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Преимущества агонистов рецепторов глюкагоноподобного пептида-1 в лечении пациентов с сахарным диабетом 2-го типа
Демидова Т.Ю., Титова В.В., Измайлова М.Я. Преимущества агонистов рецепторов глюкагоноподобного пептида-1 в лечении пациентов с сахарным диабетом 2-го типа. Терапевтический архив.
2023;95(10):876–880. DOI: 10.26442/00403660.2023.10.202425
© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.
2023;95(10):876–880. DOI: 10.26442/00403660.2023.10.202425
© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.
________________________________________________
Demidova TYu, Titova VV, Izmaylova MYa. Advantages of glucagon-like peptide-1 receptor agonists in the treatment of patients with type 2 diabetes mellitus: A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2023;95(10):876–880.
DOI: 10.26442/00403660.2023.10.202425
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Аннотация
Агонисты рецепторов глюкагоноподобного пептида-1 (арГПП-1) являются эффективным средством лечения пациентов с сахарным диабетом 2-го типа (СД 2), в основном благодаря увеличению секреции инсулина и подавления высвобождения глюкагона за счет стимуляции соответствующих рецепторов. Принимая во внимание их положительное влияние на основные сердечно-сосудистые события, препараты данной группы с доказанными кардиопротективными эффектами рекомендованы для пациентов с СД 2 и клиническими сердечно-сосудистыми заболеваниями и их множественными факторами риска. В данной статье мы представляем обзор текущих клинических исследований, касающихся клинической эффективности и безопасности применения арГПП-1, и обсуждаем текущие перспективы применения арГПП-1 для лечения пациентов с СД 2.
Ключевые слова: агонисты рецепторов глюкагоноподобного пептида-1, сахарный диабет 2-го типа, сердечно-сосудистые исходы
Ключевые слова: агонисты рецепторов глюкагоноподобного пептида-1, сахарный диабет 2-го типа, сердечно-сосудистые исходы
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Glucagon-like peptide-1 receptor agonists (arGLP1) are an effective treatment for patients with type 2 diabetes mellitus (T2DM), mainly due to increasing insulin secretion and suppressing glucagon release by stimulating the respective receptors. Taking into account their positive effect on major cardiovascular events, drugs in this group with proven cardioprotective effects are recommended for patients with T2DM and clinical cardiovascular diseases or multiple cardiovascular risk factors. In this paper, we present an overview of current clinical studies on the clinical efficacy and safety of arGLP1 and discuss current prospects for arGLP1 as a therapy for patients with T2DM.
Keywords: glucagon-like peptide-1 receptor agonists, type 2 diabetes mellitus, cardiovascular outcomes
Полный текст
Список литературы
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21. Pfeffer MA, Claggett B, Diaz R, et al. Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome. N Engl J Med. 2015;373(23):2247-57. DOI:10.1056/NEJMoa1509225
22. Holman RR, Bethel MA, Mentz RJ, et al. Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2017;377(13):1228-39. DOI:10.1056/NEJMoa1612917
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24. Margulies KB, Anstrom KJ, Hernandez AF, et al. GLP-1 agonist therapy for advanced heart failure with reduced ejection fraction: design and rationale for the functional impact of GLP-1 for heart failure treatment study. Circ Heart Fail. 2014;7(4):673-9. DOI:10.1161/CIRCHEARTFAILURE.114.000346
25. Meier JJ, Rosenstock J, Hincelin-Méry A, et al. Contrasting Effects of Lixisenatide and Liraglutide on Postprandial Glycemic Control, Gastric Emptying, and Safety Parameters in Patients With Type 2 Diabetes on Optimized Insulin Glargine With or Without Metformin: A Randomized, Open-Label Trial. Diabetes Care. 2015;38(7):1263-73. DOI:10.2337/dc14-1984
26. Sattar N, Lee MMY, Kristensen SL, et al. Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials. Lancet Diabetes Endocrinol. 2021;9(10):653-62. DOI:10.1016/S2213-8587(21)00203-5
27. Giugliano D, Maiorino MI, Bellastella G, et al. GLP-1 receptor agonists for prevention of cardiorenal outcomes in type 2 diabetes: An updated meta-analysis including the REWIND and PIONEER 6 trials. Diabetes Obes Metab. 2019;21(11):2576-80. DOI:10.1111/dom.13847
28. Giugliano D, Scappaticcio L, Longo M, et al. GLP-1 receptor agonists and cardiorenal outcomes in type 2 diabetes: an updated meta-analysis of eight CVOTs. Cardiovasc Diabetol. 2021;20(1):189. DOI:10.1186/s12933-021-01366-8
29. Giugliano D, Ceriello A, De Nicola L, et al. Primary versus secondary cardiorenal prevention in type 2 diabetes: which newer antihyperglycaemic drug matters? Diabetes Obes Metab. 2020;22:149‑57. DOI:10.1111/dom.13881
