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Аутоиммунные и йододефицитные заболевания щитовидной железы как «вершина айсберга» полиорганной патологии - Журнал Терапевтический архив №10 Вопросы эндокринологии 2024
Аутоиммунные и йододефицитные заболевания щитовидной железы как «вершина айсберга» полиорганной патологии
Трошина Е.А. Аутоиммунные и йододефицитные заболевания щитовидной железы как «вершина айсберга» полиорганной патологии. Терапевтический архив. 2024;96(10):923–931 .
DOI: 10.26442/00403660.2024.10.202855
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
DOI: 10.26442/00403660.2024.10.202855
DOI: 10.26442/00403660.2024.10.202855
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
________________________________________________
DOI: 10.26442/00403660.2024.10.202855
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Аннотация
В статье представлены современные данные об этиологии, патогенезе, диагностике и лечении аутоиммунных и йододефицитных заболеваний в контексте возможных ассоциаций с другими аутоиммунными и неаутоиммунными соматическими патологиями. Заболевания щитовидной железы (ЩЖ) представлены в виде «сигнальной патологии», требующей внимания врачей, рассмотрены вопросы синдрома множественных аутоиммунных поражений, обязательным компонентом которых является заболевание ЩЖ, чаще всего аутоиммунное. Приводятся данные о возможной взаимосвязи аутоиммунных, йододефицитных и опухолевых заболеваний ЩЖ с точки зрения единых механизмов патогенеза и взаимовлияний. Сделаны акценты на клинические проявления тиреотоксикоза и гипотиреоза, их влияния на сердечно-сосудистую систему, связь с течением ревматических и прочих заболеваний. Показана важность персонализации диагностики патологии ЩЖ, обязательного исключения возможных ассоциированных заболеваний.
Ключевые слова: щитовидная железа, аутоиммунные заболевания щитовидной железы, йододефицитные заболевания щитовидной железы, аутоиммунитет, аутоиммунный полигландулярный синдром, зоб
Keywords: thyroid gland, autoimmune diseases of the thyroid gland, iodine deficiency diseases of the thyroid gland, autoimmunity, autoimmune polyglandular syndrome, goiter
Ключевые слова: щитовидная железа, аутоиммунные заболевания щитовидной железы, йододефицитные заболевания щитовидной железы, аутоиммунитет, аутоиммунный полигландулярный синдром, зоб
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Keywords: thyroid gland, autoimmune diseases of the thyroid gland, iodine deficiency diseases of the thyroid gland, autoimmunity, autoimmune polyglandular syndrome, goiter
Полный текст
Список литературы
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2. Betterle C, Furmaniak J, Sabbadin C, et al. Type 3 autoimmune polyglandular syndrome (APS-3) or type 3 multiple autoimmune syndrome (MAS-3): An expanding galaxy. J Endocrinol Invest. 2023;46(4):643-65. DOI:10.1007/s40618-022-01994-1
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4. Tańska K, Gietka-Czernel M, Glinicki P, Kozakowski J. Thyroid autoimmunity and its negative impact on female fertility and maternal pregnancy outcomes. Front Endocrinol (Lausanne). 2023;13:1049665. DOI:10.3389/fendo.2022.1049665
5. Chiovato L, Magri F, Carlé A. Hypothyroidism in context: Where we’ve been and where we’re going. Adv Ther. 2019;36(Suppl. 2):47-58. DOI:0.1007/s12325-019-01080-8
6. Dos Santos Valsecchi VA, Betoni FR, Ward LS, et al. Clinical and molecular impact of concurrent thyroid autoimmune disease and thyroid cancer: From the bench to bedside. Rev Endocr Metab Disord. 2024;25(1):5-17. DOI:10.1007/s11154-023-09846-w
7. Eschler DC, Hasham A, Tomer Y. Cutting edge: The etiology of autoimmune thyroid diseases. Clin Rev Allergy Immunol. 2011;41(2):190-7. DOI:10.1007/s12016-010-8245-8
8. Sterenborg RBTM, Steinbrenner I, Li Y, et al. Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications. Nat Commun. 2024;15(1):888. DOI:10.1038/s41467-024-44701-9
9. Lee HJ, Stefan-Lifshitz M, Li CW, Tomer Y. Genetics and epigenetics of autoimmune thyroid diseases: Translational implications. Best Pract Res Clin Endocrinol Metab. 2023;37(2):101661. DOI:10.1016/j.beem.2022.101661
10. Troshina EA, Nikonova TV, Svitich OA, Iukina MIu. Autoimmunnyi poliglianduliarnyi sindrom vzroslykh. Pod red. II Dedova, EA Troshinoi. Moscow: GEOTAR-Media, 2019 (in Russian).
