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Лекарственные повреждения печени: диагноз исключения - Журнал Терапевтический архив №8 Вопросы лечения 2023
Лекарственные повреждения печени: диагноз исключения
Маев И.В., Полунина Т.Е. Лекарственные повреждения печени: диагноз исключения. Терапевтический архив. 2023;95(8):611–620. DOI: 10.26442/00403660.2023.08.202329
© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.
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Аннотация
Лекарственное повреждение печени (ЛПП) остается проблемой в клинической практике и до сих пор является диагнозом исключения. Несмотря на низкую частоту заболеваемости среди населения в целом, ЛПП является причиной большинства случаев острой печеночной недостаточности, с летальностью до 50%. При наличии большого количества сообщений в медицинских источниках о механизмах ЛПП не установлено четкой причинно-следственной связи между ними, лекарствами и факторами риска. Современная клиническая практика основана на сочетании тщательного изучения анамнеза факторов риска, времени приема лекарственных препаратов и биологически
активных добавок, на анализе лабораторно-инструментальных исследований. Это подтверждается международными критериями метода оценки причинно-следственных связей при ЛПП Rousell Uclaf Causality Assessment Method (RUCAM), который считается одним из основных диагностических алгоритмов при ЛПП. Статья посвящена современной классификации ЛПП, факторам риска, алгоритмам диагнос-
тики, причинно-следственным связям, клинической оценке, перспективным биомаркерам функции печени и специфическому лечению.
Ключевые слова: лекарственное повреждение печени, острый гепатит, острая печеночная недостаточность, алгоритмы диагностики, RUCAM, биомаркеры, специфическое лечение
Keywords: drug-induced liver injury, acute hepatitis, acute liver failure, diagnostic algorithms, RUCAM, biomarkers, specific treatment
активных добавок, на анализе лабораторно-инструментальных исследований. Это подтверждается международными критериями метода оценки причинно-следственных связей при ЛПП Rousell Uclaf Causality Assessment Method (RUCAM), который считается одним из основных диагностических алгоритмов при ЛПП. Статья посвящена современной классификации ЛПП, факторам риска, алгоритмам диагнос-
тики, причинно-следственным связям, клинической оценке, перспективным биомаркерам функции печени и специфическому лечению.
Ключевые слова: лекарственное повреждение печени, острый гепатит, острая печеночная недостаточность, алгоритмы диагностики, RUCAM, биомаркеры, специфическое лечение
________________________________________________
Keywords: drug-induced liver injury, acute hepatitis, acute liver failure, diagnostic algorithms, RUCAM, biomarkers, specific treatment
Полный текст
Список литературы
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20. Hosack T, Damry D, Biswas S. Drug-induced liver injury: a comprehensive review. Therap Adv Gastroenterol. 2023;16:1-13. DOI:10.1177/17562848231163410
21. Hoofnagle JH, Björnsson E. Drug-induced liver injury – Types and phenotypes. N Engl J Med. 2019;381(3):264-73. DOI:10.1056/NEJMra1816149
22. Koch DG, Speiser JL, Durkalski V, et al. The natural history of severe acute liver injury. Am J Gastroenterol. 2017;112(9):1389-96. DOI:10.1038/ajg.2017.98
23. Dara L, Liu ZX, Kaplowitz N. Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int. 2016;36(2):158-65. DOI:10.1111/liv.12988
24. Danan G, Benichou C. Causality assessment of adverse reactions to drugs–I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol. 1993;46(11):1323-30. DOI:10.1016/0895-4356(93)90101-6
25. Benichou C, Danan G, Flahault A. Causality assessment of adverse reactions to drugs–II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge. J Clin Epidemiol. 1993;46(11):1331-6. DOI:10.1016/0895-4356(93)90102-7
26. Katarey D, Verma S. Drug-induced liver injury. Clin Med (Lond). 2016;16(Suppl. 6):s104-9. DOI:10.7861/clinmedicine.16-6-s104
27. Castiella A, Zapata E, Lucena MI, et al. Druginduced autoimmune liver disease: a diagnostic dilemma of an increasingly reported disease. World J Hepatol. 2014;6(4):160-8. DOI:10.4254/wjh.v6.i4.160
28. Andrade RJ, Lucena MI, Carmen Fernández M, et al. Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology. 2005;129(2):512-21. DOI:10.1016/j.gastro.2005.05.006
