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Эрозивно-язвенные поражения пищеварительного тракта: оптимизация диагностики и тактики ведения
Эрозивно-язвенные поражения пищеварительного тракта: оптимизация диагностики и тактики ведения
Осадчук М.А., Осадчук А.М. Эрозивно-язвенные поражения пищеварительного тракта: оптимизация диагностики и тактики ведения. Терапевтический архив. 2022;94(2):271–276.
DOI: 10.26442/00403660.2022.02.201376
DOI: 10.26442/00403660.2022.02.201376
DOI: 10.26442/00403660.2022.02.201376
________________________________________________
DOI: 10.26442/00403660.2022.02.201376
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
Эрозивно-язвенные поражения пищеварительного тракта являются одной из актуальнейших проблем в клинической практике внутренних заболеваний из-за чрезвычайно широкой распространенности, наличия тяжелых осложнений, нередко с летальным исходом, трудностей диагностики, обусловленных большим числом бессимптомно протекающих патологий и затруднениями в рациональном выборе терапии. Особого внимания заслуживают данные о том, что в период глобальной пандемии инфекция COVID-19 способна достаточно часто вызывать развитие эрозивно-язвенных повреждений желудочно-кишечного тракта. В связи с этим представляется важным применение лекарственных средств, способных не только предупредить возникновение эрозивно-язвенных поражений и стриктур на всем протяжении желудочно-кишечного тракта, но и эффективно достигать эпителизации повреждений слизистой оболочки ротовой полости, пищевода, желудка, тонкой и толстой кишки. Одним из них является Ребамипид-CЗ (НАО «Северная звезда»), характеризующийся достаточно высоким профилем безопасности и эффективности. Представляется важным рассмотреть вопросы оптимизации профилактики и лечения эрозивно-язвенных поражений различных отделов желудочно-кишечного тракта различной этиологии с учетом возможности применения ребамипида как в составе комплексной терапии, так и изолированно.
Ключевые слова: эрозии и язвы пищеварительного тракта, клиника, диагностика, лечение, ребамипид
Keywords: erosion and ulceration of the digestive tract, clinical picture, diagnosis, treatment, rebamipide
Ключевые слова: эрозии и язвы пищеварительного тракта, клиника, диагностика, лечение, ребамипид
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Keywords: erosion and ulceration of the digestive tract, clinical picture, diagnosis, treatment, rebamipide
Полный текст
Список литературы
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3. Wang D, Mann JR, DuBois RN. The role of prostaglandins and other eicosanoids in the gastrointestinal tract. Gastroenterology. 2005;128(5):1445-61. DOI:10.1053/j.gastro.2004.09.080
4. De Petris G, Caldero SG, Chen L, et al. Histopathological changes in the gastrointestinal tract due to medications: an update for the surgical pathologist (part II of II). Int J Surg Pathol. 2014;22(3):202-11. DOI:10.1177/1066896913502230
5. Hreinsson JP, Kalaitzakis E, Gudmundsson S, Björnsson ES. Upper gastrointestinal bleeding: incidence, etiology and outcomes in a population-based setting. Scand J Gastroenterol. 2013;48(4):439-47. DOI:10.3109/00365521.2012.763174
6. Lin L, Jiang X, Zhang Z, et al. Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. Gut. 2020;69(6):997-1001. DOI:10.1136/gutjnl-2020-321013
7. Drozdov VN, Meshcheryakov YV, Serebrova SY, Shikh EV. NSAID-induced damage to the gastrointestinal tract: new opportunities for the prevention of gastro- and enteropathies. Medical Counsil. 2020;12(21):166-74 (in Russian). DOI:10.21518/2079-701X-2019-21-166-174
8. Yasuda T, Chiba H, Satomi T, et al. Preventive effect of rebamipide gargle on chemoradiotherpy-induced oral mucositis in patients with oral cancer: a pilot study. J Oral Maxillofac Res. 2012;2(4):e3. DOI:10.5037/jomr.2011.2403
9. Peterson DE. New strategies for management of oral mucositis in cancer patients. J Support Oncol. 2006;4(2 Suppl 1):9-13.
