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Синдром гипогонадизма у мужчин с воспалительными заболеваниями суставов - Журнал Терапевтический архив №5 Вопросы ревматологии 2023
Синдром гипогонадизма у мужчин с воспалительными заболеваниями суставов
Паневин Т.С., Роживанов Р.В., Насонов Е.Л. Синдром гипогонадизма у мужчин с воспалительными заболеваниями суставов. Терапевтический архив. 2023;95(5):429–433.
DOI: 10.26442/00403660.2023.05.202199
© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.
DOI: 10.26442/00403660.2023.05.202199
© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.
________________________________________________
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Аннотация
Большинство ревматических заболеваний характеризуется половым диморфизмом как в распространенности, так и особенностях клинического течения. Повышенная продукция провоспалительных цитокинов при воспалительных заболеваниях суставов может сопровождаться снижением уровня мужских половых гормонов, и наоборот, наличие гипогонадизма у мужчин увеличивает риск развития некоторых ревматических заболеваний. В обзоре представлены данные о взаимосвязи дефицита тестостерона и основных воспалительных заболеваний суставов, а также о влиянии тестостерон-заместительной терапии на их проявления.
Ключевые слова: тестостерон, андрогены, гипогонадизм, ревматоидный артрит, подагра, спондилоартрит
Кeywords: testosterone, androgens, hypogonadism, rheumatoid arthritis, gout, spondyloarthritis
Ключевые слова: тестостерон, андрогены, гипогонадизм, ревматоидный артрит, подагра, спондилоартрит
________________________________________________
Кeywords: testosterone, androgens, hypogonadism, rheumatoid arthritis, gout, spondyloarthritis
Полный текст
Список литературы
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42. Cutolo M, Seriolo B, Villaggio B, et al. Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis. Ann N Y Acad Sci. 2002;966:131-42. DOI:10.1111/j.1749-6632.2002.tb04210
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3. Паневин Т.С. Влияние тестостерона на пуриновый обмен и подагру. Андрология и генитальная хирургия. 2021;22(3):11-7 [Panevin TS. Influence of testosterone on purine metabolism and gout. Andrology and Genital Surgery. 2021;22(3):11-7 (in Russian)]. DOI:10.17650/1726-9784-2021-22-3-11-17
4. Rettew JA, Huet-Hudson YM, Marriott I. Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity. Biol Reprod. 2008;78(3):432-7. DOI:10.1095/biolreprod.107.063545
5. Corcoran MP, Meydani M, Lichtenstein AH, et al. Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in macrophages from older men and postmenopausal women. J Endocrinol. 2010;206(2):217-24. DOI:10.1677/JOE-10-0057
6. Malkin CJ, Pugh PJ, Jones RD, et al. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab. 2004;89(7):3313-8. DOI:10.1210/jc.2003-031069
7. Torres-Chávez KE, Sanfins JM, Clemente-Napimoga JT, et al. Effect of gonadal steroid hormones on formalin-induced temporomandibular joint inflammation. Eur J Pain. 2012;16(2):204-16. DOI:10.1016/j.ejpain.2011.06.007
8. Дедов И.И., Мокрышева Н.Г., Мельниченко Г.А., и др. Проект клинических рекомендаций «Синдром гипогонадизма у мужчин». Ожирение и метаболизм. 2021;18(4):496-507 [Dedov II, Mokrysheva NG, Melnichenko GA, et al. Draft of Russian clinical practice guidelines “Male hypogonadism”. Obesity and Metabolism. 2021;18(4):496-507 (in Russian)]. DOI:10.14341/omet12817
9. Wang C, Nieschlag E, Swerdloff R, et al. Investigation, Treatment, and Monitoring of Late-Onset Hypogonadism in Males: ISA, ISSAM, EAU, EAA, and ASA Recommendations. J Androl. 2008;30(1):1-9. DOI:10.2164/jandrol.108.006486
10. Corona G, Mannucci E, Forti G, Maggi M. Hypogonadism, ED, metabolic syndrome and obesity: a pathological link supporting cardiovascular diseases. Int J Androl. 2009;32(6):587-98. DOI:10.1111/j.1365-2605.2008.00951.x
11. Al Hayek A, Ajlouni K, Khader Y, et al. Prevalence of low testosterone levels in men with type 2 diabetes mellitus: a cross-sectional study. J Family Community Med. 2013;20(3):179-86. DOI:10.4103/2230-8229.122006
12. Corona G, Giagulli VA, Maseroli E, et al. Testosterone supplementation and body composition: results from a meta-analysis of observational studies. J Endocrinol Invest. 2016;39(9):967-81. DOI:10.1007/s40618-016-0480-2
