Гидролизаты плаценты человека: от В.П. Филатова до наших дней

1. Филатов В.П. Тканевая терапия. Клиническая медицина. М., 1950, Т. XXVIII, №1, c. 22-8 [Filatov VP. Tkanevaya terapiya. Klinicheskaia meditsina. Moscow, 1950, T. XXVIII, No.1, p. 22-8 (in Russian)].
2. Максимов В.А., Громова О.А., Диброва Е.А. Сборник авторефератов докторских и кандидатских диссертаций по проблеме тканевой терапии плаценты человека. М.: Печатное бюро «Модуль», 2022 [Maksimov VA, Gromova OA, Dibrova EA. Sbornik avtoreferatov doktorskikh i kandidatskikh dissertatsii po probleme tkanevoi terapii platsenty cheloveka. Moscow: Pechatnoe biuro "Modul'", 2022 (in Russian)].
3. Торшин И.Ю., Згода В.Г., Громова О.А., и др. Анализ легкой пептидной фракции Лаеннека методами современной протеомики. Фармакокинетика и фармакодинамика. 2016;(4):31-42 [Torshin IYu, Zgoda VG, Gromova OA, et al. Analysis of the light peptide fraction of Laennec by proteomic methods. Pharmacokinetics and Pharmacodynamics. 2016;(4):31-42 (in Russian)].
4. Громова О.А., Торшин И.Ю., Волков А.Ю., и др. Препарат Лаеннек: элементный состав и фармакологическое действие. Пластическая хирургия и косметология. 2011;2:327-33 [Gromova OA, Torshin IYu, Volkov AYu, et al. Preparation Laennec: elemental composition and key role in the pharmacological action. Plastic Surgery and Cosmetology. 2011;2:327-33 (in Russian)].
5. Гилельс А.В., Громова О.А., Торшин И.Ю., и др. Экспериментальный анализ витаминного состава препарата «Лаеннек». Вестник эстетической медицины. 2013;12(3):80-7 [Gilels AV, Gromova OA, Torshin IYu, et al. Experimental analysis of the vitamin composition of the Laennec preparation. Bulletin of Aesthetic Medicine. 
2013;12(3):80-7 (in Russian)]. 
6. Торшин И.Ю., Громова О.А. Мировой опыт использования гидролизатов плаценты человека в терапии. Экспериментальная и клиническая гастроэнтерология. 2019;170(10):79-89 [Torshin IYu, Gromova OA. Worldwide experience of the therapeutic use of the human placental hydrolytes. Experimental and Clinical Gastroenterology. 2019;1(10):79-89 (in Russian)]. DOI:10.31146/1682-8658-ecg-170-10-79-89
7. Торшин И.Ю., Громова О.А., Стаховская Л.В., и др. Анализ 19,9 млн публикаций базы данных PubMed/MEDLINE методами искусственного интеллекта: подходы к обобщению накопленных данных и феномен «fake news». Фармакоэкономика. Современная фармакоэкономика и фармакоэпидемиология. 2020;13(2):146-63 [Torshin IYu, Gromova OA, Stakhovskaya LV, et al. Analysis of 19.9 million publications from the PubMed/MEDLINE database using artificial intelligence methods: approaches to the generalizations of accumulated data and the phenomenon of «fake news». Farmakoekonomika. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(2):146-63 (in Russian)]. 
DOI:10.17749/2070-4909/farmakoekonomika.2020.021
8. Минушкин О.Н., Масловский Л.В., Елизаветина Г.А., и др. Применение препарата Лаеннек в гастроэнтерологической практике. Эффективная фармакотерапия. Гастроэнтерология. 2014;50:18-23 [Minushkin ON, Maslovsky LV, Yelizavetina GA, et al. Administration of Laennec in Gatroenterology. Effektivnaya farmakoterapiya. Gastroenterologiya. 2014;50:18-23 (in Russian)].