29. David S, Hamilton JP. Drug-induced liver injury. US Gastroenterol Hepatol Rev. 2010;6:73-80.
30. Kullak-Ublick GA, Andrade RJ, Merz M, et al. Drug-induced liver injury: recent advances in diagnosis and risk assessment. Gut. 2017;66(6):1154‑64. DOI:10.1136/gutjnl-2016-313369
31. Cantor HM, Dumont AE. Hepatic suppression of sensitization to antigen absorbed into the portal system. Nature. 1967;215(5102):744-5. DOI:10.1038/215744a0
32. Singh D, Cho WC, Upadhyay G. Drug-Induced Liver Toxicity and Prevention by Herbal Antioxidants: An Overview. Front Physiol. 2016;6:363. DOI:10.3389/fphys.2015.00363
33. Lleo A, Rimassa L, Colombo M. Hepatotoxicity of immune check point inhibitors: approach and management. Dig Liver Dis. 2019;51(8):1074-8. DOI:10.1016/j.dld.2019.06.017
34. Wang W, Lie P, Guo M, He J. Risk of hepatotoxicity in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis of published data. Int J Cancer. 2017;141(5):1018-28. DOI:10.1002/ijc.30678
35. Brahmer JR, Lacchetti C, Schneider BJ, et al. Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2018;36(17):1714-68. DOI:10.1200/JCO.2017.77.6385
36. Danan G, Teschke R. RUCAM in drug and herb induced liver injury: the update. Int J Mol Sci. 2015;17(1):14. DOI:10.3390/ijms17010014
37. Yang H, Guo D, Xu Y, et al. Comparison of different liver test thresholds for drug-induced liver injury: updated RUCAM versus other methods. Front Pharmacol. 2019;10:816. DOI:10.3389/fphar.2019.00816
38. Lee WM, Hynan LS, Rossaro L, et al. Intravenous N-acetylcysteine improves transplantfree survival in early stage nonacetaminophen acute liver failure. Gastroenterology. 2009;137(3):856-64. DOI:10.1053/j.gastro.2009.06.006
39. Karkhanis J, Verna EC, Chang MS, et al. Steroid use in acute liver failure. Hepatology. 2014;59(2):612-21. DOI:10.1002/hep.26678
40. Mohty M, Malard F, Abecasis M, et al. Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group. Bone Marrow Transplant. 2020;55(3):485‑95. DOI:10.1038/s41409-019-0705-z
2. Chalasani NP, Maddur H, Russo MW, et al. ACG clinical guideline: diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol. 2021;116(5):878-98. DOI:10.14309/ajg.0000000000001259
3. Aithal GP, Watkins PB, Andrade RJ, et al. Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther. 2011;89(6):806-15. DOI:10.1038/clpt.2011.58
4. Hayashi PH, Lucena MI, Fontana RJ, et al. A Revised Electronic Version of RUCAM for the Diagnosis of DILI. Hepatology. 2022;76(1):18-31. DOI:10.1002/hep.32327
5. Bernal W, Wendon J. Acute Liver Failure. N Engl J Med. 2013;369(26):2525‑34. DOI:10.1056/NEJMra1208937
6. Bunchorntavakul C, Reddy KR. Acetaminophen-related hepatotoxicity. Clin Liver Dis. 2013;17(4):587-607. DOI:10.1016/j.cld.2013.07.005
7. Sandhu N, Navarro V. Drug-Induced Liver Injury in GI Practice. Hepatol Commun. 2020;4(5):631-45. DOI:10.1002/hep4.1503
8. Björnsson ES, Bergmann OM, Björnsson HK, et al. Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology. 2013;144(7):1419‑25. DOI:10.1053/j.gastro.2013.02.006
9. Vega M, Verma M, Beswick D, et al. The incidence of drug- and herbal and dietary supplement-induced liver injury: preliminary findings from gastroenterologist-based surveillance in the population of the state of Delaware. Drug Saf. 2017;40(9):783-7. DOI:10.1007/s40264-017-0547-9