13. Garbagnati E, Boschetti M. Uric acid homeostasis in lean and obese girls during pubertal development. Metabolism. 1994;43(7):819-21. DOI:10.1016/0026-0495(94)90260-7
14. Doghramji PP, Wortmann RL. Hyperuricemia and gout: new concepts in diagnosis and management. Postgrad Med. 2012;124:98-109. DOI:10.3810/pgm.2012.11.2616
15. Stamp LK, Wells JE, Pitama S, et al. Hyperuricaemia and gout in New Zealand rural and urban Māori and non-Māori communities. Int Med J. 2013;43(6):678-84. DOI:10.1111/imj.12062
16. Pizzichini M, Di Stefano A, Resconi G, et al. Influence of testosterone on purine nucleotide turnover in rat kidney. Horm Metab Res.1990;22:334‑8. DOI:10.1055/s-2007-1004914
17. Marinello E, Leoncini R, Terzuoli L, et al. Effect of testosterone on purine nucleotide metabolism in rat liver. Horm Metab Res. 2004;36:614-9. DOI:10.1055/s-2007-1004914
18. Condorelli RA, Calogero AE, Di Mauro M, et al. Androgen excess and metabolic disorders in women with PCOS: beyond the body mass index. J Endocrinol Investig. 2018;41:383-8. DOI:10.1007/s40618-017-0762-3
19. Mu L, Pan J, Yang L, et al. Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome. Reprod Biol Endocrinol. 2018;16(1):104. DOI:10.1186/s12958-018-0419-x
20. Pui K, Waddell C, Dalbeth N. Early onset of hyperuricaemia and gout following treatment for female to male gender reassignment. Rheumatology (Oxford). 2008;47(12):1840-1. DOI:10.1093/rheumatology/ken391
21. Kurahashi H, Watanabe M, Sugimoto M, et al. Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder. Endocr J. 2013;60(12):1321-7. DOI:10.1507/endocrj.ej13-0203
22. Ebert T, Jockenhövel F, Morales A, Shabsigh R. The Current Status of Therapy for Symptomatic Late-Onset Hypogonadism with Transdermal Testosterone Gel. Eur Urol. 2005;47(2):137-46. DOI:10.1016/j.eururo.2004.09.015
23. Cao W, Zheng R-D, Xu S-H, et al. Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes. Int J Endocrinol. 2017;2017:4375253. DOI:10.1155/2017/4375253
24. He Y, Yang Q, Qing Y. Altered expression of androgen and its receptor might be involved in the pathogenesis of primary gouty arthritis. Gout and Hyperuricemia. 2015;2(2):56-61. DOI:10.3966/GH1506020203
25. Lim JH, Kim Y-K, Kim Y-S, et al. Relationship Between Serum Uric Acid Levels, Metabolic Syndrome, and Arterial Stiffness in Korean. Korean Circ J. 2010;40(7):314-20. DOI:10.4070/kcj.2010.40.7.314
26. Tong G, Hua X, Zhong Y, et al. Intensive insulin therapy increases sex hormone-binding globulin in newly diagnosed type 2 diabetic patients. Eur J Endocrinol. 2014;170(2):237-45. DOI:10.1530/eje-13-0557
27. Kuczera P, Adamczak M, Wiecek A. Endocrine Abnormalities in Patients with Chronic Kidney Disease. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2015;36(2):109-18. DOI:10.1515/prilozi-2015-0059
28. Mukhin IV, Ignatenko GA, Nikolenko VY. Dyshormonal disorders in gout: experimental and clinical studies. Bull Exp Biol Med. 2002;133:491‑3. DOI:10.1023/a:1019826107916
29. Marinello E, Riario-Sforza G, Marcolongo R. Plasma follicle-stimulating hormone, luteinizing hormone, and sex hormones in patients with gout. Arthritis Rheum. 1985;28(2):127-31. DOI:10.1002/art.1780280203
30. Baillargeon J, Al Snih S, Raji MA, et al. Hypogonadism and the risk of rheumatic autoimmune disease. Clin Rheumatol. 2016;35(12):2983-7. DOI:10.1007/s10067-016-3330-x
31. Pikwer M, Giwercman A, Bergstrom U, et al. Association between testosterone levels and risk of future rheumatoid arthritis in men: a population-based case-control study. Ann Rheum Dis. 2014;73:573-9. DOI:10.1136/annrheumdis-2012-202781
32. Yang DD, Krasnova A, Nead KT, et al. Androgen deprivation therapy and risk of rheumatoid arthritis in patients with localized prostate cancer. Ann Oncol. 2018;29(2):386-91. DOI:10.1093/annonc/mdx744
33. Forslind K, Hafström I, Ahlmén M, Svensson B; BARFOT Study Group. Sex: a major predictor of remission in early rheumatoid arthritis? Ann Rheum Dis. 2007;66(1):46-52. DOI:10.1136/ard.2006.056937
34. Прокаева Т.Б. Ревматоидный артрит у мужчин: автореф. дис. ... канд. мед. наук. М., 1991 [Prokaeva TB. Revmatoidnyi artrit u muzhchin: avtoref. dis. ... kand. med. nauk. Moscow, 1991 (in Russian)].