10. Peterson DE, Bensadoun R-J, Roila F, ESMO Guidelines Working Group. Management of oral and gastrointestinal mucositis: ESMO Clinical Practice Guidelines. Ann Oncol. 2011;22 Suppl. 6:vi78-84. DOI:10.1093/annonc/mdr391
11. Akagi S, Fujiwara T, Nishida M, et al. The effectiveness of rebamipide mouthwash therapy for radiotherapy and chemoradiotherapy-induced oral mucositis in patients with head and neck cancer: a systematic review and meta-analysis. J Pharm Health Care Sci. 2019;5:16. DOI:10.1186/s40780-019-0146-2
12. Yokota T, Ogawa T, Takahashi S, et al. Efficacy and safety of rebamipide liquid for chemoradiotherapy-induced oral mucositis in patients with head and neck cancer: a multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II study. BMC Cancer. 2017;17(1):314. DOI:10.1186/s12885-017-3295-4
13. Chaitanya B, Pai KM, Yathiraj PH, et al. Rebamipide gargle in preventive management of chemo-radiotherapy induced oral mucositis. Oral Oncol. 2017;72:179-82. DOI:10.1016/j.oraloncology.2017.07.024
14. Kim SH, Jeong JB, Kim JW, et al. Clinical and endoscopic characteristics of drug-induced esophagitis. World J Gastroenterol. 2014;20(31):10994-9. DOI:10.3748/wjg.v20.i31.10994
15. Ruigómez A, García Rodríguez LA, Wallander M-A, et al. Natural history of gastro-oesophageal reflux disease diagnosed in general practice. Aliment Pharmacol Ther. 2004;20(7):751-60. DOI:10.1111/j.1365-2036.2004.02169.x
16. Osadchuk AM, Davydkin IL, Gricenko TA, Osadchuk MA. Gastroesophageal reflux disease and esophagitis associated with the use of drugs: the modern state of the problem. Terapevticheskii Arkhiv (Ter. Arkh.). 2019;91(8):135-40 (in Russian). DOI:10.26442/00403660.2019.08.000228
17. van Soest EM, Dieleman JP, Siersema PD, et al. Tricyclic antidepressants and the risk of reflux esophagitis. Am J Gastroenterol. 2007;102(9):1870-7.
DOI:10.1111/j.1572-0241.2007.01320.x
18. Hasan MQ, Mondal NT, Perveen I, et al. Clinical and Endoscopic Characteristics of Medication Induced Esophageal Injury. Faridpur Med Coll J. 2020;14(1):2-7. DOI:10.3329/fmcj.v14i1.46157
19. Ivashkin VT, Maev IV, Truhmanov AS, Rumyanceva DE. Modern achievements in the diagnosis and treatment of the refractory gastroesophageal reflux disease. Terapevticheskii Arkhiv (Ter. Arkh.). 2018;90(8):4-12 (in Russian). DOI:10.26442/terarkh20189084-12
20. Hong SJ, Park S-H, Moon JS, et al. The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study. Gut Liver. 2016;10(6):910-6. DOI:10.5009/gnl15537
21. Ivashkin VT, Maev IV, Trukhmanov AS, et al. Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease. Russian Journal of Gastroenterology, Hepatology, Coloproctology.. 2020;30(4):70-97 (in Russian). DOI:10.22416/1382-4376-2020-30-4-70-97
22. Arakawa T, Higuchi K, Fujiwara Y, et al. 15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications. Dig Dis Sci. 2005;50 Suppl. 1:S3-11. DOI:10.1007/s10620-005-2800-9
23. Sy ML, Prieto RJ, Pang A, et al. Effectiveness of rebamipide in the prevention of esophageal stricture formation in advanced corrosive esophagitis: a prospective randomised control study. Gut. 2018;67(Suppl 2):A53-3. DOI:10.1136/gutjnl-2018-IDDFabstracts.118
24. Pilotto A, Franceschi M, Leandro G, Di Mario F. Geriatric Gastroenterology Study Group (Societè Italiana Gerontologie Geriatria). NSAID and aspirin use by the elderly in general practice: effect on gastrointestinal symptoms and therapies. Drugs Aging. 2003;20(9):701-10. DOI:10.2165/00002512-200320090-00006
25. Tarasconi A, Coccolini F, Biffl WL, et al. Perforated and bleeding peptic ulcer: WSES guidelines. World J Emerg Surg. 2020;15:3. DOI:10.1186/s13017-019-0283-9
26. Iijima K, Kanno T, Koike T, Shimosegawa T. Helicobacter pylori-negative, non-steroidal anti-inflammatory drug: negative idiopathic ulcers in Asia. World J Gastroenterol. 2014;20(3):706-13. DOI:10.3748/wjg.v20.i3.706
27. Dore MP, Soro S, Niolu C, et al. Clinical features and natural history of idiopathic peptic ulcers: a retrospective case-control study. Scand J Gastroenterol. 2019;54(11):1315-21. DOI:10.1080/00365521.2019.1679247
28. Rajabalinia H, Ghobakhlou M, Nikpour S, et al. Non-Helicobacter pylori, non-NSAIDs peptic ulcers: a descriptive study on patients referred to Taleghani hospital with upper gastrointestinal bleeding. Gastroenterol Hepatol Bed Bench. 2012;5(4):190-6.
