Поражение почек, ассоциированное с противоопухолевой терапией: фокус на нежелательные явления современных иммуноонкологических препаратов - Журнал Терапевтический архив № 6 Вопросы нефрологии 2021

Поражение почек, ассоциированное с противоопухолевой терапией: фокус на нежелательные явления современных иммуноонкологических препаратов

Камышова Е.С., Бобкова И.Н., Секачева М.И. Поражение почек, ассоциированное с противоопухолевой терапией: фокус на нежелательные явления современных иммуноонкологических препаратов. Терапевтический архив. 2021; 93 (6): 649–660. DOI: 10.26442/00403660.2021.06.200860

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Kamyshova ES, Bobkova IN, Sekacheva MI. Kidney injury associated with antitumor therapy: focus on the adverse events of modern immuno-oncological drugs. Terapevticheskii Arkhiv (Ter. Arkh). 2021; 93 (6): 649–660.
DOI: 10.26442/00403660.2021.06.200860

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Аннотация

Ингибиторы иммунных контрольных точек (ИКТ), в том числе антиген цитотоксических Т-лимфоцитов 4 (cytotoxic T-lymphocyte antigen 4 –
CTLA-4), рецептор запрограммированной гибели 1 (programmed death 1 – PD-1) и его лиганд 1 (PD-ligand-1 – PD-L1), представляют собой иммуноонкологические препараты нового поколения, которые к настоящему времени продемонстрировали эффективность при ряде злокачественных новообразований. Механизм действия ингибиторов ИКТ заключается в потенцировании иммунного отчета за счет устранения тормозящего влияния опухолевых клеток на активацию Т-лимфоцитов. Однако чрезмерная активация иммунной системы может стать причиной развития особого класса иммуноопосредованных нежелательных явлений (иоНЯ) со стороны ряда органов и систем, в том числе почек. Несмотря на то, что иммуноопосредованное поражение почек на фоне терапии ингибиторами ИКТ развивается относительно редко, оно может быть серьезным и определять прогноз пациента, что обусловливает необходимость ранней диагностики и своевременного начала лечения. В связи с этим приобретает особую актуальность информированность о проявлениях иоНЯ со стороны почек на фоне иммунотерапии не только онкологов и нефрологов, но и врачей других специальностей. В настоящем обзоре описаны основные варианты иммуноопосредованного поражения почек, обусловленного терапией ингибиторами ИКТ, обсуждены возможные предикторы и механизмы их развития, рассмотрены общие принципы диагностики и ведения пациентов с учетом степени тяжести иоНЯ.

Ключевые слова: ингибиторы иммунных контрольных точек, антиген цитотоксических Т-лимфоцитов 4, рецептор запрограммированной гибели 1, лиганд рецептора запрограммированной гибели 1, иммуноопосредованные нежелательные явления со стороны почек

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Immune checkpoint inhibitors (ICIs), including cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) and programmed death protein 1 (PD-1) or its ligand (PD-L1), are a new generation of immuno-oncological drugs that to date have demonstrated efficacy in a number of malignancies. The mechanism of ICT inhibitors action consist in the potentiation of the immune response by eliminating the tumor cells inhibitory effect on the T-lymphocytes activation. However, excessive immune system activation can cause the development of a special class of immune-related adverse events (irAEs) involved a wide variety of organs and systems, including the kidneys. Despite the fact that immuno-mediated kidney injury caused by ICI therapy develops quite rarely, it can be serious and determine the patient's prognosis, which necessitates early diagnosis and timely start of treatment. In this regard, awareness of the manifestations of ICI-associated renal irAEs is particularly relevant not only for oncologists and for nephrologists, but for doctors of other specialties. In this review, we elucidated the main variants of immuno-mediated kidney injury caused by ICI therapy, discussed possible predictors and mechanisms of their development, and considers the general principles of diagnosis and management of patients according to the severity of irAEs.

Keywords: immune checkpoint inhibitors, cytotoxic T-lymphocyte associated antigen 4, programmed death protein 1, programmed cell death 1 ligand 1, renal immune-related adverse events

