История открытия бактерии Helicobacter pylori - Журнал Терапевтический архив №2 Вопросы гастроэнтерологии 2022

История открытия бактерии Helicobacter pylori

Бордин Д.С., Шенгелия М.И., Иванова В.А., Войнован И.Н. История открытия бактерии Helicobacter pylori. Терапевтический архив. 2022;94(2):283–288. DOI: 10.26442/00403660.2022.02.201377

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Bordin DS, Shengelia MI, Ivanova VA, Voynovan IN. The history of the discovery of the Helicobacter pylori. Terapevticheskii Arkhiv (Ter. Arkh.). 2022;94(2):283–288. DOI: 10.26442/00403660.2022.02.201377

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Аннотация

Helicobacter pylori – спиралевидная грамотрицательная бактерия, которая колонизирует слизистую оболочку желудка. Присутствие микроорганизма у человека было описано более века назад, но от момента обнаружения до признания ее роли в этиологии и патогенезе заболеваний желудка исследователям пришлось преодолеть долгий путь критики и недоверия. Спиралевидные бактерии неоднократно упоминались в медицинской литературе, однако считалось, что они являлись контаминантами, и любые свидетельства наличия бактерии в желудке игнорировались медицинским сообществом. Открытие Н. pylori привело к революционному переосмыслению механизмов развития ряда заболеваний: была доказана роль бактерии в развитии хронического гастрита, язвенной болезни, рака желудка и MALT-лимфомы. Изменились принципы их профилактики и лечения. За это открытие Барри Маршалл и Робин Уоррен были удостоены Нобелевской премии в области медицины и физиологии в 2005 г.

Ключевые слова: Helicobacter pylori, открытие, Р. Уоррен, Б. Маршалл, Нобелевская премия 2005 г., язвенная болезнь, гастрит

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Helicobacter pylori is a spiral-shaped gram-negative bacterium that colonizes the stomach lining. The presence of a microorganism in humans was described more than a century ago, but from detection to recognition of its role in the etiology and pathogenesis of diseases of the stomach, researchers had to overcome a long path of criticism and mistrust. Coiled bacteria have been mentioned several times in the medical literature, but these bacteria were thought to be contaminants, and any evidence of the bacteria in the stomach was ignored by the medical community. The discovery of H. pylori led to a revolutionary rethinking of the mechanisms of development of a number of diseases: the role of bacteria in the development of chronic gastritis, peptic ulcer disease, stomach cancer and MALT lymphoma was proved. The principles of their prevention and treatment have changed. For this discovery in 2005, Barry Marshall and Robin Warren were awarded the Nobel Prize in Medicine and Physiology.

Keywords: Helicobacter pylori, discovery, R. Warren, B. Marshall, Nobel 2005, gastric ulcer, gastritis