11. Laboratornaia diagnostika. Pod red. EA Kondrashevoi, AIu Ostrovskogo. Moscow: Medizdat, 2018 (in Russian).
12. Morita S, Arima T, Matsuda M. Prevalence of nonthyroid specific autoantibodies in autoimmune thyroid diseases. J Clin Endocrinol Metab. 1995;80(4):1203-6. DOI:10.1210/jcem.80.4.7714090
13. Troshina EA. Chronic autoimmune thyroiditis is a "signal disease" in the multiorgan autoimmune syndrome. Problems of Endocrinology. 2023;69(4):4-10 (in Russian). DOI:10.14341/probl13361
14. Betterle C, Zanchetta R. Update on autoimmune polyendocrine syndromes (APS). Acta Biomed. 2003;74(1):9-33. PMID:12817789
15. Kahaly JG. Polyglandular autoimmune syndromes. Eur J Endocrinol. 2009;161(1):11-20. DOI:10.1530/EJE-09-0044
16. Betterle C, Dal Pra C, Mantero F, Zanchetta R. Аutoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: Autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev. 2002;23(3):327-64. DOI:10.1210/edrv.23.3.0466
17. Troshina EA, Larina AA, Terekhova MA. Polyglandular autoimmune syndrome in adults: Molecular genetic and clinical characteristics (lecture). Consilium Medicum. 2019;21(4):91-6 (in Russian). DOI:10.26442/20751753.2019.4.190361
18. Savvateeva EN, Yukina MY, Nuralieva NF, et al. Multiplex autoantibody detection in patients with autoimmune polyglandular syndromes. Int J Mol Sci. 2021;22(11):5502. DOI:10.3390/ijms22115502
19. Betterle C, Sabbadin C, Scaroni C, Presotto F. Autoimmune polyendocrine syndromes (APS) or multiple autoimmune syndromes (MAS). In: Colao A, Jaffrain-Rea ML, Beckers A. (eds). Polyendocrine Disorders and Endocrine Neoplastic Syndromes. Endocrinology. Springer, Cham., 2019. DOI:10.1007/978-3-319-73082-0_1-1
20. Larina AA, Troshina EA, Yukina MYu. A clinical case of type 2 familial polyglandular autoimmune syndrome. Doctor.Ru. 2019;10(165):63-5 (in Russian).
DOI:10.31550/1727-2378-2019-165-10-63-65
21. Koizumi S, Kamisawa T, Kuruma S, et al. Organ correlation in IgG4-related diseases. J Korean Med Sci. 2015;30(6):743-8. DOI:10.3346/jkms.2015.30.6.743
22. Takeshima K, Li Y, Kakudo K, et al. Proposal of diagnostic criteria for IgG4-related thyroid disease. Endocr J. 2021;68(1):1-6. DOI:10.1507/endocrj.EJ20-0557
23. Tywanek E, Michalak A, Świrska J, Zwolak A. Autoimmunity, new potential biomarkers and the thyroid gland – The perspective of Hashimoto's thyroiditis and its treatment. Int J Mol Sci. 2024;25(9):4703. DOI:10.3390/ijms25094703
24. Endokrinologiia i sistemnye zabolevaniia. Pod red. P Portinkasy, G Friubek, KhM Natkho; per. s angl. pod red. EA Troshinoi. Moscow: GEOTAR-Media, 2023 (in Russian).
