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Факторы риска панкреатита и рака поджелудочной железы
Факторы риска панкреатита и рака поджелудочной железы
Григорьева И.Н., Ефимова О.В. Факторы риска панкреатита и рака поджелудочной железы. Терапевтический архив. 2021; 93 (8): 876–882. DOI: 10.26442/00403660.2021.08.200970
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Аннотация
Цель. Оценить и сравнить частоту потребления алкоголя, табакокурения, уровни основных макронутриентов, витаминов и минеральных элементов в рационе питания у больных острым (ОП) и хроническим панкреатитом (ХП) и раком поджелудочной железы (РПЖ).
Материалы и методы. В ходе наблюдательного клинического кросс-секционного неконтролируемого исследования по типу «серия случаев» обследованы 65 больных ОП или ХП (1-я группа) и 45 больных РПЖ (2-я группа). Проведено анкетирование больных: опросник по табакокурению, частотный опросник по потреблению алкоголя, опросник по оценке частоты потребления пищевых продуктов.
Результаты. Частота табакокурения (33,8, 20,0%; p>0,05), потребления алкоголя ≥1 раза в неделю в течение последнего года (21,5, 15,6%; p>0,05) значительно не различалась между двумя группами. Наиболее высокие показатели потребления общего, растительного, животного белка, общих углеводов, рафинированного сахара, животного жира, холестерина, насыщенных жирных кислот, мононенасыщенных жирных кислот, пищевых волокон, витаминов (β-каротина, витаминов В1, В2, С, PP), минеральных элементов (железа, калия, кальция, магния, натрия, фосфора) и суточной энергоценности рациона питания определены при РПЖ, по сравнению с группой ОП и ХП. Среди больных 1-й группы дефицитное потребление жирорастворимых витамина А (93,3, 54,8%; p=0,009) и витамина Е (80,0, 48,4%; p=0,041) встречалось чаще в подгруппе больных с экскреторной недостаточностью поджелудочной железы, чем без таковой, а шанс наличия гиперхолестеринемии ассоциирован с дефицитным потреблением витамина Е [Ex(B)=3,3, 95% доверительный интервал 1,5–9,3; p=0,027].
Заключение. Не выявлено различий в частоте табакокурения и потребления алкоголя между пациентами с ОП, ХП и РПЖ. Наиболее высокие показатели основных макронутриентов, суточной энергоценности рациона питания, микронутриентов (кроме витаминов А, Е) определены при РПЖ по сравнению с группой больных ОП и ХП. Среди больных ОП и ХП при экскреторной недостаточности поджелудочной железы отмечено более низкое потребление жирорастворимых витаминов и получены ассоциации гиперхолестеринемии с дефицитным потреблением витамина Е.
Ключевые слова: острый панкреатит, хронический панкреатит, рак поджелудочной железы, табакокурение, потребление алкоголя
Materials and methods. At the observational clinical cross-sectional uncontrolled case-study 65 patients with AP or CP (group 1) and 45 patients with PC (group 2) were examined. A survey of patients was carried out: questionnaire on tobacco smoking, a frequency questionnaire on alcohol consumption, a questionnaire for assessing the frequency of food consumption.
Results. The frequency of smoking (33.8, 20.0%; p>0.05), alcohol consumption ≥1 times/week during the last year (21.5, 15.6%; p>0.05) did not differ significantly between the two groups. The highest consumption rates of total, vegetable, animal protein, total carbohydrates, refined sugar, animal fat, cholesterol, MUFA, dietary fiber, vitamins (β-carotene, vitamin B1, B2, C, PP), mineral elements (iron, potassium, calcium, magnesium, sodium, phosphorus) and the daily energy content of the diet were determined in PC than in the AP and CP group. Among patients of group 1, deficient intake of fat-soluble vitamin A (93.3, 54.8%; p=0.009) and vitamin E (80.0, 48.4%; p=0.041) was more common in the subgroup of patients with excretory pancreatic insufficiency than without it, and the chance of having hypercholesterolemia was associated with a deficient intake of vitamin E [Ex(B)=3.3, 95% CI 1.5–9.3; p=0.027].
Conclusion. There were no differences in the frequency of smoking and alcohol consumption between patients with AP and CP and PC. The highest indices of the main macronutrients, daily energy content of the diet, micronutrients (except for vitamins A, E) were found in PC than in the group of patients with AP and CP. Among patients with AP and CP with excretory pancreatic insufficiency, a lower intake of fat-soluble vitamins was noted and associations of hypercholesterolemia with deficient intake of vitamin E were obtained.
Keywords: acute pancreatitis, chronic pancreatitis, pancreatic cancer, tobacco smoking, alcohol consumption, nutrition
Материалы и методы. В ходе наблюдательного клинического кросс-секционного неконтролируемого исследования по типу «серия случаев» обследованы 65 больных ОП или ХП (1-я группа) и 45 больных РПЖ (2-я группа). Проведено анкетирование больных: опросник по табакокурению, частотный опросник по потреблению алкоголя, опросник по оценке частоты потребления пищевых продуктов.
