 2013;19(1):6-17 
(In Russ.) doi: 10.18705/1607-419X-2013-19-1-6-17
8. Flythe JE, Brunelli SM. Blood pressure variability among chronic dialysis patients: recent advances in knowledge. Curr Opin Nephrol Hypertens. 2015;24(2):163-9. doi: 10.1097/MNH.0000000000000107
9. Rothwell PM. Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension. Lancet. 2010;375(9718):938-48. doi: 10.1016/S0140-6736(10)60309-1
10. Kramer A, Pippias M, Noordzij M, et al. The European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) Registry Annual Report 2016: a summary. Clin Kidney J. 2019;12(5):702-20. doi: 10.1093/ckj/sfz011
11. Rubinger D, Backenroth R, Sapoznikov D. Sympathetic Nervous System Function and Dysfunction in Chronic Hemodialysis Patients. Semin Dial. 2013;26(3):333-43. doi: 10.1111/sdi.12093
12. Gutiérrez-Adrianzén OA, Moraes ME, Almeida AP, et al. Pathophysiological, cardiovascular and neuroendocrine changes in hypertensive patients during the hemodialysis session. J Hum Hypertens. 2015;29(6):366-72. doi: 10.1038/jhh.2014.93
13. Karpetas A, Loutradis C, Bikos A, et al. Blood pressure variability is increasing from the first to the second day of the interdialytic interval in hemodialysis patients. J Hypertens. 2017;35(12):2517-26. doi: 10.1097/HJH.0000000000001478
14. Wang JG, Yan P, Jeffers BW. Effects of amlodipine and other classes of antihypertensive drugs on long-term blood pressure variability: evidence from randomized controlled trials. J Am Soc Hypertens. 2014;8(5):340-9. doi: 10.1016/j.jash.2014.02.004
15. Rossignol P, Cridlig J, Lehert P, et al. Visit-to-visit blood pressure variability is a strong predictor of cardiovascular events in hemodialysis: insights from FOSIDIAL. Hypertension. 2012;60(2):339-46. doi: 10.1161/HYPERTENSIONAHA.111.190397
16. Juhanoja EP, Niiranen TJ, Johansson JK, et al. Outcome-Driven Thresholds for Increased Home Blood Pressure Variability. Hypertension. 2017;69(4):599-607. doi: 10.1161/HYPERTENSIONAHA.116.08603
17. Stevens SL, Wood S, Koshiaris C, et al. Blood pressure variability and cardiovascular disease: systematic review and meta-analysis. BMJ. 2016;354:i4098. doi: 10.1136/bmj.i4098
18. Feng Y, Li Z, Liu J, et al. Association of short-term blood pressure variability with cardiovascular mortality among incident hemodialysis patients. Ren Fail. 2018;40(1):259-64. doi: 10.1080/0886022X.
2018.1456456
19. Liao R, Li J, Xiong Y, et al. Association of Peridialysis Blood Pressure and Its Variability with Cardiovascular Events in Hemodialysis Patients. Kidney Blood Press Res. 2018;43(4):1352-62. doi: 10.1159/000492595
20. Selvarajah V, Pasea L, Ojha S, et al. Pre-Dialysis Systolic Blood Pressure-Variability Is Independently Associated with All-Cause Mortality in Incident Haemodialysis Patients. PLoS One. 2014;9(1):e86514. doi: 10.1371/journal.pone.0086514
21. Norioka N, Iwata S, Yanagi S, et al. Higher visit-to-visit intra-dialytic blood pressure is associated with the progression of aortic valve stenosis in chronic hemodialysis patients. Heart Vessels. 2016;31(9):1491-6. doi: 10.1007/s00380-015-0756-z
22. Cheng Y, Zhang F, Zhu J, et al. Influence of blood pressure variability on the life of arteriovenous fistulae in maintenance hemodialysis patients. Clin Hemorheol Microcirc. 2016;62(2):129-37. doi: 10.3233/CH-151959
23. Flythe JE, Brunelli SM. Blood pressure variability and dialysis: variability may not always be the spice of life. J Am Soc Nephrol. 2014;25(4):650-3. doi: 10.1681/ASN.2013111237
24. Shafi T, Sozio SM, Bandeen-Roche K, et al. DEcIDE Network Patient Outcomes in End Stage Renal Disease Study Investigators. Predialysis Systolic BP Variability and Outcomes in Hemodialysis Patients. J Am Soc Nephrol. 2014;25(4):799-809. doi: 10.1681/ASN.2013060667
25. Umemoto S, Ogihara T, Matsuzaki M, et al. Effects of calcium channel blocker-based combinations on intra-individual blood pressure variability: post hoc analysis of the COPE trial. Hypertens Res. 2016;39(1):46-53. doi: 10.1038/hr.2015.104
26. Loutradis C, Bikos A, Raptis V, et al. Nebivolol reduces short-term blood pressure variability more potently than irbesartan in patients with intradialytic hypertension. Hypertens Res. 2019;42(7):1001-10. doi: 10.1038/s41440-018-0194-2
27. Chang TI, Flythe JE, Brunelli SM, et al. Visit-to-visit systolic blood pressure variability and outcomes in hemodialysis. J Hum Hypertens. 2014;28(1):18-24. doi: 10.1038/jhh.2013.49
28. Wang Y, Qin Y, Fan X, et al. Variability in Predialysis Systolic Blood Pressure and Long-Term Outcomes in Hemodialysis Patients. Kidney Blood Press Res. 2018;43(1):115-24. doi: 10.1159/000487111

А.С. Токарева, Н.Ю. Боровкова

ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России, Нижний Новгород, Россия

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A.S. Tokareva, N.Yu. Borovkova

Privolzhsky Research Medical University, Nizhny Novgorod, Russia