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Список литературы

1 Buckley MJ, O'Morain CA. Helicobacter biology – discovery. Br Med Bull. 1998;54(1):7-16. DOI:10.1093/oxfordjournals.bmb.a011681
2. Malfertheiner P, Megraud F, O'Morain CA, et al; European Helicobacter and Microbiota Study Group and Consensus panel. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 2017;66(1):6-30. DOI:10.1136/gutjnl-2016-312288
3. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984;1(8390):1311-5.
DOI:10.1016/s0140-6736(84)91816-6
4. Helicobacter pylori: революция в гастроэнтерологии. Под ред. В.Т. Ивашкина, Ф. Мегро, Т.Л. Лапина. М.: Триада Х, 1999 [Helicobacter pylori: revoliutsiia v gastroenterologii. Pod red. VT Ivashkina, F Megro, TL Lapina. Moscow: Triada X, 1999 (in Russian)].
5. Blaser MJ. An endangered species in the stomach. Sci Am. 2005;292(2):38-45. DOI:10.1038/scientificamerican0205-38
6. Konturek JW. Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer. J Physiol Pharmacol. 2003;54 Suppl. 3:23-41.
7. Marshall BJ. One Hundred Years of Discovery and Rediscovery of Helicobacter pylori and Its Association with Peptic Ulcer Disease. In: Mobley HLT, Mendz GL, Hazell SL, ed. Helicobacter pylori: Physiology and Genetics. Washington (DC): ASM Press, 2001. Chapter 3.
8. Ito S. Anatomic structure of the gastric mucosa. Alimentary Canal. American Physiological Society. Washington (DC), 1967; p. 705-41.
9. Steer HW, Colin-Jones DG. Mucosal changes in gastric ulceration and their response to carbenoxolone sodium. Gut. 1975;16(8):590-7. DOI:10.1136/gut.16.8.590
10. Marshall B, ed. Helicobacter pioneers: Firsthand accounts from the scientists who discovered helicobacters 1892–1982. Wiley-Blackwell, 2002. Сhapter 10;
p. 105-18.
11. Pajares JM, Gisbert JP. Helicobacter pylori: its discovery and relevance for medicine. Rev Esp Enferm Dig. 2006;98(10):770-85. DOI:10.4321/s1130-01082006001000007
12. Warren JR, Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983;1(8336):1273-5.
13. Infection with Helicobacter pylori. IARC Monogr Eval Carcinog Risks Hum. 1994;61:177-240.
14. Current European concepts in the management of Helicobacter pylori infection. The Maastricht Consensus Report. European Helicobacter Pylori Study Group. Gut. 1997;41(1):8-13. Erratum in: Gut. 1997;41(2):276. DOI:10.1136/gut.41.1.8
15. Ahmed N. 23 years of the discovery of Helicobacter pylori: is the debate over? Ann Clin Microbiol Antimicrob. 2005;4:17. DOI:10.1186/1476-0711-4-17
16. Mégraud F, Lehours P, Vale FF. The history of Helicobacter pylori: from phylogeography to paleomicrobiology. Clin Microbiol Infect. 2016;22(11):922-7. DOI:10.1016/j.cmi.2016.07.013
17. Maixner F, Thorell K, Granehäll L, et al. Helicobacter pylori in ancient human remains. World J Gastroenterol. 2019;25(42):6289-98. DOI:10.3748/wjg.v25.i42.6289
18. Chiang TH, Chang WJ, Chen SL, et al. Mass eradication of Helicobacter pylori to reduce gastric cancer incidence and mortality: a long-term cohort study on Matsu Islands. Gut. 2021;70(2):243-50. DOI:10.1136/gutjnl-2020-322200
19. Показатели заболеваемости населения города Москвы за 2016–2020 годы. Составители: М.О. Бочарова, Г.А. Ерашова, Т.Ю. Куракина, А.М. Подчернина. М.: ГБУ «НИИОЗММ ДЗМ», 2021. 224 с. [Pokazateli zabolevaemosti naseleniia goroda Moskvy za 2016–2020 gody. Compiled by MO Bocharova, GA Erashova, TIu Kurakina, AM Podchernina. Moscow: GBU «NIIOZMM DZM», 2021. 224 p. (in Russian)].
20. International Agency for Research on Cancer Helicobacter pylori Working Group. Helicobacter pylori Eradication as a Strategy for Preventing Gastric Cancer. IARC Working Group Reports, No.8. Lyon, France: International Agency for Research on Cancer, 2014. Available at: https://publications.iarc.fr/Book-And-Report-Series/Iarc-Working-Group-Reports/-Em-Helicobacter-Pylo.... Accessed: 10.02.2022.