10. Polunina TE, Maev IV. Medicinal Hepatitis. Consilium Medicum. Gastroenterologiia. 2008;1:3-9 (in Russian).
11. Korenskaya EG, Paramonova OV. Drug-induced liver injury is one of the important problems in the comorbid patient. Consilium Medicum. 2019;21(8):78-83 (in Russian). DOI:10.26442/20751753.2019.8.190355
12. Butorova LI, Kalinin AV, Loginov AF. Lekarstvennye porazheniia pecheni: Uchebno-metodicheskoe posobie. Moscow: Institut usovershenstvovaniia vrachei FGU «NMKhTs im. N.I. Pirogova», 2010 (in Russian).
13. Galimova SF. Lekarstvennye porazheniia pecheni (Chast' 1-ia). Rossiiskii zhurnal gastroenterologii, gepatologii, koloproktologii. 2012;3:38-48 (in Russian).
14. Bueverov AO, Bogomolov PO, Bueverova EL. Hepatotoxicity of Antibacterial Agents in Clinical Practice. Klin mikrobiol antimikrob khimioter. 2015;17(3):207‑16 (in Russian).
15. Drug-induced liver injury (DILI): Current status and future directions for drug development and the post-market setting. A consensus by a CIOMS Working Group. Geneva, 2020. DOI:10.56759/ojsg8296
16. Maksimov ML, Simakova SA. A Review of Cases of Development of Acute Hepatic Insufficiency Due to the Intake of Biologically Active Additives. Safety and Risk of Pharmacotherapy. 2018;6(2):68-77 (in Russian). DOI:10.30895/2312-7821-2018-6-2-68-77
17. European Association for the Study of the Liver; Clinical Practice Guideline Panel: Chair; Panel members; EASL Governing Board representative. EASL clinical practice guidelines: drug-induced liver injury. J Hepatol. 2019;70(6):1222-61. DOI:10.1016/j.jhep.2019.02.014
18. Polunina TE. Drug-induced liver injury. RMJ. Medical Review. 2018;7(1):7-12 (in Russian).
19. Ivashkin VT, Baranovsky AYu, Raikhelson KL, et al. Drug-Induced Liver Injuries (Clinical Guidelines for Physicians). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(1):101‑31 (in Russian). DOI:10.22416/1382-4376-2019-29-1-101-131
20. Hosack T, Damry D, Biswas S. Drug-induced liver injury: a comprehensive review. Therap Adv Gastroenterol. 2023;16:1-13. DOI:10.1177/17562848231163410
21. Hoofnagle JH, Björnsson E. Drug-induced liver injury – Types and phenotypes. N Engl J Med. 2019;381(3):264-73. DOI:10.1056/NEJMra1816149
22. Koch DG, Speiser JL, Durkalski V, et al. The natural history of severe acute liver injury. Am J Gastroenterol. 2017;112(9):1389-96. DOI:10.1038/ajg.2017.98
23. Dara L, Liu ZX, Kaplowitz N. Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int. 2016;36(2):158-65. DOI:10.1111/liv.12988
24. Danan G, Benichou C. Causality assessment of adverse reactions to drugs–I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol. 1993;46(11):1323-30. DOI:10.1016/0895-4356(93)90101-6
25. Benichou C, Danan G, Flahault A. Causality assessment of adverse reactions to drugs–II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge. J Clin Epidemiol. 1993;46(11):1331-6. DOI:10.1016/0895-4356(93)90102-7
26. Katarey D, Verma S. Drug-induced liver injury. Clin Med (Lond). 2016;16(Suppl. 6):s104-9. DOI:10.7861/clinmedicine.16-6-s104
27. Castiella A, Zapata E, Lucena MI, et al. Druginduced autoimmune liver disease: a diagnostic dilemma of an increasingly reported disease. World J Hepatol. 2014;6(4):160-8. DOI:10.4254/wjh.v6.i4.160
28. Andrade RJ, Lucena MI, Carmen Fernández M, et al. Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology. 2005;129(2):512-21. DOI:10.1016/j.gastro.2005.05.006