9. Пальцев А.И., Еремина А.А., Торгашов М.Н. Гепатозащитная роль гидролизата плаценты – Лаеннека в лечении больных с вирусно-паразитарными заболеваниями печени. Экспериментальная и клиническая гастроэнтерология. 2016;11(135):94-9 [Paltsev AI, Eremina AA, Torgashov MN. Hepatoprotective role of placenta hydrolyzate – Laennec in the treatment of patients with viral and parasitic liver diseases. Experimental and Clinical Gastroenterology. 2016;11(135):94-9 (in Russian)].
10. Максимов В.А., Бунтин С.Е., Бунтина В.Г., и др. О влиянии плацентарного препарата Лаеннек на моторную функцию билиарного тракта у пациентов с жировой дистрофией печени. Эффективная фармакотерапия. Гастроэнтерология. 2015;37:12-5 [Maksimov VA, Buntin SE, Buntina VG, et al. Regarding an Influence of Placental Drug Laennec on Motor Function of Biliary Tract in Patients with Fatty Liver Dystrophy. Effektivnaya farmakoterapiya. Gastroenterologiya. 2015;37:12-5 (in Russian)].
11. Лазебник Л.Б., Радченко В.Г., Селиверстов П.В., и др. Современное представление о фиброзе печени и подходах к его лечению у больных неалкогольным стеатогепатитом. Экспериментальная и клиническая гастроэнтерология. 2017;148(12):98-109 [Lazebnik LB, Radchenko VG, Seliverstov PV, et al. The contemporary understanding of liver fibrosis and approaches to treatment in patients with nonalcoholic steatohepatitis. Experimental and Clinical Gastro­ente­rology. 2017;148(12):98-109 (in Russian)].
12. Громова О.А., Торшин И.Ю., Згода В.Г., Томилова И.К. Молекулярные механизмы действия препарата Лаеннек против формирования метаболического синдрома и ожирения. Терапия. 2017;5:73-83 [Gromova OA, Torshin IYu, Zgoda VG, Tomilova IK. Molecular mechanisms of action of Laennec Against Development Of Metabolic Syndrome And Obesity. Therapy. 2017;5:73-83 (in Russian)].
13. Ghoneum M, El-Gerbed MSA. Human placental extract ameliorates methotrexate-induced hepatotoxicity in rats via regulating antioxidative and anti-inflammatory responses. Cancer Chemother Pharmacol. 2021;88(6):961-71. DOI:10.1007/s00280-021-04349-4
14. Bak DH, Na J, Choi MJ, et al. Anti-apoptotic effects of human placental hydrolysate against hepatocyte toxicity in vivo and in vitro. Int J Mol Med. 2018;42(5):2569-83. DOI:10.3892/ijmm.2018.3830
15. Yamauchi A, Tone T, Toledo A, et al. Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis. Biomed Res. 2020;41(1):1-12. DOI:10.2220/biomedres.41.1
16. Yamauchi A, Kamiyoshi A, Koyama T, et al. Placental extract ameliorates non-alcoholic steatohepatitis (NASH) by exerting protective effects on endothelial cells. Heliyon. 2017;3(9):e00416. DOI:10.1016/j.heliyon.2017.e00416
17. Shimokobe H, Sumida Y, Tanaka S, et al. Human placental extract treatment for non-alcoholic steatohepatitis non-responsive to  lifestyle intervention: A pilot study. Hepatol Res. 2015;45(9):1034-40. DOI:10.1111/hepr.12432
18. Samiei F, Jamshidzadeh A, Noorafshan A, Ghaderi A. Human Placental Extract Ameliorates Structural Lung Changes Iinduced by Amiodarone in Rats. Iran J Pharm Res. 2016;15(Suppl.):75-82.
19. Жидоморов Н.Ю., Громова О.А., Торшин И.Ю., и др. Лаеннек как кардиопротектор. Эстетическая медицина. 2013;4:531-8 [Zhidomorov NYu, Gromova OA, Torshin IYu, et al. Laennek kak kardioprotektor. Esteticheskaya meditsina. 2013;4:531-8 (in Russian)]. 