30. Giugliano D, Chiodini P, Maiorino MI, et al. Cardiovascular outcome trials and major cardiovascular events: does glucose matter? A systematic review with meta-analysis. J Endocrinol Invest. 2019;42:1165-9. DOI:10.1007/s40618-019-01047-0
31. Almutairi M, Al Batran R, Ussher JR. Glucagon-like peptide-1 receptor action in the vasculature. Peptides. 2019;111:26-32. DOI:10.1016/j.peptides.2018.09.002
32. Alicic RZ, Cox EJ, Neumiller JJ, Tuttle KR. Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence. Nat Rev Nephrol. 2021;17:227-44. DOI:10.1038/s41581-020-00367-2
33. Tuttle KR, Lakshmanan MC, Rayner B, et al. Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial. Lancet Diabetes Endocrinol. 2018;6(8):605-17. DOI:10.1016/S2213-8587(18)30104-9
34. Gerstein HC, Colhoun HM, Dagenais GR, et al. Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial. Lancet. 2019;394(10193):131-8. DOI:10.1016/S0140-6736(19)31150-X
35. Zavattaro M, Caputo M, Samà MT, et al. One-year treatment with liraglutide improved renal function in patients with type 2 diabetes: a pilot prospective study. Endocrine. 2015;50(3):620-6. DOI:10.1007/s12020-014-0519-0
36. Davies MJ, Bain SC, Atkin SL, et al. Efficacy and Safety of Liraglutide Versus Placebo as Add-on to Glucose-Lowering Therapy in Patients With Type 2 Diabetes and Moderate Renal Impairment (LIRA-RENAL): A Randomized Clinical Trial. Diabetes Care. 2016;39(2):222-30. DOI:10.2337/dc14-2883
37. Mann JFE, Hansen T, Idorn T, et al. Effects of once-weekly subcutaneous semaglutide on kidney function and safety in patients with type 2 diabetes: a post-hoc analysis of the SUSTAIN 1-7 randomised controlled trials. Lancet Diabetes Endocrinol. 2020;8(11):880-93. DOI:10.1016/S2213-8587(20)30313-2
38. Bethel MA, Mentz RJ, Merrill P, et al. Renal outcomes in the EXenatide Study of Cardiovascular Event Lowering (EXSCEL). Diabetes. 2018;6(Suppl. 1):522. DOI:10.2337/db18-522-P
39. van der Aart-van der Beek AB, Clegg LE, Penland RC, et al. Effect of once-weekly exenatide on estimated glomerular filtration rate slope depends on baseline renal risk: a post hoc analysis of the EXSCEL trial. Diabetes Obes Metab. 2020;22(12):2493-8. DOI:10.1111/dom.14175
40. Monami M, Nardini C, Mannucci E. Efficacy and Safety of Sodium Glucose Co-Transport-2 Inhibitors in Type 2 Diabetes: A Meta-Analysis of Randomized Clinical Trials. Diabetes Obes Metab. 2014;16(5):457-66. DOI:10.1111/dom.12244
41. Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med. 2015;373(22):2117-28. DOI:10.1056/NEJMoa1504720
42. Wright AK, Carr MJ, Kontopantelis E, et al. Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes. Diabetes Care. 2022;45(4):909-18. DOI:10.2337/dc21-1113
43. Gourdy P, Darmon P, Dievart F, et al. Combining glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) in patients with type 2 diabetes mellitus (T2DM). Cardiovasc Diabetol. 2023;22(1):79. DOI:10.1186/s12933-023-01798-4
44. Wang Y, Li L, Yang M, et al. Glucagon-like peptide-1 receptor agonists versus insulin in inadequately controlled patients with type 2 diabetes mellitus: a meta-analysis of clinical trials. Diabetes, Obes Metab. 2011;13(11):972-81. DOI:10.1111/j.1463-1326.2011.01436.x
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2. Panjwani N, Mulvihill EE, Longuet C, et al. GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice. Endocrinology. 2013;154(1):127-39. DOI:10.1210/en.2012-1937
3. Nauck MA, Meier JJ, Cavender MA, et al. Cardiovascular actions and clinical outcomes with glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Circulation. 2017;136:849-70. DOI:10.1161/CIRCULATIONAHA. 117.028136
4. Marso SP, Daniels GH, Brown-Frandsen K, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2016;375(4):311-22. DOI:10.1056/NEJMoa1603827
5. Marso SP, Bain SC, Consoli A, et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016;375 (19):1834-44. DOI:10.1056/NEJMoa1607141
6. Hernandez AF, Green JB, Janmohamed S, et al. Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial. Lancet. 2018;392(10157):1519-29. DOI:10.1016/S0140-6736(18) 32261-X
7. Gerstein HC, Colhoun HM, Dagenais GR, et al. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial. Lancet. 2019;394(10193):121-30. DOI:10.1016/S0140-6736(19)31149-3
8. Gerstein HC, Sattar N, Rosenstock J, et al. Cardiovascular and renal outcomes with efpeglenatide in type 2 diabetes. N Engl J Med. 2021;385(10):896-907. DOI:10.1056/NEJMoa2108269
9. Bethel MA, Patel RA, Merrill P, et al. Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis. Lancet Diabetes Endocrinol. 2018;6(2):105-13. DOI:10.1016/S2213-8587(17)30412-6
10. Sattar N, Lee MMY, Kristensen SL, et al. Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials. Lancet Diabetes Endocrinol. 2021;9(10):653-62. DOI:10.1016/S2213- 8587(21)00203-5