Результаты. Частота табакокурения (33,8, 20,0%; p>0,05), потребления алкоголя ≥1 раза в неделю в течение последнего года (21,5, 15,6%; p>0,05) значительно не различалась между двумя группами. Наиболее высокие показатели потребления общего, растительного, животного белка, общих углеводов, рафинированного сахара, животного жира, холестерина, насыщенных жирных кислот, мононенасыщенных жирных кислот, пищевых волокон, витаминов (β-каротина, витаминов В1, В2, С, PP), минеральных элементов (железа, калия, кальция, магния, натрия, фосфора) и суточной энергоценности рациона питания определены при РПЖ, по сравнению с группой ОП и ХП. Среди больных 1-й группы дефицитное потребление жирорастворимых витамина А (93,3, 54,8%; p=0,009) и витамина Е (80,0, 48,4%; p=0,041) встречалось чаще в подгруппе больных с экскреторной недостаточностью поджелудочной железы, чем без таковой, а шанс наличия гиперхолестеринемии ассоциирован с дефицитным потреблением витамина Е [Ex(B)=3,3, 95% доверительный интервал 1,5–9,3; p=0,027].
Заключение. Не выявлено различий в частоте табакокурения и потребления алкоголя между пациентами с ОП, ХП и РПЖ. Наиболее высокие показатели основных макронутриентов, суточной энергоценности рациона питания, микронутриентов (кроме витаминов А, Е) определены при РПЖ по сравнению с группой больных ОП и ХП. Среди больных ОП и ХП при экскреторной недостаточности поджелудочной железы отмечено более низкое потребление жирорастворимых витаминов и получены ассоциации гиперхолестеринемии с дефицитным потреблением витамина Е.
Ключевые слова: острый панкреатит, хронический панкреатит, рак поджелудочной железы, табакокурение, потребление алкоголя
________________________________________________
Materials and methods. At the observational clinical cross-sectional uncontrolled case-study 65 patients with AP or CP (group 1) and 45 patients with PC (group 2) were examined. A survey of patients was carried out: questionnaire on tobacco smoking, a frequency questionnaire on alcohol consumption, a questionnaire for assessing the frequency of food consumption.
Results. The frequency of smoking (33.8, 20.0%; p>0.05), alcohol consumption ≥1 times/week during the last year (21.5, 15.6%; p>0.05) did not differ significantly between the two groups. The highest consumption rates of total, vegetable, animal protein, total carbohydrates, refined sugar, animal fat, cholesterol, MUFA, dietary fiber, vitamins (β-carotene, vitamin B1, B2, C, PP), mineral elements (iron, potassium, calcium, magnesium, sodium, phosphorus) and the daily energy content of the diet were determined in PC than in the AP and CP group. Among patients of group 1, deficient intake of fat-soluble vitamin A (93.3, 54.8%; p=0.009) and vitamin E (80.0, 48.4%; p=0.041) was more common in the subgroup of patients with excretory pancreatic insufficiency than without it, and the chance of having hypercholesterolemia was associated with a deficient intake of vitamin E [Ex(B)=3.3, 95% CI 1.5–9.3; p=0.027].
Conclusion. There were no differences in the frequency of smoking and alcohol consumption between patients with AP and CP and PC. The highest indices of the main macronutrients, daily energy content of the diet, micronutrients (except for vitamins A, E) were found in PC than in the group of patients with AP and CP. Among patients with AP and CP with excretory pancreatic insufficiency, a lower intake of fat-soluble vitamins was noted and associations of hypercholesterolemia with deficient intake of vitamin E were obtained.
Keywords: acute pancreatitis, chronic pancreatitis, pancreatic cancer, tobacco smoking, alcohol consumption, nutrition
Полный текст
Список литературы
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2. Loly JP, Meurisse N, Gast P, et al. Alcool and Pancreatic Complications. Rev Med Liege. 2019;74(5-6):342-8.
3. Kume K, Masamune A, Ariga H, Shimosegawa T. Alcohol Consumption and the Risk for Developing Pancreatitis: A Case-Control Study in Japan. Pancreas. 2015;44(1):53-8. DOI:10.1158/1055-9965.EPI-08-0880
4. Wang YT, Gou YW, Jin WW, et al. Association Between Alcohol Intake and the Risk of Pancreatic Cancer: A Dose-Response Meta-Analysis of Cohort Studies. BMC Cancer. 2016;16:212. DOI:10.1186/s12885-016-2241-1
5. Go VL, Gukovskaya A, Pandol SJ. Alcohol and pancreatic cancer. Alcohol. 2005;35(3):205-11 DOI:10.1016/j.alcohol.2005.03.010
6. Barreto SG. How does cigarette smoking cause acute pancreatitis? Pancreatology. 2016;16(2):157-63. DOI:10.1016/j.pan.2015.09.002
7. Aune D, Schlesinger S, Norat T, et al. Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. Ann Oncol. 2012;23(4):843-52. DOI:10.1007/s10654-017-0353-9
8. Lynch SM, Vrieling A, Lubin JH, et al. Cigarette Smoking and Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Cohort Consortium. Am J Epidemiol. 2009;70(4):403-13. DOI:10.1093/aje/kwp134
9. Bosetti C, Rosato V, Li D, et al. Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium. Ann Oncol. 2014;25(10):2065-72. DOI:10.1093/annonc/mdu276
10. Andriulli A, Ippolito AM, Festa V, et al. Exocrine Pancreatic Insufficiency, as Assessed by Fecal Elastase-1 Levels, in Diabetic Patients: An Estimate of Prevalence in Prospective Studies. J Diabetes Metab. 2014;5:379. DOI:10.4172/2155-6156.1000379
11. Ye X, Lu G, Huai J, Ding J. Impact of Smoking on the Risk of Pancreatitis: A Systematic Review and Meta-Analysis. PLoS One. 2015;10(4):e0124075. DOI:10.1371/journal.pone.0124075
12. Law R, Parsi M, Lopez R. Cigarette smoking is independently associated with chronic pancreatitis. Pancreatology. 2010;10(1):54-9. DOI:10.1159/000225927
13. Lin HH, Chang HY, Chiang YT. Smoking, drinking, and pancreatitis: a population-based cohort study in Taiwan. Pancreas. 2014;43(7):1117-22. DOI:10.1097/MPA.0000000000000209
14. Sun X, Huang X, Zhao R, Chen B. Meta-analysis: Tobacco smoking may enhance the risk of acute pancreatitis. Pancreatology. 2015;15(3):286-94.