Список литературы

1. Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711-23. DOI:10.1056/NEJMoa1003466
2. Tian T, Olson S, Whitacre JM, Harding A. The origins of cancer robustness and evolvability. Integr Biol (Camb). 2011;3(1):17-30. DOI:10.1039/c0ib00046a
3. Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39(1):1-10. DOI:10.1016/j.immuni.2013.07.012
4. Gianchecchi E, Fierabracci A. Inhibitory Receptors and Pathways of Lymphocytes: The Role of PD-1 in Treg Development and Their Involvement in Autoimmunity Onset and Cancer Progression. Front Immunol. 2018;9:2374. Published 2018 Oct 17. doi:10.3389/fimmu.2018.02374.
5. Murakami N, Riella LV. Co-inhibitory pathways and their importance in immune regulation. Transplantation. 2014;98(1):3-14. DOI:10.1097/TP.0000000000000169
6. Hryniewicki AT, Wang C, Shatsky RA, Coyne CJ. Management of Immune Checkpoint Inhibitor Toxicities: A Review and Clinical Guideline for Emergency Physicians. J Emerg Med. 2018;55(4):489-502. DOI:10.1016/j.jemermed.2018.07.005
7. Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996;271(5256):1734-6. DOI:10.1126/science.271.5256.1734
8. Boussiotis VA. Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway. N Engl J Med. 2016;375(18):1767-78. DOI:10.1056/NEJMra1514296
9. Wing K, Onishi Y, Prieto-Martin P, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science. 2008;322(5899):271-5. DOI:10.1126/science.1160062
10. Anari F, Ramamurthy C, Zibelman M. Impact of tumor microenvironment composition on therapeutic responses and clinical outcomes in cancer. Future Oncol. 2018;14(14):1409-21. DOI:10.2217/fon-2017-0585
11. Postow MA, Callahan MK, Wolchok JD. Immune Checkpoint Blockade in Cancer Therapy. J Clin Oncol. 2015;33(17):1974-82. DOI:10.1200/JCO.2014.59.4358
12. Харкевич Г.Ю., Орлова К.В. Иммуно-опосредованные нежелательные явления ингибиторов блокаторов иммунного ответа. Практическая онкология. 2016;17(2):110-8 [Kharkevich GYu, Orlova KV. Immunooposredovannyye nezhelatel'nyye yavleniya ingibitorov blokatorov immunnogo otveta. Prakticheskaya onkologiya. 2016;17(2):110-8 (in Russian)]. DOI:10.31917/1702110
13. Qin S, Xu L, Yi M, et al. Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4. Mol Cancer. 2019;18(1):155. DOI:10.1186/s12943-019-1091-2
14. Marin-Acevedo JA, Dholaria B, Soyano AE, et al. Next generation of immune checkpoint therapy in cancer: new developments and challenges. J Hematol Oncol. 2018;11(1):39. DOI:10.1186/s13045-018-0582-8
15. Postow MA, Sidlow R, Hellmann MD. Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. N Engl J Med. 2018;378(2):158-68. DOI:10.1056/NEJMra1703481
16. Champiat S, Lambotte O, Barreau E, et al. Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper. Ann Oncol. 2016;27(4):559-74. DOI:10.1093/annonc/mdv623
17. Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443-54. DOI:10.1056/NEJMoa1200690
18. Michot JM, Bigenwald C, Champiat S, et al. Immune-related adverse events with immune checkpoint blockade: a comprehensive review. Eur J Cancer. 2016;54:139-48. DOI:10.1016/j.ejca.2015.11.016
19. Реутова Е.В., Лактионов К.П., Бредер В.В., и др. Иммуноопосредованные нежелательные явления, связанные с лечением препаратами, блокирующими контрольные точки Т-лимфоцитов. Злокачественные опухоли. 2016(20):68-76 [Reutova EV, Laktionov KP, Breder VV, et al. Immune-mediated adverse events associated with immune checkpoint inhibitors therapy. Malignant Tumours. 2016(4):68-76 (in Russian)]. DOI:10.18027/2224-5057-2016-4-68-76
20. Voskens CJ, Goldinger SM, Loquai C, et al. The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma fr om the ipilimumab network. PLoS One. 2013;8(1):e53745. DOI:10.1371/journal.pone.0053745
21. Cortazar FB, Marrone KA, Troxell ML, et al. Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors. Kidney Int. 2016;90(3):638-47. DOI:10.1016/j.kint.2016.04.008
22. Hofmann L, Forschner A, Loquai C, et al. Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy. Eur J Cancer. 2016;60:190-209. DOI:10.1016/j.ejca.2016.02.025
23. Perazella MA, Shirali AC. Nephrotoxicity of Cancer Immunotherapies: Past, Present and Future. J Am Soc Nephrol. 2018;29(8):2039-52. DOI:10.1681/ASN.2018050488
24. Mamlouk O, Selamet U, Machado S, et al. Nephrotoxicity of immune checkpoint inhibitors beyond tubulointerstitial nephritis: single-center experience. J Immunother Cancer. 2019;7(1):2. DOI:10.1186/s40425-018-0478-8
25. Patel V, Elias R, Formella J, et al. Acute interstitial nephritis, a potential predictor of response to immune checkpoint inhibitors in renal cell carcinoma. J Immunother Cancer. 2020;8(2):e001198. DOI:10.1136/jitc-2020-001198
26. Common Terminology Criteria for Adverse Events (СТСАЕ) v5.0. Available at: https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm#ctc_40. Accessed: 11.03.2021.
27. Seethapathy H, Zhao S, Chute DF, et al. The Incidence, Causes, and Risk Factors of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors. Clin J Am Soc Nephrol. 2019;14(12):1692-700. DOI:10.2215/CJN.00990119
28. Manohar S, Kompotiatis P, Thongprayoon C, et al. Programmed cell death protein 1 inhibitor treatment is associated with acute kidney injury and hypocalcemia: meta-analysis. Nephrol Dial Transplant. 2019;34(1):108-17. DOI:10.1093/ndt/gfy105
29. Cortazar FB, Kibbelaar ZA, Glezerman IG, et al. Clinical Features and Outcomes of Immune Checkpoint Inhibitor-Associated AKI: A Multicenter Study. J Am Soc Nephrol. 2020;31(2):435-46. DOI:10.1681/ASN.2019070676