11. American Diabetes Association. Diabetes Care. 2023;46(suppl. 1):S1-298.
12. Htike ZZ, Zaccardi F, Papamargaritis D, et al. Efficacy and safety of glucagon-like peptide-1 receptor agonists in type 2 diabetes: A systematic review and mixed-treatment comparison analysis. Diabetes Obes Metab. 2017;19(4):524-36. DOI:10.1111/dom.12849
13. Verdich C, Flint A, Gutzwiller JP, et al. A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans. J Clin Endocrinol Metab. 2001;86(9):4382-9. DOI:10.1210/jcem.86.9.7877
14. Raun K, von Voss P, Knudsen LB. Liraglutide, a once-daily human glucagon-like peptide-1 analog, minimizes food intake in severely obese minipigs. Obesity (Silver Spring). 2007;15(7):1710-6. DOI:10.1038/oby.2007.204
15. Rowlands J, Heng J, Newsholme P, Carlessi R. Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function. Front Endocrinol (Lausanne). 2018;9:672. DOI:10.3389/fendo.2018.00672
16. Vilsbøll T, Christensen M, Junker AE, et al. Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ. 2012;344:d7771. DOI:10.1136/bmj.d7771
17. Tsapas A, Karagiannis T, Kakotrichi P, et al. Comparative efficacy of glucose-lowering medications on body weight and blood pressure in patients with type 2 diabetes: A systematic review and network meta-analysis. Diabetes Obes Metab. 2021;23(9):2116-24. DOI:10.1111/dom.14451
18. Apovian CM, Bergenstal RM, Cuddihy RM, et al. Effects of exenatide combined with lifestyle modification in patients with type 2 diabetes. Am J Med.
2010;123(5):468.e9-e4.68E17. DOI:10.1016/j.amjmed.2009.11.019
19. DeFronzo RA, Ratner RE, Han J, et al. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care. 2005;28(5):1092-100. DOI:10.2337/diacare.28.5.1092
20. Buse JB, Henry RR, Han J, et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care. 2004;27(11):2628-35. DOI:10.2337/diacare.27.11.2628
21. Pfeffer MA, Claggett B, Diaz R, et al. Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome. N Engl J Med. 2015;373(23):2247-57. DOI:10.1056/NEJMoa1509225
22. Holman RR, Bethel MA, Mentz RJ, et al. Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2017;377(13):1228-39. DOI:10.1056/NEJMoa1612917
23. Margulies KB, Hernandez AF, Redfield MM, et al. Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial. JAMA. 2016;316(5):500-8. DOI:10.1001/jama.2016.10260
24. Margulies KB, Anstrom KJ, Hernandez AF, et al. GLP-1 agonist therapy for advanced heart failure with reduced ejection fraction: design and rationale for the functional impact of GLP-1 for heart failure treatment study. Circ Heart Fail. 2014;7(4):673-9. DOI:10.1161/CIRCHEARTFAILURE.114.000346
25. Meier JJ, Rosenstock J, Hincelin-Méry A, et al. Contrasting Effects of Lixisenatide and Liraglutide on Postprandial Glycemic Control, Gastric Emptying, and Safety Parameters in Patients With Type 2 Diabetes on Optimized Insulin Glargine With or Without Metformin: A Randomized, Open-Label Trial. Diabetes Care. 2015;38(7):1263-73. DOI:10.2337/dc14-1984
26. Sattar N, Lee MMY, Kristensen SL, et al. Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials. Lancet Diabetes Endocrinol. 2021;9(10):653-62. DOI:10.1016/S2213-8587(21)00203-5
27. Giugliano D, Maiorino MI, Bellastella G, et al. GLP-1 receptor agonists for prevention of cardiorenal outcomes in type 2 diabetes: An updated meta-analysis including the REWIND and PIONEER 6 trials. Diabetes Obes Metab. 2019;21(11):2576-80. DOI:10.1111/dom.13847
28. Giugliano D, Scappaticcio L, Longo M, et al. GLP-1 receptor agonists and cardiorenal outcomes in type 2 diabetes: an updated meta-analysis of eight CVOTs. Cardiovasc Diabetol. 2021;20(1):189. DOI:10.1186/s12933-021-01366-8
29. Giugliano D, Ceriello A, De Nicola L, et al. Primary versus secondary cardiorenal prevention in type 2 diabetes: which newer antihyperglycaemic drug matters? Diabetes Obes Metab. 2020;22:149‑57. DOI:10.1111/dom.13881
