Распространенность саркопении у пациентов с ревматологической патологией
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Lavrishcheva IV, Jakovenko AA, Rumyantsev ASh. The prevalence of sarcopenia in patients with rheumatological pathology. Terapevticheskii Arkhiv (Ter. Arkh.). 2021; 93 (5): 568–572. DOI: 10.26442/00403660.2021.05.200788
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Материалы и методы. Обследованы 317 пациентов с документированной ревматологической патологией, среди них 201 женщина
и 116 мужчин, возраст пациентов колебался в диапазоне от 21 до 58 лет, средний возраст на момент включения пациентов в исследование составил 41,1±7,3 года. Диагностику саркопении выполняли с помощью метода, рекомендованного The European Working Group on Sarcopenia in Older People 2.
Результаты. Снижение массы скелетных мышц по данным индекса аппендикулярной скелетной мускулатуры составило 31,2% (99 пациентов), снижение мышечной силы по данным кистевой динамометрии отмечалось у 44,5% (141) пациентов, низкая работоспособность скелетной мускулатуры по результатам NIH Toolbox 4 Meter Walk Gait Speed Test – у 42,8% (135) пациентов. Распространенность предполагаемой саркопении (probable sarcopenia) составила 13,3% (42 пациента) и саркопении, в том числе тяжелой степени, – 31,2% (99) пациентов. Получены статистически значимые различия между группами пациентов в зависимости от длительности ревматологического заболевания и распространенности саркопении (χ2=19,328; р=0,001).
Заключение. Саркопения встречается у 1/3 госпитализированных ревматологических пациентов.
Ключевые слова: распространенность, саркопения, ревматологические заболевания
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Aim. To assess the prevalence of sarcopenia in rheumatological patients.
Materials and methods. 317 patients with rheumatological pathology were examined, among them 201 women and 116 men, the age of patients ranged from 21 to 58 years, the average age at the time of inclusion of patients in the study was 41.1±7.3 years. Sarcopenia was diagnosed using the method recommended by The European Working Group on Sarcopenia in Older People 2.
Results. The frequency of occurrence of a decrease in the appendicular skeletal muscle mass to the appendicular skeletal muscle mass index was 31.2% (99 patients), a decrease in muscle strength according to the wrist dynamometry was observed in 44.5% (141) patients, low skeletal muscle performance according to the results NIH Toolbox 4 Meter Walk Gait Speed Test in 42.8% (135) patients. The prevalence of suspected sarcopenia (probable sarcopenia) was 13.3% (42 patients) and sarcopenia, including severe 31.2% (99) patients. Statistically significant differences were obtained between groups of patients depending on the duration of rheumatological disease and the prevalence of sarcopenia (χ2=19.328; p=0.001).
Conclusion. Sarcopenia occurs in a third of hospitalized rheumatological patients.
Keywords: prevalence, sarcopenia, rheumatological diseases
For citation:
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12. El Maghraoui A, Ebo’o FB, Sadni S, et al. Is there a relation between pre-sarcopenia, sarcopenia, cachexia and osteoporosis in patients with ankylosing spondylitis? BMC Musculoskelet Disord. 2016;17:268. DOI:10.1186/s12891-016-1155-z
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14. Sergi G, De Rui M, Veronese N, et al. Assessing appendicular skeletal muscle mass with bioelectrical impedance analysis in free-living Caucasian older adults. Clin Nutr. 2015;34(4):667-73.DOI:10.1016/j.clnu.2014.07.010
15. Human Energy Requirements: Report of a Joint FAO/WHO/UNU Expert Consultation. Available at: http://www.fao.org/3/a-y5686e.pdf. Accessed: 05.11.2018.
16. Barone M, Viggiani MT, Anelli MG. Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors. J Clin Med. 2018;7(12):504. DOI:10.3390/jcm7120504
17. Polyzos SA, Margioris AN. Sarcopenic obesity. Hormones (Athens). 2018;17(3):321-31. DOI:10.1007/s42000-018-0049-x
18. Stenholm S, Harris ТВ, Hantanen T, et al. Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutri Metab Care. 2008;11(6):693-700. DOI:10.1097/MCO.0b013e328312c37d
19. Zamboni M, Mazzali G, Fantin F, et al. Sarcopenic obesity: a new category of obesity in the elderly. Nutr Metab Cardiovasc Dis. 2008;18(5):388-95. DOI:10.1016/j.numecd.2007.10.002
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1. Blau HM, Cosgrove BD, Ho ATV. The central role of muscle stem cells in regenerative failure with aging. Nat Med. 2015;21:854-62. DOI:10.1038/nm.3918
2. Järvinen TA, Järvinen M, Kalimo H. Regeneration of injured skeletal muscle after the injury. Muscles Ligaments Tendons J. 2014;3(4):337-45.