30. Wanchoo R, Karam S, Uppal NN, et al. Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review. Am J Nephrol. 2017;45(2):160-9. DOI:10.1159/000455014
31. Meraz-Muñoz A, Amir E, Ng P, et al. Acute kidney injury associated with immune checkpoint inhibitor therapy: incidence, risk factors and outcomes. J Immunother Cancer. 2020;8(1):e000467. DOI:10.1136/jitc-2019-000467
32. Chen G, Qin Y, Fan QQ, et al. Renal adverse effects following the use of different immune checkpoint inhibitor regimens: A real-world pharmacoepidemiology study of post-marketing surveillance data. Cancer Med. 2020;9(18):6576-85. DOI:10.1002/cam4.3198
33. Glutsch V, Grän F, Weber J, Gesierich A, Goebeler M, Schilling B. Response to combined ipilimumab and nivolumab after development of a nephrotic syndrome related to PD-1 monotherapy. J Immunother Cancer. 2019;7(1):181. DOI:10.1186/s40425-019-0655-4
34. Okawa S, Fujiwara K, Shimonishi A, et al. Rapidly Progressive Acute Kidney Injury Associated with Nivolumab Treatment. Case Rep Oncol. 2020;13(1):85-90. DOI:10.1159/000505235
35. Belliere J, Meyer N, Mazieres J, et al. Acute interstitial nephritis related to immune checkpoint inhibitors. Br J Cancer. 2016;115(12):1457-61. DOI:10.1038/bjc.2016.358
36. Kidney Disease: Improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2:1-138. DOI:10.1038/kisup.2012.1
37. Захарова Е.В., Остроумова О.Д. Онконефрология: поражения почек при использовании противоопухолевых препаратов. Нефрология и диализ. 2020;22(3):383-95 [Zakharova EV, Ostroumova OD. Onco-nephrology: Anticancer Drug-induced Kidney Damage. Nephrology and Dialysis. 2020;22(3):383-95 (in Russian)].
DOI:10.28996/2618-9801-2020-3-383-95
38. Franzin R, Netti GS, Spadaccino F, et al. The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Wh ere Do We Stand? Front Immunol. 2020;11:574271. DOI:10.3389/fimmu.2020.574271
39. Kitchlu A, Fingrut W, Avila-Casado C, et al. Nephrotic Syndrome With Cancer Immunotherapies: A Report of 2 Cases. Am J Kidney Dis. 2017;70(4):581-5. DOI:10.1053/j.ajkd.2017.04.026
40. El Bitar S, Weerasinghe C, El-Charabaty E, Odaimi M. Renal Tubular Acidosis an Adverse Effect of PD-1 Inhibitor Immunotherapy. Case Rep Oncol Med. 2018;2018:8408015. DOI:10.1155/2018/8408015
41. Charmetant X, Teuma C, Lake J, et al. A new expression of immune checkpoint inhibitors' renal toxicity: when distal tubular acidosis precedes creatinine elevation. Clin Kidney J. 2019;13(1):42-5. DOI:10.1093/ckj/sfz051
42. Herrmann SM, Alexander MP, Romero MF, Zand L. Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor-A Report of 3 Cases. Kidney Med. 2020;2(5):657-62. DOI:10.1016/j.xkme.2020.05.015
43. Izzedine H, Gueutin V, Gharbi C, et al. Kidney injuries related to ipilimumab. Invest New Drugs. 2014;32(4):769-73. DOI:10.1007/s10637-014-0092-7
44. Thajudeen B, Madhrira M, Bracamonte E, Cranmer LD. Ipilimumab granulomatous interstitial nephritis. Am J Ther. 2015;22(3):e84-e87.
DOI:10.1097/MJT.0b013e3182a32ddc
45. Lemoine M, Dilly B, Curie A, et al. Ipilimumab-induced renal granulomatous arteritis: a case report. BMC Nephrol. 2019;20(1):366. DOI:10.1186/s12882-019-1552-2
46. Fadel F, El Karoui K, Knebelmann B. Anti-CTLA4 antibody-induced lupus nephritis. N Engl J Med. 2009;361(2):211-2. DOI:10.1056/NEJMc0904283
47. Kidd JM, Gizaw AB. Ipilimumab-associated minimal-change disease. Kidney Int. 2016;89(3):720. DOI:10.1016/j.kint.2015.11.028
48. Shirali AC, Perazella MA, Gettinger S. Association of Acute Interstitial Nephritis With Programmed Cell Death 1 Inhibitor Therapy in Lung Cancer Patients. Am J Kidney Dis. 2016;68(2):287-91. DOI:10.1053/j.ajkd.2016.02.057
49. Escandon J, Peacock S, Trabolsi A, et al. Interstitial nephritis in melanoma patients secondary to PD-1 checkpoint inhibitor. J Immunother Cancer. 2017;5:3. DOI:10.1186/s40425-016-0205-2
50. Bottlaender L, Breton AL, de Laforcade L, et al. Acute interstitial nephritis after sequential ipilumumab - nivolumab therapy of metastatic melanoma. J Immunother Cancer. 2017;5(1):57.0DOI:10.1186/s40425-017-0261-2
51. Uchida A, Watanabe M, Nawata A, et al. Tubulointerstitial nephritis as adverse effect of programmed cell death 1 inhibitor, nivolumab, showed distinct histological findings. CEN Case Rep. 2017;6(2):169-74. DOI:10.1007/s13730-017-0269-y
52. Koda R, Watanabe H, Tsuchida M, et al. Immune checkpoint inhibitor (nivolumab)-associated kidney injury and the importance of recognizing concomitant medications known to cause acute tubulointerstitial nephritis: a case report. BMC Nephrol. 2018;19(1):48. DOI:10.1186/s12882-018-0848-y
53. Tabei A, Watanabe M, Ikeuchi H, et al. The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature. Intern Med. 2018;57(21):3135-9. DOI:10.2169/internalmedicine.0444-17
54. Hattahara K, Yamasaki T, Sawada A, et al. Hinyokika Kiyo. 2019;65(5):157-61. DOI:10.14989/ActaUrolJap_65_5_157
55. Sise ME, Seethapathy H, Reynolds KL. Diagnosis and Management of Immune Checkpoint Inhibitor-Associated Renal Toxicity: Illustrative Case and Review. Oncologist. 2019;24(6):735-42. DOI:10.1634/theoncologist.2018-0764
56. Cassol C, Satoskar A, Lozanski G, et al. Anti-PD-1 Immunotherapy May Induce Interstitial Nephritis With Increased Tubular Epithelial Expression of PD-L1. Kidney Int Rep. 2019;4(8):1152-60. DOI:10.1016/j.ekir.2019.06.001