29. David S, Hamilton JP. Drug-induced liver injury. US Gastroenterol Hepatol Rev. 2010;6:73-80.
30. Kullak-Ublick GA, Andrade RJ, Merz M, et al. Drug-induced liver injury: recent advances in diagnosis and risk assessment. Gut. 2017;66(6):1154‑64. DOI:10.1136/gutjnl-2016-313369
31. Cantor HM, Dumont AE. Hepatic suppression of sensitization to antigen absorbed into the portal system. Nature. 1967;215(5102):744-5. DOI:10.1038/215744a0
32. Singh D, Cho WC, Upadhyay G. Drug-Induced Liver Toxicity and Prevention by Herbal Antioxidants: An Overview. Front Physiol. 2016;6:363. DOI:10.3389/fphys.2015.00363
33. Lleo A, Rimassa L, Colombo M. Hepatotoxicity of immune check point inhibitors: approach and management. Dig Liver Dis. 2019;51(8):1074-8. DOI:10.1016/j.dld.2019.06.017
34. Wang W, Lie P, Guo M, He J. Risk of hepatotoxicity in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis of published data. Int J Cancer. 2017;141(5):1018-28. DOI:10.1002/ijc.30678
35. Brahmer JR, Lacchetti C, Schneider BJ, et al. Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2018;36(17):1714-68. DOI:10.1200/JCO.2017.77.6385
36. Danan G, Teschke R. RUCAM in drug and herb induced liver injury: the update. Int J Mol Sci. 2015;17(1):14. DOI:10.3390/ijms17010014
37. Yang H, Guo D, Xu Y, et al. Comparison of different liver test thresholds for drug-induced liver injury: updated RUCAM versus other methods. Front Pharmacol. 2019;10:816. DOI:10.3389/fphar.2019.00816
38. Lee WM, Hynan LS, Rossaro L, et al. Intravenous N-acetylcysteine improves transplantfree survival in early stage nonacetaminophen acute liver failure. Gastroenterology. 2009;137(3):856-64. DOI:10.1053/j.gastro.2009.06.006
39. Karkhanis J, Verna EC, Chang MS, et al. Steroid use in acute liver failure. Hepatology. 2014;59(2):612-21. DOI:10.1002/hep.26678
40. Mohty M, Malard F, Abecasis M, et al. Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group. Bone Marrow Transplant. 2020;55(3):485‑95. DOI:10.1038/s41409-019-0705-z
2. Chalasani NP, Maddur H, Russo MW, et al. ACG clinical guideline: diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol. 2021;116(5):878-98. DOI:10.14309/ajg.0000000000001259
3. Aithal GP, Watkins PB, Andrade RJ, et al. Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther. 2011;89(6):806-15. DOI:10.1038/clpt.2011.58
4. Hayashi PH, Lucena MI, Fontana RJ, et al. A Revised Electronic Version of RUCAM for the Diagnosis of DILI. Hepatology. 2022;76(1):18-31. DOI:10.1002/hep.32327
5. Bernal W, Wendon J. Acute Liver Failure. N Engl J Med. 2013;369(26):2525‑34. DOI:10.1056/NEJMra1208937
6. Bunchorntavakul C, Reddy KR. Acetaminophen-related hepatotoxicity. Clin Liver Dis. 2013;17(4):587-607. DOI:10.1016/j.cld.2013.07.005
7. Sandhu N, Navarro V. Drug-Induced Liver Injury in GI Practice. Hepatol Commun. 2020;4(5):631-45. DOI:10.1002/hep4.1503
8. Björnsson ES, Bergmann OM, Björnsson HK, et al. Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology. 2013;144(7):1419‑25. DOI:10.1053/j.gastro.2013.02.006
9. Vega M, Verma M, Beswick D, et al. The incidence of drug- and herbal and dietary supplement-induced liver injury: preliminary findings from gastroenterologist-based surveillance in the population of the state of Delaware. Drug Saf. 2017;40(9):783-7. DOI:10.1007/s40264-017-0547-9
10. Полунина Т.Е., Маев И.В. Лекарственный гепатит. Consilium Medicum. Гастроэнтерология. 2008;1:3-9 [Polunina TE, Maev IV. Medicinal Hepatitis. Consilium Medicum. Gastroenterologiia. 2008;1:3-9 (in Russian)].
