Dzhioeva ON. Functional methods of amyloid cardiomyopathy diagnostic in practice and in expert centers: A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2023;95(1):96–102. DOI: 10.26442/00403660.2023.01.202081
Функциональная диагностика амилоидной кардиомиопатии в условиях практики и экспертных центров
Джиоева О.Н. Функциональная диагностика амилоидной кардиомиопатии в условиях практики и экспертных центров. Терапевтический архив. 2023;95(1):96–102. DOI: 10.26442/00403660.2023.01.202081
Dzhioeva ON. Functional methods of amyloid cardiomyopathy diagnostic in practice and in expert centers: A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2023;95(1):96–102. DOI: 10.26442/00403660.2023.01.202081
Статья представляет собой свод рекомендаций по интерпретации данных электрокардио- и эхокардиографии у пациентов с подозрением на амилоидоз сердца. Амилоидная кардиомиопатия – прогрессирующее заболевание, которое характеризуется развернутой картиной застойной сердечной недостаточности, низким качеством жизни и плохим прогнозом. В настоящее время появились медикаментозные препараты, способные улучшить прогноз у пациентов с амилоидозом сердца. Повышение осведомленности специалистов о специфических инструментальных признаках заболевания является важной и актуальной задачей.
The article is a set of recommendations for the interpretation of electrocardiography and echocardiography data in patients with suspected amyloidosis of the heart. Amyloid cardiomyopathy is a progressive disease characterized by a detailed picture of congestive heart failure, poor quality of life and poor prognosis. Currently, medications have appeared that can improve the prognosis in patients with amyloidosis of the heart. Therefore, raising awareness of specialists about specific instrumental signs of the disease is an important and urgent task.
Keywords: amyloidosis of the heart, amyloid cardiomyopathy, electrocardiography, echocardiography, functional diagnostics
1. Терещенко С.Н., Жиров И.В., Моисеева О.М., и др. Практические рекомендации по диагностике транстиретиновой амилоидной кардиомиопатии (ATTR-КМП или транстиретинового амилоидоза сердца). Терапевтический архив. 2022;94(4):584-95 [Tereshchenko SN, Zhirov IV, Moiseeva OM, et al. Practical guidelines for the diagnosis and treatment of transthyretin amyloid cardiomyopathy (ATTR-CM or transthyretin cardiac amyloidosis). Terapevticheskii Arkhiv (Ter. Arkh.). 2022;94(4):584-95 (in Russian)]. DOI:10.26442/00403660.2022.04.201465
2. Cavalcante JL, Rijal S, Abdelkarim I, et al. Cardiac amyloidosis is prevalent in older patients with aortic stenosis and carries worse prognosis. J Cardiovasc Magn Reson. 2017;19(1):98. DOI:10.1186/s12968-017-0415-x
3. Cyrille NB, Goldsmith J, Alvarez J, Maurer MS. Prevalence and prognostic significance of low QRS voltage among the three main types of cardiac amyloidosis. Am J Cardiol. 2014;114(7):1089-93. DOI:10.1016/j.amjcard.2014.07.026
4. Cappelli F, Vignini E, Martone R, et al. Baseline ECG Features and Arrhythmic Profile in Transthyretin Versus Light Chain Cardiac Amyloidosis. Circ Heart Fail. 2020;13(3):e006619. DOI:10.1161/CIRCHEARTFAILURE.119.006619
5. Damy T, Maurer MS, Rapezzi C, et al. Clinical, ECG and echocardiographic clues to the diagnosis of TTR-related cardiomyopathy. Open Heart. 2016;3(1):e000289.
