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Современная парадигма применения глюкокортикостероидов для лечения иммуновоспалительных заболеваний почек
Современная парадигма применения глюкокортикостероидов для лечения иммуновоспалительных заболеваний почек
Буланов Н.М., Бобкова И.Н., Моисеев С.В. Современная парадигма применения глюкокортикостероидов для лечения иммуновоспалительных заболеваний почек. Терапевтический архив. 2023;95(6):451–456.
DOI: 10.26442/00403660.2023.06.202265
© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.
DOI: 10.26442/00403660.2023.06.202265
DOI: 10.26442/00403660.2023.06.202265
© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.
________________________________________________
DOI: 10.26442/00403660.2023.06.202265
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
С начала 1950-х годов глюкокортикостероиды (ГКС) остаются одним из основных компонентов терапии иммуновоспалительных заболеваний почек. Однако многочисленные нежелательные явления длительной терапии ГКС стали основанием для разработки новых подходов к иммуносупрессивной терапии. В настоящее время накоплена доказательная база, обосновывающая возможность применения стероид-сберегающих схем терапии многих форм гломерулонефритов. Так, рандомизированное контролируемое исследование PEXIVAS показало эффективность и безопасность быстрого снижения дозы ГКС начиная со 2-й недели комбинированной терапии поражения почек, ассоциированного с васкулитами, ассоциированными с антителами к цитоплазме нейтрофилов. В крупных исследованиях продемонстрирована возможность применения более низких доз преднизолона 0,3–0,5 мг/кг в составе мультитаргетных схем лечения наиболее тяжелых классов волчаночного нефрита. Применение ингибиторов кальцинейрина позволяет использовать низкие дозы ГКС для индукции ремиссии мембранозной нефропатии, а ритуксимаба – воздержаться от назначения ГКС у пациентов с умеренным риском прогрессирования заболевания. Назначение монотерапии ГКС в средней дозе показало свою эффективность в лечении иммуноглобулин-A-нефропатии. Длительное применение ГКС в высокой дозе остается 1-й линией лечения болезни минимальных изменений и фокально-сегментарного гломерулосклероза, однако у пациентов с рецидивирующим и стероидзависимым вариантами заболеваний добавление к терапии такролимуса или ритуксимаба позволяет добиться стероид-сберегающего эффекта. В настоящее время подвергнута пересмотру и роль пульс-терапии ГКС, хотя она и остается одним из обязательных компонентов терапии ряда заболеваний. Таким образом, общая тенденция направлена на сокращение максимальных доз и/или продолжительности лечения ГКС. Однако реализация этого подхода требует четкой верификации диагноза заболевания, персонализированной оценки тяжести его течения, а также потенциальных рисков и пользы.
Ключевые слова: глюкокортикостероиды, гломерулонефрит, нефротический синдром, системные васкулиты, системная красная волчанка
Keywords: corticosteroids, glomerulonephritis, nephrotic syndrome, systemic vasculitis, systemic lupus erythematosus
Ключевые слова: глюкокортикостероиды, гломерулонефрит, нефротический синдром, системные васкулиты, системная красная волчанка
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Keywords: corticosteroids, glomerulonephritis, nephrotic syndrome, systemic vasculitis, systemic lupus erythematosus
Полный текст
Список литературы
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18. Guillevin L, Pagnoux C, Karras A, et al. Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis. N Engl J Med. 2014;371(19):1771-80. DOI:10.1056/NEJMoa1404231
19. Smith RM, Jones RB, Specks U, et al. Rituximab as therapy to induce remission after relapse in ANCA-associated vasculitis. Ann Rheum Dis. 2020;79(9):1243-9. DOI:10.1136/annrheumdis-2019-216863