25. Bai MF, Gao CY, Yang CK, et al. Effects of thyroid dysfunction on the severity of coronary artery lesions and its prognosis. J Cardiol. 2014;64(6):496-500. DOI:10.1016/j.jjcc.2014.03.009
26. Panevin TS, Zotkin EG, Troshina EA. Autoimmune polyendocrine syndrome in adults. Focus on rheumatological aspects of the problem: A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2023;95(10):881-7 (in Russian). DOI:10.26442/00403660.2023.10.202484
27. Girón-Pïllado M, Cruz-Bautista I, Saavedra-González V, et al. Autoimmune thyroid disease in primary Sjögren's syndrome: Real-life screening practice and clinical outcomes. Curr Rheumatol Rev. 2022;18(3):272-7. DOI:10.2174/1573397118666220127105546
28. Luo W, Mao P, Zhang L, Yang Z. Association between systemic lupus erythematosus and thyroid dysfunction: A meta-analysis. Lupus. 2018;27(13):2120-8. DOI:10.1177/0961203318805849
29. Gordon T, Isenberg D. The endocrinologic associations of the autoimmune rheumatic diseases. Semin Arthritis Rheum. 1987;17(1):58-70. DOI:10.1016/0049-0172(87)90016-3
30. Posselt RT, Coelho VN, Pigozzo DC, et al. Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study. Sao Paulo Med J. 2017;135(6):535-40. DOI:10.1590/1516-3180.2017.0089110617
31. Husebye ES, Anderson MS, Kämpe O. Autoimmune polyendocrine syndromes. N Engl J Med. 2018;378(12):1132-41. DOI:10.1056/NEJMra1713301
32. Nagayama Y. Thyroid autoimmunity and thyroid cancer – The pathogenic connection: A 2018 update. Horm Metab Res. 2018;50(12):922-31. DOI:10.1055/a-0648-4593
33. Ferrari SM, Fallahi P, Galdiero MR, et al. Immune and inflammatory cells in thyroid cancer microenvironment. Int J Mol Sci. 2019;20(18):4413. DOI:10.3390/ijms20184413
34. Bergdorf K, Ferguson DC, Mehrad M, et al. Papillary thyroid carcinoma beh * avior: Clues in the tumor microenvironment. Endocr Relat Cancer. 2019;26(6):601-14.
DOI:10.1530/ERC-19-0074
35. Kim M, Kim TH, Shin DY, et al.; Korean Thyroid Cancer Study Group (KTCSG). Tertiary care experience of Sorafenib in the treatment of progressive radioiodine-refractory differentiated thyroid carcinoma: A Korean multicenter study. Thyroid. 2018;28(3):340-8. DOI:10.1089/thy.2017.0356 [Correction to: Thyroid. 2018;28(5):686. DOI:10.1089/thy.2017.0356.correx].
36. Na KJ, Choi H. Immune landscape of papillary thyroidcancer and immunotherapeutic implications. Endocr Relat Cancer. 2018;25(5):523-31. DOI:10.1530/ERC-17-0532
37. Troshina EA, Platonova NM, Abdulkhabirova FM, Gerasimov GA. Iododefitsitnye zabolevaniia v Rossiiskoi Federatsii: vremia priniatiia reshenii. Pod red. II Dedova, GA Mel'nichenko. Moscow: Konti-Print, 2012 (in Russian).
38. Troshina EA, Platonova NM, Panfilova EA. Dynamics of epidemiological indicators of thyroid pathology in the population of the Russian Federation: analytical report for the period 2009–2018. Problems of Endocrinology. 2021;67(2):10-9 (in Russian). DOI:10.14341/probl12433
39. Yilmaz D, Baykan O, Baykan H. The frequency of thyroid dysfunction in patients with a diagnosis of depressive disorder. Niger J Clin Pract. 2023;26(10):1575-8. DOI:10.4103/njcp.njcp_72_23
40. Troshina EA, Platonova NM, Suplotova LA, et al. Defitsit ioda i assotsiirovannye s nim zabolevaniia. Pod obshch. red. GA Mel'nichenko, EA Troshinoi. Moscow: GEOTAR-Media, 2024 (in Russian).