29. Osadchuk MA, Osadchuk AM, Sibryaev AA. H. pylori-negative peptic ulcer: state-of-the-art. Russian Journal of Gastroenterology, Hepatology, Coloproctology.. 2014;24(1):4-9 (in Russian).
30. Wong GL-H, Wong VW-S, Chan Y, et al. High incidence of mortality and recurrent bleeding in patients with Helicobacter pylori-negative idiopathic bleeding ulcers. Gastroenterology. 2009;137(2):525-31. DOI:10.1053/j.gastro.2009.05.006
31. Chung C-S, Chiang T-H, Lee Y-C. A systematic approach for the diagnosis and treatment of idiopathic peptic ulcers. Korean J Intern Med. 2015;30(5):559-70. DOI:10.3904/kjim.2015.30.5.559
32. Ivashkin VT, Maev IV, Tsar’kov PV, et al. Diagnosis and Treatment of Peptic Ulcer in Adults (Clinical Guidelines of the Russian Gastroenterological Association, Russian Society of Colorectal Surgeons and the Russian Endoscopic Society). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2020;30(1):49-70 (in Russian).
DOI:10.22416/1382-4376-2020-30-1-49-70
33. Karateev AE, Nasonov EL, Ivashkin VT, et al. Rational use of nonsteroidal anti-inflammatory drugs. Clinical guidelines. Rheumatology Science and Practice. 2018;56:1-29 (in Russian). DOI:10.14412/1995-4484-2018-1-29
34. Kim JH, Park S-H, Cho C-S, et al. Preventive efficacy and safety of rebamipide in nonsteroidal anti-inflammatory drug-induced mucosal toxicity. Gut Liver. 2014;8(4):371-9. DOI:10.5009/gnl.2014.8.4.371
35. Takayama M, Matsui S, Kawasaki M, et al. Efficacy of treatment with rebamipide for endoscopic submucosal dissection-induced ulcers. World J Gastroenterol. 2013;19(34):5706-12. DOI:10.3748/wjg.v19.i34.5706
36. Thong-Ngam D, Chayanupatkul M, Klaikeaw N, et al. Effect of rebamipide on gastric ulcer healing caused by Helicobacter pylori and/or NSAIDs or non NSAIDs-non H. pylori. J Med Assoc Thai. 2009;92(9):1207-12.
37. Kim GH, Lee HL, Joo MK, et al. Efficacy and Safety of Rebamipide versus Its New Formulation, AD-203, in Patients with Erosive Gastritis: A Randomized, Double-Blind, Active Control, Noninferiority, Multicenter, Phase 3 Study. Gut Liver. 2021;15(6):841-50. DOI:10.5009/gnl20338
38. Baltes P, Steinbrück I, Brandt L, et al. Inflammatory Lesions in the Small Bowel. Video Journal and Encyclopedia of GI Endoscopy. 2013;1(1):241-3.