20. Walsh M, Merkel PA, Mahr A, Jayne D. Effects of duration of glucocorticoid therapy on relapse rate in antineutrophil cytoplasmic antibody-associated vasculitis: A meta-analysis. Arthritis Care Res (Hoboken). 2010;62(8):1166-73. DOI:10.1002/acr.20176
21. Zeher M, Doria A, Lan J, et al. Efficacy and safety of enteric-coated mycophenolate sodium in combination with two glucocorticoid regimens for the treatment of active lupus nephritis. Lupus. 2011;20(14):1484-93. DOI:10.1177/0961203311418269
22. Ruiz-Irastorza G, Danza A, Perales I, et al. Prednisone in lupus nephritis: how much is enough? Autoimmun Rev. 2014;13(2):206-14. DOI:10.1016/j.autrev.2013.10.013
23. Fanouriakis A, Kostopoulou M, Cheema K, et al. 2019 Update of the Joint European League against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of lupus nephritis. Ann Rheum Dis. 2020;79(6):S713-23. DOI:10.1136/annrheumdis-2020-216924
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25. Rovin BH, Solomons N, Pendergraft WF, et al. A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis. Kidney Int. 2019;95(1):219-31. DOI:10.1016/j.kint.2018.08.025
26. Condon MB, Ashby D, Pepper RJ, et al. Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids. Ann Rheum Dis. 2013;72(8):1280-6. DOI:10.1136/annrheumdis-2012-202844
27. Novikov PI, Moiseev SV. Glucocorticoids in systemic lupus erythematosus: future of steroid-sparing therapy. Klinicheskaia farmakologiia i terapiia. 2022;31(4):18-27 (in Russian). DOI:10.32756/0869-5490-2022-4-18-27
28. Ji L, Xie W, Zhang Z. Low-dose glucocorticoids should be withdrawn or continued in systemic lupus erythematosus? A systematic review and meta-analysis on risk of flare and damage accrual. Rheumatology (Oxford). 2021;60(12):5517-26. DOI:10.1093/rheumatology/keab149
29. Mathian A, Pha M, Haroche J, et al. Withdrawal of low-dose prednisone in SLE patients with a clinically quiescent disease for more than 1 year: a randomised clinical trial. Ann Rheum Dis. 2020;79(3):339-46. DOI:10.1136/annrheumdis-2019-216303
30. Ji L, Gao D, Hao Y, et al. Low-dose glucocorticoids withdrawn in systemic lupus erythematosus: a desirable and attainable goal. Rheumatology (Oxford). 2022;62(1):181-9. DOI:10.1093/rheumatology/keac225
31. Ji L, Xie W, Fasano S, Zhang Z. Risk factors of flare in patients with systemic lupus erythematosus after glucocorticoids withdrawal. A systematic review and meta-analysis. Lupus Sci Med. 2022;9(1):e000603. DOI:10.1136/lupus-2021-000603
32. Van Den Brand JAJG, Ruggenenti P, Chianca A, et al. Safety of Rituximab Compared with Steroids and Cyclophosphamide for Idiopathic Membranous Nephropathy. J Am Soc Nephrol. 2017;28(9):2729-37. DOI:10.1681/ASN.2016091022
33. Qiu TT, Zhang C, Zhao HW, Zhou JW. Calcineurin inhibitors versus cyclophosphamide for idiopathic membranous nephropathy: A systematic review and meta-analysis of 21 clinical trials. Autoimmun Rev. 2017;16(2):136-45. DOI:10.1016/j.autrev.2016.12.005
34. Fervenza FC, Appel GB, Barbour SJ, et al. Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy. N Engl J Med. 2019;381(1):36-46. DOI:10.1056/NEJMoa1814427
35. Dahan K, Debiec H, Plaisier E, et al. Rituximab for Severe Membranous Nephropathy: A 6-Month Trial with Extended Follow-Up. J Am Soc Nephrol. 2017;28(1):348-58. DOI:10.1681/ASN.2016040449
36. Fernández-Juárez G, Rojas-Rivera J, Logt AE van de, et al. The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy. Kidney Int. 2021;99(4):986-98. DOI:10.1016/j.kint.2020.10.014
37. Scolari F, Delbarba E, Santoro D, et al. Rituximab or Cyclophosphamide in the Treatment of Membranous Nephropathy: The RI-CYCLO Randomized Trial. J Am Soc Nephrol. 2021;32(4):972-82. DOI:10.1681/ASN.2020071091
38. Batyushin MM, Bobkoba IN, Bobrova LA, et al. Membranous nephropathy. Association of Nephrologists of Russia. Available at: https://rusnephrology.org/wp-content/uploads/2021/09/membranous.pdf. Accessed: 09.03.2023 (in Russian).