41. Vargas-Uricoechea H. Molecular mechanisms in autoimmune thyroid disease. Cells. 2023;12(6):918. DOI:10.3390/cells12060918
42. Dedov II, Platonova NM, Troshina EA, et al. Prevention of iodine deficiency diseases: regional target programs are in focus. Problems of Endocrinology. 2022;68(3):16-20 (in Russian). DOI:10.14341/probl13119
43. Gerasimov GA. The program for the elimination of IDZ in Russia needs legislative support. Finance, Law, Management. 2004;9:30-2 (in Russian).
2. Betterle C, Furmaniak J, Sabbadin C, et al. Type 3 autoimmune polyglandular syndrome (APS-3) or type 3 multiple autoimmune syndrome (MAS-3): An expanding galaxy. J Endocrinol Invest. 2023;46(4):643-65. DOI:10.1007/s40618-022-01994-1
3. Tomer Y, Huber A. The etiology of autoimmune thyroid disease: A story of genes and environment. J Autoimmun. 2009;32(3-4):231-9. DOI:10.1016/j.jaut.2009.02.007
4. Tańska K, Gietka-Czernel M, Glinicki P, Kozakowski J. Thyroid autoimmunity and its negative impact on female fertility and maternal pregnancy outcomes. Front Endocrinol (Lausanne). 2023;13:1049665. DOI:10.3389/fendo.2022.1049665
5. Chiovato L, Magri F, Carlé A. Hypothyroidism in context: Where we’ve been and where we’re going. Adv Ther. 2019;36(Suppl. 2):47-58. DOI:0.1007/s12325-019-01080-8
6. Dos Santos Valsecchi VA, Betoni FR, Ward LS, et al. Clinical and molecular impact of concurrent thyroid autoimmune disease and thyroid cancer: From the bench to bedside. Rev Endocr Metab Disord. 2024;25(1):5-17. DOI:10.1007/s11154-023-09846-w
7. Eschler DC, Hasham A, Tomer Y. Cutting edge: The etiology of autoimmune thyroid diseases. Clin Rev Allergy Immunol. 2011;41(2):190-7. DOI:10.1007/s12016-010-8245-8
8. Sterenborg RBTM, Steinbrenner I, Li Y, et al. Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications. Nat Commun. 2024;15(1):888. DOI:10.1038/s41467-024-44701-9
9. Lee HJ, Stefan-Lifshitz M, Li CW, Tomer Y. Genetics and epigenetics of autoimmune thyroid diseases: Translational implications. Best Pract Res Clin Endocrinol Metab. 2023;37(2):101661. DOI:10.1016/j.beem.2022.101661
10. Трошина Е.А., Никонова Т.В., Свитич О.А., Юкина М.Ю. Аутоиммунный полигляндулярный синдром взрослых. Под ред. И.И. Дедова, Е.А. Трошиной. М.: ГЭОТАР-Медиа, 2019 [Troshina EA, Nikonova TV, Svitich OA, Iukina MIu. Autoimmunnyi poliglianduliarnyi sindrom vzroslykh. Pod red. II Dedova, EA Troshinoi. Moscow: GEOTAR-Media, 2019 (in Russian)].
11. Лабораторная диагностика. Под ред. Е.А. Кондрашевой, А.Ю. Островского. М.: Медиздат, 2018 [Laboratornaia diagnostika. Pod red. EA Kondrashevoi, AIu Ostrovskogo. Moscow: Medizdat, 2018 (in Russian)].