DOI:10.1136/openhrt-2015-000289
6. Dungu J, Sattianayagam PT, Whelan CJ, et al. The electrocardiographic features associated with cardiac amyloidosis of variant transthyretin isoleucine 122 type in Afro-Caribbean patients. Am Heart J. 2012;164(1):72-9. DOI:10.1016/j.ahj.2012.04.013
7. Gillmore JD, Maurer MS, Falk RH, et al. Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis. Circulation. 2016;133(24):2404-12. DOI:10.1161/CIRCULATIONAHA.116.021612
8. Maurer MS, Hanna M, Grogan M, et al; THAOS Investigators. Genotype and Phenotype of Transthyretin Cardiac Amyloidosis: THAOS (Transthyretin Amyloid Outcome Survey). J Am Coll Cardiol. 2016;68(2):161-72. DOI:10.1016/j.jacc.2016.03.596
9. Murtagh B, Hammill SC, Gertz MA, et al. Electrocardiographic findings in primary systemic amyloidosis and biopsy-proven cardiac involvement. Am J Cardiol. 2005;95(4):535-7. DOI:10.1016/j.amjcard.2004.10.028
10. Okin PM, Roman MJ, Devereux RB, Kligfield P. Electrocardiographic identification of increased left ventricular mass by simple voltage-duration products. J Am Coll Cardiol. 1995;25(2):417-23. DOI:10.1016/0735-1097(94)00371-v
11. Rapezzi C, Merlini G, Quarta CC, et al. Systemic cardiac amyloidoses: disease profiles and clinical courses of the 3 main types. Circulation. 2009;120(13):1203-12. DOI:10.1161/CIRCULATIONAHA.108.843334
12. Rapezzi C, Quarta CC, Obici L, et al. Disease profile and differential diagnosis of hereditary transthyretin-related amyloidosis with exclusively cardiac phenotype: an Italian perspective. Eur Heart J. 2013;34(7):520-8. DOI:10.1093/eurheartj/ehs123
13. Rapezzi C, Quarta CC, Riva L, et al. Transthyretin-related amyloidoses and the heart: a clinical overview. Nat Rev Cardiol. 2010;7(7):398-408. DOI:10.1038/nrcardio.2010.67
14. Ridolfi RL, Bulkley BH, Hutchins GM. The conduction system in cardiac amyloidosis. Clinical and pathologic features of 23 patients. Am J Med. 1977;62(5):677-86. DOI:10.1016/0002-9343(77)90870-1
15. Ruberg FL, Grogan M, Hanna M, et al. Transthyretin Amyloid Cardiomyopathy: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019;73(22):2872-91. DOI:10.1016/j.jacc.2019.04.003
16. Sperry BW, Vranian MN, Hachamovitch R, et al. Are classic predictors of voltage valid in cardiac amyloidosis? A contemporary analysis of electrocardiographic findings. Int J Cardiol. 2016;214:477-81. DOI:10.1016/j.ijcard.2016.04.030
17. Zhao L, Li J, Tian Z, Fang Q. Clinical correlates and prognostic values of pseudoinfarction in cardiac light-chain amyloidosis. J Cardiol. 2016;68(5):426-30. DOI:10.1016/j.jjcc.2015.11.004
18. Cuddy SAM, Chetrit M, Jankowski M, et al. Practical Points for Echocardiography in Cardiac Amyloidosis. J Am Soc Echocardiogr. 2022;35(9):A31-40. DOI:10.1016/j.echo.2022.06.006
19. Mitchell C, Rahko PS, Blauwet LA, et al. Guidelines for Performing a Comprehensive Transthoracic Echocardiographic Examination in Adults: Recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr. 2019;32(1):1-64. DOI:10.1016/j.echo.2018.06.004
20. AbouEzzeddine OF, Davies DR, Scott CG, et al. Prevalence of Transthyretin Amyloid Cardiomyopathy in Heart Failure With Preserved Ejection Fraction. JAMA Cardiol. 2021;6(11):1267-74. DOI:10.1001/jamacardio.2021.3070
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1. Tereshchenko SN, Zhirov IV, Moiseeva OM, et al. Practical guidelines for the diagnosis and treatment of transthyretin amyloid cardiomyopathy (ATTR-CM or transthyretin cardiac amyloidosis). Terapevticheskii Arkhiv (Ter. Arkh.). 2022;94(4):584-95 (in Russian). DOI:10.26442/00403660.2022.04.201465
2. Cavalcante JL, Rijal S, Abdelkarim I, et al. Cardiac amyloidosis is prevalent in older patients with aortic stenosis and carries worse prognosis. J Cardiovasc Magn Reson. 2017;19(1):98. DOI:10.1186/s12968-017-0415-x
3. Cyrille NB, Goldsmith J, Alvarez J, Maurer MS. Prevalence and prognostic significance of low QRS voltage among the three main types of cardiac amyloidosis. Am J Cardiol. 2014;114(7):1089-93. DOI:10.1016/j.amjcard.2014.07.026
4. Cappelli F, Vignini E, Martone R, et al. Baseline ECG Features and Arrhythmic Profile in Transthyretin Versus Light Chain Cardiac Amyloidosis. Circ Heart Fail. 2020;13(3):e006619. DOI:10.1161/CIRCHEARTFAILURE.119.006619
5. Damy T, Maurer MS, Rapezzi C, et al. Clinical, ECG and echocardiographic clues to the diagnosis of TTR-related cardiomyopathy. Open Heart. 2016;3(1):e000289.