DOI:10.1016/j.pan.2015.03.001
15. Shakeri R, Kamangar F, Mohamadnejad M, et al. Opium use, cigarette smoking, and alcohol consumption in relation to pancreatic cancer. Medicine (Baltimore). 2016;95(28):e3922. DOI:10.1097/MD.0000000000003922
16. Jamil K, Jayaraman A, Ahmad J, et al. TNF-alpha -308G/A and -238G/A polymorphisms and its protein network associated with type 2 diabetes mellitus. Saudi J Biol Sci. 2017;24(6):1195-203. DOI:10.1016/j.sjbs.2016.05.012
17. Grigor’eva IN. Acute and chronic pancreatitis. Novosibirsk: Nauka, 2011 (in Russian)
18. Thomas T, Mah L, Barreto SG. Systematic Review of Diet in the Pathogenesis of Acute Pancreatitis: A Tale of Too Much or Too Little? J Gastroenterol. 2012;18(5):310-5. DOI:10.4103/1319-3767.101124
19. Hong Y, Jia Y, Su Y, et al. High-Fat Diet Aggravates Acute Pancreatitis via TLR4-Mediated Necroptosis and Inflammation in Rats. Oxid Med Cell Longev. 2020;2020:8172714. DOI:10.1155/2020/8172714
20. Storck LJ, Imoberdorf R, Ballmer PE. Nutrition in Gastrointestinal Disease: Liver, Pancreatic, and Inflammatory Bowel Disease. J Clin Med. 2019;8(8):E1098. DOI:10.3390/jcm8081098
21. Maev IV, Kucheryavyi YA, Andreev DN, Bideeva TV. Nutritional status in patients with chronic pancreatitis. Terapevticheskii Arkhiv (Ter. Arkh.). 2016;88(2):81-9 (in Russian)
DOI:10.17116/terarkh201688281-89
22. Domínguez-Muñoz JE, Phillips M. Nutritional Therapy in Chronic Pancreatitis. Gastroenterol. Clin North Am. 2018;47(1):95-106.
DOI:10.1016/j.gtc.2017.09.004
23. Zheng J, Guinter MA, Merchant AT, et al. Dietary Patterns and Risk of Pancreatic Cancer: A Systematic Review. Nutr Rev. 2017;75(11):883-908. DOI:10.1093/nutrit/nux038
24. Molina-Montes E, Sánchez M-J, Buckland G, et al. Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort. Br J Cancer. 2017;116(6):811-20. DOI:10.1038/bjc.2017.14
25. Schulpen M, Peeters PH, van den Brandt PA. Mediterranean Diet Adherence and Risk of Pancreatic Cancer: A Pooled Analysis of Two Dutch Cohorts. Int
J Cancer. 2019; 144(7):1550-60. DOI:10.1002/ijc.31872
26. Setiawan VW, Pandol SJ, Porcel J, et al. Prospective study of alcohol drinking, smoking, and pancreatitis: the multiethnic cohort. Pancreas. 2016;45:819-25. DOI:10.1097/MPA.0000000000000657
27. Brunner E, Stallone D, Juneja M, et al. Dietary assessment in Whitehall II: comparison of 7 d diet diary and food frequency questionnaire and validity against biomarkers. Br J Nutr. 2001;86(3):405-14. DOI:10.1079/bjn2001414
28. Martinchik AN, Baturin АK, Baeva VS, et al. Development of the method of research of actual nutrition according to the analysis of the frequency of food consumption: the creation of a questionnaire and an overall assessment of the reliability of the method. Problems of Nutrition.1998;67(3):8-13 (in Russian)
29. Daminova LT, Muminova SU. Diabetes mellitus and exocrine pancreatic insufficiency (review). International Journal of Endocrinology. 2018;14(1):55-9 (in Russian)
DOI:10.22141/2224-0721.14.1.2018.127093
30. Alsamarrai A, Das SLM, Windsor JA, Petrov MS. Factors That Affect Risk for Pancreatic Disease in the General Population: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. Clin Gastroenterol Hepatol. 2014;12(10):1635-44. DOI:10.1016/j.cgh.2014.01.038
31. Lew D, Afghani E, Pandol S. Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment. Dig Dis Sci. 2017;62(7):1702-12. DOI:10.1007/s10620-017-4602-2
32. Singhvi A, Yadav D. Myths and Realities about alcohol and smoking in chronic pancreatitis. Curr Opin Gastroenterol. 2018;34(5):355-61. DOI:10.1097/MOG.0000000000000466
33. Mikhailova OD, Vakhrushev YM, Grigus YI. Characteristics of the nutritional characteristics of patients with chronic pancreatitis in urban and rural areas. Vyatka Medical Bulletin. 2018;1(57):51-7 (in Russian)
34. Gubensek J, Buturovic-Ponikvar J, Romozi K, Ponikvar R. Factors Affecting Outcome in Acute Hypertriglyceridemic Pancreatitis Treated with Plasma Exchange: An Observational Cohort Study. PLoS One. 2014;9(7):e102748. DOI:10.1371/journal.pone.0102748
35. Chang НН, Moro A, Takakura K, et al. Incidence of Pancreatic Cancer Is Dramatically Increased by a High Fat, High Calorie Diet in KrasG12D Mice. PLoS One. 2017;12(9):e0184455. DOI:10.1371/journal.pone.0184455
36. Bhardwaj P, Thareja S, Prakash S, Saraya A. Micronutrient antioxidant intake in patients with chronic pancreatitis. Trop Gastroenterol. 2004;25(2):69-72.
