1. Ивашкин В.Т., Шелыгин Ю.А., Баранская Е.К. и др. Клинические рекомендации Российской гастроэнтерологической ассоциации и Ассоциации колопроктологов России по диагностике и лечению синдрома раздраженного кишечника. Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. 2017;27(5):76-93 [Ivashkin VT, Shelygin YuA, Baranskaya EK, et al. Clinical recommendations of the Russian gastroenterological Association and the Association of coloproctologists of Russia for the diagnosis and treatment of irritable bowel syndrome. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2017;27(5):76-93 (In Russ.)].
2. Саблин О.А., Ильчишина Т.А. Cиндром раздраженного кишечника: обзор Римских критериев IV с позиции российских клиницистов. Экспериментальная и клиническая гастроэнтерология. 2016;12(136):92-100 [Sablin OA, Ilchishina TA. Irritable bowel Syndrome: review of Roman criteria IV from the position of Russian clinicians. Experimental and clinical gastroenterology. 2016;12(136):92-100 (In Russ.)].
3. Chey WD, Kurlander J, Eswaran S. Irritable bowel syndrome: a clinical review. JAMA. 2015;313(9):949-58. doi: 10.1001/jama.2015.0954
4. Altobelli E, Del Negro V, Angeletti PM, Latella G. Low-FODMAP diet improves irritable bowel syndrome symptoms: A meta-analysis. Nutrients. 2017;9:940. doi:10.3390/nu9090940
5. Hayes PA, Fraher MH, Quigley EM. Irritable bowel syndrome: the role of food in pathogenesis and management. Gastroenterol Hepatol (NY). 2014;10:164-74.
6. Cordain L, Eaton SB, Sebastian A, et al. Origins and evolution of the Western diet: Health implications for the 21st century. Am J Clin Nutr. 2005;81:341-54. doi: 10.1038/ajg.2013.105
7. Monsbakken KW, Vandvik PO, Farup PG. Perceived food intolerance in subjects with irritable bowel syndrome – Etiology, prevalence and consequences. Eur J Clin Nutr. 2006;60:667-72. doi: 10.1038 / sj.ejcn.1602367
8. Reding KW, Cain KC, Jarrett ME, et al. Relationship between Patterns of Alcohol Consumption and Gastrointestinal Symptoms among Patients with Irritable Bowel Syndrome. Am J Gastroenterol. 2013;108(2):270-6. doi: 10.1038/ajg.2012.414
9. Camilleri M. Management Options for Irritable Bowel Syndrome. Mayo Clin Proc. 2018;93(12):1858-72. doi: 10.1016/j.mayocp.2018.04.032
10. Soltani S, Hassanzadeh Keshteli A, Esmaillzadeh A, Adibi P. Food Item Avoidance of Patients with Irritable Bowel Syndrome Compared with Healthy People. Iran Med. 2019;22(7):369-75.
11. Tuck CJ, Vanner SJ. Dietary therapies for functional bowel symptoms: Recent advances, challenges, and future directions. Neurogastroenterol Motil. 2018;30:132-8. doi: 10.1111/nmo.13238
12. Cozma-Petruţ A, Loghin F, Miere D, Dumitraşcu DL. Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients! World J Gastroenterol. 2017;23(21):3771-83. doi: 10.3748/wjg.v23.i21.3771
13. Ford AC, Moayyedi P, Lacy BE, et al. American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. Am J Gastroenterol. 2014;109:2-26. doi: 10.1038/ajg.2014.187
14. Moayyedi P, Andrews CN, MacQueen G, et al. Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Irritable Bowel Syndrome (IBS). J Can Assoc Gastroenterol. 2019;1:6-29. doi: 10.1093/jcag/gwy071
15. Практические рекомендации Всемирной гастроэнтерологической организации «Синдром раздраженного кишечника: глобальная перспектива». Обновление. 2015 [Practical Recommendations of the world Gastroenterological Organization "Irritable bowel Syndrome: a global perspective". Update. 2015 (In Russ.)]. doi: 10.1097/MCG.0000000000000653
16. Moayyedi P, Quigley EM, Lacy BE, et al. The Effect of Dietary Intervention on Irritable Bowel Syndrome: A Systematic Review. Clin Transl Gastroenterol. 2015;6:107. doi: 10.1038/ctg.2015.21
17. Певзнер М.И. Основы лечебного питания. М.: Медгиз, 1958 [Pevsner MI. Fundamentals of therapeutic nutrition. Moscow: Medgiz, 1958 (In Russ.)].