35. Tengstrand B, Carlström K, Hafström I. Bioavailable testosterone in men with rheumatoid arthritis-high frequency of hypogonadism. Rheumatology (Oxford). 2002;41(3):285-9. DOI:10.1093/rheumatology/41.3.285
36. Gordon D, Beastall GH, Thomson JA, Sturrock RD. Prolonged hypogonadism in male patients with rheumatoid arthritis during flares in disease activity. Br J Rheumatol. 1988;27(6):440-4. DOI:10.1093/rheumatology/27.6.440
37. Cutolo M, Balleari E, Giusti M, et al. Androgen replacement therapy in male patients with rheumatoid arthritis. Arthritis Rheum. 1991;34(1):1‑5. DOI:10.1002/art.1780340102
38. Tengstrand B, Carlström K, Hafström I. Gonadal hormones in men with rheumatoid arthritis – from onset through 2 years. J Rheumatol. 2009;36(5):887-92. DOI:10.3899/jrheum.080558
39. Cutolo M, Sulli A, Capellino S, et al. Anti-TNF and sex hormones. Ann N Y Acad Sci. 2006;1069:391-400. DOI:10.1196/annals.1351.037
40. Кондрашов А.А., Шостак Н.А. Композиционный состав тела у больных ревматоидным артритом мужского пола с учетом андрогенного статуса. Научно-практическая ревматология. 2021;59(6):700-7 [Kondrashov AA, Shostak NA. Composition of the body in male patients with rheumatoid arthritis with account of androgenic status. Rheumatology Science and Practice. 2021;59(6):700-7 (in Russian)]. DOI:10.47360/1995-4484-2021-700-707
41. Straub RH, Härle P, Sarzi-Puttini P, Cutolo M. Tumor necrosis factor-neutralizing therapies improve altered hormone axes: an alternative mode of antiinflammatory action. Arthritis Rheum. 2006;54(7):2039-46. DOI:10.1002/art.21946
42. Cutolo M, Seriolo B, Villaggio B, et al. Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis. Ann N Y Acad Sci. 2002;966:131-42. DOI:10.1111/j.1749-6632.2002.tb04210
43. Ивахненко О.И., Дубинина Т.В., Коротаева Т.В., Лила А.М. Клинико-экономическая оценка применения генно-инженерных биологических препаратов и таргетных синтетических препаратов при анкилозирующем спондилите в условиях системы здравоохранения Российской Федерации. Современная ревматология. 2022;16(4):46‑56 [Ivakhnenko OI, Dubinina TV, Korotaeva TV, Lila A.M. Clinical and economic evaluation of the use of biologic disease-modifying antirheumatic drugs and targeted synthetic antirheumatic drugs for ankylosing spondylitis in context of the Russian healthcare system. Modern Rheumatology Journal. 2022;16(4):46-56 (in Russian)]. DOI:10.14412/1996-7012-2022-4-46-56
44. Perez-Garcia LF, Te Winkel B, Carrizales JP, et al. Sexual function and reproduction can be impaired in men with rheumatic diseases: A systematic review. Semin Arthritis Rheum. 2020;50(3):557-73. DOI:10.1016/j.semarthrit.2020.02.002
45. Melillo N, Corrado A, Quarta L, et al. Psoriatic arthritis and Klinefelter syndrome: case report. Clin Rheumatol. 2007;26(3):443-4. DOI:10.1007/s10067-005-0153-6
46. Ramonda R, Foresta C, Ortolan A, et al. Influence of tumor necrosis factor α inhibitors on testicular function and semen in spondyloarthritis patients. Fertil Steril. 2014;101(2):359-65. DOI:10.1016/j.fertnstert.2013.10.048
47. Almeida BP, Saad CG, Souza FH, et al. Testicular Sertoli cell function in ankylosing spondylitis. Clin Rheumatol. 2013;32(7):1075-9. DOI:10.1007/s10067-013-2215-5
48. McNeilly AS. Diagnostic applications for inhibin and activins. Mol Cell Endocrinol. 2012;359(1-2):121-5. DOI:10.1016/j.mce.2011.06.017
2. Walker WH. Non-classical actions of testosterone and spermatogenesis. Philos Trans R Soc Lond B Biol Sci. 2010;365(1546):1557-69. DOI:10.1098/rstb.2009.0258
3. Паневин Т.С. Влияние тестостерона на пуриновый обмен и подагру. Андрология и генитальная хирургия. 2021;22(3):11-7 [Panevin TS. Influence of testosterone on purine metabolism and gout. Andrology and Genital Surgery. 2021;22(3):11-7 (in Russian)]. DOI:10.17650/1726-9784-2021-22-3-11-17
4. Rettew JA, Huet-Hudson YM, Marriott I. Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity. Biol Reprod. 2008;78(3):432-7. DOI:10.1095/biolreprod.107.063545