30. Giugliano D, Chiodini P, Maiorino MI, et al. Cardiovascular outcome trials and major cardiovascular events: does glucose matter? A systematic review with meta-analysis. J Endocrinol Invest. 2019;42:1165-9. DOI:10.1007/s40618-019-01047-0
31. Almutairi M, Al Batran R, Ussher JR. Glucagon-like peptide-1 receptor action in the vasculature. Peptides. 2019;111:26-32. DOI:10.1016/j.peptides.2018.09.002
32. Alicic RZ, Cox EJ, Neumiller JJ, Tuttle KR. Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence. Nat Rev Nephrol. 2021;17:227-44. DOI:10.1038/s41581-020-00367-2
33. Tuttle KR, Lakshmanan MC, Rayner B, et al. Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial. Lancet Diabetes Endocrinol. 2018;6(8):605-17. DOI:10.1016/S2213-8587(18)30104-9
34. Gerstein HC, Colhoun HM, Dagenais GR, et al. Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial. Lancet. 2019;394(10193):131-8. DOI:10.1016/S0140-6736(19)31150-X
35. Zavattaro M, Caputo M, Samà MT, et al. One-year treatment with liraglutide improved renal function in patients with type 2 diabetes: a pilot prospective study. Endocrine. 2015;50(3):620-6. DOI:10.1007/s12020-014-0519-0
36. Davies MJ, Bain SC, Atkin SL, et al. Efficacy and Safety of Liraglutide Versus Placebo as Add-on to Glucose-Lowering Therapy in Patients With Type 2 Diabetes and Moderate Renal Impairment (LIRA-RENAL): A Randomized Clinical Trial. Diabetes Care. 2016;39(2):222-30. DOI:10.2337/dc14-2883
37. Mann JFE, Hansen T, Idorn T, et al. Effects of once-weekly subcutaneous semaglutide on kidney function and safety in patients with type 2 diabetes: a post-hoc analysis of the SUSTAIN 1-7 randomised controlled trials. Lancet Diabetes Endocrinol. 2020;8(11):880-93. DOI:10.1016/S2213-8587(20)30313-2
38. Bethel MA, Mentz RJ, Merrill P, et al. Renal outcomes in the EXenatide Study of Cardiovascular Event Lowering (EXSCEL). Diabetes. 2018;6(Suppl. 1):522. DOI:10.2337/db18-522-P
39. van der Aart-van der Beek AB, Clegg LE, Penland RC, et al. Effect of once-weekly exenatide on estimated glomerular filtration rate slope depends on baseline renal risk: a post hoc analysis of the EXSCEL trial. Diabetes Obes Metab. 2020;22(12):2493-8. DOI:10.1111/dom.14175
40. Monami M, Nardini C, Mannucci E. Efficacy and Safety of Sodium Glucose Co-Transport-2 Inhibitors in Type 2 Diabetes: A Meta-Analysis of Randomized Clinical Trials. Diabetes Obes Metab. 2014;16(5):457-66. DOI:10.1111/dom.12244
41. Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med. 2015;373(22):2117-28. DOI:10.1056/NEJMoa1504720
42. Wright AK, Carr MJ, Kontopantelis E, et al. Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes. Diabetes Care. 2022;45(4):909-18. DOI:10.2337/dc21-1113
43. Gourdy P, Darmon P, Dievart F, et al. Combining glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) in patients with type 2 diabetes mellitus (T2DM). Cardiovasc Diabetol. 2023;22(1):79. DOI:10.1186/s12933-023-01798-4
44. Wang Y, Li L, Yang M, et al. Glucagon-like peptide-1 receptor agonists versus insulin in inadequately controlled patients with type 2 diabetes mellitus: a meta-analysis of clinical trials. Diabetes, Obes Metab. 2011;13(11):972-81. DOI:10.1111/j.1463-1326.2011.01436.x
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Авторы
Т.Ю. Демидова, В.В. Титова*, М.Я. Измайлова
ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия
*meteora-vica@mail.ru
ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия
*meteora-vica@mail.ru
________________________________________________
Tatiana Yu. Demidova, Victoria V. Titova*, Maryam Ya. Izmaylova
Pirogov Russian National Research Medical University, Moscow, Russia
*meteora-vica@mail.ru
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