18. Pavlidou E. Wine: An Aspiring Agent in Promoting Longevity and Preventing Chronic Diseases. Diseases. 2018;6(3):73. doi: 10.3390/diseases6030073
19. Keys A, Menotti A, Aravanis C, et al. The Seven Countries Study: 2289 Deaths in 15 Years. Prev Med. 1984;13:141-54. doi: 10.1093/oxfordjournals.aje.a114480
20. McKenzie YA, Bowyer RK, Leach H, et al. British Dietetic Association systematic review and evidence-based practice guidelines for the dietary management of irritable bowel syndrome in adults (2016 update). J Hum Nutr Diet. 2016;29:549-75. doi: 10.1111/jhn.12385
21. McKenzie YA, Alder A, Anderson W,  et al. British Dietetic Association evidence-based guidelines for the dietary management of irritable bowel syndrome in adults. J Hum Nutr Dietetics. 2012;25(3):260-74. doi: 10.1111/j.1365-277X.2012.01242.x
22. Gonlachanvit S. Are rice and spicy diet good for functional gastrointestinal disorders? J Neurogastroenterol Motil. 2010;16:131-8. doi: 10.5056/jnm.2010.16.2.131
23. Gonlachanvit S, Mahayosnond A, Kullavanijaya P. Effects of chili on postprandial gastrointestinal symptoms in diarrhoea predominant irritable bowel syndrome: evidence for capsaicin-sensitive visceral nociception hypersensitivity. Neurogastroenterol Motil. 2009;21:23-32. doi: 10.1111/j.1365-2982.2008.01167.x
24. Esmaillzadeh A, Keshteli AH, Hajishafiee M, et al. Consumption of spicy foods and the prevalence of irritable bowel syndrome. World J Gastroenterol. 2013;19:6465-71. doi: 10.3748/wjg.v19.i38.6465
25. Simrén M, Abrahamsson H, Björnsson ES. Lipid-induced colonic hypersensitivity in the irritable bowel syndrome: the role of bowel habit, sex, and psychologic factors. Clin Gastroenterol Hepatol. 2007;5:201-8. doi: 10.1016/j.cgh.2006.09.032
26. Caldarella MP, Milano A, Laterza F, et al. Visceral sensitivity and symptoms in patients with constipation- or diarrhea-predominant irritable bowel syndrome (IBS): effect of a low-fat intraduodenal infusion. Am J Gastroenterol. 2005;100:383-9. doi: 10.1111/j.1572-0241.2005.40100.x
27. Michalak A, Mosińska P, Fichna J. Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer. Front Pharmacol. 2016;7:459. doi: 10.3389/fphar.2016.00459
28. McRorie JW. Evidence-Based Approach to Fiber Supplements and Clinically Meaningful Health Benefits, Part 1: What to Look for and How to Recommend an Effective Fiber Therapy. Nutr Today. 2015;50:82-9. doi: 10.1097/NT.0000000000000082
29. Eswaran S, Muir J, Chey WD. Fiber and Functional Gastrointestinal Disorders. Am J Gastroenterol. 2013;108:718-27. doi: 10.1038/ajg.2013.63
30. Bijkerk CJ, de Wit NJ, Muris JW, et al. Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial. BMJ. 2009;339:b3154. doi: 10.1136/bmj.b3154
31. Lee SM, Han HW, Yim SY. Beneficial effects of soy milk and fiber on high cholesterol diet-induced alteration of gut microbiota and inflammatory gene expression in rats. Food Funct. 2015;6(2):492-500. doi: 10.1039/c4fo00731j
32. Rona RJ, Keil T, Summers C, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol. 2007;120:638-46. doi: 10.1016/j.jaci.2007.05.026
33. Biesiekierski JR, Iven J. Non-coeliac gluten sensitivity: piecing the puzzle together. United European Gastroenterol J. 2015;3:160-5. doi: 10.1177/2050640615578388
34. Парфенов А.И., Быкова С.В., Сабельникова Е.А. и др. Всероссийский консенсус по диагностике и лечению целиакии у детей и взрослых. Терапевтический архив. 2017;89(3):94-107 [Parfenov AI, Bikova SV, Sabelnikova EA, et al. All-Russian consensus on the diagnosis and treatment of celiac disease in children and adults. Therapeutic archive. 2017;89(3):94-107 (In Russ.)]. doi: 10.17116/terarkh201789394-107
35. Gaesser GA, Angadi SS. Gluten-free diet: Imprudent dietary advice for the general population? J Acad Nutr Diet. 2012;112(9):1330-3. doi: 10.1016/j.jand.2012.06.009
36. Wild D, Robins GG, Burley VJ, et al. Evidence of high sugar intake, and low fibre and mineral intake, in the gluten-free diet. Aliment Pharmacol Ther. 2010;32(4):573-81. doi: 10.1111/j.1365-2036.2010.04386.x