5. Corcoran MP, Meydani M, Lichtenstein AH, et al. Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in macrophages from older men and postmenopausal women. J Endocrinol. 2010;206(2):217-24. DOI:10.1677/JOE-10-0057
6. Malkin CJ, Pugh PJ, Jones RD, et al. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab. 2004;89(7):3313-8. DOI:10.1210/jc.2003-031069
7. Torres-Chávez KE, Sanfins JM, Clemente-Napimoga JT, et al. Effect of gonadal steroid hormones on formalin-induced temporomandibular joint inflammation. Eur J Pain. 2012;16(2):204-16. DOI:10.1016/j.ejpain.2011.06.007
8. Дедов И.И., Мокрышева Н.Г., Мельниченко Г.А., и др. Проект клинических рекомендаций «Синдром гипогонадизма у мужчин». Ожирение и метаболизм. 2021;18(4):496-507 [Dedov II, Mokrysheva NG, Melnichenko GA, et al. Draft of Russian clinical practice guidelines “Male hypogonadism”. Obesity and Metabolism. 2021;18(4):496-507 (in Russian)]. DOI:10.14341/omet12817
9. Wang C, Nieschlag E, Swerdloff R, et al. Investigation, Treatment, and Monitoring of Late-Onset Hypogonadism in Males: ISA, ISSAM, EAU, EAA, and ASA Recommendations. J Androl. 2008;30(1):1-9. DOI:10.2164/jandrol.108.006486
10. Corona G, Mannucci E, Forti G, Maggi M. Hypogonadism, ED, metabolic syndrome and obesity: a pathological link supporting cardiovascular diseases. Int J Androl. 2009;32(6):587-98. DOI:10.1111/j.1365-2605.2008.00951.x
11. Al Hayek A, Ajlouni K, Khader Y, et al. Prevalence of low testosterone levels in men with type 2 diabetes mellitus: a cross-sectional study. J Family Community Med. 2013;20(3):179-86. DOI:10.4103/2230-8229.122006
12. Corona G, Giagulli VA, Maseroli E, et al. Testosterone supplementation and body composition: results from a meta-analysis of observational studies. J Endocrinol Invest. 2016;39(9):967-81. DOI:10.1007/s40618-016-0480-2
13. Garbagnati E, Boschetti M. Uric acid homeostasis in lean and obese girls during pubertal development. Metabolism. 1994;43(7):819-21. DOI:10.1016/0026-0495(94)90260-7
14. Doghramji PP, Wortmann RL. Hyperuricemia and gout: new concepts in diagnosis and management. Postgrad Med. 2012;124:98-109. DOI:10.3810/pgm.2012.11.2616
15. Stamp LK, Wells JE, Pitama S, et al. Hyperuricaemia and gout in New Zealand rural and urban Māori and non-Māori communities. Int Med J. 2013;43(6):678-84. DOI:10.1111/imj.12062
16. Pizzichini M, Di Stefano A, Resconi G, et al. Influence of testosterone on purine nucleotide turnover in rat kidney. Horm Metab Res.1990;22:334‑8. DOI:10.1055/s-2007-1004914
17. Marinello E, Leoncini R, Terzuoli L, et al. Effect of testosterone on purine nucleotide metabolism in rat liver. Horm Metab Res. 2004;36:614-9. DOI:10.1055/s-2007-1004914
18. Condorelli RA, Calogero AE, Di Mauro M, et al. Androgen excess and metabolic disorders in women with PCOS: beyond the body mass index. J Endocrinol Investig. 2018;41:383-8. DOI:10.1007/s40618-017-0762-3
19. Mu L, Pan J, Yang L, et al. Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome. Reprod Biol Endocrinol. 2018;16(1):104. DOI:10.1186/s12958-018-0419-x
20. Pui K, Waddell C, Dalbeth N. Early onset of hyperuricaemia and gout following treatment for female to male gender reassignment. Rheumatology (Oxford). 2008;47(12):1840-1. DOI:10.1093/rheumatology/ken391
21. Kurahashi H, Watanabe M, Sugimoto M, et al. Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder. Endocr J. 2013;60(12):1321-7. DOI:10.1507/endocrj.ej13-0203
22. Ebert T, Jockenhövel F, Morales A, Shabsigh R. The Current Status of Therapy for Symptomatic Late-Onset Hypogonadism with Transdermal Testosterone Gel. Eur Urol. 2005;47(2):137-46. DOI:10.1016/j.eururo.2004.09.015
23. Cao W, Zheng R-D, Xu S-H, et al. Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes. Int J Endocrinol. 2017;2017:4375253. DOI:10.1155/2017/4375253
24. He Y, Yang Q, Qing Y. Altered expression of androgen and its receptor might be involved in the pathogenesis of primary gouty arthritis. Gout and Hyperuricemia. 2015;2(2):56-61. DOI:10.3966/GH1506020203