12. Morita S, Arima T, Matsuda M. Prevalence of nonthyroid specific autoantibodies in autoimmune thyroid diseases. J Clin Endocrinol Metab. 1995;80(4):1203-6. DOI:10.1210/jcem.80.4.7714090
13. Трошина Е.А. Хронический аутоиммунный тиреоидит – «сигнальное заболевание» в составе мультиорганного аутоиммунного синдрома. Проблемы эндокринологии. 2023;69(4):4-10 [Troshina EA. Chronic autoimmune thyroiditis is a "signal disease" in the multiorgan autoimmune syndrome. Problems of Endocrinology. 2023;69(4):4-10 (in Russian)]. DOI:10.14341/probl13361
14. Betterle C, Zanchetta R. Update on autoimmune polyendocrine syndromes (APS). Acta Biomed. 2003;74(1):9-33. PMID:12817789
15. Kahaly JG. Polyglandular autoimmune syndromes. Eur J Endocrinol. 2009;161(1):11-20. DOI:10.1530/EJE-09-0044
16. Betterle C, Dal Pra C, Mantero F, Zanchetta R. Аutoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: Autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev. 2002;23(3):327-64. DOI:10.1210/edrv.23.3.0466
17. Трошина Е.А., Ларина А.А., Терехова М.А. Аутоиммунный полигландулярный синдром взрослых: молекулярно-генетические и клинические характеристики (лекция). Consilium Medicum. 2019;21(4):91-6 [Troshina EA, Larina AA, Terekhova MA. Polyglandular autoimmune syndrome in adults: Molecular genetic and clinical characteristics (lecture). Consilium Medicum. 2019;21(4):91-6 (in Russian)]. DOI:10.26442/20751753.2019.4.190361
18. Savvateeva EN, Yukina MY, Nuralieva NF, et al. Multiplex autoantibody detection in patients with autoimmune polyglandular syndromes. Int J Mol Sci. 2021;22(11):5502. DOI:10.3390/ijms22115502
19. Betterle C, Sabbadin C, Scaroni C, Presotto F. Autoimmune polyendocrine syndromes (APS) or multiple autoimmune syndromes (MAS). In: Colao A, Jaffrain-Rea ML, Beckers A. (eds). Polyendocrine Disorders and Endocrine Neoplastic Syndromes. Endocrinology. Springer, Cham., 2019. DOI:10.1007/978-3-319-73082-0_1-1
20. Ларина А.А., Трошина Е.А., Юкина М.Ю. Семейные формы аутоиммунного полигландулярного синдрома 2-го типа: клинический случай. Доктор.Ру. 2019;10(165):63-5 [Larina AA, Troshina EA, Yukina MYu. A clinical case of type 2 familial polyglandular autoimmune syndrome. Doctor.Ru. 2019;10(165):63-5 (in Russian)].
DOI:10.31550/1727-2378-2019-165-10-63-65
21. Koizumi S, Kamisawa T, Kuruma S, et al. Organ correlation in IgG4-related diseases. J Korean Med Sci. 2015;30(6):743-8. DOI:10.3346/jkms.2015.30.6.743
22. Takeshima K, Li Y, Kakudo K, et al. Proposal of diagnostic criteria for IgG4-related thyroid disease. Endocr J. 2021;68(1):1-6. DOI:10.1507/endocrj.EJ20-0557
23. Tywanek E, Michalak A, Świrska J, Zwolak A. Autoimmunity, new potential biomarkers and the thyroid gland – The perspective of Hashimoto's thyroiditis and its treatment. Int J Mol Sci. 2024;25(9):4703. DOI:10.3390/ijms25094703
24. Эндокринология и системные заболевания. Под ред. П. Портинкасы, Г. Фрюбек, Х.М. Натхо; пер. с англ. под ред. Е.А. Трошиной. М.: ГЭОТАР-Медиа, 2023 [Endokrinologiia i sistemnye zabolevaniia. Pod red. P Portinkasy, G Friubek, KhM Natkho; per. s angl. pod red. EA Troshinoi. Moscow: GEOTAR-Media, 2023 (in Russian)].