37. Lee AR, Ng DL, Zivin J, et al. Economic burden of a gluten-free diet. 
J Hum Nutr Diet. 2007;20(5):423-30. doi: 10.1111/j.1365-277X.2007.00763.x
38. Кодекс Алиментариус. Органические пищевые продукты. М.: Весь мир, 2006; с. 74 [Codex Alimentarius. Organic food products. Moscow: All the world, 2006; p. 74 (In Russ).]
39. Marsh A, Eslick EM, Eslick GD. Does a diet low in FODMAPs reduce symptoms associated with functional gastrointestinal disorders? A comprehensive systematic review and meta-analysis. Eur J Nutr. 2016;55:897-906. doi: 10.1007/s00394-015-0922-1
40. Dionne J, Ford AC, Yuan Y, et al. A Systematic Review and Meta-Analysis Evaluating the Efficacy of a Gluten-Free Diet and a Low FODMAPs Diet in Treating Symptoms of Irritable Bowel Syndrome. Am J Gastroenterol. 2018;113(9):1290-300. doi: 10.1038/s41395-018-0195-4
41. Rej A, Avery A, Ford AC, et al. Clinical Application of Dietary Therapies in Irritable Bowel Syndrome. J Gastrointestin Liver Dis. 2018;27(3):307-16. doi: 10.15403/jgld.2014.1121.273.avy
42. Biesiekierski JR, Newnham ED, Irving PM, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol. 2011;106:508-14. doi: 10.1038/ajg.2010.487
43. Aziz I, Trott N, Briggs R, et al. Efficacy of a gluten-free diet in subjects with irritablebowel syndrome-diarrhea unaware of their HLA-DQ2/8 geno-type. Clin Gastroenterol Hepatol. 2016;14:696-703. doi: 10.1016/j.cgh.2015.12.031
44. Barmeyer C, Schumann M, Meyer T, et al. Long-term response to gluten-free diet as evidence for non-celiac wheat sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome. Int J Colorectal Dis. 2017;32:29-39. doi: 10.1007/s00384-016-2663-x
45. Vazquez-Roque MI, Camilleri M, Smyrk T, et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology. 2013;144:903-11. doi: 10.1053/j.gastro.2013.01.049
46. Pinto-Sanchez MI, Verd EF. Non-coeliac gluten sensitivity:are we closer to separating the wheat from the chaff? Gut. 2016;65:1921-2. doi: 10.1136/gutjnl-2016-312471
47. Skodje GI, Sarna VK, Minelle IH, et al. Fructan, Rather Than Gluten, induces symptoms in patients with self-reported nonceliac gluten sensitivity. Gastroenterology. 2018;154:529-39. doi: 10.1053/j.gastro.2017.10.040
48. Biesiekierski JR, Peters SL, Newnham ED, et al. No effects of gluten in patients with selfreported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology. 2013;145:320-8. doi: 10.1053/j.gastro.2013.04.051
49. Bonder MJ, Tigchelaar EF, Cai X, et al. The influence of a short-term gluten-free diet on the human gut microbiome. Genome Med. 2016;8:45. doi: 10.1186/s13073-016-0295-у
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51. Rumessen JJ, Gudmand-Høyer E. Fructans of chicory: Intestinal transport and fermentation of different chain lengths and relation to fructose and sorbitol malabsorption. Am J Clin Nutr. 1998;68:357-64. doi: 10.1093/ajcn / 68.2.357
52. Shepherd SJ, Parker FC, Muir JG, et al. Dietary triggers of abdominal symptoms in patients with irritable bowel syndrome: randomized placebo-controlled evidence. Clin Gastroenterol Hepatol. 2008;6:765-71. doi: 10.1016/j.cgh.2008.02.058