25. Lim JH, Kim Y-K, Kim Y-S, et al. Relationship Between Serum Uric Acid Levels, Metabolic Syndrome, and Arterial Stiffness in Korean. Korean Circ J. 2010;40(7):314-20. DOI:10.4070/kcj.2010.40.7.314
26. Tong G, Hua X, Zhong Y, et al. Intensive insulin therapy increases sex hormone-binding globulin in newly diagnosed type 2 diabetic patients. Eur J Endocrinol. 2014;170(2):237-45. DOI:10.1530/eje-13-0557
27. Kuczera P, Adamczak M, Wiecek A. Endocrine Abnormalities in Patients with Chronic Kidney Disease. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2015;36(2):109-18. DOI:10.1515/prilozi-2015-0059
28. Mukhin IV, Ignatenko GA, Nikolenko VY. Dyshormonal disorders in gout: experimental and clinical studies. Bull Exp Biol Med. 2002;133:491‑3. DOI:10.1023/a:1019826107916
29. Marinello E, Riario-Sforza G, Marcolongo R. Plasma follicle-stimulating hormone, luteinizing hormone, and sex hormones in patients with gout. Arthritis Rheum. 1985;28(2):127-31. DOI:10.1002/art.1780280203
30. Baillargeon J, Al Snih S, Raji MA, et al. Hypogonadism and the risk of rheumatic autoimmune disease. Clin Rheumatol. 2016;35(12):2983-7. DOI:10.1007/s10067-016-3330-x
31. Pikwer M, Giwercman A, Bergstrom U, et al. Association between testosterone levels and risk of future rheumatoid arthritis in men: a population-based case-control study. Ann Rheum Dis. 2014;73:573-9. DOI:10.1136/annrheumdis-2012-202781
32. Yang DD, Krasnova A, Nead KT, et al. Androgen deprivation therapy and risk of rheumatoid arthritis in patients with localized prostate cancer. Ann Oncol. 2018;29(2):386-91. DOI:10.1093/annonc/mdx744
33. Forslind K, Hafström I, Ahlmén M, Svensson B; BARFOT Study Group. Sex: a major predictor of remission in early rheumatoid arthritis? Ann Rheum Dis. 2007;66(1):46-52. DOI:10.1136/ard.2006.056937
34. Прокаева Т.Б. Ревматоидный артрит у мужчин: автореф. дис. ... канд. мед. наук. М., 1991 [Prokaeva TB. Revmatoidnyi artrit u muzhchin: avtoref. dis. ... kand. med. nauk. Moscow, 1991 (in Russian)].
35. Tengstrand B, Carlström K, Hafström I. Bioavailable testosterone in men with rheumatoid arthritis-high frequency of hypogonadism. Rheumatology (Oxford). 2002;41(3):285-9. DOI:10.1093/rheumatology/41.3.285
36. Gordon D, Beastall GH, Thomson JA, Sturrock RD. Prolonged hypogonadism in male patients with rheumatoid arthritis during flares in disease activity. Br J Rheumatol. 1988;27(6):440-4. DOI:10.1093/rheumatology/27.6.440
37. Cutolo M, Balleari E, Giusti M, et al. Androgen replacement therapy in male patients with rheumatoid arthritis. Arthritis Rheum. 1991;34(1):1‑5. DOI:10.1002/art.1780340102
38. Tengstrand B, Carlström K, Hafström I. Gonadal hormones in men with rheumatoid arthritis – from onset through 2 years. J Rheumatol. 2009;36(5):887-92. DOI:10.3899/jrheum.080558
39. Cutolo M, Sulli A, Capellino S, et al. Anti-TNF and sex hormones. Ann N Y Acad Sci. 2006;1069:391-400. DOI:10.1196/annals.1351.037
40. Кондрашов А.А., Шостак Н.А. Композиционный состав тела у больных ревматоидным артритом мужского пола с учетом андрогенного статуса. Научно-практическая ревматология. 2021;59(6):700-7 [Kondrashov AA, Shostak NA. Composition of the body in male patients with rheumatoid arthritis with account of androgenic status. Rheumatology Science and Practice. 2021;59(6):700-7 (in Russian)]. DOI:10.47360/1995-4484-2021-700-707
41. Straub RH, Härle P, Sarzi-Puttini P, Cutolo M. Tumor necrosis factor-neutralizing therapies improve altered hormone axes: an alternative mode of antiinflammatory action. Arthritis Rheum. 2006;54(7):2039-46. DOI:10.1002/art.21946
42. Cutolo M, Seriolo B, Villaggio B, et al. Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis. Ann N Y Acad Sci. 2002;966:131-42. DOI:10.1111/j.1749-6632.2002.tb04210