57. Irifuku T, Satoh A, Tani H, et al. Acute tubulointerstitial nephritis and IgM deposits on glomerular capillary walls after immunotherapy with nivolumab for metastatic renal cell carcinoma. CEN Case Rep. 2020;9(1):48-54. DOI:10.1007/s13730-019-00424-1
58. Nakatani Y, Kawakami H, Ichikawa M, et al. Nivolumab-induced acute granulomatous tubulointerstitial nephritis in a patient with gastric cancer. Invest New Drugs. 2018;36(4):726-31. DOI:10.1007/s10637-018-0596-7
59. Kishi S, Minato M, Saijo A, et al. IgA Nephropathy after Nivolumab Therapy for Postoperative Recurrence of Lung Squamous Cell Carcinoma. Intern Med. 2018;57(9):1259-63. DOI:10.2169/internalmedicine.9814-17
60. Tanabe K, Kanzaki H, Wada T, et al. Nivolumab-induced IgA nephropathy in a patient with advanced gastric cancer: A case report. Medicine (Baltimore). 2020;99(21):e20464.
DOI:10.1097/MD.0000000000020464
61. Jung K, Zeng X, Bilusic M. Nivolumab-associated acute glomerulonephritis: a case report and literature review. BMC Nephrol. 2016;17(1):188. DOI:10.1186/s12882-016-0408-2
62. Gallan AJ, Alexander E, Reid P, et al. Renal Vasculitis and Pauci-immune Glomerulonephritis Associated With Immune Checkpoint Inhibitors. Am J Kidney Dis. 2019;74(6):853-6. DOI:10.1053/j.ajkd.2019.04.016
63. Daanen RA, Maas RJH, Koornstra RHT, et al. Nivolumab-associated Nephrotic Syndrome in a Patient With Renal Cell Carcinoma: A Case Report. J Immunother. 2017;40(9):345-8. DOI:10.1097/CJI.0000000000000189
64. Izzedine H, Mathian A, Champiat S, et al. Renal toxicities associated with pembrolizumab. Clin Kidney J. 2019;12(1):81-8. DOI:10.1093/ckj/sfy100
65. Basnet S, Dhital R, Tharu B. Acute Tubulointerstitial Nephritis: A Case Report on Rare Adverse Effect of Pembrolizumab. Medicina (Kaunas). 2019;55(5):176. DOI:10.3390/medicina55050176
66. Taki T, Oda N, Fujioka Y, et al. Successful Treatment of Non-small-cell Lung Cancer with Atezolizumab Following Tubulointerstitial Nephritis Due to Pembrolizumab. Intern Med. 2020;59(13):1639-42. DOI:10.2169/internalmedicine.4260-19
67. Oki R, Hirakawa Y, Kimura H, et al. Renal Effects after Pembrolizumab Treatment for Non-small Cell Lung Carcinoma. Intern Med. 2020;59(7):977-81. DOI:10.2169/internalmedicine.3928-19
68. Heo MH, Kim HK, Lee H, Ahn MJ. Antineutrophil Cytoplasmic Antibody-Associated Rapid Progressive Glomerulonephritis after Pembrolizumab Treatment in Thymic Epithelial Tumor: A Case Report. J Thorac Oncol. 2017;12(8):e103-e105. DOI:10.1016/j.jtho.2017.03.011
69. Cho J, Kim HS, Ku BM, et al. Pembrolizumab for Patients With Refractory or Relapsed Thymic Epithelial Tumor: An Open-Label Phase II Trial. J Clin Oncol. 2019;37(24):2162-70. DOI:10.1200/JCO.2017.77.3184
70. Bickel A, Koneth I, Enzler-Tschudy A, et al. Pembrolizumab-associated minimal change disease in a patient with malignant pleural mesothelioma. BMC Cancer. 2016;16:656. DOI:10.1186/s12885-016-2718-y
71. Murakami N, Borges TJ, Yamashita M, Riella LV. Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma [published correction appears in Clin Kidney J. 2016 Aug;9(4):649]. Clin Kidney J. 2016;9(3):411-7. DOI:10.1093/ckj/sfw024
72. Gordon L, Dokouhaki P, Hagel K, Prasad B. Acute kidney injury from immune checkpoint inhibitor use. BMJ Case Rep. 2019;12(10):e231211. DOI:10.1136/bcr-2019-231211
73. Person F, Chahoud-Schriefer T, Fehrle W, et al. Severe Acute Kidney Injury Due to Nivolumab/Ipilimumab-induced Granulomatosis and Fibrinoid Vascular Necrosis. J Immunother. 2020;43(1):29-31. DOI:10.1097/CJI.0000000000000296
74. Hultin S, Nahar K, Menzies AM, et al. Histological diagnosis of immune checkpoint inhibitor induced acute renal injury in patients with metastatic melanoma: a retrospective case series report. BMC Nephrol. 2020;21(1):391. DOI:10.1186/s12882-020-02044-9
75. Perazella MA, Shirali AC. Immune checkpoint inhibitor nephrotoxicity: what do we know and what should we do? Kidney Int. 2020;97(1):62-74. DOI:10.1016/j.kint.2019.07.022
76. Kitchlu A, Jhaveri KD, Wadhwani S, et al. A Systematic Review of Immune Checkpoint Inhibitor-Associated Glomerular Disease. Kidney Int Rep. 2020;6(1):66-77. DOI:10.1016/j.ekir.2020.10.002
77. Izzedine H, Mateus C, Boutros C, et al. Renal effects of immune checkpoint inhibitors. Nephrol Dial Transplant. 2017;32(6):936-42. DOI:10.1093/ndt/gfw382
78. Hu R, Chen M, Xu Y, et al. Renal immune-related adverse events of immune checkpoint inhibitor. Asia Pac J Clin Oncol. 2020;16(6):305-11. DOI:10.1111/ajco.13387
79. Spanou Z, Keller M, Britschgi M, et al. Involvement of drug-specific T cells in acute drug-induced interstitial nephritis. J Am Soc Nephrol. 2006;17(10):2919-27. DOI:10.1681/ASN.2006050418
80. Nishimura H, Nose M, Hiai H, et al. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity. 1999;11(2):141-51. DOI:10.1016/s1074-7613(00)80089-8
81. Benfaremo D, Manfredi L, Luchetti MM, Gabrielli A. Musculoskeletal and Rheumatic Diseases Induced by Immune Checkpoint Inhibitors: A Review of the Literature. Curr Drug Saf. 2018;13(3):150-64. DOI:10.2174/1574886313666180508122332
82. Abdel-Wahab N, Shah M, Suarez-Almazor ME. Adverse Events Associated with Immune Checkpoint Blockade in Patients with Cancer: A Systematic Review of Case Reports. PLoS One. 2016;11(7):e0160221. DOI:10.1371/journal.pone.0160221