20. Yamauchi A, Kamiyoshi A, Sakurai T, et al. Placental extract suppresses cardiac hypertrophy and fibrosis in an angiotensin II-induced cachexia model in mice. Heliyon. 2019;5(10):e02655. DOI:10.1016/j.heliyon.2019.e02655
21. Bak DH, Na J, Im SI, et al. Antioxidant effect of human placenta hydrolysate against oxidative stress on muscle atrophy. J Cell Physiol. 2019;234(2):1643-58. DOI:10.1002/jcp.27034
22. Jazayeri MH, Barzaman K, Nedaeinia R, et al. Human placental extract attenuates neurological symptoms in the experimental autoimmune encephalomyelitis model of multiple sclerosis-a putative approach in MS disease? Auto Immun Highlights. 2020;11(1):14. DOI:10.1186/s13317-020-00137-x
23. Назаренко О.А., Громова О.А., Гришина Т.Р., и др. Коррекция Лаеннеком хронической перегрузки железом печени, почек и головного мозга. Фармакокинетика и фармакодинамика. 2017;2:39-44 [Nazarenko OA, Gromova OA, Grishina TR, et al. Correction by Laennec of chronic iron overload liver, kidneys and brain. Farmakokinetika i farmakodinamika. 2017;2:39-44 (in Russian)].
24. Громова О.А., Торшин И.Ю., Максимов В.А., и др. Пептиды в составе препарата Лаеннек, способствующие устранению гиперферритинемии и перегрузки железом. ­Фармакоэкономика. Современная фармакоэкономика и фармакоэпидемиология. 2020;13(4):68-80 [Gromova OA, Torshin IYu, Maksimov VA, et al. Peptides contained in the composition of Laennec that contribute to the treatment of hyperferritinemia and iron overload disorders. Farmakoekonomika. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(4):413-25 (in Russian)]. DOI:10.17749/2070-4909/farmakoekonomika.2020.070
25. Yamauchi A, Kamiyoshi A, Sakurai T, et al. Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism. Heliyon. 2019;5(5):e01637. DOI:10.1016/j.heliyon.2019.e01637
26. Nensat C, Songjang W, Tohtong R, et al. Porcine placenta extract improves high-glucose-induced angiogenesis impairment. BMC Complement Med Ther. 2021;21(1):66. DOI:10.1186/s12906-021-03243-z
27. de Toledo A, Nomoto K, Hirano E, Tohda C. Horse Placental Extract Enhances Neurogenesis in the Presence of Amyloid β. Nutrients. 2021;13(5):1672. DOI:10.3390/nu13051672
28. Ito K, Yamada R, Matsumoto N, Imamura T. Evaluation of fibroblast growth factor activity exerted by placental extract used as a cosmetic ingredient. J Cosmet Dermatol. 2018;17(5):821-9. DOI:10.1111/jocd.12434
29. Kwon JW, Hong SE, Kang SR, Park BY. Effect of Human Placental Extract Treatment on Random-Pattern Skin Flap Survival in Rats. J Invest Surg. 2019;32(4):304-13. 
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30. Nagata M, Nakamura T, Hata Y, et al. JBP485 promotes corneal epithelial wound healing. Sci Rep. 2015;5:14776. DOI:10.1038/srep14776
31. Yamasaki M, Hasegawa S, Takahashi H, et al. Placental extracts induce the expression of antioxidant enzyme genes and suppress melanogenesis in B16 melanoma cells. Nat Prod Res. 2015;29(22):2103-6. DOI:10.1080/14786419.2014.986660
32. Громова О.А., Торшин И.Ю., Диброва Е.А., и др. Молекулярные механизмы воздействия экстрактов плаценты человека на пигментообразование кожи. Вестник эстетической медицины. 2012;11(3):70-7 [Gromova OA, Torshin IYu, Dibrova EA, et al. Molekuliarnye mekhanizmy vozdeistviia ekstraktov platsenty cheloveka na pigmentoobrazovanie kozhi. Vestnik esteticheskoi meditsiny. 2012;11(3):70-7 (in Russian)].