21. Sugano K. Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis. Gastric Cancer. 2019;22(3):435-445.
DOI:10.1007/s10120-018-0876-0
22. Yoon SB, Park JM, Lim CH, et al. Effect of Helicobacter pylori eradication on metachronous gastric cancer after endoscopic resection of gastric tumors: a meta-analysis. Helicobacter. 2014;19(4):243-8. DOI:10.1111/hel.12146
23. Nyssen OP, Vaira D, Tepes B, et al. Room for Improvement in the Treatment of Helicobacter pylori Infection: Lessons from the European Registry on H. pylori Management (Hp-EuReg). J Clin Gastroenterol. 2022;56(2):98-108. DOI:10.1097/MCG.0000000000001482
24. Бордин Д.С. Ошибки диагностики и лечения инфекции Helicobacter pylori: в преддверии новых согласительных документов. Экспериментальная и клиническая гастроэнтерология. 2021;(9):5-14 [Bordin DS. Errors in the diagnosis and treatment of Helicobacter pylori infection: in anticipation of new conciliation documents. Experimental and Clinical Gastroenterology. 2021;(9):5-14 (in Russian)]. DOI:10.31146/1682-8658-ecg-193-9-5-14
25. Лазебник Л.Б., Бордин Д.С; исследовательская группа программы «ПАРАД». Ведение пациентов с Helicobacter pylori-ассоциированными заболеваниями в условиях реальной клинической практики. Промежуточные результаты наблюдательной программы. Экспериментальная и клиническая гастроэнтерология. 2013;5:93-101 [Lazebnik LB, Bordin DS; Research Group "Parad". Management of patients with Helicobacter pylori-related illness in the ordinary clinical practice. Intermediate results of monitoring program. Eksp Klin Gastroenterol. 2013;5:93-101 (in Russian)].
26. McNicholl AG, Bordin DS, Lucendo A, et al. Combination of Bismuth and Standard Triple Therapy Eradicates Helicobacter pylori Infection in More than 90% of Patients. Clin Gastroenterol Hepatol. 2020;18(1):89-98. DOI:10.1016/j.cgh.2019.03.048
27. Nyssen OP, Bordin D, Tepes B, et al; Hp-EuReg Investigators. European Registry on Helicobacter pylori management (Hp-EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients. Gut. 2021;70(1):40-54. DOI:10.1136/gutjnl-2020-321372
28. Nyssen OP, Perez-Aisa A, Tepes B, et al; Hp-EuReg Investigators. Adverse Event Profile During the Treatment of Helicobacter pylori: A Real-World Experience of 22,000 Patients From the European Registry on H. pylori Management (Hp-EuReg). Am J Gastroenterol. 2021;116(6):1220-29. DOI:10.14309/ajg.0000000000001246
29. Бордин Д.С., Кролевец Т.С., Ливзан М.А., и др. Приверженность врачей первичного звена рекомендациям по диагностике и лечению заболеваний, ассоциированных с Helicobacter pylori. Эффективная фармакотерапия. 2019;15(36):22-31 [Bordin DS, Krolevets TS, Livzan MA, et al. Consent of Doctors to Guidelines for the Diagnosis and Treatment of Diseases Associated with Helicobacter pylori. Effektivnaia farmakoterapiia. 2019;15(36):22-31 (in Russian)]. DOI:10.33978/2307-3586-2019-15-36-22-31
30. Бордин Д.С., Кролевец Т.С., Ливзан М.А. Готовы ли врачи первичного звена соблюдать протоколы диагностики и лечения заболеваний, ассоциированных с Helicobacter pylori: результаты опроса 2020–2021 годов. Альманах клинической медицины. 2021;49(7):455-68 [Bordin DS, Krolevets TS, Livzan MA. Are physicians ready to comply with the guidelines for diagnosis and management of Helicobacter pylori-associated diseases: the survey results 2020–2021. Almanac of Clinical Medicine. 2021;49(7):455-68 (in Russian)]. DOI:10.18786/2072-0505-2021-49-051
31. Лазебник Л.Б., Бордин Д.С., Дехнич Н.Н., и др. Необходимость усиления мер по диагностике и лечению хеликобактерной инфекции в России. Меморандум. Экспериментальная и клиническая гастроэнтерология.
2021;3:83-96 [Lazebnik LB, Bordin DS, Dekhnich NN, et al. The need to strengthen measures for the diagnosis and treatment of Helicobacter pylori infection in Russia. Memorandum. Experimental and Clinical Gastroenterology. 2021;3:83-96 (in Russian)]. DOI:10.31146/1682-8658-ecg-187-3-83-96