43. Ивахненко О.И., Дубинина Т.В., Коротаева Т.В., Лила А.М. Клинико-экономическая оценка применения генно-инженерных биологических препаратов и таргетных синтетических препаратов при анкилозирующем спондилите в условиях системы здравоохранения Российской Федерации. Современная ревматология. 2022;16(4):46‑56 [Ivakhnenko OI, Dubinina TV, Korotaeva TV, Lila A.M. Clinical and economic evaluation of the use of biologic disease-modifying antirheumatic drugs and targeted synthetic antirheumatic drugs for ankylosing spondylitis in context of the Russian healthcare system. Modern Rheumatology Journal. 2022;16(4):46-56 (in Russian)]. DOI:10.14412/1996-7012-2022-4-46-56
44. Perez-Garcia LF, Te Winkel B, Carrizales JP, et al. Sexual function and reproduction can be impaired in men with rheumatic diseases: A systematic review. Semin Arthritis Rheum. 2020;50(3):557-73. DOI:10.1016/j.semarthrit.2020.02.002
45. Melillo N, Corrado A, Quarta L, et al. Psoriatic arthritis and Klinefelter syndrome: case report. Clin Rheumatol. 2007;26(3):443-4. DOI:10.1007/s10067-005-0153-6
46. Ramonda R, Foresta C, Ortolan A, et al. Influence of tumor necrosis factor α inhibitors on testicular function and semen in spondyloarthritis patients. Fertil Steril. 2014;101(2):359-65. DOI:10.1016/j.fertnstert.2013.10.048
47. Almeida BP, Saad CG, Souza FH, et al. Testicular Sertoli cell function in ankylosing spondylitis. Clin Rheumatol. 2013;32(7):1075-9. DOI:10.1007/s10067-013-2215-5
48. McNeilly AS. Diagnostic applications for inhibin and activins. Mol Cell Endocrinol. 2012;359(1-2):121-5. DOI:10.1016/j.mce.2011.06.017
________________________________________________
2. Walker WH. Non-classical actions of testosterone and spermatogenesis. Philos Trans R Soc Lond B Biol Sci. 2010;365(1546):1557-69. DOI:10.1098/rstb.2009.0258
3. Паневин Т.С. Влияние тестостерона на пуриновый обмен и подагру. Андрология и генитальная хирургия. 2021;22(3):11-7 [Panevin TS. Influence of testosterone on purine metabolism and gout. Andrology and Genital Surgery. 2021;22(3):11-7 (in Russian)]. DOI:10.17650/1726-9784-2021-22-3-11-17
4. Rettew JA, Huet-Hudson YM, Marriott I. Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity. Biol Reprod. 2008;78(3):432-7. DOI:10.1095/biolreprod.107.063545
5. Corcoran MP, Meydani M, Lichtenstein AH, et al. Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in macrophages from older men and postmenopausal women. J Endocrinol. 2010;206(2):217-24. DOI:10.1677/JOE-10-0057
6. Malkin CJ, Pugh PJ, Jones RD, et al. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab. 2004;89(7):3313-8. DOI:10.1210/jc.2003-031069
7. Torres-Chávez KE, Sanfins JM, Clemente-Napimoga JT, et al. Effect of gonadal steroid hormones on formalin-induced temporomandibular joint inflammation. Eur J Pain. 2012;16(2):204-16. DOI:10.1016/j.ejpain.2011.06.007
8. Дедов И.И., Мокрышева Н.Г., Мельниченко Г.А., и др. Проект клинических рекомендаций «Синдром гипогонадизма у мужчин». Ожирение и метаболизм. 2021;18(4):496-507 [Dedov II, Mokrysheva NG, Melnichenko GA, et al. Draft of Russian clinical practice guidelines “Male hypogonadism”. Obesity and Metabolism. 2021;18(4):496-507 (in Russian)]. DOI:10.14341/omet12817
9. Wang C, Nieschlag E, Swerdloff R, et al. Investigation, Treatment, and Monitoring of Late-Onset Hypogonadism in Males: ISA, ISSAM, EAU, EAA, and ASA Recommendations. J Androl. 2008;30(1):1-9. DOI:10.2164/jandrol.108.006486
10. Corona G, Mannucci E, Forti G, Maggi M. Hypogonadism, ED, metabolic syndrome and obesity: a pathological link supporting cardiovascular diseases. Int J Androl. 2009;32(6):587-98. DOI:10.1111/j.1365-2605.2008.00951.x
11. Al Hayek A, Ajlouni K, Khader Y, et al. Prevalence of low testosterone levels in men with type 2 diabetes mellitus: a cross-sectional study. J Family Community Med. 2013;20(3):179-86. DOI:10.4103/2230-8229.122006
12. Corona G, Giagulli VA, Maseroli E, et al. Testosterone supplementation and body composition: results from a meta-analysis of observational studies. J Endocrinol Invest. 2016;39(9):967-81. DOI:10.1007/s40618-016-0480-2
13. Garbagnati E, Boschetti M. Uric acid homeostasis in lean and obese girls during pubertal development. Metabolism. 1994;43(7):819-21. DOI:10.1016/0026-0495(94)90260-7