37. Roberts KM, Golian P, Nahikian-Nelms M, et al. Does the Healthy Eating Index and Mediterranean Diet Score Identify the Nutritional Adequacy of Dietary Patterns in Chronic Pancreatitis? Dig Dis Sci. 2019;64(8):2318-26. DOI:10.1007/s10620-019-05536-3
38. Reddy MRG, Venkata MS, Putcha UK, Jeyakumar SM. Vitamin A deficiency induces endoplasmic reticulum stress and apoptosis in pancreatic islet cells: Implications of stearoyl-CoA desaturase 1-mediated oleic acid synthesis. Exp Cell Res. 2018;364(1):104-12. DOI:10.1016/j.yexcr.2018.01.040
39. Soetart N, Rochel D, Drut A, Jaillardon L. Serum cobalamin and folate as prognostic factors in canine exocrine pancreatic insufficiency: An observational cohort study of 299 dogs. Vet J. 2019;243:15-20. DOI:10.1016/j.tvjl.2018.11.003
40. Larsson SC, Håkansson N, Giovannucci E, Wolk A. Folate intake and pancreatic cancer incidence: a prospective study of Swedish women and men. J Natl Cancer Inst. 2006;98(6):407-13. DOI:10.1093/jnci/djj094
41. Sabui S, Subramanian VS, Kapadia R, Said HM. Adaptive regulation of pancreatic acinar mitochondrial thiamin pyrophosphate uptake process: possible involvement of epigenetic mechanism(s). Am J Physiol Gastrointest Liver Physiol. 2017;31(5):G448-55. DOI:10.1152/ajpgi.00192.2017
42. Schick V, Scheiber JA, Mooren FC, et al. Effect of magnesium supplementation and depletion on the onset and course of acute experimental pancreatitis. Gut. 2014;63(9):1469-80. DOI:10.1136/gutjnl-2012-304274
2. Loly JP, Meurisse N, Gast P, et al. Alcool and Pancreatic Complications. Rev Med Liege. 2019;74(5-6):342-8.
3. Kume K, Masamune A, Ariga H, Shimosegawa T. Alcohol Consumption and the Risk for Developing Pancreatitis: A Case-Control Study in Japan. Pancreas. 2015;44(1):53-8. DOI:10.1158/1055-9965.EPI-08-0880
4. Wang YT, Gou YW, Jin WW, et al. Association Between Alcohol Intake and the Risk of Pancreatic Cancer: A Dose-Response Meta-Analysis of Cohort Studies. BMC Cancer. 2016;16:212. DOI:10.1186/s12885-016-2241-1
5. Go VL, Gukovskaya A, Pandol SJ. Alcohol and pancreatic cancer. Alcohol. 2005;35(3):205-11 DOI:10.1016/j.alcohol.2005.03.010
6. Barreto SG. How does cigarette smoking cause acute pancreatitis? Pancreatology. 2016;16(2):157-63. DOI:10.1016/j.pan.2015.09.002
7. Aune D, Schlesinger S, Norat T, et al. Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. Ann Oncol. 2012;23(4):843-52. DOI:10.1007/s10654-017-0353-9
8. Lynch SM, Vrieling A, Lubin JH, et al. Cigarette Smoking and Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Cohort Consortium. Am J Epidemiol. 2009;70(4):403-13. DOI:10.1093/aje/kwp134
9. Bosetti C, Rosato V, Li D, et al. Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium. Ann Oncol. 2014;25(10):2065-72. DOI:10.1093/annonc/mdu276
10. Andriulli A, Ippolito AM, Festa V, et al. Exocrine Pancreatic Insufficiency, as Assessed by Fecal Elastase-1 Levels, in Diabetic Patients: An Estimate of Prevalence in Prospective Studies. J Diabetes Metab. 2014;5:379. DOI:10.4172/2155-6156.1000379
11. Ye X, Lu G, Huai J, Ding J. Impact of Smoking on the Risk of Pancreatitis: A Systematic Review and Meta-Analysis. PLoS One. 2015;10(4):e0124075. DOI:10.1371/journal.pone.0124075
12. Law R, Parsi M, Lopez R. Cigarette smoking is independently associated with chronic pancreatitis. Pancreatology. 2010;10(1):54-9. DOI:10.1159/000225927
13. Lin HH, Chang HY, Chiang YT. Smoking, drinking, and pancreatitis: a population-based cohort study in Taiwan. Pancreas. 2014;43(7):1117-22. DOI:10.1097/MPA.0000000000000209
