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Заболевания органов дыхания и ожирение: особый фенотип или независимые события
Заболевания органов дыхания и ожирение: особый фенотип или независимые события
Щепихин Е.И., Шмелев Е.И., Зайцева А.С. Заболевания органов дыхания и ожирение: особый фенотип или независимые события. Терапевтический архив. 2022;94(3):442–447.
DOI: 10.26442/00403660.2022.03.201412
DOI: 10.26442/00403660.2022.03.201412
DOI: 10.26442/00403660.2022.03.201412
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DOI: 10.26442/00403660.2022.03.201412
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
Совокупность факторов, среди которых западноевропейские особенности пищевого поведения, гиподинамия и генетическая предрасположенность, приводит к драматическому увеличению массы жировой ткани. Особое место занимает абдоминальное ожирение, при котором происходит аккумуляция жировой ткани в брыжейке тонкой кишки и сальнике. Развивающиеся в условиях висцерального ожирения инсулинорезистентность, дислипидемия и системное воспаление являются одними из ключевых компонентов патогенеза сахарного диабета 2-го типа, кардиоваскулярных заболеваний, неалкогольной жировой болезни печени и поджелудочной железы, поликистоза яичников, некоторых форм онкологических заболеваний (рак молочной железы, эндометрия, толстой и прямой кишки). Вместе с тем патогенетическая роль жировой ткани не ограничивается участием в онкогенезе и формировании кардиометаболического континуума. Установлено участие жировой ткани в патогенезе многих респираторных заболеваний, в числе которых бронхиальная астма, обструктивное апноэ сна и легочная гипертензия. В работе представлен обзор современных данных по иммунологическим, патофизиологическим и клиническим особенностям фенотипа сочетания респираторных заболеваний с избыточной массой тела и ожирением.
Ключевые слова: ожирение, хроническая обструктивная болезнь легких, астма, воспаление, интерстициальные заболевания легких, интерстициальные заболевания легких, метаболический синдром
Keywords: obesity, chronic obstructive pulmonary disease, asthma, inflammation, interstitial lung disease, Interstitial lung disease, metabolic syndrome
Ключевые слова: ожирение, хроническая обструктивная болезнь легких, астма, воспаление, интерстициальные заболевания легких, интерстициальные заболевания легких, метаболический синдром
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Keywords: obesity, chronic obstructive pulmonary disease, asthma, inflammation, interstitial lung disease, Interstitial lung disease, metabolic syndrome
Полный текст
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3. Brock JM, Billeter A, Müller-Stich BP, Herth F. Obesity and the Lung: What We Know Today. Respiration. 2020;99(10):856-66. DOI:10.1159/000509735
4. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415-45. DOI:10.1146/annurev-immunol-031210-101322
5. Makki K, Froguel P, Wolowczuk I. Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. ISRN Inflamm. 2013;2013:139239. DOI:10.1155/2013/139239
6. Сhawla A, Nguyen KD, Goh YP. Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol. 2011;11:738-49. DOI:10.1038/nri3071
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9. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011;11:85-97. DOI:10.1038/nri2921
10. Kiernan K, MacIver NJ. The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease. Front Immunol. 2021;11:622468. DOI:10.3389/fimmu.2020.622468
11. Pham DV, Park PH. Recent insights on modulation of inflammasomes by adipokines: a critical event for the pathogenesis of obesity and metabolism-associated diseases. Arch Pharm Res. 2020;43(10):997-1016. DOI:10.1007/s12272-020-01274-7
12. Chwalba A, Machura E, Ziora K, Ziora D. The role of adipokines in the pathogenesis and course of selected respiratory diseases. Endokrynol Pol. 2019;70(6):504-10. DOI:10.5603/EP.a2019.0051
13. Fang H, Judd RL. Adiponectin Regulation and Function. Compr Physiol. 2018;8(3):1031-63. DOI:10.1002/cphy.c170046
14. Mattioli B, Straface E, Quaranta MG, et al. Leptin Promotes Differentiation and Survival of Human Dendritic Cells and Licenses Them for Th1 Priming. J Immunol. 2005;174(11):6820. DOI:10.4049/jimmunol.174.11.6820
15. Tsiotra PC, Boutati E, Dimitriadis G, Raptis SA. High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells. Biomed Res Int. 2013;2013:487081. DOI:10.1155/2013/487081
16. Frasca D, Blomberg BB. Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging. Front Immunol. 2017;8:1003. DOI:10.3389/fimmu.2017.01003
17. Song J, Deng T. The Adipocyte and Adaptive Immunity. Front Immunol. 2020;11:593058. DOI:10.3389/fimmu.2020.593058
18. Marangoni RG, Korman BD, Wei J, et al. Myofibroblasts in murine cutaneous fibrosis originate from adiponectin-positive intradermal progenitors. Arthritis Rheumatol. 2015;67:1062-73. DOI:10.1002/art.38990
19. Ohashi K, Parker JL, Ouchi N, et al. Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem. 2010;285:6153-60. DOI:10.1074/jbc.M109.088708
20. Mandal P, Pratt BT, Barnes M, et al. Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin. J Biol Chem. 2011;286:13460-9. DOI:10.1074/jbc.M110.204644
21. Lakota K, Wei J, Carns M, et al. Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker? Arthritis Res Ther. 2012;14:R102. DOI:10.1186/ar3827
22. Żółkiewicz J, Stochmal A, Rudnicka L. The role of adipokines in systemic sclerosis: a missing link? Arch Dermatol Res. 2019;311(4):251-63.
DOI:10.1007/s00403-019-01893-1
23. Koo P, Gartman EJ, Sethi JM, McCool FD. Physiology in Medicine: physiological basis of diaphragmatic dysfunction with abdominal herniasimplications for therapy. J Appl Physiol (1985). 2015;118:142-7. DOI:10.1152/japplphysiol.00276.2014
24. Salome CM, King GG, Berend N. Physiology of obesity and effects on lung function. J Appl Physiol. 2010;108:206-11. DOI:10.1152/japplphysiol.00694.2009
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Авторы
Е.И. Щепихин*, Е.И. Шмелев, А.С. Зайцева
ФГБНУ «Центральный научно-исследовательский институт туберкулеза», Москва, Россия
*shhepikhin11@yandex.ru
Central Tuberculosis Research Institute, Moscow, Russia
*shhepikhin11@yandex.ru
ФГБНУ «Центральный научно-исследовательский институт туберкулеза», Москва, Россия
*shhepikhin11@yandex.ru
________________________________________________
Central Tuberculosis Research Institute, Moscow, Russia
*shhepikhin11@yandex.ru
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