DOI:10.1016/S2212-0971(13)70103-1
39. Drapkina OM, Korneeva ON. Small bowel injuries due to nonsteroidal anti-inflammatory drugs and antiplatelet therapy: Approaches to prevention and treatment. Terapevticheskii Arkhiv (Ter. Arkh.). 2016;88(12):133-9 (in Russian). DOI:10.17116/terarkh20168812133-139
40. Watari I, Oka S, Tanaka S, et al. Comparison of small-bowel mucosal injury between low-dose aspirin and non-aspirin non-steroidal anti-inflammatory drugs: a capsule endoscopy study. Digestion. 2014;89(3):225-31. DOI:10.1159/000358287
41. Kessler WF, Shires GT, Fahey TJ. Surgical complications of nonsteroidal antiinflammatory drug-induced small bowel ulceration. J Am Coll Surg. 1997;185(3):250-4. DOI:10.1016/s1072-7515(97)00067-7
42. Balabantseva AP, Karateev AE. The frequency and clinical and endoscopic features of mixed NSAIDs-induced gastrointestinal injuries. Mod Rheumatol J. 2018;12(4):95-100 (in Russian). DOI:10.14412/1996-7012-2018-4-95-100
43. Zhang S, Qing Q, Bai Y, et al. Rebamipide helps defend against nonsteroidal anti-inflammatory drugs induced gastroenteropathy: a systematic review and meta-analysis. Dig Dis Sci. 2013;58(7):1991-2000. DOI:10.1007/s10620-013-2606-0
44. Guo C-G, Leung WK. Potential Strategies in the Prevention of Nonsteroidal Anti-inflammatory Drugs-Associated Adverse Effects in the Lower Gastrointestinal Tract. Gut Liver. 2020;14(2):179-89. DOI:10.5009/gnl19201
45. Satoh K, Yoshino J, Akamatsu T, et al. Evidence-based clinical practice guidelines for peptic ulcer disease 2015. J Gastroenterol. 2016;51(3):177-94. DOI:10.1007/s00535-016-1166-4
46. Okayama M, Tsubouchi R, Nishio H, et al. Protective effect of intra-rectal administration of rebamipide on dextran sulfate sodium-induced rat colitis. Digestion. 2004;70(4):240-9. DOI:10.1159/000083716
47. Takagi T, Naito Y, Uchiyama K, et al. Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution. World J Gastroenterol. 2011;17(33):3802-9. DOI:10.3748/wjg.v17.i33.3802
48. Matsumoto S, Tsuji K, Shirahama S. Rebamipide enema therapy for left-sided ischemic colitis patients accompanied by ulcers: open label study. World J Gastroenterol. 2008;14(25):4059-64. DOI:10.3748/wjg.14.4059
49. Makiyama K, Takeshima F, Hamamoto T. Efficacy of rebamipide enemas in active distal ulcerative colitis and proctitis: a prospective study report. Dig Dis Sci. 2005;50(12):2323-2329. DOI:10.1007/s10620-005-3055-1
50. Miyata M, Kasugai K, Ishikawa T, et al. Rebamipide enemas-new effective treatment for patients with corticosteroid dependent or resistant ulcerative colitis. Dig Dis Sci. 2005;50 (Suppl. 1):S119-23. DOI:10.1007/s10620-005-2816-1
51. Furuta R, Ando T, Watanabe O, et al. Rebamipide enema therapy as a treatment for patients with active distal ulcerative colitis. J Gastroenterol Hepatol. 2007;22(2):261-7. DOI:10.1111/j.1440-1746.2006.04399.x
52. Rebamipide for use in prevention and treatment of crohn’s disease. European patent application. Application number: 19020504.7. Bulletin 2021/13. Date of publication: 31.03.2021. Available at: https://data.epo.org/publication-server/pdf-document/EP19020504NWA1.pdf?PN=EP3797772%20EP%203797772&.... Accessed: 18.09. 2021.