14. Sun X, Huang X, Zhao R, Chen B. Meta-analysis: Tobacco smoking may enhance the risk of acute pancreatitis. Pancreatology. 2015;15(3):286-94. DOI:10.1016/j.pan.2015.03.001
15. Shakeri R, Kamangar F, Mohamadnejad M, et al. Opium use, cigarette smoking, and alcohol consumption in relation to pancreatic cancer. Medicine (Baltimore). 2016;95(28):e3922. DOI:10.1097/MD.0000000000003922
16. Jamil K, Jayaraman A, Ahmad J, et al. TNF-alpha -308G/A and -238G/A polymorphisms and its protein network associated with type 2 diabetes mellitus. Saudi J Biol Sci. 2017;24(6):1195-203. DOI:10.1016/j.sjbs.2016.05.012
17. Григорьева И.Н. Острый и хронический панкреатит. Новосибирск: Наука, 2011 [Grigor’eva IN. Acute and chronic pancreatitis. Novosibirsk: Nauka, 2011 (in Russian)].
18. Thomas T, Mah L, Barreto SG. Systematic Review of Diet in the Pathogenesis of Acute Pancreatitis: A Tale of Too Much or Too Little? J Gastroenterol. 2012;18(5):310-5. DOI:10.4103/1319-3767.101124
19. Hong Y, Jia Y, Su Y, et al. High-Fat Diet Aggravates Acute Pancreatitis via TLR4-Mediated Necroptosis and Inflammation in Rats. Oxid Med Cell Longev. 2020;2020:8172714. DOI:10.1155/2020/8172714
20. Storck LJ, Imoberdorf R, Ballmer PE. Nutrition in Gastrointestinal Disease: Liver, Pancreatic, and Inflammatory Bowel Disease. J Clin Med. 2019;8(8):E1098. DOI:10.3390/jcm8081098
21. Маев И.В., Кучерявый Ю.А., Андреев Д.Н., Бидеева Т.В. Статус питания больных хроническим панкреатитом. Терапевтический архив. 2016;88(2):81-9 [Maev IV, Kucheryavyi YA, Andreev DN, Bideeva TV. Nutritional status in patients with chronic pancreatitis. Terapevticheskii Arkhiv (Ter. Arkh.). 2016;88(2):81-9 (in Russian)]. DOI:10.17116/terarkh201688281-89
22. Domínguez-Muñoz JE, Phillips M. Nutritional Therapy in Chronic Pancreatitis. Gastroenterol. Clin North Am. 2018;47(1):95-106. DOI:10.1016/j.gtc.2017.09.004
23. Zheng J, Guinter MA, Merchant AT, et al. Dietary Patterns and Risk of Pancreatic Cancer: A Systematic Review. Nutr Rev. 2017;75(11):883-908. DOI:10.1093/nutrit/nux038
24. Molina-Montes E, Sánchez M-J, Buckland G, et al. Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort. Br J Cancer. 2017;116(6):811-20. DOI:10.1038/bjc.2017.14
25. Schulpen M, Peeters PH, van den Brandt PA. Mediterranean Diet Adherence and Risk of Pancreatic Cancer: A Pooled Analysis of Two Dutch Cohorts. Int
J Cancer. 2019; 144(7):1550-60. DOI:10.1002/ijc.31872
26. Setiawan VW, Pandol SJ, Porcel J, et al. Prospective study of alcohol drinking, smoking, and pancreatitis: the multiethnic cohort. Pancreas. 2016;45:819-25. DOI:10.1097/MPA.0000000000000657
27. Brunner E, Stallone D, Juneja M, et al. Dietary assessment in Whitehall II: comparison of 7 d diet diary and food frequency questionnaire and validity against biomarkers. Br J Nutr. 2001;86(3):405-14. DOI:10.1079/bjn2001414
28. Мартинчик А.Н., Батурин А.К., Баева В.С., и др. Разработка метода исследования фактического питания по анализу частоты потребления пищевых продуктов: создание вопросника и общая оценка достоверности метода. Вопр. питания. 1998;67(3):8-13 [Martinchik AN, Baturin АK, Baeva VS, et al. Development of the method of research of actual nutrition according to the analysis of the frequency of food consumption: the creation of a questionnaire and an overall assessment of the reliability of the method. Problems of Nutrition.1998;67(3):8-13 (in Russian)].