39. Rauen T, Wied S, Fitzner C, et al. After ten years of follow-up, no difference between supportive care plus immunosuppression and supportive care alone in IgA nephropathy. Kidney Int. 2020;98(4):1044‑52. DOI:10.1016/j.kint.2020.04.046
40. Rauen T, Eitner F, Fitzner C, et al. Intensive Supportive Care plus Immunosuppression in IgA Nephropathy. N Engl J Med. 2015;373(23):2225-36. DOI:10.1056/NEJMoa1415463
41. Manno C, Torres DD, Rossini M, et al. Randomized controlled clinical trial of corticosteroids plus ACE-inhibitors with long-term follow-up in proteinuric IgA nephropathy. Nephrol Dial Transplant. 2009;24(12):3694-701. DOI:10.1093/ndt/gfp356
42. Pozzi C, Bolasco PG, Fogazzi G, et al. Corticosteroids in IgA nephropathy: A randomised controlled trial. Lancet. 1999;353(9156):883-7. DOI:10.1016/s0140-6736(98)03563-6
43. Lv J, Wong MG, Hladunewich MA, et al. Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial. JAMA. 2022;327(19):1888-98. DOI:10.1001/jama.2022.5368
44. Batyushin MM, Bobkoba IN, Vatazin AV, et al. Glomerular diseases: immunoglobulin A-nephropathy. Association of Nephrologists of Russia. Available at: https://rusnephrology.org/wp-content/uploads/2021/04/iga_060421-1.pdf. Accessed: 09.03.2023 (in Russian).
45. Fellström BC, Barratt J, Cook H, et al. Targeted-release budesonide versus placebo in patients with IgA nephropathy (NEFIGAN): a double-blind, randomised, placebo-controlled phase 2b trial. Lancet. 2017;389(10084):2117-27. DOI:10.1016/S0140-6736(17)30550-0
46. Tam WK F, Tumlin J, Barratt J, et al. SUN-036 Spleen tyrosine kinase (SYK) inhibition in IgA nephropathy: a global, phase II, randomised placebo-controlled trial of fostamatinib. Kidney Int Rep. 2019;4(7):S168. DOI:10.1016/j.ekir.2019.05.431
47. Lafayette RA, Rovin BH, Reich HN, et al. Tolerability and Efficacy of Narsoplimab, a Novel MASP-2 Inhibitor for the Treatment of IgA Nephropathy. Kidney Int Rep. 2020;5(11):2032-41.
DOI:10.1016/j.ekir.2020.08.003
48. Bobkova IN, Vatazin AV, Dobronravov VA, et al. Glomerular diseases: focal segmental glomerulosclerosis. 2022. Russian Association of Nephrologists. Available at: https://rusnephrology.org/wp-content/uploads/2021/04/fsgs.pdf. Accessed: 09.03.2023 (in Russian).
49. Medjeral-Thomas NR, Lawrence C, Condon M, et al. Randomized, Controlled Trial of Tacrolimus and Prednisolone Monotherapy for Adults with De Novo Minimal Change Disease: A Multicenter, Randomized, Controlled Trial. Clin J Am Soc Nephrol. 2020;15(2):209‑18. DOI:10.2215/CJN.06180519
50. Li X, Liu Z, Wang L, et al. Tacrolimus Monotherapy after Intravenous Methylprednisolone in Adults with Minimal Change Nephrotic Syndrome. J Am Soc Nephrol. 2017;28(4):1286-95.