53. Kurata S, Nakashima T, Osaki T, et al. Rebamipide protects small intestinal mucosal injuries caused by indomethacin by modulating intestinal microbiota and the gene expression in intestinal mucosa in a rat model. J Clin Biochem Nutr. 2015;56(1):20-7. DOI:10.3164/jcbn.14-67
54. Tanigawa T, Watanabe T, Higashimori A, et al. Rebamipide ameliorates indomethacin-induced small intestinal damage and proton pump inhibitor-induced exacerbation of this damage by modulation of small intestinal microbiota. PLOS ONE. 2021;16(1):e0245995. DOI:10.1371/journal.pone.0245995
55. Tanigawa T, Watanabe T, Otani K, et al. Rebamipide inhibits indomethacin-induced small intestinal injury: possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5. Eur J Pharmacol. 2013;704(1-3):64-9. DOI:10.1016/j.ejphar.2013.02.010
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8. Yasuda T, Chiba H, Satomi T, et al. Preventive effect of rebamipide gargle on chemoradiotherpy-induced oral mucositis in patients with oral cancer: a pilot study. J Oral Maxillofac Res. 2012;2(4):e3. DOI:10.5037/jomr.2011.2403
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11. Akagi S, Fujiwara T, Nishida M, et al. The effectiveness of rebamipide mouthwash therapy for radiotherapy and chemoradiotherapy-induced oral mucositis in patients with head and neck cancer: a systematic review and meta-analysis. J Pharm Health Care Sci. 2019;5:16. DOI:10.1186/s40780-019-0146-2
12. Yokota T, Ogawa T, Takahashi S, et al. Efficacy and safety of rebamipide liquid for chemoradiotherapy-induced oral mucositis in patients with head and neck cancer: a multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II study. BMC Cancer. 2017;17(1):314. DOI:10.1186/s12885-017-3295-4
13. Chaitanya B, Pai KM, Yathiraj PH, et al. Rebamipide gargle in preventive management of chemo-radiotherapy induced oral mucositis. Oral Oncol. 2017;72:179-82. DOI:10.1016/j.oraloncology.2017.07.024
14. Kim SH, Jeong JB, Kim JW, et al. Clinical and endoscopic characteristics of drug-induced esophagitis. World J Gastroenterol. 2014;20(31):10994-9. DOI:10.3748/wjg.v20.i31.10994
15. Ruigómez A, García Rodríguez LA, Wallander M-A, et al. Natural history of gastro-oesophageal reflux disease diagnosed in general practice. Aliment Pharmacol Ther. 2004;20(7):751-60. DOI:10.1111/j.1365-2036.2004.02169.x
16. Осадчук А.М., Давыдкин И.Л., Гриценко Т.А., Осадчук М.А. Гастроэзофагеальная рефлюксная болезнь и эзофагит, ассоциированные с применением лекарственных препаратов: современное состояние проблемы. Терапевтический архив. 2019;91(8):135-40 [Osadchuk AM, Davydkin IL, Gricenko TA, Osadchuk MA. Gastroesophageal reflux disease and esophagitis associated with the use of drugs: the modern state of the problem. Terapevticheskii Arkhiv (Ter. Arkh.). 2019;91(8):135-40 (in Russian)].
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17. van Soest EM, Dieleman JP, Siersema PD, et al. Tricyclic antidepressants and the risk of reflux esophagitis. Am J Gastroenterol. 2007;102(9):1870-7.
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18. Hasan MQ, Mondal NT, Perveen I, et al. Clinical and Endoscopic Characteristics of Medication Induced Esophageal Injury. Faridpur Med Coll J. 2020;14(1):2-7. DOI:10.3329/fmcj.v14i1.46157
19. Ивашкин В.Т., Маев И.В., Трухманов А.С., Румянцева Д.Е. Современные достижения в диагностике и лечении рефрактерной формы гастроэзофагеальной рефлюксной болезни. Терапевтический архив. 2018;90(8):4-12 [Ivashkin VT, Maev IV, Truhmanov AS, Rumyanceva DE. Modern achievements in the diagnosis and treatment of the refractory gastroesophageal reflux disease. Terapevticheskii Arkhiv (Ter. Arkh.). 2018;90(8):4-12 (in Russian)]. DOI:10.26442/terarkh20189084-12
20. Hong SJ, Park S-H, Moon JS, et al. The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study. Gut Liver. 2016;10(6):910-6. DOI:10.5009/gnl15537
21. Ивашкин В.Т., Маев И.В., Трухманов А.С., и др. Рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению гастроэзофагеальной рефлюксной болезни. Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. 2020;30(4):70-97 [Ivashkin VT, Maev IV, Trukhmanov AS, et al. Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease. Russian Journal of Gastroenterology, Hepatology, Coloproctology.. 2020;30(4):70-97 (in Russian)]. DOI:10.22416/1382-4376-2020-30-4-70-97