14. Doghramji PP, Wortmann RL. Hyperuricemia and gout: new concepts in diagnosis and management. Postgrad Med. 2012;124:98-109. DOI:10.3810/pgm.2012.11.2616
15. Stamp LK, Wells JE, Pitama S, et al. Hyperuricaemia and gout in New Zealand rural and urban Māori and non-Māori communities. Int Med J. 2013;43(6):678-84. DOI:10.1111/imj.12062
16. Pizzichini M, Di Stefano A, Resconi G, et al. Influence of testosterone on purine nucleotide turnover in rat kidney. Horm Metab Res.1990;22:334‑8. DOI:10.1055/s-2007-1004914
17. Marinello E, Leoncini R, Terzuoli L, et al. Effect of testosterone on purine nucleotide metabolism in rat liver. Horm Metab Res. 2004;36:614-9. DOI:10.1055/s-2007-1004914
18. Condorelli RA, Calogero AE, Di Mauro M, et al. Androgen excess and metabolic disorders in women with PCOS: beyond the body mass index. J Endocrinol Investig. 2018;41:383-8. DOI:10.1007/s40618-017-0762-3
19. Mu L, Pan J, Yang L, et al. Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome. Reprod Biol Endocrinol. 2018;16(1):104. DOI:10.1186/s12958-018-0419-x
20. Pui K, Waddell C, Dalbeth N. Early onset of hyperuricaemia and gout following treatment for female to male gender reassignment. Rheumatology (Oxford). 2008;47(12):1840-1. DOI:10.1093/rheumatology/ken391
21. Kurahashi H, Watanabe M, Sugimoto M, et al. Testosterone replacement elevates the serum uric acid levels in patients with female to male gender identity disorder. Endocr J. 2013;60(12):1321-7. DOI:10.1507/endocrj.ej13-0203
22. Ebert T, Jockenhövel F, Morales A, Shabsigh R. The Current Status of Therapy for Symptomatic Late-Onset Hypogonadism with Transdermal Testosterone Gel. Eur Urol. 2005;47(2):137-46. DOI:10.1016/j.eururo.2004.09.015
23. Cao W, Zheng R-D, Xu S-H, et al. Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes. Int J Endocrinol. 2017;2017:4375253. DOI:10.1155/2017/4375253
24. He Y, Yang Q, Qing Y. Altered expression of androgen and its receptor might be involved in the pathogenesis of primary gouty arthritis. Gout and Hyperuricemia. 2015;2(2):56-61. DOI:10.3966/GH1506020203
25. Lim JH, Kim Y-K, Kim Y-S, et al. Relationship Between Serum Uric Acid Levels, Metabolic Syndrome, and Arterial Stiffness in Korean. Korean Circ J. 2010;40(7):314-20. DOI:10.4070/kcj.2010.40.7.314
26. Tong G, Hua X, Zhong Y, et al. Intensive insulin therapy increases sex hormone-binding globulin in newly diagnosed type 2 diabetic patients. Eur J Endocrinol. 2014;170(2):237-45. DOI:10.1530/eje-13-0557
27. Kuczera P, Adamczak M, Wiecek A. Endocrine Abnormalities in Patients with Chronic Kidney Disease. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2015;36(2):109-18. DOI:10.1515/prilozi-2015-0059
28. Mukhin IV, Ignatenko GA, Nikolenko VY. Dyshormonal disorders in gout: experimental and clinical studies. Bull Exp Biol Med. 2002;133:491‑3. DOI:10.1023/a:1019826107916
29. Marinello E, Riario-Sforza G, Marcolongo R. Plasma follicle-stimulating hormone, luteinizing hormone, and sex hormones in patients with gout. Arthritis Rheum. 1985;28(2):127-31. DOI:10.1002/art.1780280203
30. Baillargeon J, Al Snih S, Raji MA, et al. Hypogonadism and the risk of rheumatic autoimmune disease. Clin Rheumatol. 2016;35(12):2983-7. DOI:10.1007/s10067-016-3330-x
31. Pikwer M, Giwercman A, Bergstrom U, et al. Association between testosterone levels and risk of future rheumatoid arthritis in men: a population-based case-control study. Ann Rheum Dis. 2014;73:573-9. DOI:10.1136/annrheumdis-2012-202781
32. Yang DD, Krasnova A, Nead KT, et al. Androgen deprivation therapy and risk of rheumatoid arthritis in patients with localized prostate cancer. Ann Oncol. 2018;29(2):386-91. DOI:10.1093/annonc/mdx744
33. Forslind K, Hafström I, Ahlmén M, Svensson B; BARFOT Study Group. Sex: a major predictor of remission in early rheumatoid arthritis? Ann Rheum Dis. 2007;66(1):46-52. DOI:10.1136/ard.2006.056937
34. Прокаева Т.Б. Ревматоидный артрит у мужчин: автореф. дис. ... канд. мед. наук. М., 1991 [Prokaeva TB. Revmatoidnyi artrit u muzhchin: avtoref. dis. ... kand. med. nauk. Moscow, 1991 (in Russian)].