83. Wuthrich RP, Glimcher LH, Yui MA, et al. MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Kidney Int. 1990;37(2):783-92. DOI:10.1038/ki.1990.46
84. Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010;236:219-42.
DOI:10.1111/j.1600-065X.2010.00923.x
85. Schoop R, Wahl P, Le Hir M, et al. Suppressed T-cell activation by IFN-gamma-induced expression of PD-L1 on renal tubular epithelial cells. Nephrol Dial Transplant. 2004;19(11):2713-20. DOI:10.1093/ndt/gfh423
86. Murakami N, Motwani S, Riella LV. Renal complications of immune checkpoint blockade. Curr Probl Cancer. 2017;41(2):100-10.
DOI:10.1016/j.currproblcancer.2016.12.004
87. Marco T, Anna P, Annalisa T, et al. The mechanisms of acute interstitial nephritis in the era of immune checkpoint inhibitors in melanoma. Ther Adv Med Oncol. 2019;11:1758835919875549. DOI:10.1177/1758835919875549
88. Herrmann SM, Perazella MA. Immune Checkpoint Inhibitors and Immune-Related Adverse Renal Events. Kidney Int Rep. 2020;5(8):1139-48. DOI:10.1016/j.ekir.2020.04.018
89. Kim SH, Park SJ, Han KH, et al. Pathogenesis of minimal change nephrotic syndrome: an immunological concept. Korean J Pediatr. 2016;59(5):205-11. DOI:10.3345/kjp.2016.59.5.205
90. Jarrot PA, Kaplanski G. Pathogenesis of ANCA-associated vasculitis: An update. Autoimmun Rev. 2016;15(7):704-13. DOI:10.1016/j.autrev.2016.03.007
91. Zha H, Han X, Zhu Y, et al. Blocking C5aR signaling promotes the anti-tumor efficacy of PD-1/PD-L1 blockade. Oncoimmunology. 2017;6(10):e1349587. DOI:10.1080/2162402X.2017.1349587
92. Zakharova EV, Stolyarevich ES. Renal consequences of Lymphoproliferative Disorders and Monoclonal Gammopathy. Urol Nephrol Open Access. 2015;2(4):47–55.0
DOI:10.15406/unoaj.2015.02.00047
93. Колина И.Б., Бобкова И.Н. Нефропатии при злокачественных новообразованиях (лекция). Альманах клинической медицины. 2014;30:108-16 [Kolina IB, Bobkova IN. Nephropathies in malignant tumors. Al’manakh klinicheskoy meditsiny. 2014;30:108-16
(in Russian)].
94. Centanni M, Moes DJAR, Trocóniz IF, et al. Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors. Clin Pharmacokinet. 2019;58(7):835-57. DOI:10.1007/s40262-019-00748-2
95. Hirsch JS, Wanchoo R, Ng JH, et al. Jhaveri Use of Immune Checkpoint Inhibitors in End Stage Kidney Disease Patients, Single Center Experience and Review of the Literature. Kidney360. 2020;1:399-402. DOI:10.34067/KID.0000422020
96. Tabei T, Natsume I, Kobayashi K. Successful treatment of metastatic clear cell carcinoma with nivolumab in a patient receiving dialysis treatment. Int J Urol. 2017;24(9):708-10. DOI:10.1111/iju.13420
97. Cappelli LC, Dorak MT, Bettinotti MP, et al. Association of HLA-DRB1 shared epitope alleles and immune checkpoint inhibitor-induced inflammatory arthritis. Rheumatology (Oxford). 2019;58(3):476-80. DOI:10.1093/rheumatology/key358
98. Kennedy LC, Bhatia S, Thompson JA, Grivas P. Preexisting Autoimmune Disease: Implications for Immune Checkpoint Inhibitor Therapy in Solid Tumors. J Natl Compr Canc Netw. 2019;17(6):750-7. DOI:10.6004/jnccn.2019.7310
99. Abolhassani AR, Schuler G, Kirchberger MC, Heinzerling L. C-reactive protein as an early marker of immune-related adverse events. J Cancer Res Clin Oncol. 2019;145(10):2625-31. DOI:10.1007/s00432-019-03002-1
100. Romo-Tena J, Gómez-Martín D, Alcocer-Varela J. CTLA-4 and autoimmunity: new insights into the dual regulator of tolerance. Autoimmun Rev. 2013;12(12):1171-6. DOI:10.1016/j.autrev.2013.07.002
101. Caturegli P, Di Dalmazi G, Lombardi M, et al. Hypophysitis Secondary to Cytotoxic T-Lymphocyte-Associated Protein 4 Blockade: Insights into Pathogenesis from an Autopsy Series. Am J Pathol. 2016;186(12):3225-35. DOI:10.1016/j.ajpath.2016.08.020
102. Brahmer JR, Lacchetti C, Schneider BJ, et al. Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2018;36(17):1714-68. DOI:10.1200/JCO.2017.77.6385
103. Проценко С.А., Антимоник Н.Ю., Берштейн Л.М., и др. Практические рекомендации по управлению иммуноопосредованными нежелательными явлениями. Злокачественные опухоли. 2019;3-S2:704-34 [Protsenko SA, Antimonik NYu, Bershteyn LM, et al. Prakticheskiye rekomendatsii po upravleniyu immunooposredovannymi nezhelatel'nymi yavleniyami. Zlokachestvennyye opukholi. 2019;3-S2:704-34 (in Russian)].
104. Thompson JA, Schneider BJ, Brahmer J, et al. Management of Immunotherapy-Related Toxicities, Version 1.2019. J Natl Compr Canc Netw. 2019;17(3):255-89. DOI:10.6004/jnccn.2019.0013
105. Zheng K, Qiu W, Wang H, et al. Clinical recommendations on diagnosis and treatment of immune checkpoint inhibitor-induced renal immune-related adverse events. Thorac Cancer. 2020;11(6):1746-51. DOI:10.1111/1759-7714.13405
106. Sprangers B. Pembrolizumab-related renal toxicities: diagnosis first, treatment later. Clin Kidney J. 2019;12(1):78-80. DOI:10.1093/ckj/sfy114
107. Perazella MA, Sprangers B. AKI in Patients Receiving Immune Checkpoint Inhibitors. Clin J Am Soc Nephrol. 2019;14(7):1077-9. DOI:10.2215/CJN.02340219
108. Manohar S, Ghamrawi R, Chengappa M, et al. Acute interstitial nephritis and checkpoint inhibitor therapy. Single center experience of management and drug rechallenge. Kidney 360. 2020;1:16-24. DOI:10.34067/KID.0000152019
109. Pannu N, James M, Hemmelgarn B, Klarenbach S; Alberta Kidney Disease Network. Association between AKI, recovery of renal function, and long-term outcomes after hospital discharge. Clin J Am Soc Nephrol. 2013;8(2):194-202.
DOI:10.2215/CJN.06480612