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1 Buckley MJ, O'Morain CA. Helicobacter biology – discovery. Br Med Bull. 1998;54(1):7-16. DOI:10.1093/oxfordjournals.bmb.a011681
2. Malfertheiner P, Megraud F, O'Morain CA, et al; European Helicobacter and Microbiota Study Group and Consensus panel. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 2017;66(1):6-30. DOI:10.1136/gutjnl-2016-312288
3. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984;1(8390):1311-5.
DOI:10.1016/s0140-6736(84)91816-6
4. Helicobacter pylori: revoliutsiia v gastroenterologii. Pod red. VT Ivashkina, F Megro, TL Lapina. Moscow: Triada X, 1999 (in Russian).
5. Blaser MJ. An endangered species in the stomach. Sci Am. 2005;292(2):38-45. DOI:10.1038/scientificamerican0205-38
6. Konturek JW. Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer. J Physiol Pharmacol. 2003;54 Suppl. 3:23-41.
7. Marshall BJ. One Hundred Years of Discovery and Rediscovery of Helicobacter pylori and Its Association with Peptic Ulcer Disease. In: Mobley HLT, Mendz GL, Hazell SL, ed. Helicobacter pylori: Physiology and Genetics. Washington (DC): ASM Press, 2001. Chapter 3.
8. Ito S. Anatomic structure of the gastric mucosa. Alimentary Canal. American Physiological Society. Washington (DC), 1967; p. 705-41.
9. Steer HW, Colin-Jones DG. Mucosal changes in gastric ulceration and their response to carbenoxolone sodium. Gut. 1975;16(8):590-7. DOI:10.1136/gut.16.8.590
10. Marshall B, ed. Helicobacter pioneers: Firsthand accounts from the scientists who discovered helicobacters 1892–1982. Wiley-Blackwell, 2002. Сhapter 10;
p. 105-18.
11. Pajares JM, Gisbert JP. Helicobacter pylori: its discovery and relevance for medicine. Rev Esp Enferm Dig. 2006;98(10):770-85. DOI:10.4321/s1130-01082006001000007
12. Warren JR, Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983;1(8336):1273-5.
13. Infection with Helicobacter pylori. IARC Monogr Eval Carcinog Risks Hum. 1994;61:177-240.
14. Current European concepts in the management of Helicobacter pylori infection. The Maastricht Consensus Report. European Helicobacter Pylori Study Group. Gut. 1997;41(1):8-13. Erratum in: Gut. 1997;41(2):276. DOI:10.1136/gut.41.1.8
15. Ahmed N. 23 years of the discovery of Helicobacter pylori: is the debate over? Ann Clin Microbiol Antimicrob. 2005;4:17. DOI:10.1186/1476-0711-4-17
16. Mégraud F, Lehours P, Vale FF. The history of Helicobacter pylori: from phylogeography to paleomicrobiology. Clin Microbiol Infect. 2016;22(11):922-7. DOI:10.1016/j.cmi.2016.07.013
17. Maixner F, Thorell K, Granehäll L, et al. Helicobacter pylori in ancient human remains. World J Gastroenterol. 2019;25(42):6289-98. DOI:10.3748/wjg.v25.i42.6289
18. Chiang TH, Chang WJ, Chen SL, et al. Mass eradication of Helicobacter pylori to reduce gastric cancer incidence and mortality: a long-term cohort study on Matsu Islands. Gut. 2021;70(2):243-50. DOI:10.1136/gutjnl-2020-322200
19. Pokazateli zabolevaemosti naseleniia goroda Moskvy za 2016–2020 gody. Compiled by MO Bocharova, GA Erashova, TIu Kurakina, AM Podchernina. Moscow: GBU «NIIOZMM DZM», 2021. 224 p. (in Russian).
20. International Agency for Research on Cancer Helicobacter pylori Working Group. Helicobacter pylori Eradication as a Strategy for Preventing Gastric Cancer. IARC Working Group Reports, No.8. Lyon, France: International Agency for Research on Cancer, 2014. Available at: https://publications.iarc.fr/Book-And-Report-Series/Iarc-Working-Group-Reports/-Em-Helicobacter-Pylo.... Accessed: 10.02.2022.