DOI:10.1681/ASN.2016030342
51. Duncan N, Dhaygude A, Owen J, et al. Treatment of focal and segmental glomerulosclerosis in adults with tacrolimus monotherapy. Nephrol Dial Transplant. 2004;19(12):3062-7. DOI:10.1093/ndt/gfh536
52. Goumenos DS, Tsagalis G, El Nahas AM, et al. Immunosuppressive treatment of idiopathic focal segmental glomerulosclerosis: a five-year follow-up study. Nephron Clin Pract. 2006;104(2):c75-82. DOI:1159/000093993
53. Papakrivopoulou E, Shendi AM, Salama AD, et al. Effective treatment with rituximab for the maintenance of remission in frequently relapsing minimal change disease. Nephrology (Carlton). 2016;21(10):893-900. DOI:10.1111/nep.12744
54. Ren H, Lin L, Shen P, et al. Rituximab treatment in adults with refractory minimal change disease or focal segmental glomerulosclerosis. Oncotarget. 2017;8(55):93438-43. DOI:10.18632/oncotarget.21833
2. Barnett HL, McNamara H, McCrory W, et al. The effects of ACTH and cortisone on the nephrotic syndrome. AMA Am J Dis Child. 1950;80(3):519-20.
3. Chaudhuri JN, Ghosal SP. Observations on prednisolone treated cases of nephrotic syndrome; a preliminary report. Indian J Pediatr. 1958;25(123):201-9.
4. Fahey JL, Leonard E, Churg J, Godman G. Wegener’s granulomatosis. Am J Med. 1954;17(2):168-79.
5. Thorn GW, Forsham PH, Frawley TF, et al. The clinical usefulness of ACTH and cortisone. N Engl J Med. 1950;242(21):824-34.
6. Pollak VE, Pirani CL, Kark RM. Effect of large doses of prednisone on the renal lesions and life span of patients with lupus glomerulonephritis. J Lab Clin Med. 1961;57:495-511.
7. Тареев Е.М., Насонова В.А. Место стероидных гормонов в комплексном лечении так называемых больших коллагенозов. Советская медицина. 1960;12:3-12 [Tareev EM, Nasonova VA. The place of steroid hormones in the complex treatment of the so called major collagenosis. Soviet Meidicine. 1960;12:3-12 (in Russian)].
8. Austin HA, Klippel JH, Balow JE, et al. Therapy of lupus nephritis. Controlled trial of prednisone and cytotoxic drugs. N Engl J Med. 1986;314(10):614-9.
9. Fauci AS, Haynes BF, Katz P, Wolff SM. Wegener’s granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983;98(1):76-85.
10. Wilson CB, Dixon FJ. Anti-glomerular basement membrane antibody-induced glomerulonephritis. Kidney Int. 1973;3(2):74-89.
11. Black DAK, Rose G, Brewer DB. Controlled trial of prednisone in adult patients with the nephrotic syndrome. Br Med J. 1970;3(5720):421.
12. Mebrahtu TF, Morgan AW, Keeley A, et al. Dose dependency of iatrogenic glucocorticoid excess and adrenal insufficiency and mortality: a cohort study in England. J Clin Endocrinol Metab. 2019;104(9):3757-67. DOI:10.1210/jc.2019-00153
13. Walsh M, Merkel P, Peh C, et al. Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis. N Engl J Med. 2020;382(7):622‑31. DOI:10.1056/NEJMoa1803537
14. Rovin BH, Adler SG, Barratt J, et al. KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases. Kidney Int. 2021;100(4):S1-276. DOI:10.1016/j.kint.2021.05.021
15. Буланов Н.М., Добронравов В.А., Захарова Е.В., и др. Поражение почек при АНЦА-ассоциированных васкулитах (АНЦА-ассоциированный гломерулонефрит). Ассоциация нефрологов России. Режим доступа: https://rusnephrology.org/wp-content/uploads/2021/02/ANCA.pdf. Ссылка активна на 09.03.2023 [Bulanov NM, Dobronravov VA, Zakharova EV, et al. Kidney damage in ANCA-associated vasculitis (ANCA-associated glomerulonephritis). Association of Nephrologists of Russia. Available at: https://rusnephrology.org/wp-content/uploads/2021/02/ANCA.pdf. Accessed: 09.03.2023 (in Russian)].
