Психические расстройства и когнитивные нарушения у больных антифосфолипидным синдромом
Психические расстройства и когнитивные нарушения у больных антифосфолипидным синдромом
Борисова А.Б., Лисицына Т.А., Вельтищев Д.Ю. и др. Психические расстройства и когнитивные нарушения у больных антифосфолипидным синдромом. Терапевтический архив. 2020; 92 (5): 92–103. DOI: 10.26442/00403660.2020.05.000625
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Borisova A.B., Lisitsyna T.A., Veltishchev D.Yu., et al. Mental disorders and cognitive impairment in patients with antiphospholipid syndrome. Therapeutic Archive. 2020; 92 (5): 92–103. DOI: 10.26442/00403660.2020.05.000625
Психические расстройства и когнитивные нарушения у больных антифосфолипидным синдромом
Борисова А.Б., Лисицына Т.А., Вельтищев Д.Ю. и др. Психические расстройства и когнитивные нарушения у больных антифосфолипидным синдромом. Терапевтический архив. 2020; 92 (5): 92–103. DOI: 10.26442/00403660.2020.05.000625
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Borisova A.B., Lisitsyna T.A., Veltishchev D.Yu., et al. Mental disorders and cognitive impairment in patients with antiphospholipid syndrome. Therapeutic Archive. 2020; 92 (5): 92–103. DOI: 10.26442/00403660.2020.05.000625
Психические расстройства (преимущественно расстройства тревожно-депрессивного спектра) и когнитивные нарушения часто встречаются у пациентов с антифосфолипидным синдромом (АФС), однако их распространенность, структура и механизмы возникновения недостаточно изучены. В обзоре приведены данные литературы о частоте, спектре и возможных причинах психических расстройств и когнитивных нарушений у больных АФС, патогенетических механизмах этих нарушений, в частности – важной роли антифосфолипидных антител, стрессовых факторов, хронического воспаления, рассмотрен вопрос взаимосвязи АФС и психических расстройств, а также когнитивных нарушений. Отдельное внимание уделено влиянию психических расстройств и когнитивных нарушений на приверженность пациентов лечению, качество их жизни, а также особенностям психофармакотерапии психических расстройств у больных АФС. Целью обзора является актуализация междисциплинарной проблемы психических расстройств и когнитивных нарушений у пациентов с АФС и необходимости внедрения партнерской модели помощи.
Mental disorders (mainly anxiety and depressive disorders) and cognitive impairment are often found in patients with antiphospholipid syndrome (APS), but their prevalence, structure, and mechanisms of occurrence are not well researched. The review provides literature data on the frequency, spectrum and possible causes of mental disorders and cognitive impairment in patients with APS, the pathogenetic mechanisms of these disorders (in particular, the important role of antiphospholipid antibodies, stress factors, chronic inflammation), the relationship between APS, mental disorders and as well as cognitive impairment is examined. Special attention is paid to the influence of mental disorders and cognitive impairment on patients' adherence to treatment, their quality of life, as well as the particularities of psychopharmacotherapy of mental disorders in patients with APS. The aim of the review is to actualize the interdisciplinary problem of mental disorders and cognitive impairment in patients with APS and the need to introduce a partnership model of care.
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1 Московский научно-исследовательский институт психиатрии – филиал ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии им. В.П. Сербского» Минздрава России, Москва, Россия;
2 ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», Москва, Россия;
3 ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия;
4 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
1 Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction,
Moscow, Russia;
2 Nasonova Research Institute of Rheumatology, Moscow, Russia;
3 Pirogov Russian National Research Medical University, Moscow, Russia;
4 Russian Medical Academy of Continuous Professional Education, Moscow, Russia