33. Kwon TR, Oh CT, Choi EJ, et al. Human placental extract exerts hair growth-promoting effects through the GSK-3beta signaling pathway in human dermal papilla cells. Int J Mol Med. 2015;36(4):1088-96. DOI:10.3892/ijmm.2015.2316
34. Лучина Е.Н. Возможности применения препарата Лаеннек в лечении рубцовых изменений кожи. Экспериментальная и клиничес­кая дерматокосметология. 2012;4:36-40 [Luchina EN. Possibilities of using Laennec to treat skin scarring changes. Experimental and Clinical Gastroenterology. 2012;4:36-40 (in Russian)].
35. Awan KH, Patil S, Habib SR, et al. Evaluation of medicinal interventions for the management of oral submucous fibrosis: a systematic review of the literature. J Contemp Dent Pract. 2014;15(6):812-7. DOI:10.5005/jp-journals-10024-1623
36. Патент РФ 2606040 от 01.04.2015. Усманова И.Н., Герасимова Л.П., Кабирова М.Ф. и др. Способ лечения хронического воспаления тканей пародонта и слизистой оболочки с элементами гиперкератоза у лиц молодого возраста. Режим доступа: https://patenton.ru/patent/RU2606040C2.pdf. Ссылка активна на 03.02.2022 [Patent RUS 2606040/01.04.2015. Usmanova IN, Gerasimova LP, Kabirova MF, et al. Sposob lecheniya khronicheskogo vospaleniya tkanei parodonta i slizistoi obolochki s elementami giperkeratoza u lits molodogo vozrasta. Available at: https://patenton.ru/patent/RU2606040C2.pdf. Accessed: 03.02.2022 (in Russian)].
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38. Дудник Е.Н., Калита А.В., Диброва Е.А., и др. Вегетативный тонус у пациентов с синдромом хронической усталости: эффекты акупунктурного введения препарата «Лаеннек». Кремлевская медицина. Клинический вестник. 2008;4:94-6 [Dudnik EN, Kalita  AV, Dibrova EA, et al. Vegetativnyi tonus u patsientov s sindromom khronicheskoi ustalosti: effekty akupunkturnogo vvedeniia preparata "Laennek". Kremlevskaya meditsina. Klinicheskii vestnik. 2008;4:94-6 (in Russian)].
39. Park SB, Kim KN, Sung E, et al. Human Placental Extract as a Subcutaneous Injection Is Effective in Chronic Fatigue Syndrome: A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study. Biol Pharm Bull. 2016;39(5):674-9. DOI:10.1248/bpb.b15-00623
40. Громова О.А., Торшин И.Ю., Згода В.Г., Диброва Е.А. Регуляторное действие пептидов Лаеннека на митохондриальные процессы. Терапия. 2017;7:71-84 [Gromova OA, Torshin IYu, Zgoda VG, Dibrova EA. Regulatory action of Laennec peptides on mitochondrial processes. Therapy. 2017;7:71-84 (in Russian)].
41. Gromova O.A. Prospective of gerontological applications of Laennec: fundamental studies & molecular mechanisms. Congress of anti-age medicine, plenary session. Tokyo, 2017. Available at: http://www.jplaa.jp/images/pdf/%E7%A0%94%E7%A9%B6%E8%A6%81%E8%A6%A7_%E7%AC%AC2021%E5%90%88%E4%BD%B5%.... Accessed: 03.02.2022.
42. Леонов С.В., Марусич Е.И., Громова О.А., и др. Антивозрастной эффект гидролизата плаценты человека: доказательный стандарт. Терапия. 2017;4:75-83 [Leonov SV, Marusich EI, Gromova OA, et al. Anti-aging effect of human placenta hydrolysate. Evidence-based standard. Therapy. 2017;4:75-83 (in Russian)].
43. Торшин И., Громова О., Диброва Е., и др. Влияние препарата «ЛАЕННЕК» на маркеры старения. Эстетическая медицина. 2017;2:157-67 [Torshin I, Gromova O, Dibrova E., et al. Vliyanie preparata "LAENNEK" na markery stareniya. Esteticheskaya meditsina. 2017;2:157-67 (in Russian)].