3. Ryall JG, Schertzer JD, Lynch GS. Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness. Biogerontology. 2008;9:213-28. DOI:10.1007/s10522-008-9131-0
4. Turner NJ, Badylak SF. Regeneration of skeletal muscle. Cell Tissue Res. 2012;347:759-74. DOI:10.1007/s00441-011-1185-1187
5. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31. DOI:10.1093/ageing/afy169
6. Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet. 2019;393(10191):2636-46. DOI:10.1016/S0140-6736(19)31138-9
7. Mijnarends DM, Koster A, Schols JM, et al. Physical activity and incidence of sarcopenia:the population-based AGES-Reykjavik Study. Age Ageing. 2016;45(5):614-20. DOI:10.1093/ageing/afw090
8. Cederholm T, Jensen GL, Correia M, et al. GLIM criteria for the diagnosis of malnutrition – A consensus report from the global clinical nutrition community. Clin Nutr. 2019;38(1):1-9. DOI:10.1016/j.clnu.2018.08.002
9. Ogbechi J, Clanchy FI, Huang YS, et al. IDO activation, inflammation and musculoskeletal disease. Exp Gerontol. 2020;131:110820. DOI:10.1016/j.exger.2019.110820
10. Krajewska-Włodarczyk M, Owczarczyk-Saczonek A, Placek W. Changes in body composition and bone mineral density in postmenopausal women with psoriatic arthritis. Reumatologia. 2017;55:215-21.DOI:10.5114/reum.2017.71627
11. Torii M, Hashimoto M, Hanai A, et al. Prevalence and factors associated with sarcopenia in patients with rheumatoid arthritis. Mod Rheumatol. 2019;29(4):589-95. DOI:10.1080/14397595.2018.1510565
12. El Maghraoui A, Ebo’o FB, Sadni S, et al. Is there a relation between pre-sarcopenia, sarcopenia, cachexia and osteoporosis in patients with ankylosing spondylitis? BMC Musculoskelet Disord. 2016;17:268. DOI:10.1186/s12891-016-1155-z
13. Ngeuleu A, Allali F, Medrare L, et al. Sarcopenia in rheumatoid arthritis: Prevalence, influence of disease activity and associated factors. Rheumatol Int. 2017;37:1015-20. DOI:10.1007/s00296-017-3665-x
14. Sergi G, De Rui M, Veronese N, et al. Assessing appendicular skeletal muscle mass with bioelectrical impedance analysis in free-living Caucasian older adults. Clin Nutr. 2015;34(4):667-73.DOI:10.1016/j.clnu.2014.07.010
15. Human Energy Requirements: Report of a Joint FAO/WHO/UNU Expert Consultation. Available at: http://www.fao.org/3/a-y5686e.pdf. Accessed: 05.11.2018.
16. Barone M, Viggiani MT, Anelli MG. Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors. J Clin Med. 2018;7(12):504. DOI:10.3390/jcm7120504
17. Polyzos SA, Margioris AN. Sarcopenic obesity. Hormones (Athens). 2018;17(3):321-31. DOI:10.1007/s42000-018-0049-x
18. Stenholm S, Harris ТВ, Hantanen T, et al. Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutri Metab Care. 2008;11(6):693-700. DOI:10.1097/MCO.0b013e328312c37d
19. Zamboni M, Mazzali G, Fantin F, et al. Sarcopenic obesity: a new category of obesity in the elderly. Nutr Metab Cardiovasc Dis. 2008;18(5):388-95. DOI:10.1016/j.numecd.2007.10.002
1 ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России, Санкт-Петербург, Россия;
2 ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России, Санкт-Петербург, Россия;
3 ФГБОУ ВО «Санкт-Петербургский государственный университет», Санкт-Петербург, Россия
*leptin-rulit@mail.ru
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Iuliia V. Lavrishcheva1, Aleksandr A. Jakovenko*2, Aleksandr Sh. Rumyantsev3
1 Almazov National Medical Research Centre, Saint Petersburg, Russia;
2 Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia;
3 Saint Petersburg State University, Saint Petersburg, Russia
*leptin-rulit@mail.ru