16. Chanouzas D, McGregor JG, Poulton CJ, et al. Increase in adverse events with pulsed methylprednisolone used for induction of remission in severe anca associated vasculitis. Nephrol Dial Transplant. 2015;30(Suppl. 3):iii117-8. DOI:10.1093/ndt/gfv171.41
17. Jayne DRW, Merkel PA, Schall TJ, Bekker P. Avacopan for the Treatment of ANCA-Associated Vasculitis. N Engl J Med. 2021;384(7):599-609. DOI:10.1056/NEJMoa2023386
18. Guillevin L, Pagnoux C, Karras A, et al. Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis. N Engl J Med. 2014;371(19):1771-80. DOI:10.1056/NEJMoa1404231
19. Smith RM, Jones RB, Specks U, et al. Rituximab as therapy to induce remission after relapse in ANCA-associated vasculitis. Ann Rheum Dis. 2020;79(9):1243-9. DOI:10.1136/annrheumdis-2019-216863
20. Walsh M, Merkel PA, Mahr A, Jayne D. Effects of duration of glucocorticoid therapy on relapse rate in antineutrophil cytoplasmic antibody-associated vasculitis: A meta-analysis. Arthritis Care Res (Hoboken). 2010;62(8):1166-73. DOI:10.1002/acr.20176
21. Zeher M, Doria A, Lan J, et al. Efficacy and safety of enteric-coated mycophenolate sodium in combination with two glucocorticoid regimens for the treatment of active lupus nephritis. Lupus. 2011;20(14):1484-93. DOI:10.1177/0961203311418269
22. Ruiz-Irastorza G, Danza A, Perales I, et al. Prednisone in lupus nephritis: how much is enough? Autoimmun Rev. 2014;13(2):206-14. DOI:10.1016/j.autrev.2013.10.013
23. Fanouriakis A, Kostopoulou M, Cheema K, et al. 2019 Update of the Joint European League against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of lupus nephritis. Ann Rheum Dis. 2020;79(6):S713-23. DOI:10.1136/annrheumdis-2020-216924
24. Бобкова И.Н., Буланов Н.М., Ватазин А.В., и др. Диагностика и лечение волчаночного нефрита. Ассоциация нефрологов России. Режим доступа: https://rusnephrology.org/wp-content/uploads/2021/09/lupus.pdf. Ссылка активна на 09.03.2023 [Bobkoba IN, Bulanov NM, Vatazin AV, et al. Diagnosis and treatment of lupus nephritis. Association of Nephrologists of Russia. Available at: https://rusnephrology.org/wp-content/uploads/2021/09/lupus.pdf. Accessed: 09.03.2023 (in Russian)].
25. Rovin BH, Solomons N, Pendergraft WF, et al. A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis. Kidney Int. 2019;95(1):219-31. DOI:10.1016/j.kint.2018.08.025
26. Condon MB, Ashby D, Pepper RJ, et al. Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids. Ann Rheum Dis. 2013;72(8):1280-6. DOI:10.1136/annrheumdis-2012-202844
27. Новиков П.И., Моисеев С.В. Глюкокортикостероиды при системной красной волчанке: перспективы стероидосберегающей терапии. Клиническая фармакология и терапия. 2022;31(4):18-27 [Novikov PI, Moiseev SV. Glucocorticoids in systemic lupus erythematosus: future of steroid-sparing therapy. Klinicheskaia farmakologiia i terapiia. 2022;31(4):18-27 (in Russian)]. DOI:10.32756/0869-5490-2022-4-18-27
28. Ji L, Xie W, Zhang Z. Low-dose glucocorticoids should be withdrawn or continued in systemic lupus erythematosus? A systematic review and meta-analysis on risk of flare and damage accrual. Rheumatology (Oxford). 2021;60(12):5517-26. DOI:10.1093/rheumatology/keab149
29. Mathian A, Pha M, Haroche J, et al. Withdrawal of low-dose prednisone in SLE patients with a clinically quiescent disease for more than 1 year: a randomised clinical trial. Ann Rheum Dis. 2020;79(3):339-46. DOI:10.1136/annrheumdis-2019-216303