44. Shin EH, Kim M, Hada B, et al. Effects of Human Placenta Extract (Laennec) on Ligament Healing in a Rodent Model. Biol Pharm Bull. 2019;42(12):1988-95.
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45. Chang SW, Kim JY, Kim MJ, et al. Combined effects of mineral trioxide aggregate and human placental extract on rat pulp tissue and growth, differentiation and angiogenesis in human dental pulp cells. Acta Odontol Scand. 2016;74(4):298-306. DOI:10.3109/00016357.2015.1120882
46. Громова О.А., Торшин И.Ю., Диброва Е.А., и др. Гидролизаты плаценты человека в реконструктивной терапии соединительной ткани хряща и суставов. Терапия. 2016;6:43-53 [Gromova OA, Torshin IYu, Dibrova EA, et al. Human placenta hydrolyzates in reconstructive therapy of connective tissue of cartilage and joints. Therapy. 2016;6:43-53 (in Russian)].
47. Park KM, Cho TH. Therapeutic effect of acupuncture point injection with placental extract in knee osteoarthritis. J Integr Med. 2017;15(2):135-41.
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48. Торшин И.Ю., Громова О.А., Диброва Е.А., и др. Пептиды в составе препарата Лаеннек, потенцирующие его антивирусные эффекты в лечении атопического дерматита герпетической инфекции. Российский аллергологический журнал. 2018;15(1-1):82-90 [Torshin IYu, Gromova OA, Dibrova EA, et al. Peptidy v sostave preparata Laennek, potentsiruyushchie ego antivirusnye effekty v lechenii atopicheskogo dermatita gerpeticheskoi infektsii. Russian Journal of Allergy. 2018;15(1-1):82-90 (in Russian)]. DOI:10.36691/RJA191
49. Елисютина О.Г., Феденко Е.С., Шабанова И.Ф., Каримова И.М. Первый опыт применения препарата Лаеннек при атопическом дерматите в России. Российский аллергологический журнал. 2010;1:97-104 [Elisyutina OG, Fedenko ES, Shabanova IF, Karimova I.M. Pervyi opyt primeneniya preparata Laennek pri atopicheskom dermatite v Rossii. Russian Journal of Allergy. 2018;15(1-1):82-90 (in Russian)].
50. Зуйкова И.Н., Шульженко А.Е., Щубелко Р.В., и др. Рецидивирующий генитальный герпес: стандартные подходы и новые перспективы терапии. Российский аллергологический журнал. 2014;6:47-57 [Zuikova IN, Shulzhenko AE, Shchubelko RV, et al. Treatment of recurrent herpes virus infection: standard approaches and new perspectives. Russian Journal of Allergy. 2014;6:47-57 (in Russian)]. DOI:10.36691/RJA521
51. Kim EH, Kim YI, Jang SG, et al. Antiviral effects of human placenta hydrolysate (Laennec(®)) against SARS-CoV-2 in vitro and in the ferret model. J Microbiol. 2021;59(11):1056-62. DOI:10.1007/s12275-021-1367-2
52. Максимов В.А., Торшин И.Ю., Чучалин А.Г., и др. Эффективность и безопасность полипептидного препарата (Лаеннек) в терапии COVID-19. Экспериментальная и клиническая гастроэнтерология. 2020;178(6):55-63 [Maksimov VA, Torshin IYu, Chuchalin AG, et al. The effectiveness and safety of a polypeptide drug (Laennec) for the treatment of COVID-19. Experimental and Clinical Gastroentero­logy. 2020;178(6):55-63  (in Russian)]. DOI:10.31146/1682-8658-ecg-178-6-55-63
53. Goswami S, Sarkar R, Saha P, et al. Effect of human placental extract in the management of biofilm mediated drug resistance – A focus on wound management. Microb Pathog. 2017;111:307-15. DOI:10.1016/j.micpath.2017.08.041
54. AbdRabou MA, Mehany ABM, Farrag IM, et al. Therapeutic Effect of Murine Bone Marrow-Derived Mesenchymal Stromal/Stem Cells and Human Placental Extract on Testicular Toxicity Resulting from Doxorubicin in Rats. Biomed Res Int. 2021;2021:9979670. DOI:10.1155/2021/9979670
55. Choi JH, Jung J, Na KH, et al. Effect of mesenchymal stem cells and extracts derived from the placenta on trophoblast invasion and immune responses. Stem Cells Dev. 2014;23(2):132-45. DOI:10.1089/scd.2012.0674
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1. Filatov VP. Tkanevaya terapiya. Klinicheskaia meditsina. Moscow, 1950, T. XXVIII, No.1, p. 22-8 (in Russian).