22. Arakawa T, Higuchi K, Fujiwara Y, et al. 15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications. Dig Dis Sci. 2005;50 Suppl. 1:S3-11. DOI:10.1007/s10620-005-2800-9
23. Sy ML, Prieto RJ, Pang A, et al. Effectiveness of rebamipide in the prevention of esophageal stricture formation in advanced corrosive esophagitis: a prospective randomised control study. Gut. 2018;67(Suppl 2):A53-3. DOI:10.1136/gutjnl-2018-IDDFabstracts.118
24. Pilotto A, Franceschi M, Leandro G, Di Mario F. Geriatric Gastroenterology Study Group (Societè Italiana Gerontologie Geriatria). NSAID and aspirin use by the elderly in general practice: effect on gastrointestinal symptoms and therapies. Drugs Aging. 2003;20(9):701-10. DOI:10.2165/00002512-200320090-00006
25. Tarasconi A, Coccolini F, Biffl WL, et al. Perforated and bleeding peptic ulcer: WSES guidelines. World J Emerg Surg. 2020;15:3. DOI:10.1186/s13017-019-0283-9
26. Iijima K, Kanno T, Koike T, Shimosegawa T. Helicobacter pylori-negative, non-steroidal anti-inflammatory drug: negative idiopathic ulcers in Asia. World J Gastroenterol. 2014;20(3):706-13. DOI:10.3748/wjg.v20.i3.706
27. Dore MP, Soro S, Niolu C, et al. Clinical features and natural history of idiopathic peptic ulcers: a retrospective case-control study. Scand J Gastroenterol. 2019;54(11):1315-21. DOI:10.1080/00365521.2019.1679247
28. Rajabalinia H, Ghobakhlou M, Nikpour S, et al. Non-Helicobacter pylori, non-NSAIDs peptic ulcers: a descriptive study on patients referred to Taleghani hospital with upper gastrointestinal bleeding. Gastroenterol Hepatol Bed Bench. 2012;5(4):190-6.
29. Осадчук М.А., Осадчук А.М., Сибряев А.А. H. pylori-негативная язвенная болезнь: современное состояние проблемы. Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. 2014;24(1):4-9 [Osadchuk MA, Osadchuk AM, Sibryaev AA. H. pylori-negative peptic ulcer: state-of-the-art. Russian Journal of Gastroenterology, Hepatology, Coloproctology.. 2014;24(1):4-9 (in Russian)].
30. Wong GL-H, Wong VW-S, Chan Y, et al. High incidence of mortality and recurrent bleeding in patients with Helicobacter pylori-negative idiopathic bleeding ulcers. Gastroenterology. 2009;137(2):525-31. DOI:10.1053/j.gastro.2009.05.006
31. Chung C-S, Chiang T-H, Lee Y-C. A systematic approach for the diagnosis and treatment of idiopathic peptic ulcers. Korean J Intern Med. 2015;30(5):559-70. DOI:10.3904/kjim.2015.30.5.559
32. Ивашкин В.Т., Маев И.В., Царьков П.В., и др. Диагностика и лечение язвенной болезни у взрослых (Клинические рекомендации Российской гастроэнтерологической ассоциации, Российского общества колоректальных хирургов и Российского эндоскопического общества). Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. 2020;30(1):49-70 [Ivashkin VT, Maev IV, Tsar’kov PV, et al. Diagnosis and Treatment of Peptic Ulcer in Adults (Clinical Guidelines of the Russian Gastroenterological Association, Russian Society of Colorectal Surgeons and the Russian Endoscopic Society). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2020;30(1):49-70 (in Russian)]. DOI:10.22416/1382-4376-2020-30-1-49-70
33. Каратеев А.Е., Насонов Е.Л., Ивашкин В.Т., и др. Рациональное использование нестероидных противовоспалительных препаратов. Клинические рекомендации. Научно-практическая ревматология. 2018;56:1-29 [Karateev AE, Nasonov EL, Ivashkin VT, et al. Rational use of nonsteroidal anti-inflammatory drugs. Clinical guidelines. Rheumatology Science and Practice. 2018;56:1-29 (in Russian)]. DOI:10.14412/1995-4484-2018-1-29
34. Kim JH, Park S-H, Cho C-S, et al. Preventive efficacy and safety of rebamipide in nonsteroidal anti-inflammatory drug-induced mucosal toxicity. Gut Liver. 2014;8(4):371-9. DOI:10.5009/gnl.2014.8.4.371
35. Takayama M, Matsui S, Kawasaki M, et al. Efficacy of treatment with rebamipide for endoscopic submucosal dissection-induced ulcers. World J Gastroenterol. 2013;19(34):5706-12. DOI:10.3748/wjg.v19.i34.5706
36. Thong-Ngam D, Chayanupatkul M, Klaikeaw N, et al. Effect of rebamipide on gastric ulcer healing caused by Helicobacter pylori and/or NSAIDs or non NSAIDs-non H. pylori. J Med Assoc Thai. 2009;92(9):1207-12.