11. Коренская Е.Г., Парамонова О.В. Лекарственные поражения печени – одна из важных проблем у коморбидного пациента. Consilium Medicum. 2019;21(8):78-83 [Korenskaya EG, Paramonova OV. Drug-induced liver injury is one of the important problems in the comorbid patient. Consilium Medicum. 2019;21(8):78-83 (in Russian)]. DOI:10.26442/20751753.2019.8.190355
12. Буторова Л.И., Калинин А.В., Логинов А.Ф. Лекарственные поражения печени: Учебно-методическое пособие. М.: Институт усовершенствования врачей ФГУ «НМХЦ им. Н.И. Пирогова», 2010 [Butorova LI, Kalinin AV, Loginov AF. Lekarstvennye porazheniia pecheni: Uchebno-metodicheskoe posobie. Moscow: Institut usovershenstvovaniia vrachei FGU «NMKhTs im. N.I. Pirogova», 2010 (in Russian)].
13. Галимова С.Ф. Лекарственные поражения печени (Часть 1-я). Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2012;3:38-48 [Galimova SF. Lekarstvennye porazheniia pecheni (Chast' 1-ia). Rossiiskii zhurnal gastroenterologii, gepatologii, koloproktologii. 2012;3:38-48 (in Russian)].
14. Буеверов А.О., Богомолов П.О., Буеверова Е.Л. Гепатотоксичность антибактериальных препаратов в терапевтической практике. Клин микробиол антимикроб химиотер. 2015;17(3):207‑16 [Bueverov AO, Bogomolov PO, Bueverova EL. Hepatotoxicity of Antibacterial Agents in Clinical Practice. Klin mikrobiol antimikrob khimioter. 2015;17(3):207‑16 (in Russian)].
15. Drug-induced liver injury (DILI): Current status and future directions for drug development and the post-market setting. A consensus by a CIOMS Working Group. Geneva, 2020. DOI:10.56759/ojsg8296
16. Максимов М.Л., Симакова С.А. Обзор случаев развития острой печеночной недостаточности вследствие приема биологически активных добавок. Безопасность и риск фармакотерапии. 2018;6(2):68-77 [Maksimov ML, Simakova SA. A Review of Cases of Development of Acute Hepatic Insufficiency Due to the Intake of Biologically Active Additives. Safety and Risk of Pharmacotherapy. 2018;6(2):68-77 (in Russian)]. DOI:10.30895/2312-7821-2018-6-2-68-77
17. European Association for the Study of the Liver; Clinical Practice Guideline Panel: Chair; Panel members; EASL Governing Board representative. EASL clinical practice guidelines: drug-induced liver injury. J Hepatol. 2019;70(6):1222-61. DOI:10.1016/j.jhep.2019.02.014
18. Полунина Т.Е. Лекарственные повреждения печени. РМЖ. Медицинское обозрение. 2018;7(1):7-12 [Polunina TE. Drug-induced liver injury. RMJ. Medical Review.