DOI:10.1136/openhrt-2015-000289
6. Dungu J, Sattianayagam PT, Whelan CJ, et al. The electrocardiographic features associated with cardiac amyloidosis of variant transthyretin isoleucine 122 type in Afro-Caribbean patients. Am Heart J. 2012;164(1):72-9. DOI:10.1016/j.ahj.2012.04.013
7. Gillmore JD, Maurer MS, Falk RH, et al. Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis. Circulation. 2016;133(24):2404-12. DOI:10.1161/CIRCULATIONAHA.116.021612
8. Maurer MS, Hanna M, Grogan M, et al; THAOS Investigators. Genotype and Phenotype of Transthyretin Cardiac Amyloidosis: THAOS (Transthyretin Amyloid Outcome Survey). J Am Coll Cardiol. 2016;68(2):161-72. DOI:10.1016/j.jacc.2016.03.596
9. Murtagh B, Hammill SC, Gertz MA, et al. Electrocardiographic findings in primary systemic amyloidosis and biopsy-proven cardiac involvement. Am J Cardiol. 2005;95(4):535-7. DOI:10.1016/j.amjcard.2004.10.028
10. Okin PM, Roman MJ, Devereux RB, Kligfield P. Electrocardiographic identification of increased left ventricular mass by simple voltage-duration products. J Am Coll Cardiol. 1995;25(2):417-23. DOI:10.1016/0735-1097(94)00371-v
11. Rapezzi C, Merlini G, Quarta CC, et al. Systemic cardiac amyloidoses: disease profiles and clinical courses of the 3 main types. Circulation. 2009;120(13):1203-12. DOI:10.1161/CIRCULATIONAHA.108.843334
12. Rapezzi C, Quarta CC, Obici L, et al. Disease profile and differential diagnosis of hereditary transthyretin-related amyloidosis with exclusively cardiac phenotype: an Italian perspective. Eur Heart J. 2013;34(7):520-8. DOI:10.1093/eurheartj/ehs123
13. Rapezzi C, Quarta CC, Riva L, et al. Transthyretin-related amyloidoses and the heart: a clinical overview. Nat Rev Cardiol. 2010;7(7):398-408. DOI:10.1038/nrcardio.2010.67
14. Ridolfi RL, Bulkley BH, Hutchins GM. The conduction system in cardiac amyloidosis. Clinical and pathologic features of 23 patients. Am J Med. 1977;62(5):677-86. DOI:10.1016/0002-9343(77)90870-1
15. Ruberg FL, Grogan M, Hanna M, et al. Transthyretin Amyloid Cardiomyopathy: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019;73(22):2872-91. DOI:10.1016/j.jacc.2019.04.003
16. Sperry BW, Vranian MN, Hachamovitch R, et al. Are classic predictors of voltage valid in cardiac amyloidosis? A contemporary analysis of electrocardiographic findings. Int J Cardiol. 2016;214:477-81. DOI:10.1016/j.ijcard.2016.04.030
17. Zhao L, Li J, Tian Z, Fang Q. Clinical correlates and prognostic values of pseudoinfarction in cardiac light-chain amyloidosis. J Cardiol. 2016;68(5):426-30. DOI:10.1016/j.jjcc.2015.11.004
18. Cuddy SAM, Chetrit M, Jankowski M, et al. Practical Points for Echocardiography in Cardiac Amyloidosis. J Am Soc Echocardiogr. 2022;35(9):A31-40. DOI:10.1016/j.echo.2022.06.006
19. Mitchell C, Rahko PS, Blauwet LA, et al. Guidelines for Performing a Comprehensive Transthoracic Echocardiographic Examination in Adults: Recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr. 2019;32(1):1-64. DOI:10.1016/j.echo.2018.06.004
20. AbouEzzeddine OF, Davies DR, Scott CG, et al. Prevalence of Transthyretin Amyloid Cardiomyopathy in Heart Failure With Preserved Ejection Fraction. JAMA Cardiol. 2021;6(11):1267-74. DOI:10.1001/jamacardio.2021.3070
Авторы
О.Н. Джиоева*
ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава России, Москва, Россия;
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия
*dzhioevaon@gmail.com
________________________________________________
Olga N. Dzhioeva*
National Research Center for Therapy and Preventive Medicine, Moscow, Russia;
Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
*dzhioevaon@gmail.com