37. Kim GH, Lee HL, Joo MK, et al. Efficacy and Safety of Rebamipide versus Its New Formulation, AD-203, in Patients with Erosive Gastritis: A Randomized, Double-Blind, Active Control, Noninferiority, Multicenter, Phase 3 Study. Gut Liver. 2021;15(6):841-50. DOI:10.5009/gnl20338
38. Baltes P, Steinbrück I, Brandt L, et al. Inflammatory Lesions in the Small Bowel. Video Journal and Encyclopedia of GI Endoscopy. 2013;1(1):241-3.
DOI:10.1016/S2212-0971(13)70103-1
39. Драпкина О.М., Корнеева О.Н. Поражения тонкой кишки при применении нестероидных противовоспалительных препаратов и антитромбоцитарной терапии. Подходы к профилактике и лечению. Терапевтический архив. 2016;88(12):133-9 [Drapkina OM, Korneeva ON. Small bowel injuries due to nonsteroidal anti-inflammatory drugs and antiplatelet therapy: Approaches to prevention and treatment. Terapevticheskii Arkhiv (Ter. Arkh.). 2016;88(12):133-9 (in Russian)]. DOI:10.17116/terarkh20168812133-139
40. Watari I, Oka S, Tanaka S, et al. Comparison of small-bowel mucosal injury between low-dose aspirin and non-aspirin non-steroidal anti-inflammatory drugs: a capsule endoscopy study. Digestion. 2014;89(3):225-31. DOI:10.1159/000358287
41. Kessler WF, Shires GT, Fahey TJ. Surgical complications of nonsteroidal antiinflammatory drug-induced small bowel ulceration. J Am Coll Surg. 1997;185(3):250-4. DOI:10.1016/s1072-7515(97)00067-7
42. Балабанцева А.П., Каратеев А.Е. Частота и клинико-эндоскопические особенности сочетанных НПВП-индуцированных гастроинтестинальных повреждений. Современная ревматология. 2018;12(4):95-100 [Balabantseva AP, Karateev AE. The frequency and clinical and endoscopic features of mixed NSAIDs-induced gastrointestinal injuries. Mod Rheumatol J. 2018;12(4):95-100 (in Russian)]. DOI:10.14412/1996-7012-2018-4-95-100
43. Zhang S, Qing Q, Bai Y, et al. Rebamipide helps defend against nonsteroidal anti-inflammatory drugs induced gastroenteropathy: a systematic review and meta-analysis. Dig Dis Sci. 2013;58(7):1991-2000. DOI:10.1007/s10620-013-2606-0
44. Guo C-G, Leung WK. Potential Strategies in the Prevention of Nonsteroidal Anti-inflammatory Drugs-Associated Adverse Effects in the Lower Gastrointestinal Tract. Gut Liver. 2020;14(2):179-89. DOI:10.5009/gnl19201
45. Satoh K, Yoshino J, Akamatsu T, et al. Evidence-based clinical practice guidelines for peptic ulcer disease 2015. J Gastroenterol. 2016;51(3):177-94. DOI:10.1007/s00535-016-1166-4
46. Okayama M, Tsubouchi R, Nishio H, et al. Protective effect of intra-rectal administration of rebamipide on dextran sulfate sodium-induced rat colitis. Digestion. 2004;70(4):240-9. DOI:10.1159/000083716
47. Takagi T, Naito Y, Uchiyama K, et al. Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution. World J Gastroenterol. 2011;17(33):3802-9. DOI:10.3748/wjg.v17.i33.3802
48. Matsumoto S, Tsuji K, Shirahama S. Rebamipide enema therapy for left-sided ischemic colitis patients accompanied by ulcers: open label study. World J Gastroenterol. 2008;14(25):4059-64. DOI:10.3748/wjg.14.4059
49. Makiyama K, Takeshima F, Hamamoto T. Efficacy of rebamipide enemas in active distal ulcerative colitis and proctitis: a prospective study report. Dig Dis Sci. 2005;50(12):2323-2329. DOI:10.1007/s10620-005-3055-1
50. Miyata M, Kasugai K, Ishikawa T, et al. Rebamipide enemas-new effective treatment for patients with corticosteroid dependent or resistant ulcerative colitis. Dig Dis Sci. 2005;50 (Suppl. 1):S119-23. DOI:10.1007/s10620-005-2816-1
51. Furuta R, Ando T, Watanabe O, et al. Rebamipide enema therapy as a treatment for patients with active distal ulcerative colitis. J Gastroenterol Hepatol. 2007;22(2):261-7. DOI:10.1111/j.1440-1746.2006.04399.x
52. Rebamipide for use in prevention and treatment of crohn’s disease. European patent application. Application number: 19020504.7. Bulletin 2021/13. Date of publication: 31.03.2021. Available at: https://data.epo.org/publication-server/pdf-document/EP19020504NWA1.pdf?PN=EP3797772%20EP%203797772&.... Accessed: 18.09. 2021.