30. Ji L, Gao D, Hao Y, et al. Low-dose glucocorticoids withdrawn in systemic lupus erythematosus: a desirable and attainable goal. Rheumatology (Oxford). 2022;62(1):181-9. DOI:10.1093/rheumatology/keac225
31. Ji L, Xie W, Fasano S, Zhang Z. Risk factors of flare in patients with systemic lupus erythematosus after glucocorticoids withdrawal. A systematic review and meta-analysis. Lupus Sci Med. 2022;9(1):e000603. DOI:10.1136/lupus-2021-000603
32. Van Den Brand JAJG, Ruggenenti P, Chianca A, et al. Safety of Rituximab Compared with Steroids and Cyclophosphamide for Idiopathic Membranous Nephropathy. J Am Soc Nephrol. 2017;28(9):2729-37. DOI:10.1681/ASN.2016091022
33. Qiu TT, Zhang C, Zhao HW, Zhou JW. Calcineurin inhibitors versus cyclophosphamide for idiopathic membranous nephropathy: A systematic review and meta-analysis of 21 clinical trials. Autoimmun Rev. 2017;16(2):136-45. DOI:10.1016/j.autrev.2016.12.005
34. Fervenza FC, Appel GB, Barbour SJ, et al. Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy. N Engl J Med. 2019;381(1):36-46. DOI:10.1056/NEJMoa1814427
35. Dahan K, Debiec H, Plaisier E, et al. Rituximab for Severe Membranous Nephropathy: A 6-Month Trial with Extended Follow-Up. J Am Soc Nephrol. 2017;28(1):348-58. DOI:10.1681/ASN.2016040449
36. Fernández-Juárez G, Rojas-Rivera J, Logt AE van de, et al. The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy. Kidney Int. 2021;99(4):986-98. DOI:10.1016/j.kint.2020.10.014
37. Scolari F, Delbarba E, Santoro D, et al. Rituximab or Cyclophosphamide in the Treatment of Membranous Nephropathy: The RI-CYCLO Randomized Trial. J Am Soc Nephrol. 2021;32(4):972-82. DOI:10.1681/ASN.2020071091
38. Батюшин М.М., Бобкова И.Н., Боброва Л.А., и др. Мембранозная нефропатия. Ассоциация нефрологов России. Режим доступа: https://rusnephrology.org/wp-content/uploads/2021/09/membranous.pdf. Ссылка активна на 09.03.2023 [Batyushin MM, Bobkoba IN, Bobrova LA, et al. Membranous nephropathy. Association of Nephrologists of Russia. Available at: https://rusnephrology.org/wp-content/uploads/2021/09/membranous.pdf. Accessed: 09.03.2023 (in Russian)].
39. Rauen T, Wied S, Fitzner C, et al. After ten years of follow-up, no difference between supportive care plus immunosuppression and supportive care alone in IgA nephropathy. Kidney Int. 2020;98(4):1044‑52. DOI:10.1016/j.kint.2020.04.046
40. Rauen T, Eitner F, Fitzner C, et al. Intensive Supportive Care plus Immunosuppression in IgA Nephropathy. N Engl J Med. 2015;373(23):2225-36. DOI:10.1056/NEJMoa1415463
41. Manno C, Torres DD, Rossini M, et al. Randomized controlled clinical trial of corticosteroids plus ACE-inhibitors with long-term follow-up in proteinuric IgA nephropathy. Nephrol Dial Transplant. 2009;24(12):3694-701. DOI:10.1093/ndt/gfp356
42. Pozzi C, Bolasco PG, Fogazzi G, et al. Corticosteroids in IgA nephropathy: A randomised controlled trial. Lancet. 1999;353(9156):883-7. DOI:10.1016/s0140-6736(98)03563-6
43. Lv J, Wong MG, Hladunewich MA, et al. Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial. JAMA. 2022;327(19):1888-98. DOI:10.1001/jama.2022.5368
44. Батюшин М.М., Бобкова И.Н., Ватазин А.В., и др. Гломерулярные болезни: иммуноглобулин А-нефропатия. Ассоциация нефрологов России. Режим доступа: https://rusnephrology.org/wp-content/uploads/2021/04/iga_060421-1.pdf. Ссылка активна на 09.03.2023 [Batyushin MM, Bobkoba IN, Vatazin AV, et al. Glomerular diseases: immunoglobulin A-nephropathy. Association of Nephrologists of Russia. Available at: https://rusnephrology.org/wp-content/uploads/2021/04/iga_060421-1.pdf. Accessed: 09.03.2023 (in Russian)].