________________________________________________

1. Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711-23. DOI:10.1056/NEJMoa1003466
2. Tian T, Olson S, Whitacre JM, Harding A. The origins of cancer robustness and evolvability. Integr Biol (Camb). 2011;3(1):17-30. DOI:10.1039/c0ib00046a
3. Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39(1):1-10. DOI:10.1016/j.immuni.2013.07.012
4. Gianchecchi E, Fierabracci A. Inhibitory Receptors and Pathways of Lymphocytes: The Role of PD-1 in Treg Development and Their Involvement in Autoimmunity Onset and Cancer Progression. Front Immunol. 2018;9:2374. Published 2018 Oct 17. doi:10.3389/fimmu.2018.02374.
5. Murakami N, Riella LV. Co-inhibitory pathways and their importance in immune regulation. Transplantation. 2014;98(1):3-14. DOI:10.1097/TP.0000000000000169
6. Hryniewicki AT, Wang C, Shatsky RA, Coyne CJ. Management of Immune Checkpoint Inhibitor Toxicities: A Review and Clinical Guideline for Emergency Physicians. J Emerg Med. 2018;55(4):489-502. DOI:10.1016/j.jemermed.2018.07.005
7. Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996;271(5256):1734-6. DOI:10.1126/science.271.5256.1734
8. Boussiotis VA. Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway. N Engl J Med. 2016;375(18):1767-78. DOI:10.1056/NEJMra1514296
9. Wing K, Onishi Y, Prieto-Martin P, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science. 2008;322(5899):271-5. DOI:10.1126/science.1160062
10. Anari F, Ramamurthy C, Zibelman M. Impact of tumor microenvironment composition on therapeutic responses and clinical outcomes in cancer. Future Oncol. 2018;14(14):1409-21. DOI:10.2217/fon-2017-0585
11. Postow MA, Callahan MK, Wolchok JD. Immune Checkpoint Blockade in Cancer Therapy. J Clin Oncol. 2015;33(17):1974-82. DOI:10.1200/JCO.2014.59.4358
12. Kharkevich GYu, Orlova KV. Immunooposredovannyye nezhelatel'nyye yavleniya ingibitorov blokatorov immunnogo otveta. Prakticheskaya onkologiya. 2016;17(2):110-8 (in Russian) DOI:10.31917/1702110
13. Qin S, Xu L, Yi M, et al. Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4. Mol Cancer. 2019;18(1):155. DOI:10.1186/s12943-019-1091-2
14. Marin-Acevedo JA, Dholaria B, Soyano AE, et al. Next generation of immune checkpoint therapy in cancer: new developments and challenges. J Hematol Oncol. 2018;11(1):39. DOI:10.1186/s13045-018-0582-8
15. Postow MA, Sidlow R, Hellmann MD. Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. N Engl J Med. 2018;378(2):158-68. DOI:10.1056/NEJMra1703481
16. Champiat S, Lambotte O, Barreau E, et al. Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper. Ann Oncol. 2016;27(4):559-74. DOI:10.1093/annonc/mdv623
17. Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443-54. DOI:10.1056/NEJMoa1200690
18. Michot JM, Bigenwald C, Champiat S, et al. Immune-related adverse events with immune checkpoint blockade: a comprehensive review. Eur J Cancer. 2016;54:139-48. DOI:10.1016/j.ejca.2015.11.016
19. Reutova EV, Laktionov KP, Breder VV, et al. Immune-mediated adverse events associated with immune checkpoint inhibitors therapy. Malignant Tumours. 2016(4):68-76 (in Russian) DOI:10.18027/2224-5057-2016-4-68-76
20. Voskens CJ, Goldinger SM, Loquai C, et al. The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma fr om the ipilimumab network. PLoS One. 2013;8(1):e53745. DOI:10.1371/journal.pone.0053745
21. Cortazar FB, Marrone KA, Troxell ML, et al. Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors. Kidney Int. 2016;90(3):638-47. DOI:10.1016/j.kint.2016.04.008
22. Hofmann L, Forschner A, Loquai C, et al. Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy. Eur J Cancer. 2016;60:190-209. DOI:10.1016/j.ejca.2016.02.025
23. Perazella MA, Shirali AC. Nephrotoxicity of Cancer Immunotherapies: Past, Present and Future. J Am Soc Nephrol. 2018;29(8):2039-52. DOI:10.1681/ASN.2018050488
24. Mamlouk O, Selamet U, Machado S, et al. Nephrotoxicity of immune checkpoint inhibitors beyond tubulointerstitial nephritis: single-center experience. J Immunother Cancer. 2019;7(1):2. DOI:10.1186/s40425-018-0478-8
25. Patel V, Elias R, Formella J, et al. Acute interstitial nephritis, a potential predictor of response to immune checkpoint inhibitors in renal cell carcinoma. J Immunother Cancer. 2020;8(2):e001198. DOI:10.1136/jitc-2020-001198
26. Common Terminology Criteria for Adverse Events (СТСАЕ) v5.0. Available at: https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm#ctc_40. Accessed: 11.03.2021.
27. Seethapathy H, Zhao S, Chute DF, et al. The Incidence, Causes, and Risk Factors of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors. Clin J Am Soc Nephrol. 2019;14(12):1692-700. DOI:10.2215/CJN.00990119
28. Manohar S, Kompotiatis P, Thongprayoon C, et al. Programmed cell death protein 1 inhibitor treatment is associated with acute kidney injury and hypocalcemia: meta-analysis. Nephrol Dial Transplant. 2019;34(1):108-17. DOI:10.1093/ndt/gfy105
29. Cortazar FB, Kibbelaar ZA, Glezerman IG, et al. Clinical Features and Outcomes of Immune Checkpoint Inhibitor-Associated AKI: A Multicenter Study. J Am Soc Nephrol. 2020;31(2):435-46. DOI:10.1681/ASN.2019070676
30. Wanchoo R, Karam S, Uppal NN, et al. Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review. Am J Nephrol. 2017;45(2):160-9. DOI:10.1159/000455014
31. Meraz-Muñoz A, Amir E, Ng P, et al. Acute kidney injury associated with immune checkpoint inhibitor therapy: incidence, risk factors and outcomes. J Immunother Cancer. 2020;8(1):e000467. DOI:10.1136/jitc-2019-000467
32. Chen G, Qin Y, Fan QQ, et al. Renal adverse effects following the use of different immune checkpoint inhibitor regimens: A real-world pharmacoepidemiology study of post-marketing surveillance data. Cancer Med. 2020;9(18):6576-85. DOI:10.1002/cam4.3198
33. Glutsch V, Grän F, Weber J, Gesierich A, Goebeler M, Schilling B. Response to combined ipilimumab and nivolumab after development of a nephrotic syndrome related to PD-1 monotherapy. J Immunother Cancer. 2019;7(1):181. DOI:10.1186/s40425-019-0655-4
34. Okawa S, Fujiwara K, Shimonishi A, et al. Rapidly Progressive Acute Kidney Injury Associated with Nivolumab Treatment. Case Rep Oncol. 2020;13(1):85-90. DOI:10.1159/000505235
35. Belliere J, Meyer N, Mazieres J, et al. Acute interstitial nephritis related to immune checkpoint inhibitors. Br J Cancer. 2016;115(12):1457-61. DOI:10.1038/bjc.2016.358
36. Kidney Disease: Improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2:1-138. DOI:10.1038/kisup.2012.1
37. Zakharova EV, Ostroumova OD. Onco-nephrology: Anticancer Drug-induced Kidney Damage. Nephrology and Dialysis. 2020;22(3):383-95 (in Russian)
DOI:10.28996/2618-9801-2020-3-383-95
38. Franzin R, Netti GS, Spadaccino F, et al. The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Wh ere Do We Stand? Front Immunol. 2020;11:574271. DOI:10.3389/fimmu.2020.574271
39. Kitchlu A, Fingrut W, Avila-Casado C, et al. Nephrotic Syndrome With Cancer Immunotherapies: A Report of 2 Cases. Am J Kidney Dis. 2017;70(4):581-5. DOI:10.1053/j.ajkd.2017.04.026