53. Briet F, Achour L, Flourié B, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr. 1995;49:501-7.
54. Halmos EP, Power VA, Shepherd SJ, et al. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology. 2014;146:67-75. doi: 10.1053/j.gastro.2013.09.046
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56. Gibson PR, Shepherd SJ. Personal view: food for thought-western lifestyle and susceptibility to Crohn's disease. The FODMAP hypothesis. Aliment Pharmacol Ther. 2005;21(12):1399-409. doi: 10.1111/j.1365-2036.2005.02506.x
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________________________________________________

1. Ivashkin VT, Shelygin YuA, Baranskaya EK, et al. Clinical recommendations of the Russian gastroenterological Association and the Association of coloproctologists of Russia for the diagnosis and treatment of irritable bowel syndrome. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2017;27(5):76-93 (In Russ.)
2. Sablin OA, Ilchishina TA. Irritable bowel Syndrome: review of Roman criteria IV from the position of Russian clinicians. Experimental and clinical gastroenterology. 2016;12(136):92-100 (In Russ.)
3. Chey WD, Kurlander J, Eswaran S. Irritable bowel syndrome: a clinical review. JAMA. 2015;313(9):949-58. doi: 10.1001/jama.2015.0954
4. Altobelli E, Del Negro V, Angeletti PM, Latella G. Low-FODMAP diet improves irritable bowel syndrome symptoms: A meta-analysis. Nutrients. 2017;9:940. doi:10.3390/nu9090940
5. Hayes PA, Fraher MH, Quigley EM. Irritable bowel syndrome: the role of food in pathogenesis and management. Gastroenterol Hepatol (NY). 2014;10:164-74.
6. Cordain L, Eaton SB, Sebastian A, et al. Origins and evolution of the Western diet: Health implications for the 21st century. Am J Clin Nutr. 2005;81:341-54. doi: 10.1038/ajg.2013.105
7. Monsbakken KW, Vandvik PO, Farup PG. Perceived food intolerance in subjects with irritable bowel syndrome – Etiology, prevalence and consequences. Eur J Clin Nutr. 2006;60:667-72. doi: 10.1038 / sj.ejcn.1602367
8. Reding KW, Cain KC, Jarrett ME, et al. Relationship between Patterns of Alcohol Consumption and Gastrointestinal Symptoms among Patients with Irritable Bowel Syndrome. Am J Gastroenterol. 2013;108(2):270-6. doi: 10.1038/ajg.2012.414
9. Camilleri M. Management Options for Irritable Bowel Syndrome. Mayo Clin Proc. 2018;93(12):1858-72. doi: 10.1016/j.mayocp.2018.04.032
10. Soltani S, Hassanzadeh Keshteli A, Esmaillzadeh A, Adibi P. Food Item Avoidance of Patients with Irritable Bowel Syndrome Compared with Healthy People. Iran Med. 2019;22(7):369-75.
11. Tuck CJ, Vanner SJ. Dietary therapies for functional bowel symptoms: Recent advances, challenges, and future directions. Neurogastroenterol Motil. 2018;30:132-8. doi: 10.1111/nmo.13238
12. Cozma-Petruţ A, Loghin F, Miere D, Dumitraşcu DL. Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients! World J Gastroenterol. 2017;23(21):3771-83. doi: 10.3748/wjg.v23.i21.3771
13. Ford AC, Moayyedi P, Lacy BE, et al. American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. Am J Gastroenterol. 2014;109:2-26. doi: 10.1038/ajg.2014.187
14. Moayyedi P, Andrews CN, MacQueen G, et al. Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Irritable Bowel Syndrome (IBS). J Can Assoc Gastroenterol. 2019;1:6-29. doi: 10.1093/jcag/gwy071
15. Practical Recommendations of the world Gastroenterological Organization "Irritable bowel Syndrome: a global perspective". Update. 2015 (In Russ.) doi: 10.1097/MCG.0000000000000653
16. Moayyedi P, Quigley EM, Lacy BE, et al. The Effect of Dietary Intervention on Irritable Bowel Syndrome: A Systematic Review. Clin Transl Gastroenterol. 2015;6:107. doi: 10.1038/ctg.2015.21