21. Sugano K. Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis. Gastric Cancer. 2019;22(3):435-445.
DOI:10.1007/s10120-018-0876-0
22. Yoon SB, Park JM, Lim CH, et al. Effect of Helicobacter pylori eradication on metachronous gastric cancer after endoscopic resection of gastric tumors: a meta-analysis. Helicobacter. 2014;19(4):243-8. DOI:10.1111/hel.12146
23. Nyssen OP, Vaira D, Tepes B, et al. Room for Improvement in the Treatment of Helicobacter pylori Infection: Lessons from the European Registry on H. pylori Management (Hp-EuReg). J Clin Gastroenterol. 2022;56(2):98-108. DOI:10.1097/MCG.0000000000001482
24. Bordin DS. Errors in the diagnosis and treatment of Helicobacter pylori infection: in anticipation of new conciliation documents. Experimental and Clinical Gastroenterology. 2021;(9):5-14 (in Russian). DOI:10.31146/1682-8658-ecg-193-9-5-14
25. Lazebnik LB, Bordin DS; Research Group "Parad". Management of patients with Helicobacter pylori-related illness in the ordinary clinical practice. Intermediate results of monitoring program. Eksp Klin Gastroenterol. 2013;5:93-101 (in Russian).
26. McNicholl AG, Bordin DS, Lucendo A, et al. Combination of Bismuth and Standard Triple Therapy Eradicates Helicobacter pylori Infection in More than 90% of Patients. Clin Gastroenterol Hepatol. 2020;18(1):89-98. DOI:10.1016/j.cgh.2019.03.048
27. Nyssen OP, Bordin D, Tepes B, et al; Hp-EuReg Investigators. European Registry on Helicobacter pylori management (Hp-EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients. Gut. 2021;70(1):40-54. DOI:10.1136/gutjnl-2020-321372
28. Nyssen OP, Perez-Aisa A, Tepes B, et al; Hp-EuReg Investigators. Adverse Event Profile During the Treatment of Helicobacter pylori: A Real-World Experience of 22,000 Patients From the European Registry on H. pylori Management (Hp-EuReg). Am J Gastroenterol. 2021;116(6):1220-29. DOI:10.14309/ajg.0000000000001246
29. Bordin DS, Krolevets TS, Livzan MA, et al. Consent of Doctors to Guidelines for the Diagnosis and Treatment of Diseases Associated with Helicobacter pylori. Effektivnaia farmakoterapiia. 2019;15(36):22-31 (in Russian). DOI:10.33978/2307-3586-2019-15-36-22-31
30. Bordin DS, Krolevets TS, Livzan MA. Are physicians ready to comply with the guidelines for diagnosis and management of Helicobacter pylori-associated diseases: the survey results 2020–2021. Almanac of Clinical Medicine. 2021;49(7):455-68 (in Russian). DOI:10.18786/2072-0505-2021-49-051
31. Lazebnik LB, Bordin DS, Dekhnich NN, et al. The need to strengthen measures for the diagnosis and treatment of Helicobacter pylori infection in Russia. Memorandum. Experimental and Clinical Gastroenterology. 2021;3:83-96 (in Russian). DOI:10.31146/1682-8658-ecg-187-3-83-96

Авторы

Д.С. Бордин*1–3, М.И. Шенгелия1, В.А. Иванова1, И.Н. Войнован1

1 ГБУЗ «Московский клинический научный центр им. А.С. Логинова» Департамента здравоохранения г. Москвы, Москва, Россия;
2 ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия;
3 ФГБОУ ВО «Тверской государственный медицинский университет» Минздрава России, Тверь, Россия
*d.bordin@mknc.ru

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Dmitry S. Bordin*1–3, Mariam I. Shengelia1, Valeriya A. Ivanova1, Irina N. Voynovan1

1 Loginov Moscow Clinical Scientific Center, Moscow, Russia;
2 Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia;
3 Tver State Medical University, Tver, Russia
*d.bordin@mknc.ru

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