40. El Bitar S, Weerasinghe C, El-Charabaty E, Odaimi M. Renal Tubular Acidosis an Adverse Effect of PD-1 Inhibitor Immunotherapy. Case Rep Oncol Med. 2018;2018:8408015. DOI:10.1155/2018/8408015
41. Charmetant X, Teuma C, Lake J, et al. A new expression of immune checkpoint inhibitors' renal toxicity: when distal tubular acidosis precedes creatinine elevation. Clin Kidney J. 2019;13(1):42-5. DOI:10.1093/ckj/sfz051
42. Herrmann SM, Alexander MP, Romero MF, Zand L. Renal Tubular Acidosis and Immune Checkpoint Inhibitor Therapy: An Immune-Related Adverse Event of PD-1 Inhibitor-A Report of 3 Cases. Kidney Med. 2020;2(5):657-62. DOI:10.1016/j.xkme.2020.05.015
43. Izzedine H, Gueutin V, Gharbi C, et al. Kidney injuries related to ipilimumab. Invest New Drugs. 2014;32(4):769-73. DOI:10.1007/s10637-014-0092-7
44. Thajudeen B, Madhrira M, Bracamonte E, Cranmer LD. Ipilimumab granulomatous interstitial nephritis. Am J Ther. 2015;22(3):e84-e87.
DOI:10.1097/MJT.0b013e3182a32ddc
45. Lemoine M, Dilly B, Curie A, et al. Ipilimumab-induced renal granulomatous arteritis: a case report. BMC Nephrol. 2019;20(1):366. DOI:10.1186/s12882-019-1552-2
46. Fadel F, El Karoui K, Knebelmann B. Anti-CTLA4 antibody-induced lupus nephritis. N Engl J Med. 2009;361(2):211-2. DOI:10.1056/NEJMc0904283
47. Kidd JM, Gizaw AB. Ipilimumab-associated minimal-change disease. Kidney Int. 2016;89(3):720. DOI:10.1016/j.kint.2015.11.028
48. Shirali AC, Perazella MA, Gettinger S. Association of Acute Interstitial Nephritis With Programmed Cell Death 1 Inhibitor Therapy in Lung Cancer Patients. Am J Kidney Dis. 2016;68(2):287-91. DOI:10.1053/j.ajkd.2016.02.057
49. Escandon J, Peacock S, Trabolsi A, et al. Interstitial nephritis in melanoma patients secondary to PD-1 checkpoint inhibitor. J Immunother Cancer. 2017;5:3. DOI:10.1186/s40425-016-0205-2
50. Bottlaender L, Breton AL, de Laforcade L, et al. Acute interstitial nephritis after sequential ipilumumab - nivolumab therapy of metastatic melanoma. J Immunother Cancer. 2017;5(1):57.0DOI:10.1186/s40425-017-0261-2
51. Uchida A, Watanabe M, Nawata A, et al. Tubulointerstitial nephritis as adverse effect of programmed cell death 1 inhibitor, nivolumab, showed distinct histological findings. CEN Case Rep. 2017;6(2):169-74. DOI:10.1007/s13730-017-0269-y
52. Koda R, Watanabe H, Tsuchida M, et al. Immune checkpoint inhibitor (nivolumab)-associated kidney injury and the importance of recognizing concomitant medications known to cause acute tubulointerstitial nephritis: a case report. BMC Nephrol. 2018;19(1):48. DOI:10.1186/s12882-018-0848-y
53. Tabei A, Watanabe M, Ikeuchi H, et al. The Analysis of Renal Infiltrating Cells in Acute Tubulointerstitial Nephritis Induced by Anti-PD-1 Antibodies: A Case Report and Review of the Literature. Intern Med. 2018;57(21):3135-9. DOI:10.2169/internalmedicine.0444-17
54. Hattahara K, Yamasaki T, Sawada A, et al. Hinyokika Kiyo. 2019;65(5):157-61. DOI:10.14989/ActaUrolJap_65_5_157
55. Sise ME, Seethapathy H, Reynolds KL. Diagnosis and Management of Immune Checkpoint Inhibitor-Associated Renal Toxicity: Illustrative Case and Review. Oncologist. 2019;24(6):735-42. DOI:10.1634/theoncologist.2018-0764
56. Cassol C, Satoskar A, Lozanski G, et al. Anti-PD-1 Immunotherapy May Induce Interstitial Nephritis With Increased Tubular Epithelial Expression of PD-L1. Kidney Int Rep. 2019;4(8):1152-60. DOI:10.1016/j.ekir.2019.06.001
57. Irifuku T, Satoh A, Tani H, et al. Acute tubulointerstitial nephritis and IgM deposits on glomerular capillary walls after immunotherapy with nivolumab for metastatic renal cell carcinoma. CEN Case Rep. 2020;9(1):48-54. DOI:10.1007/s13730-019-00424-1
58. Nakatani Y, Kawakami H, Ichikawa M, et al. Nivolumab-induced acute granulomatous tubulointerstitial nephritis in a patient with gastric cancer. Invest New Drugs. 2018;36(4):726-31. DOI:10.1007/s10637-018-0596-7
59. Kishi S, Minato M, Saijo A, et al. IgA Nephropathy after Nivolumab Therapy for Postoperative Recurrence of Lung Squamous Cell Carcinoma. Intern Med. 2018;57(9):1259-63. DOI:10.2169/internalmedicine.9814-17
60. Tanabe K, Kanzaki H, Wada T, et al. Nivolumab-induced IgA nephropathy in a patient with advanced gastric cancer: A case report. Medicine (Baltimore). 2020;99(21):e20464.
DOI:10.1097/MD.0000000000020464
61. Jung K, Zeng X, Bilusic M. Nivolumab-associated acute glomerulonephritis: a case report and literature review. BMC Nephrol. 2016;17(1):188. DOI:10.1186/s12882-016-0408-2
62. Gallan AJ, Alexander E, Reid P, et al. Renal Vasculitis and Pauci-immune Glomerulonephritis Associated With Immune Checkpoint Inhibitors. Am J Kidney Dis. 2019;74(6):853-6. DOI:10.1053/j.ajkd.2019.04.016
63. Daanen RA, Maas RJH, Koornstra RHT, et al. Nivolumab-associated Nephrotic Syndrome in a Patient With Renal Cell Carcinoma: A Case Report. J Immunother. 2017;40(9):345-8. DOI:10.1097/CJI.0000000000000189
64. Izzedine H, Mathian A, Champiat S, et al. Renal toxicities associated with pembrolizumab. Clin Kidney J. 2019;12(1):81-8. DOI:10.1093/ckj/sfy100
65. Basnet S, Dhital R, Tharu B. Acute Tubulointerstitial Nephritis: A Case Report on Rare Adverse Effect of Pembrolizumab. Medicina (Kaunas). 2019;55(5):176. DOI:10.3390/medicina55050176
66. Taki T, Oda N, Fujioka Y, et al. Successful Treatment of Non-small-cell Lung Cancer with Atezolizumab Following Tubulointerstitial Nephritis Due to Pembrolizumab. Intern Med. 2020;59(13):1639-42. DOI:10.2169/internalmedicine.4260-19
67. Oki R, Hirakawa Y, Kimura H, et al. Renal Effects after Pembrolizumab Treatment for Non-small Cell Lung Carcinoma. Intern Med. 2020;59(7):977-81. DOI:10.2169/internalmedicine.3928-19
68. Heo MH, Kim HK, Lee H, Ahn MJ. Antineutrophil Cytoplasmic Antibody-Associated Rapid Progressive Glomerulonephritis after Pembrolizumab Treatment in Thymic Epithelial Tumor: A Case Report. J Thorac Oncol. 2017;12(8):e103-e105. DOI:10.1016/j.jtho.2017.03.011
69. Cho J, Kim HS, Ku BM, et al. Pembrolizumab for Patients With Refractory or Relapsed Thymic Epithelial Tumor: An Open-Label Phase II Trial. J Clin Oncol. 2019;37(24):2162-70. DOI:10.1200/JCO.2017.77.3184
70. Bickel A, Koneth I, Enzler-Tschudy A, et al. Pembrolizumab-associated minimal change disease in a patient with malignant pleural mesothelioma. BMC Cancer. 2016;16:656. DOI:10.1186/s12885-016-2718-y
71. Murakami N, Borges TJ, Yamashita M, Riella LV. Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma [published correction appears in Clin Kidney J. 2016 Aug;9(4):649]. Clin Kidney J. 2016;9(3):411-7. DOI:10.1093/ckj/sfw024
72. Gordon L, Dokouhaki P, Hagel K, Prasad B. Acute kidney injury from immune checkpoint inhibitor use. BMJ Case Rep. 2019;12(10):e231211. DOI:10.1136/bcr-2019-231211
73. Person F, Chahoud-Schriefer T, Fehrle W, et al. Severe Acute Kidney Injury Due to Nivolumab/Ipilimumab-induced Granulomatosis and Fibrinoid Vascular Necrosis. J Immunother. 2020;43(1):29-31. DOI:10.1097/CJI.0000000000000296
74. Hultin S, Nahar K, Menzies AM, et al. Histological diagnosis of immune checkpoint inhibitor induced acute renal injury in patients with metastatic melanoma: a retrospective case series report. BMC Nephrol. 2020;21(1):391. DOI:10.1186/s12882-020-02044-9