45. Fellström BC, Barratt J, Cook H, et al. Targeted-release budesonide versus placebo in patients with IgA nephropathy (NEFIGAN): a double-blind, randomised, placebo-controlled phase 2b trial. Lancet. 2017;389(10084):2117-27. DOI:10.1016/S0140-6736(17)30550-0
46. Tam WK F, Tumlin J, Barratt J, et al. SUN-036 Spleen tyrosine kinase (SYK) inhibition in IgA nephropathy: a global, phase II, randomised placebo-controlled trial of fostamatinib. Kidney Int Rep. 2019;4(7):S168. DOI:10.1016/j.ekir.2019.05.431
47. Lafayette RA, Rovin BH, Reich HN, et al. Tolerability and Efficacy of Narsoplimab, a Novel MASP-2 Inhibitor for the Treatment of IgA Nephropathy. Kidney Int Rep. 2020;5(11):2032-41.
DOI:10.1016/j.ekir.2020.08.003
48. Бобкова И.Н., Ватазин А.В., Добронравов В.А., и др. Гломерулярные болезни: фокально-сегментарный гломерулосклероз. 2022. Ассоциация нефрологов России. Режим доступа: https://rusnephrology.org/wp-content/uploads/2021/04/fsgs.pdf. Ссылка активна на 09.03.2023 [Bobkova IN, Vatazin AV, Dobronravov VA, et al. Glomerular diseases: focal segmental glomerulosclerosis. 2022. Russian Association of Nephrologists. Available at: https://rusnephrology.org/wp-content/uploads/2021/04/fsgs.pdf. Accessed: 09.03.2023 (in Russian)].
49. Medjeral-Thomas NR, Lawrence C, Condon M, et al. Randomized, Controlled Trial of Tacrolimus and Prednisolone Monotherapy for Adults with De Novo Minimal Change Disease: A Multicenter, Randomized, Controlled Trial. Clin J Am Soc Nephrol. 2020;15(2):209‑18. DOI:10.2215/CJN.06180519
50. Li X, Liu Z, Wang L, et al. Tacrolimus Monotherapy after Intravenous Methylprednisolone in Adults with Minimal Change Nephrotic Syndrome. J Am Soc Nephrol. 2017;28(4):1286-95.
DOI:10.1681/ASN.2016030342
51. Duncan N, Dhaygude A, Owen J, et al. Treatment of focal and segmental glomerulosclerosis in adults with tacrolimus monotherapy. Nephrol Dial Transplant. 2004;19(12):3062-7. DOI:10.1093/ndt/gfh536
52. Goumenos DS, Tsagalis G, El Nahas AM, et al. Immunosuppressive treatment of idiopathic focal segmental glomerulosclerosis: a five-year follow-up study. Nephron Clin Pract. 2006;104(2):c75-82. DOI:1159/000093993
53. Papakrivopoulou E, Shendi AM, Salama AD, et al. Effective treatment with rituximab for the maintenance of remission in frequently relapsing minimal change disease. Nephrology (Carlton). 2016;21(10):893-900. DOI:10.1111/nep.12744
54. Ren H, Lin L, Shen P, et al. Rituximab treatment in adults with refractory minimal change disease or focal segmental glomerulosclerosis. Oncotarget. 2017;8(55):93438-43. DOI:10.18632/oncotarget.21833
________________________________________________
2. Barnett HL, McNamara H, McCrory W, et al. The effects of ACTH and cortisone on the nephrotic syndrome. AMA Am J Dis Child. 1950;80(3):519-20.
3. Chaudhuri JN, Ghosal SP. Observations on prednisolone treated cases of nephrotic syndrome; a preliminary report. Indian J Pediatr. 1958;25(123):201-9.