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19. Ивашкин В.Т., Барановский А.Ю., Райхельсон К.Л., и др. Лекарственные поражения печени (клинические рекомендации для врачей). Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2019;29(1):101-31 [Ivashkin VT, Baranovsky AYu, Raikhelson KL, et al. Drug-Induced Liver Injuries (Clinical Guidelines for Physicians). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(1):101‑31 (in Russian)]. DOI:10.22416/1382-4376-2019-29-1-101-131
20. Hosack T, Damry D, Biswas S. Drug-induced liver injury: a comprehensive review. Therap Adv Gastroenterol. 2023;16:1-13. DOI:10.1177/17562848231163410
21. Hoofnagle JH, Björnsson E. Drug-induced liver injury – Types and phenotypes. N Engl J Med. 2019;381(3):264-73. DOI:10.1056/NEJMra1816149
22. Koch DG, Speiser JL, Durkalski V, et al. The natural history of severe acute liver injury. Am J Gastroenterol. 2017;112(9):1389-96. DOI:10.1038/ajg.2017.98
23. Dara L, Liu ZX, Kaplowitz N. Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int. 2016;36(2):158-65. DOI:10.1111/liv.12988
24. Danan G, Benichou C. Causality assessment of adverse reactions to drugs–I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol. 1993;46(11):1323-30. DOI:10.1016/0895-4356(93)90101-6
25. Benichou C, Danan G, Flahault A. Causality assessment of adverse reactions to drugs–II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge. J Clin Epidemiol. 1993;46(11):1331-6. DOI:10.1016/0895-4356(93)90102-7
26. Katarey D, Verma S. Drug-induced liver injury. Clin Med (Lond). 2016;16(Suppl. 6):s104-9. DOI:10.7861/clinmedicine.16-6-s104
27. Castiella A, Zapata E, Lucena MI, et al. Druginduced autoimmune liver disease: a diagnostic dilemma of an increasingly reported disease. World J Hepatol. 2014;6(4):160-8. DOI:10.4254/wjh.v6.i4.160
28. Andrade RJ, Lucena MI, Carmen Fernández M, et al. Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology. 2005;129(2):512-21. DOI:10.1016/j.gastro.2005.05.006
29. David S, Hamilton JP. Drug-induced liver injury. US Gastroenterol Hepatol Rev. 2010;6:73-80.
30. Kullak-Ublick GA, Andrade RJ, Merz M, et al. Drug-induced liver injury: recent advances in diagnosis and risk assessment. Gut. 2017;66(6):1154‑64. DOI:10.1136/gutjnl-2016-313369
31. Cantor HM, Dumont AE. Hepatic suppression of sensitization to antigen absorbed into the portal system. Nature. 1967;215(5102):744-5. DOI:10.1038/215744a0
32. Singh D, Cho WC, Upadhyay G. Drug-Induced Liver Toxicity and Prevention by Herbal Antioxidants: An Overview. Front Physiol. 2016;6:363. DOI:10.3389/fphys.2015.00363
33. Lleo A, Rimassa L, Colombo M. Hepatotoxicity of immune check point inhibitors: approach and management. Dig Liver Dis. 2019;51(8):1074-8. DOI:10.1016/j.dld.2019.06.017
34. Wang W, Lie P, Guo M, He J. Risk of hepatotoxicity in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis of published data. Int J Cancer. 2017;141(5):1018-28. DOI:10.1002/ijc.30678
35. Brahmer JR, Lacchetti C, Schneider BJ, et al. Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2018;36(17):1714-68. DOI:10.1200/JCO.2017.77.6385
36. Danan G, Teschke R. RUCAM in drug and herb induced liver injury: the update. Int J Mol Sci. 2015;17(1):14. DOI:10.3390/ijms17010014
37. Yang H, Guo D, Xu Y, et al. Comparison of different liver test thresholds for drug-induced liver injury: updated RUCAM versus other methods. Front Pharmacol. 2019;10:816. DOI:10.3389/fphar.2019.00816