29. Даминова Л.Т., Муминова С.У. Сахарный диабет и экзокринная недостаточность поджелудочной железы (обзор литературы). Междунар. эндокринологический журн. 2018;14(1):55-9 [Daminova LT, Muminova SU. Diabetes mellitus and exocrine pancreatic insufficiency (review). International Journal of Endocrinology. 2018;14(1):55-9 (in Russian)]. DOI:10.22141/2224-0721.14.1.2018.127093
30. Alsamarrai A, Das SLM, Windsor JA, Petrov MS. Factors That Affect Risk for Pancreatic Disease in the General Population: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. Clin Gastroenterol Hepatol. 2014;12(10):1635-44. DOI:10.1016/j.cgh.2014.01.038
31. Lew D, Afghani E, Pandol S. Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment. Dig Dis Sci. 2017;62(7):1702-12. DOI:10.1007/s10620-017-4602-2
32. Singhvi A, Yadav D. Myths and Realities about alcohol and smoking in chronic pancreatitis. Curr Opin Gastroenterol. 2018;34(5):355-61. DOI:10.1097/MOG.0000000000000466
33. Михайлова О.Д., Вахрушев Я.М., Григус Я.И. Характеристика особенностей питания больных хроническим панкреатитом в городской и сельской местности. Вятский мед. вестн. 2018;1(57):51-7 [Mikhailova OD, Vakhrushev YM, Grigus YI. Characteristics of the nutritional characteristics of patients with chronic pancreatitis in urban and rural areas. Vyatka Medical Bulletin. 2018;1(57):51-7 (in Russian)].
34. Gubensek J, Buturovic-Ponikvar J, Romozi K, Ponikvar R. Factors Affecting Outcome in Acute Hypertriglyceridemic Pancreatitis Treated with Plasma Exchange: An Observational Cohort Study. PLoS One. 2014;9(7):e102748. DOI:10.1371/journal.pone.0102748
35. Chang НН, Moro A, Takakura K, et al. Incidence of Pancreatic Cancer Is Dramatically Increased by a High Fat, High Calorie Diet in KrasG12D Mice. PLoS One. 2017;12(9):e0184455. DOI:10.1371/journal.pone.0184455
36. Bhardwaj P, Thareja S, Prakash S, Saraya A. Micronutrient antioxidant intake in patients with chronic pancreatitis. Trop Gastroenterol. 2004;25(2):69-72.
37. Roberts KM, Golian P, Nahikian-Nelms M, et al. Does the Healthy Eating Index and Mediterranean Diet Score Identify the Nutritional Adequacy of Dietary Patterns in Chronic Pancreatitis? Dig Dis Sci. 2019;64(8):2318-26. DOI:10.1007/s10620-019-05536-3
38. Reddy MRG, Venkata MS, Putcha UK, Jeyakumar SM. Vitamin A deficiency induces endoplasmic reticulum stress and apoptosis in pancreatic islet cells: Implications of stearoyl-CoA desaturase 1-mediated oleic acid synthesis. Exp Cell Res. 2018;364(1):104-12. DOI:10.1016/j.yexcr.2018.01.040
39. Soetart N, Rochel D, Drut A, Jaillardon L. Serum cobalamin and folate as prognostic factors in canine exocrine pancreatic insufficiency: An observational cohort study of 299 dogs. Vet J. 2019;243:15-20. DOI:10.1016/j.tvjl.2018.11.003
40. Larsson SC, Håkansson N, Giovannucci E, Wolk A. Folate intake and pancreatic cancer incidence: a prospective study of Swedish women and men. J Natl Cancer Inst. 2006;98(6):407-13. DOI:10.1093/jnci/djj094
41. Sabui S, Subramanian VS, Kapadia R, Said HM. Adaptive regulation of pancreatic acinar mitochondrial thiamin pyrophosphate uptake process: possible involvement of epigenetic mechanism(s). Am J Physiol Gastrointest Liver Physiol. 2017;31(5):G448-55. DOI:10.1152/ajpgi.00192.2017
42. Schick V, Scheiber JA, Mooren FC, et al. Effect of magnesium supplementation and depletion on the onset and course of acute experimental pancreatitis. Gut. 2014;63(9):1469-80. DOI:10.1136/gutjnl-2012-304274