4. Fahey JL, Leonard E, Churg J, Godman G. Wegener’s granulomatosis. Am J Med. 1954;17(2):168-79.
5. Thorn GW, Forsham PH, Frawley TF, et al. The clinical usefulness of ACTH and cortisone. N Engl J Med. 1950;242(21):824-34.
6. Pollak VE, Pirani CL, Kark RM. Effect of large doses of prednisone on the renal lesions and life span of patients with lupus glomerulonephritis. J Lab Clin Med. 1961;57:495-511.
7. Tareev EM, Nasonova VA. The place of steroid hormones in the complex treatment of the so called major collagenosis. Soviet Meidicine. 1960;12:3-12 (in Russian).
8. Austin HA, Klippel JH, Balow JE, et al. Therapy of lupus nephritis. Controlled trial of prednisone and cytotoxic drugs. N Engl J Med. 1986;314(10):614-9.
9. Fauci AS, Haynes BF, Katz P, Wolff SM. Wegener’s granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983;98(1):76-85.
10. Wilson CB, Dixon FJ. Anti-glomerular basement membrane antibody-induced glomerulonephritis. Kidney Int. 1973;3(2):74-89.
11. Black DAK, Rose G, Brewer DB. Controlled trial of prednisone in adult patients with the nephrotic syndrome. Br Med J. 1970;3(5720):421.
12. Mebrahtu TF, Morgan AW, Keeley A, et al. Dose dependency of iatrogenic glucocorticoid excess and adrenal insufficiency and mortality: a cohort study in England. J Clin Endocrinol Metab. 2019;104(9):3757-67. DOI:10.1210/jc.2019-00153
13. Walsh M, Merkel P, Peh C, et al. Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis. N Engl J Med. 2020;382(7):622‑31. DOI:10.1056/NEJMoa1803537
14. Rovin BH, Adler SG, Barratt J, et al. KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases. Kidney Int. 2021;100(4):S1-276. DOI:10.1016/j.kint.2021.05.021
15. Bulanov NM, Dobronravov VA, Zakharova EV, et al. Kidney damage in ANCA-associated vasculitis (ANCA-associated glomerulonephritis). Association of Nephrologists of Russia. Available at: https://rusnephrology.org/wp-content/uploads/2021/02/ANCA.pdf. Accessed: 09.03.2023 (in Russian).
16. Chanouzas D, McGregor JG, Poulton CJ, et al. Increase in adverse events with pulsed methylprednisolone used for induction of remission in severe anca associated vasculitis. Nephrol Dial Transplant. 2015;30(Suppl. 3):iii117-8. DOI:10.1093/ndt/gfv171.41
17. Jayne DRW, Merkel PA, Schall TJ, Bekker P. Avacopan for the Treatment of ANCA-Associated Vasculitis. N Engl J Med. 2021;384(7):599-609. DOI:10.1056/NEJMoa2023386
18. Guillevin L, Pagnoux C, Karras A, et al. Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis. N Engl J Med. 2014;371(19):1771-80. DOI:10.1056/NEJMoa1404231
19. Smith RM, Jones RB, Specks U, et al. Rituximab as therapy to induce remission after relapse in ANCA-associated vasculitis. Ann Rheum Dis. 2020;79(9):1243-9. DOI:10.1136/annrheumdis-2019-216863
20. Walsh M, Merkel PA, Mahr A, Jayne D. Effects of duration of glucocorticoid therapy on relapse rate in antineutrophil cytoplasmic antibody-associated vasculitis: A meta-analysis. Arthritis Care Res (Hoboken). 2010;62(8):1166-73. DOI:10.1002/acr.20176
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Авторы
Н.М. Буланов*, И.Н. Бобкова, С.В. Моисеев
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия
*bulanov_n_m@staff.sechenov.ru
Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
*bulanov_n_m@staff.sechenov.ru
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия
*bulanov_n_m@staff.sechenov.ru
________________________________________________
Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
*bulanov_n_m@staff.sechenov.ru
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