38. Lee WM, Hynan LS, Rossaro L, et al. Intravenous N-acetylcysteine improves transplantfree survival in early stage nonacetaminophen acute liver failure. Gastroenterology. 2009;137(3):856-64. DOI:10.1053/j.gastro.2009.06.006
39. Karkhanis J, Verna EC, Chang MS, et al. Steroid use in acute liver failure. Hepatology. 2014;59(2):612-21. DOI:10.1002/hep.26678
40. Mohty M, Malard F, Abecasis M, et al. Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group. Bone Marrow Transplant. 2020;55(3):485‑95. DOI:10.1038/s41409-019-0705-z
________________________________________________
2. Chalasani NP, Maddur H, Russo MW, et al. ACG clinical guideline: diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol. 2021;116(5):878-98. DOI:10.14309/ajg.0000000000001259
3. Aithal GP, Watkins PB, Andrade RJ, et al. Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther. 2011;89(6):806-15. DOI:10.1038/clpt.2011.58
4. Hayashi PH, Lucena MI, Fontana RJ, et al. A Revised Electronic Version of RUCAM for the Diagnosis of DILI. Hepatology. 2022;76(1):18-31. DOI:10.1002/hep.32327
5. Bernal W, Wendon J. Acute Liver Failure. N Engl J Med. 2013;369(26):2525‑34. DOI:10.1056/NEJMra1208937
6. Bunchorntavakul C, Reddy KR. Acetaminophen-related hepatotoxicity. Clin Liver Dis. 2013;17(4):587-607. DOI:10.1016/j.cld.2013.07.005
7. Sandhu N, Navarro V. Drug-Induced Liver Injury in GI Practice. Hepatol Commun. 2020;4(5):631-45. DOI:10.1002/hep4.1503
8. Björnsson ES, Bergmann OM, Björnsson HK, et al. Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology. 2013;144(7):1419‑25. DOI:10.1053/j.gastro.2013.02.006
9. Vega M, Verma M, Beswick D, et al. The incidence of drug- and herbal and dietary supplement-induced liver injury: preliminary findings from gastroenterologist-based surveillance in the population of the state of Delaware. Drug Saf. 2017;40(9):783-7. DOI:10.1007/s40264-017-0547-9
10. Polunina TE, Maev IV. Medicinal Hepatitis. Consilium Medicum. Gastroenterologiia. 2008;1:3-9 (in Russian).
11. Korenskaya EG, Paramonova OV. Drug-induced liver injury is one of the important problems in the comorbid patient. Consilium Medicum. 2019;21(8):78-83 (in Russian). DOI:10.26442/20751753.2019.8.190355
12. Butorova LI, Kalinin AV, Loginov AF. Lekarstvennye porazheniia pecheni: Uchebno-metodicheskoe posobie. Moscow: Institut usovershenstvovaniia vrachei FGU «NMKhTs im. N.I. Pirogova», 2010 (in Russian).
13. Galimova SF. Lekarstvennye porazheniia pecheni (Chast' 1-ia). Rossiiskii zhurnal gastroenterologii, gepatologii, koloproktologii. 2012;3:38-48 (in Russian).
14. Bueverov AO, Bogomolov PO, Bueverova EL. Hepatotoxicity of Antibacterial Agents in Clinical Practice. Klin mikrobiol antimikrob khimioter. 2015;17(3):207‑16 (in Russian).
15. Drug-induced liver injury (DILI): Current status and future directions for drug development and the post-market setting. A consensus by a CIOMS Working Group. Geneva, 2020. DOI:10.56759/ojsg8296
16. Maksimov ML, Simakova SA. A Review of Cases of Development of Acute Hepatic Insufficiency Due to the Intake of Biologically Active Additives. Safety and Risk of Pharmacotherapy. 2018;6(2):68-77 (in Russian). DOI:10.30895/2312-7821-2018-6-2-68-77
17. European Association for the Study of the Liver; Clinical Practice Guideline Panel: Chair; Panel members; EASL Governing Board representative. EASL clinical practice guidelines: drug-induced liver injury. J Hepatol. 2019;70(6):1222-61. DOI:10.1016/j.jhep.2019.02.014