75. Perazella MA, Shirali AC. Immune checkpoint inhibitor nephrotoxicity: what do we know and what should we do? Kidney Int. 2020;97(1):62-74. DOI:10.1016/j.kint.2019.07.022
76. Kitchlu A, Jhaveri KD, Wadhwani S, et al. A Systematic Review of Immune Checkpoint Inhibitor-Associated Glomerular Disease. Kidney Int Rep. 2020;6(1):66-77. DOI:10.1016/j.ekir.2020.10.002
77. Izzedine H, Mateus C, Boutros C, et al. Renal effects of immune checkpoint inhibitors. Nephrol Dial Transplant. 2017;32(6):936-42. DOI:10.1093/ndt/gfw382
78. Hu R, Chen M, Xu Y, et al. Renal immune-related adverse events of immune checkpoint inhibitor. Asia Pac J Clin Oncol. 2020;16(6):305-11. DOI:10.1111/ajco.13387
79. Spanou Z, Keller M, Britschgi M, et al. Involvement of drug-specific T cells in acute drug-induced interstitial nephritis. J Am Soc Nephrol. 2006;17(10):2919-27. DOI:10.1681/ASN.2006050418
80. Nishimura H, Nose M, Hiai H, et al. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity. 1999;11(2):141-51. DOI:10.1016/s1074-7613(00)80089-8
81. Benfaremo D, Manfredi L, Luchetti MM, Gabrielli A. Musculoskeletal and Rheumatic Diseases Induced by Immune Checkpoint Inhibitors: A Review of the Literature. Curr Drug Saf. 2018;13(3):150-64. DOI:10.2174/1574886313666180508122332
82. Abdel-Wahab N, Shah M, Suarez-Almazor ME. Adverse Events Associated with Immune Checkpoint Blockade in Patients with Cancer: A Systematic Review of Case Reports. PLoS One. 2016;11(7):e0160221. DOI:10.1371/journal.pone.0160221
83. Wuthrich RP, Glimcher LH, Yui MA, et al. MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Kidney Int. 1990;37(2):783-92. DOI:10.1038/ki.1990.46
84. Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010;236:219-42. DOI:10.1111/j.1600-065X.2010.00923.x
85. Schoop R, Wahl P, Le Hir M, et al. Suppressed T-cell activation by IFN-gamma-induced expression of PD-L1 on renal tubular epithelial cells. Nephrol Dial Transplant. 2004;19(11):2713-20. DOI:10.1093/ndt/gfh423
86. Murakami N, Motwani S, Riella LV. Renal complications of immune checkpoint blockade. Curr Probl Cancer. 2017;41(2):100-10.
DOI:10.1016/j.currproblcancer.2016.12.004
87. Marco T, Anna P, Annalisa T, et al. The mechanisms of acute interstitial nephritis in the era of immune checkpoint inhibitors in melanoma. Ther Adv Med Oncol. 2019;11:1758835919875549. DOI:10.1177/1758835919875549
88. Herrmann SM, Perazella MA. Immune Checkpoint Inhibitors and Immune-Related Adverse Renal Events. Kidney Int Rep. 2020;5(8):1139-48. DOI:10.1016/j.ekir.2020.04.018
89. Kim SH, Park SJ, Han KH, et al. Pathogenesis of minimal change nephrotic syndrome: an immunological concept. Korean J Pediatr. 2016;59(5):205-11. DOI:10.3345/kjp.2016.59.5.205
90. Jarrot PA, Kaplanski G. Pathogenesis of ANCA-associated vasculitis: An update. Autoimmun Rev. 2016;15(7):704-13. DOI:10.1016/j.autrev.2016.03.007
91. Zha H, Han X, Zhu Y, et al. Blocking C5aR signaling promotes the anti-tumor efficacy of PD-1/PD-L1 blockade. Oncoimmunology. 2017;6(10):e1349587. DOI:10.1080/2162402X.2017.1349587
92. Zakharova EV, Stolyarevich ES. Renal consequences of Lymphoproliferative Disorders and Monoclonal Gammopathy. Urol Nephrol Open Access. 2015;2(4):47–55.0
DOI:10.15406/unoaj.2015.02.00047
93. Kolina IB, Bobkova IN. Nephropathies in malignant tumors. Al’manakh klinicheskoy meditsiny. 2014;30:108-16 (in Russian)
94. Centanni M, Moes DJAR, Trocóniz IF, et al. Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors. Clin Pharmacokinet. 2019;58(7):835-57. DOI:10.1007/s40262-019-00748-2
95. Hirsch JS, Wanchoo R, Ng JH, et al. Jhaveri Use of Immune Checkpoint Inhibitors in End Stage Kidney Disease Patients, Single Center Experience and Review of the Literature. Kidney360. 2020;1:399-402. DOI:10.34067/KID.0000422020
96. Tabei T, Natsume I, Kobayashi K. Successful treatment of metastatic clear cell carcinoma with nivolumab in a patient receiving dialysis treatment. Int J Urol. 2017;24(9):708-10. DOI:10.1111/iju.13420
97. Cappelli LC, Dorak MT, Bettinotti MP, et al. Association of HLA-DRB1 shared epitope alleles and immune checkpoint inhibitor-induced inflammatory arthritis. Rheumatology (Oxford). 2019;58(3):476-80. DOI:10.1093/rheumatology/key358
98. Kennedy LC, Bhatia S, Thompson JA, Grivas P. Preexisting Autoimmune Disease: Implications for Immune Checkpoint Inhibitor Therapy in Solid Tumors. J Natl Compr Canc Netw. 2019;17(6):750-7. DOI:10.6004/jnccn.2019.7310
99. Abolhassani AR, Schuler G, Kirchberger MC, Heinzerling L. C-reactive protein as an early marker of immune-related adverse events. J Cancer Res Clin Oncol. 2019;145(10):2625-31. DOI:10.1007/s00432-019-03002-1
100. Romo-Tena J, Gómez-Martín D, Alcocer-Varela J. CTLA-4 and autoimmunity: new insights into the dual regulator of tolerance. Autoimmun Rev. 2013;12(12):1171-6. DOI:10.1016/j.autrev.2013.07.002
101. Caturegli P, Di Dalmazi G, Lombardi M, et al. Hypophysitis Secondary to Cytotoxic T-Lymphocyte-Associated Protein 4 Blockade: Insights into Pathogenesis from an Autopsy Series. Am J Pathol. 2016;186(12):3225-35. DOI:10.1016/j.ajpath.2016.08.020
102. Brahmer JR, Lacchetti C, Schneider BJ, et al. Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2018;36(17):1714-68. DOI:10.1200/JCO.2017.77.6385
103. Protsenko SA, Antimonik NYu, Bershteyn LM, et al. Prakticheskiye rekomendatsii po upravleniyu immunooposredovannymi nezhelatel'nymi yavleniyami. Zlokachestvennyye opukholi. 2019;3-S2:704-34 (in Russian)
104. Thompson JA, Schneider BJ, Brahmer J, et al. Management of Immunotherapy-Related Toxicities, Version 1.2019. J Natl Compr Canc Netw. 2019;17(3):255-89. DOI:10.6004/jnccn.2019.0013
105. Zheng K, Qiu W, Wang H, et al. Clinical recommendations on diagnosis and treatment of immune checkpoint inhibitor-induced renal immune-related adverse events. Thorac Cancer. 2020;11(6):1746-51. DOI:10.1111/1759-7714.13405
106. Sprangers B. Pembrolizumab-related renal toxicities: diagnosis first, treatment later. Clin Kidney J. 2019;12(1):78-80. DOI:10.1093/ckj/sfy114
107. Perazella MA, Sprangers B. AKI in Patients Receiving Immune Checkpoint Inhibitors. Clin J Am Soc Nephrol. 2019;14(7):1077-9. DOI:10.2215/CJN.02340219
108. Manohar S, Ghamrawi R, Chengappa M, et al. Acute interstitial nephritis and checkpoint inhibitor therapy. Single center experience of management and drug rechallenge. Kidney 360. 2020;1:16-24. DOI:10.34067/KID.0000152019
109. Pannu N, James M, Hemmelgarn B, Klarenbach S; Alberta Kidney Disease Network. Association between AKI, recovery of renal function, and long-term outcomes after hospital discharge. Clin J Am Soc Nephrol. 2013;8(2):194-202.
DOI:10.2215/CJN.06480612

Авторы

Е.С. Камышова*, И.Н. Бобкова, М.И. Секачева

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия
*kamyshova-es@yandex.ru

________________________________________________

Elena S. Kamyshova*, Irina N. Bobkova, Marina I. Sekacheva

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
*kamyshova-es@yandex.ru

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