________________________________________________
2. Loly JP, Meurisse N, Gast P, et al. Alcool and Pancreatic Complications. Rev Med Liege. 2019;74(5-6):342-8.
3. Kume K, Masamune A, Ariga H, Shimosegawa T. Alcohol Consumption and the Risk for Developing Pancreatitis: A Case-Control Study in Japan. Pancreas. 2015;44(1):53-8. DOI:10.1158/1055-9965.EPI-08-0880
4. Wang YT, Gou YW, Jin WW, et al. Association Between Alcohol Intake and the Risk of Pancreatic Cancer: A Dose-Response Meta-Analysis of Cohort Studies. BMC Cancer. 2016;16:212. DOI:10.1186/s12885-016-2241-1
5. Go VL, Gukovskaya A, Pandol SJ. Alcohol and pancreatic cancer. Alcohol. 2005;35(3):205-11 DOI:10.1016/j.alcohol.2005.03.010
6. Barreto SG. How does cigarette smoking cause acute pancreatitis? Pancreatology. 2016;16(2):157-63. DOI:10.1016/j.pan.2015.09.002
7. Aune D, Schlesinger S, Norat T, et al. Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. Ann Oncol. 2012;23(4):843-52. DOI:10.1007/s10654-017-0353-9
8. Lynch SM, Vrieling A, Lubin JH, et al. Cigarette Smoking and Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Cohort Consortium. Am J Epidemiol. 2009;70(4):403-13. DOI:10.1093/aje/kwp134
9. Bosetti C, Rosato V, Li D, et al. Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium. Ann Oncol. 2014;25(10):2065-72. DOI:10.1093/annonc/mdu276
10. Andriulli A, Ippolito AM, Festa V, et al. Exocrine Pancreatic Insufficiency, as Assessed by Fecal Elastase-1 Levels, in Diabetic Patients: An Estimate of Prevalence in Prospective Studies. J Diabetes Metab. 2014;5:379. DOI:10.4172/2155-6156.1000379
11. Ye X, Lu G, Huai J, Ding J. Impact of Smoking on the Risk of Pancreatitis: A Systematic Review and Meta-Analysis. PLoS One. 2015;10(4):e0124075. DOI:10.1371/journal.pone.0124075
12. Law R, Parsi M, Lopez R. Cigarette smoking is independently associated with chronic pancreatitis. Pancreatology. 2010;10(1):54-9. DOI:10.1159/000225927
13. Lin HH, Chang HY, Chiang YT. Smoking, drinking, and pancreatitis: a population-based cohort study in Taiwan. Pancreas. 2014;43(7):1117-22. DOI:10.1097/MPA.0000000000000209
14. Sun X, Huang X, Zhao R, Chen B. Meta-analysis: Tobacco smoking may enhance the risk of acute pancreatitis. Pancreatology. 2015;15(3):286-94.
DOI:10.1016/j.pan.2015.03.001
15. Shakeri R, Kamangar F, Mohamadnejad M, et al. Opium use, cigarette smoking, and alcohol consumption in relation to pancreatic cancer. Medicine (Baltimore). 2016;95(28):e3922. DOI:10.1097/MD.0000000000003922
16. Jamil K, Jayaraman A, Ahmad J, et al. TNF-alpha -308G/A and -238G/A polymorphisms and its protein network associated with type 2 diabetes mellitus. Saudi J Biol Sci. 2017;24(6):1195-203. DOI:10.1016/j.sjbs.2016.05.012
17. Grigor’eva IN. Acute and chronic pancreatitis. Novosibirsk: Nauka, 2011 (in Russian)
18. Thomas T, Mah L, Barreto SG. Systematic Review of Diet in the Pathogenesis of Acute Pancreatitis: A Tale of Too Much or Too Little? J Gastroenterol. 2012;18(5):310-5. DOI:10.4103/1319-3767.101124
19. Hong Y, Jia Y, Su Y, et al. High-Fat Diet Aggravates Acute Pancreatitis via TLR4-Mediated Necroptosis and Inflammation in Rats. Oxid Med Cell Longev. 2020;2020:8172714. DOI:10.1155/2020/8172714
20. Storck LJ, Imoberdorf R, Ballmer PE. Nutrition in Gastrointestinal Disease: Liver, Pancreatic, and Inflammatory Bowel Disease. J Clin Med. 2019;8(8):E1098. DOI:10.3390/jcm8081098
21. Maev IV, Kucheryavyi YA, Andreev DN, Bideeva TV. Nutritional status in patients with chronic pancreatitis. Terapevticheskii Arkhiv (Ter. Arkh.). 2016;88(2):81-9 (in Russian)
DOI:10.17116/terarkh201688281-89
22. Domínguez-Muñoz JE, Phillips M. Nutritional Therapy in Chronic Pancreatitis. Gastroenterol. Clin North Am. 2018;47(1):95-106.