18. Polunina TE. Drug-induced liver injury. RMJ. Medical Review. 2018;7(1):7-12 (in Russian).
19. Ivashkin VT, Baranovsky AYu, Raikhelson KL, et al. Drug-Induced Liver Injuries (Clinical Guidelines for Physicians). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(1):101‑31 (in Russian). DOI:10.22416/1382-4376-2019-29-1-101-131
20. Hosack T, Damry D, Biswas S. Drug-induced liver injury: a comprehensive review. Therap Adv Gastroenterol. 2023;16:1-13. DOI:10.1177/17562848231163410
21. Hoofnagle JH, Björnsson E. Drug-induced liver injury – Types and phenotypes. N Engl J Med. 2019;381(3):264-73. DOI:10.1056/NEJMra1816149
22. Koch DG, Speiser JL, Durkalski V, et al. The natural history of severe acute liver injury. Am J Gastroenterol. 2017;112(9):1389-96. DOI:10.1038/ajg.2017.98
23. Dara L, Liu ZX, Kaplowitz N. Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int. 2016;36(2):158-65. DOI:10.1111/liv.12988
24. Danan G, Benichou C. Causality assessment of adverse reactions to drugs–I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol. 1993;46(11):1323-30. DOI:10.1016/0895-4356(93)90101-6
25. Benichou C, Danan G, Flahault A. Causality assessment of adverse reactions to drugs–II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge. J Clin Epidemiol. 1993;46(11):1331-6. DOI:10.1016/0895-4356(93)90102-7
26. Katarey D, Verma S. Drug-induced liver injury. Clin Med (Lond). 2016;16(Suppl. 6):s104-9. DOI:10.7861/clinmedicine.16-6-s104
27. Castiella A, Zapata E, Lucena MI, et al. Druginduced autoimmune liver disease: a diagnostic dilemma of an increasingly reported disease. World J Hepatol. 2014;6(4):160-8. DOI:10.4254/wjh.v6.i4.160
28. Andrade RJ, Lucena MI, Carmen Fernández M, et al. Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology. 2005;129(2):512-21. DOI:10.1016/j.gastro.2005.05.006
29. David S, Hamilton JP. Drug-induced liver injury. US Gastroenterol Hepatol Rev. 2010;6:73-80.
30. Kullak-Ublick GA, Andrade RJ, Merz M, et al. Drug-induced liver injury: recent advances in diagnosis and risk assessment. Gut. 2017;66(6):1154‑64. DOI:10.1136/gutjnl-2016-313369
31. Cantor HM, Dumont AE. Hepatic suppression of sensitization to antigen absorbed into the portal system. Nature. 1967;215(5102):744-5. DOI:10.1038/215744a0
32. Singh D, Cho WC, Upadhyay G. Drug-Induced Liver Toxicity and Prevention by Herbal Antioxidants: An Overview. Front Physiol. 2016;6:363. DOI:10.3389/fphys.2015.00363
33. Lleo A, Rimassa L, Colombo M. Hepatotoxicity of immune check point inhibitors: approach and management. Dig Liver Dis. 2019;51(8):1074-8. DOI:10.1016/j.dld.2019.06.017
34. Wang W, Lie P, Guo M, He J. Risk of hepatotoxicity in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis of published data. Int J Cancer. 2017;141(5):1018-28. DOI:10.1002/ijc.30678
35. Brahmer JR, Lacchetti C, Schneider BJ, et al. Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2018;36(17):1714-68. DOI:10.1200/JCO.2017.77.6385
36. Danan G, Teschke R. RUCAM in drug and herb induced liver injury: the update. Int J Mol Sci. 2015;17(1):14. DOI:10.3390/ijms17010014
37. Yang H, Guo D, Xu Y, et al. Comparison of different liver test thresholds for drug-induced liver injury: updated RUCAM versus other methods. Front Pharmacol. 2019;10:816. DOI:10.3389/fphar.2019.00816
38. Lee WM, Hynan LS, Rossaro L, et al. Intravenous N-acetylcysteine improves transplantfree survival in early stage nonacetaminophen acute liver failure. Gastroenterology. 2009;137(3):856-64. DOI:10.1053/j.gastro.2009.06.006
39. Karkhanis J, Verna EC, Chang MS, et al. Steroid use in acute liver failure. Hepatology. 2014;59(2):612-21. DOI:10.1002/hep.26678
40. Mohty M, Malard F, Abecasis M, et al. Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group. Bone Marrow Transplant. 2020;55(3):485‑95. DOI:10.1038/s41409-019-0705-z
Авторы
И.В. Маев, Т.Е. Полунина*
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия
*polunina@mail.ru
Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
*polunina@mail.ru
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия
*polunina@mail.ru
________________________________________________
Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
*polunina@mail.ru
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