53. Kurata S, Nakashima T, Osaki T, et al. Rebamipide protects small intestinal mucosal injuries caused by indomethacin by modulating intestinal microbiota and the gene expression in intestinal mucosa in a rat model. J Clin Biochem Nutr. 2015;56(1):20-7. DOI:10.3164/jcbn.14-67
54. Tanigawa T, Watanabe T, Higashimori A, et al. Rebamipide ameliorates indomethacin-induced small intestinal damage and proton pump inhibitor-induced exacerbation of this damage by modulation of small intestinal microbiota. PLOS ONE. 2021;16(1):e0245995. DOI:10.1371/journal.pone.0245995
55. Tanigawa T, Watanabe T, Otani K, et al. Rebamipide inhibits indomethacin-induced small intestinal injury: possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5. Eur J Pharmacol. 2013;704(1-3):64-9. DOI:10.1016/j.ejphar.2013.02.010
56. Yasuda‑Onozawa Y, Handa O, Naito Y, et al. Rebamipide upregulates mucin secretion of intestinal goblet cells via Akt phosphorylation. Molecular Medicine Reports. 2017;16(6):8216-22. DOI:10.3892/mmr.2017.7647
57. Kim BSM, Li BT, Engel A, et al. Diagnosis of gastrointestinal bleeding: A practical guide for clinicians. World J Gastrointest Pathophysiol. 2014;5(4):467-78. DOI:10.4291/wjgp.v5.i4.467
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54. Tanigawa T, Watanabe T, Higashimori A, et al. Rebamipide ameliorates indomethacin-induced small intestinal damage and proton pump inhibitor-induced exacerbation of this damage by modulation of small intestinal microbiota. PLOS ONE. 2021;16(1):e0245995. DOI:10.1371/journal.pone.0245995
55. Tanigawa T, Watanabe T, Otani K, et al. Rebamipide inhibits indomethacin-induced small intestinal injury: possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5. Eur J Pharmacol. 2013;704(1-3):64-9. DOI:10.1016/j.ejphar.2013.02.010
56. Yasuda‑Onozawa Y, Handa O, Naito Y, et al. Rebamipide upregulates mucin secretion of intestinal goblet cells via Akt phosphorylation. Molecular Medicine Reports. 2017;16(6):8216-22. DOI:10.3892/mmr.2017.7647
57. Kim BSM, Li BT, Engel A, et al. Diagnosis of gastrointestinal bleeding: A practical guide for clinicians. World J Gastrointest Pathophysiol. 2014;5(4):467-78. DOI:10.4291/wjgp.v5.i4.467
Авторы
М.А. Осадчук*1, А.М. Осадчук2
1 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
2 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*osadchuk.mikhail@yandex.ru
1 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
2 Russian Medical Academy of Continuous Professional Education, Moscow, Russia
*osadchuk.mikhail@yandex.ru
1 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
2 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*osadchuk.mikhail@yandex.ru
________________________________________________
1 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
2 Russian Medical Academy of Continuous Professional Education, Moscow, Russia
*osadchuk.mikhail@yandex.ru
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