17. Pevsner MI. Fundamentals of therapeutic nutrition. Moscow: Medgiz, 1958 (In Russ.)
18. Pavlidou E. Wine: An Aspiring Agent in Promoting Longevity and Preventing Chronic Diseases. Diseases. 2018;6(3):73. doi: 10.3390/diseases6030073
19. Keys A, Menotti A, Aravanis C, et al. The Seven Countries Study: 2289 Deaths in 15 Years. Prev Med. 1984;13:141-54. doi: 10.1093/oxfordjournals.aje.a114480
20. McKenzie YA, Bowyer RK, Leach H, et al. British Dietetic Association systematic review and evidence-based practice guidelines for the dietary management of irritable bowel syndrome in adults (2016 update). J Hum Nutr Diet. 2016;29:549-75. doi: 10.1111/jhn.12385
21. McKenzie YA, Alder A, Anderson W,  et al. British Dietetic Association evidence-based guidelines for the dietary management of irritable bowel syndrome in adults. J Hum Nutr Dietetics. 2012;25(3):260-74. doi: 10.1111/j.1365-277X.2012.01242.x
22. Gonlachanvit S. Are rice and spicy diet good for functional gastrointestinal disorders? J Neurogastroenterol Motil. 2010;16:131-8. doi: 10.5056/jnm.2010.16.2.131
23. Gonlachanvit S, Mahayosnond A, Kullavanijaya P. Effects of chili on postprandial gastrointestinal symptoms in diarrhoea predominant irritable bowel syndrome: evidence for capsaicin-sensitive visceral nociception hypersensitivity. Neurogastroenterol Motil. 2009;21:23-32. doi: 10.1111/j.1365-2982.2008.01167.x
24. Esmaillzadeh A, Keshteli AH, Hajishafiee M, et al. Consumption of spicy foods and the prevalence of irritable bowel syndrome. World J Gastroenterol. 2013;19:6465-71. doi: 10.3748/wjg.v19.i38.6465
25. Simrén M, Abrahamsson H, Björnsson ES. Lipid-induced colonic hypersensitivity in the irritable bowel syndrome: the role of bowel habit, sex, and psychologic factors. Clin Gastroenterol Hepatol. 2007;5:201-8. doi: 10.1016/j.cgh.2006.09.032
26. Caldarella MP, Milano A, Laterza F, et al. Visceral sensitivity and symptoms in patients with constipation- or diarrhea-predominant irritable bowel syndrome (IBS): effect of a low-fat intraduodenal infusion. Am J Gastroenterol. 2005;100:383-9. doi: 10.1111/j.1572-0241.2005.40100.x
27. Michalak A, Mosińska P, Fichna J. Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer. Front Pharmacol. 2016;7:459. doi: 10.3389/fphar.2016.00459
28. McRorie JW. Evidence-Based Approach to Fiber Supplements and Clinically Meaningful Health Benefits, Part 1: What to Look for and How to Recommend an Effective Fiber Therapy. Nutr Today. 2015;50:82-9. doi: 10.1097/NT.0000000000000082
29. Eswaran S, Muir J, Chey WD. Fiber and Functional Gastrointestinal Disorders. Am J Gastroenterol. 2013;108:718-27. doi: 10.1038/ajg.2013.63
30. Bijkerk CJ, de Wit NJ, Muris JW, et al. Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial. BMJ. 2009;339:b3154. doi: 10.1136/bmj.b3154
31. Lee SM, Han HW, Yim SY. Beneficial effects of soy milk and fiber on high cholesterol diet-induced alteration of gut microbiota and inflammatory gene expression in rats. Food Funct. 2015;6(2):492-500. doi: 10.1039/c4fo00731j
32. Rona RJ, Keil T, Summers C, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol. 2007;120:638-46. doi: 10.1016/j.jaci.2007.05.026
33. Biesiekierski JR, Iven J. Non-coeliac gluten sensitivity: piecing the puzzle together. United European Gastroenterol J. 2015;3:160-5. doi: 10.1177/2050640615578388
34. Parfenov AI, Bikova SV, Sabelnikova EA, et al. All-Russian consensus on the diagnosis and treatment of celiac disease in children and adults. Therapeutic archive. 2017;89(3):94-107 (In Russ.) doi: 10.17116/terarkh201789394-107
35. Gaesser GA, Angadi SS. Gluten-free diet: Imprudent dietary advice for the general population? J Acad Nutr Diet. 2012;112(9):1330-3. doi: 10.1016/j.jand.2012.06.009
36. Wild D, Robins GG, Burley VJ, et al. Evidence of high sugar intake, and low fibre and mineral intake, in the gluten-free diet. Aliment Pharmacol Ther. 2010;32(4):573-81. doi: 10.1111/j.1365-2036.2010.04386.x