35. Tengstrand B, Carlström K, Hafström I. Bioavailable testosterone in men with rheumatoid arthritis-high frequency of hypogonadism. Rheumatology (Oxford). 2002;41(3):285-9. DOI:10.1093/rheumatology/41.3.285
36. Gordon D, Beastall GH, Thomson JA, Sturrock RD. Prolonged hypogonadism in male patients with rheumatoid arthritis during flares in disease activity. Br J Rheumatol. 1988;27(6):440-4. DOI:10.1093/rheumatology/27.6.440
37. Cutolo M, Balleari E, Giusti M, et al. Androgen replacement therapy in male patients with rheumatoid arthritis. Arthritis Rheum. 1991;34(1):1‑5. DOI:10.1002/art.1780340102
38. Tengstrand B, Carlström K, Hafström I. Gonadal hormones in men with rheumatoid arthritis – from onset through 2 years. J Rheumatol. 2009;36(5):887-92. DOI:10.3899/jrheum.080558
39. Cutolo M, Sulli A, Capellino S, et al. Anti-TNF and sex hormones. Ann N Y Acad Sci. 2006;1069:391-400. DOI:10.1196/annals.1351.037
40. Кондрашов А.А., Шостак Н.А. Композиционный состав тела у больных ревматоидным артритом мужского пола с учетом андрогенного статуса. Научно-практическая ревматология. 2021;59(6):700-7 [Kondrashov AA, Shostak NA. Composition of the body in male patients with rheumatoid arthritis with account of androgenic status. Rheumatology Science and Practice. 2021;59(6):700-7 (in Russian)]. DOI:10.47360/1995-4484-2021-700-707
41. Straub RH, Härle P, Sarzi-Puttini P, Cutolo M. Tumor necrosis factor-neutralizing therapies improve altered hormone axes: an alternative mode of antiinflammatory action. Arthritis Rheum. 2006;54(7):2039-46. DOI:10.1002/art.21946
42. Cutolo M, Seriolo B, Villaggio B, et al. Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis. Ann N Y Acad Sci. 2002;966:131-42. DOI:10.1111/j.1749-6632.2002.tb04210
43. Ивахненко О.И., Дубинина Т.В., Коротаева Т.В., Лила А.М. Клинико-экономическая оценка применения генно-инженерных биологических препаратов и таргетных синтетических препаратов при анкилозирующем спондилите в условиях системы здравоохранения Российской Федерации. Современная ревматология. 2022;16(4):46‑56 [Ivakhnenko OI, Dubinina TV, Korotaeva TV, Lila A.M. Clinical and economic evaluation of the use of biologic disease-modifying antirheumatic drugs and targeted synthetic antirheumatic drugs for ankylosing spondylitis in context of the Russian healthcare system. Modern Rheumatology Journal. 2022;16(4):46-56 (in Russian)]. DOI:10.14412/1996-7012-2022-4-46-56
44. Perez-Garcia LF, Te Winkel B, Carrizales JP, et al. Sexual function and reproduction can be impaired in men with rheumatic diseases: A systematic review. Semin Arthritis Rheum. 2020;50(3):557-73. DOI:10.1016/j.semarthrit.2020.02.002
45. Melillo N, Corrado A, Quarta L, et al. Psoriatic arthritis and Klinefelter syndrome: case report. Clin Rheumatol. 2007;26(3):443-4. DOI:10.1007/s10067-005-0153-6
46. Ramonda R, Foresta C, Ortolan A, et al. Influence of tumor necrosis factor α inhibitors on testicular function and semen in spondyloarthritis patients. Fertil Steril. 2014;101(2):359-65. DOI:10.1016/j.fertnstert.2013.10.048
47. Almeida BP, Saad CG, Souza FH, et al. Testicular Sertoli cell function in ankylosing spondylitis. Clin Rheumatol. 2013;32(7):1075-9. DOI:10.1007/s10067-013-2215-5
48. McNeilly AS. Diagnostic applications for inhibin and activins. Mol Cell Endocrinol. 2012;359(1-2):121-5. DOI:10.1016/j.mce.2011.06.017
Авторы
Т.С. Паневин*1, Р.В. Роживанов2, Е.Л. Насонов1
1 ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», Москва, Россия;
2 ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России, Москва, Россия
*tarasel@list.ru
1 Nasonova Research Institute of Rheumatology, Moscow, Russia;
2 National Medical Research Center for Endocrinology, Moscow, Russia
*tarasel@list.ru
1 ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», Москва, Россия;
2 ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России, Москва, Россия
*tarasel@list.ru
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1 Nasonova Research Institute of Rheumatology, Moscow, Russia;
2 National Medical Research Center for Endocrinology, Moscow, Russia
*tarasel@list.ru
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