DOI:10.1016/j.gtc.2017.09.004
23. Zheng J, Guinter MA, Merchant AT, et al. Dietary Patterns and Risk of Pancreatic Cancer: A Systematic Review. Nutr Rev. 2017;75(11):883-908. DOI:10.1093/nutrit/nux038
24. Molina-Montes E, Sánchez M-J, Buckland G, et al. Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort. Br J Cancer. 2017;116(6):811-20. DOI:10.1038/bjc.2017.14
25. Schulpen M, Peeters PH, van den Brandt PA. Mediterranean Diet Adherence and Risk of Pancreatic Cancer: A Pooled Analysis of Two Dutch Cohorts. Int
J Cancer. 2019; 144(7):1550-60. DOI:10.1002/ijc.31872
26. Setiawan VW, Pandol SJ, Porcel J, et al. Prospective study of alcohol drinking, smoking, and pancreatitis: the multiethnic cohort. Pancreas. 2016;45:819-25. DOI:10.1097/MPA.0000000000000657
27. Brunner E, Stallone D, Juneja M, et al. Dietary assessment in Whitehall II: comparison of 7 d diet diary and food frequency questionnaire and validity against biomarkers. Br J Nutr. 2001;86(3):405-14. DOI:10.1079/bjn2001414
28. Martinchik AN, Baturin АK, Baeva VS, et al. Development of the method of research of actual nutrition according to the analysis of the frequency of food consumption: the creation of a questionnaire and an overall assessment of the reliability of the method. Problems of Nutrition.1998;67(3):8-13 (in Russian)
29. Daminova LT, Muminova SU. Diabetes mellitus and exocrine pancreatic insufficiency (review). International Journal of Endocrinology. 2018;14(1):55-9 (in Russian)
DOI:10.22141/2224-0721.14.1.2018.127093
30. Alsamarrai A, Das SLM, Windsor JA, Petrov MS. Factors That Affect Risk for Pancreatic Disease in the General Population: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. Clin Gastroenterol Hepatol. 2014;12(10):1635-44. DOI:10.1016/j.cgh.2014.01.038
31. Lew D, Afghani E, Pandol S. Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment. Dig Dis Sci. 2017;62(7):1702-12. DOI:10.1007/s10620-017-4602-2
32. Singhvi A, Yadav D. Myths and Realities about alcohol and smoking in chronic pancreatitis. Curr Opin Gastroenterol. 2018;34(5):355-61. DOI:10.1097/MOG.0000000000000466
33. Mikhailova OD, Vakhrushev YM, Grigus YI. Characteristics of the nutritional characteristics of patients with chronic pancreatitis in urban and rural areas. Vyatka Medical Bulletin. 2018;1(57):51-7 (in Russian)
34. Gubensek J, Buturovic-Ponikvar J, Romozi K, Ponikvar R. Factors Affecting Outcome in Acute Hypertriglyceridemic Pancreatitis Treated with Plasma Exchange: An Observational Cohort Study. PLoS One. 2014;9(7):e102748. DOI:10.1371/journal.pone.0102748
35. Chang НН, Moro A, Takakura K, et al. Incidence of Pancreatic Cancer Is Dramatically Increased by a High Fat, High Calorie Diet in KrasG12D Mice. PLoS One. 2017;12(9):e0184455. DOI:10.1371/journal.pone.0184455
36. Bhardwaj P, Thareja S, Prakash S, Saraya A. Micronutrient antioxidant intake in patients with chronic pancreatitis. Trop Gastroenterol. 2004;25(2):69-72.
37. Roberts KM, Golian P, Nahikian-Nelms M, et al. Does the Healthy Eating Index and Mediterranean Diet Score Identify the Nutritional Adequacy of Dietary Patterns in Chronic Pancreatitis? Dig Dis Sci. 2019;64(8):2318-26. DOI:10.1007/s10620-019-05536-3
38. Reddy MRG, Venkata MS, Putcha UK, Jeyakumar SM. Vitamin A deficiency induces endoplasmic reticulum stress and apoptosis in pancreatic islet cells: Implications of stearoyl-CoA desaturase 1-mediated oleic acid synthesis. Exp Cell Res. 2018;364(1):104-12. DOI:10.1016/j.yexcr.2018.01.040
39. Soetart N, Rochel D, Drut A, Jaillardon L. Serum cobalamin and folate as prognostic factors in canine exocrine pancreatic insufficiency: An observational cohort study of 299 dogs. Vet J. 2019;243:15-20. DOI:10.1016/j.tvjl.2018.11.003
40. Larsson SC, Håkansson N, Giovannucci E, Wolk A. Folate intake and pancreatic cancer incidence: a prospective study of Swedish women and men. J Natl Cancer Inst. 2006;98(6):407-13. DOI:10.1093/jnci/djj094
41. Sabui S, Subramanian VS, Kapadia R, Said HM. Adaptive regulation of pancreatic acinar mitochondrial thiamin pyrophosphate uptake process: possible involvement of epigenetic mechanism(s). Am J Physiol Gastrointest Liver Physiol. 2017;31(5):G448-55. DOI:10.1152/ajpgi.00192.2017
42. Schick V, Scheiber JA, Mooren FC, et al. Effect of magnesium supplementation and depletion on the onset and course of acute experimental pancreatitis. Gut. 2014;63(9):1469-80. DOI:10.1136/gutjnl-2012-304274
Авторы
И.Н. Григорьева1, О.В. Ефимова*2
1 Научно-исследовательский институт терапии и профилактической медицины – филиал ФГБНУ «Федеральный исследовательский центр “Институт цитологии и генетики“» СО Российской академии наук, Новосибирск, Россия;
2 ФКУЗ «Медико-санитарная часть Министерства внутренних дел Российской Федерации по г. Москве», Москва, Россия
*kukisyak@mail.ru
1 Scientific Research Institute of Therapy and Preventive Medicine – branch of the Federal Scientific Center “Institute of Cytology and Genetics” of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
2 Medical Unit of the Ministry of Internal Affairs of Russia in Moscow, Moscow, Russia
*kukisyak@mail.ru
1 Научно-исследовательский институт терапии и профилактической медицины – филиал ФГБНУ «Федеральный исследовательский центр “Институт цитологии и генетики“» СО Российской академии наук, Новосибирск, Россия;
2 ФКУЗ «Медико-санитарная часть Министерства внутренних дел Российской Федерации по г. Москве», Москва, Россия
*kukisyak@mail.ru
________________________________________________
1 Scientific Research Institute of Therapy and Preventive Medicine – branch of the Federal Scientific Center “Institute of Cytology and Genetics” of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
2 Medical Unit of the Ministry of Internal Affairs of Russia in Moscow, Moscow, Russia
*kukisyak@mail.ru
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