37. Lee AR, Ng DL, Zivin J, et al. Economic burden of a gluten-free diet. 
J Hum Nutr Diet. 2007;20(5):423-30. doi: 10.1111/j.1365-277X.2007.00763.x
38. Codex Alimentarius. Organic food products. Moscow: All the world, 2006; p. 74 (In Russ).
39. Marsh A, Eslick EM, Eslick GD. Does a diet low in FODMAPs reduce symptoms associated with functional gastrointestinal disorders? A comprehensive systematic review and meta-analysis. Eur J Nutr. 2016;55:897-906. doi: 10.1007/s00394-015-0922-1
40. Dionne J, Ford AC, Yuan Y, et al. A Systematic Review and Meta-Analysis Evaluating the Efficacy of a Gluten-Free Diet and a Low FODMAPs Diet in Treating Symptoms of Irritable Bowel Syndrome. Am J Gastroenterol. 2018;113(9):1290-300. doi: 10.1038/s41395-018-0195-4
41. Rej A, Avery A, Ford AC, et al. Clinical Application of Dietary Therapies in Irritable Bowel Syndrome. J Gastrointestin Liver Dis. 2018;27(3):307-16. doi: 10.15403/jgld.2014.1121.273.avy
42. Biesiekierski JR, Newnham ED, Irving PM, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol. 2011;106:508-14. doi: 10.1038/ajg.2010.487
43. Aziz I, Trott N, Briggs R, et al. Efficacy of a gluten-free diet in subjects with irritablebowel syndrome-diarrhea unaware of their HLA-DQ2/8 geno-type. Clin Gastroenterol Hepatol. 2016;14:696-703. doi: 10.1016/j.cgh.2015.12.031
44. Barmeyer C, Schumann M, Meyer T, et al. Long-term response to gluten-free diet as evidence for non-celiac wheat sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome. Int J Colorectal Dis. 2017;32:29-39. doi: 10.1007/s00384-016-2663-x
45. Vazquez-Roque MI, Camilleri M, Smyrk T, et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology. 2013;144:903-11. doi: 10.1053/j.gastro.2013.01.049
46. Pinto-Sanchez MI, Verd EF. Non-coeliac gluten sensitivity:are we closer to separating the wheat from the chaff? Gut. 2016;65:1921-2. doi: 10.1136/gutjnl-2016-312471
47. Skodje GI, Sarna VK, Minelle IH, et al. Fructan, Rather Than Gluten, induces symptoms in patients with self-reported nonceliac gluten sensitivity. Gastroenterology. 2018;154:529-39. doi: 10.1053/j.gastro.2017.10.040
48. Biesiekierski JR, Peters SL, Newnham ED, et al. No effects of gluten in patients with selfreported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology. 2013;145:320-8. doi: 10.1053/j.gastro.2013.04.051
49. Bonder MJ, Tigchelaar EF, Cai X, et al. The influence of a short-term gluten-free diet on the human gut microbiome. Genome Med. 2016;8:45. doi: 10.1186/s13073-016-0295-у
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И.Г. Бакулин, Е.Б. Авалуева, Л.С. Орешко, С.И. Ситкин, М.А. Шевяков, М.Ю. Серкова, Е.А. Семенова

ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России, 
Санкт-Петербург, Россия

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I.G. Bakulin, E.B. Avalueva, L.S. Оrеshkо, S.I. Sitkin, M.A. Shevyakov, M.U. Serkova, E.A. Semenova

Mechnikov North-Western State Medical University, Saint Petersburg, Russia