2. Maksimov VA, Gromova OA, Dibrova EA. Sbornik avtoreferatov doktorskikh i kandidatskikh dissertatsii po probleme tkanevoi terapii platsenty cheloveka. Moscow: Pechatnoe biuro "Modul'", 2022 (in Russian).
3. Torshin IYu, Zgoda VG, Gromova OA, et al. Analysis of the light peptide fraction of Laennec by proteomic methods. Pharmacokinetics and Pharmacodynamics. 2016;(4):31-42 (in Russian).
4. Gromova OA, Torshin IYu, Volkov AYu, et al. Preparation Laennec: elemental composition and key role in the pharmacological action. Plastic Surgery and Cosmetology. 2011;2:327-33 (in Russian).
5. Gilels AV, Gromova OA, Torshin IYu, et al. Experimental analysis of the vitamin composition of the Laennec preparation. Bulletin of Aesthetic Medicine. 
2013;12(3):80-7 (in Russian). 
6. Torshin IYu, Gromova OA. Worldwide experience of the therapeutic use of the human placental hydrolytes. Experimental and Clinical Gastroenterology. 2019;1(10):79-89 (in Russian). DOI:10.31146/1682-8658-ecg-170-10-79-89
7. Torshin IYu, Gromova OA, Stakhovskaya LV, et al. Analysis of 19.9 million publications from the PubMed/MEDLINE database using artificial intelligence methods: approaches to the generalizations of accumulated data and the phenomenon of «fake news». Farmakoekonomika. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(2):146-63 (in Russian). 
DOI:10.17749/2070-4909/farmakoekonomika.2020.021
8. Minushkin ON, Maslovsky LV, Yelizavetina GA, et al. Administration of Laennec in Gatroenterology. Effektivnaya farmakoterapiya. Gastroenterologiya. 2014;50:18-23 (in Russian).
9. Paltsev AI, Eremina AA, Torgashov MN. Hepatoprotective role of placenta hydrolyzate – Laennec in the treatment of patients with viral and parasitic liver diseases. Experimental and Clinical Gastroenterology. 2016;11(135):94-9 (in Russian).
10. Maksimov VA, Buntin SE, Buntina VG, et al. Regarding an Influence of Placental Drug Laennec on Motor Function of Biliary Tract in Patients with Fatty Liver Dystrophy. Effektivnaya farmakoterapiya. Gastroenterologiya. 2015;37:12-5 (in Russian).
11. Lazebnik LB, Radchenko VG, Seliverstov PV, et al. The contemporary understanding of liver fibrosis and approaches to treatment in patients with nonalcoholic steatohepatitis. Experimental and Clinical Gastro­ente­rology. 2017;148(12):98-109 (in Russian).
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О.А. Громова*1,2, И.Ю. Торшин1, А.Г. Чучалин3, В.А. Максимов2,4

1 ФИЦ «Информатика и управление» РАН, Москва, Россия;
2 Фонд им В.П. Филатова, Москва, Россия;
3 ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия;
4 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*unesco.gromova@gmail.com

________________________________________________

Olga A. Gromova*1,2, Ivan Yu. Torshin1, Alexander G. Chuchalin3, Valeriy A. Maximov2,4

1 Federal Research Center “Informatics and Management” of RAS, Moscow, Russia;
2 Filatov’s Fund, Moscow, Russia;
3 Pirogov Russian National Research Medical University, Moscow, Russia;
4 Russian Medical Academy of Continuing Professional Education, Moscow, Russia
*unesco.gromova@gmail.com