25. Bai MF, Gao CY, Yang CK, et al. Effects of thyroid dysfunction on the severity of coronary artery lesions and its prognosis. J Cardiol. 2014;64(6):496-500. DOI:10.1016/j.jjcc.2014.03.009
26. Паневин Т.С., Зоткин Е.Г., Трошина Е.А. Аутоиммунный полиэндокринный синдром взрослых. Фокус на ревматологические аспекты проблемы. Терапевтический архив. 2023;95(10):881-7 [Panevin TS, Zotkin EG, Troshina EA. Autoimmune polyendocrine syndrome in adults. Focus on rheumatological aspects of the problem: A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2023;95(10):881-7 (in Russian)]. DOI:10.26442/00403660.2023.10.202484
27. Girón-Pïllado M, Cruz-Bautista I, Saavedra-González V, et al. Autoimmune thyroid disease in primary Sjögren's syndrome: Real-life screening practice and clinical outcomes. Curr Rheumatol Rev. 2022;18(3):272-7. DOI:10.2174/1573397118666220127105546
28. Luo W, Mao P, Zhang L, Yang Z. Association between systemic lupus erythematosus and thyroid dysfunction: A meta-analysis. Lupus. 2018;27(13):2120-8. DOI:10.1177/0961203318805849
29. Gordon T, Isenberg D. The endocrinologic associations of the autoimmune rheumatic diseases. Semin Arthritis Rheum. 1987;17(1):58-70. DOI:10.1016/0049-0172(87)90016-3
30. Posselt RT, Coelho VN, Pigozzo DC, et al. Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study. Sao Paulo Med J. 2017;135(6):535-40. DOI:10.1590/1516-3180.2017.0089110617
31. Husebye ES, Anderson MS, Kämpe O. Autoimmune polyendocrine syndromes. N Engl J Med. 2018;378(12):1132-41. DOI:10.1056/NEJMra1713301
32. Nagayama Y. Thyroid autoimmunity and thyroid cancer – The pathogenic connection: A 2018 update. Horm Metab Res. 2018;50(12):922-31. DOI:10.1055/a-0648-4593
33. Ferrari SM, Fallahi P, Galdiero MR, et al. Immune and inflammatory cells in thyroid cancer microenvironment. Int J Mol Sci. 2019;20(18):4413. DOI:10.3390/ijms20184413
34. Bergdorf K, Ferguson DC, Mehrad M, et al. Papillary thyroid carcinoma beh * avior: Clues in the tumor microenvironment. Endocr Relat Cancer. 2019;26(6):601-14.
DOI:10.1530/ERC-19-0074
35. Kim M, Kim TH, Shin DY, et al.; Korean Thyroid Cancer Study Group (KTCSG). Tertiary care experience of Sorafenib in the treatment of progressive radioiodine-refractory differentiated thyroid carcinoma: A Korean multicenter study. Thyroid. 2018;28(3):340-8. DOI:10.1089/thy.2017.0356 [Correction to: Thyroid. 2018;28(5):686. DOI:10.1089/thy.2017.0356.correx].
36. Na KJ, Choi H. Immune landscape of papillary thyroidcancer and immunotherapeutic implications. Endocr Relat Cancer. 2018;25(5):523-31. DOI:10.1530/ERC-17-0532
37. Трошина Е.А., Платонова Н.М., Абдулхабирова Ф.М., Герасимов Г.А. Йододефицитные заболевания в Российской Федерации: время принятия решений. Под ред. И.И. Дедова, Г.А. Мельниченко. М.: Конти-Принт, 2012 [Troshina EA, Platonova NM, Abdulkhabirova FM, Gerasimov GA. Iododefitsitnye zabolevaniia v Rossiiskoi Federatsii: vremia priniatiia reshenii. Pod red. II Dedova, GA Mel'nichenko. Moscow: Konti-Print, 2012 (in Russian)].
38. Трошина Е.А., Платонова Н.М., Панфилова Е.А. Аналитический обзор результатов мониторинга основных эпидемиологических характеристик йододефицитных заболеваний у населения Российской Федерации за период 2009–2018 гг. Проблемы эндокринологии. 2021;67(2):10-9 [Troshina EA, Platonova NM, Panfilova EA. Dynamics of epidemiological indicators of thyroid pathology in the population of the Russian Federation: analytical report for the period 2009–2018. Problems of Endocrinology. 2021;67(2):10-9 (in Russian)]. DOI:10.14341/probl12433
39. Yilmaz D, Baykan O, Baykan H. The frequency of thyroid dysfunction in patients with a diagnosis of depressive disorder. Niger J Clin Pract. 2023;26(10):1575-8. DOI:10.4103/njcp.njcp_72_23
40. Трошина Е.А., Платонова Н.М., Суплотова Л.А., и др. Дефицит йода и ассоциированные с ним заболевания. Под общ. ред. Г.А. Мельниченко, Е.А. Трошиной. М.: ГЭОТАР-Медиа, 2024 [Troshina EA, Platonova NM, Suplotova LA, et al. Defitsit ioda i assotsiirovannye s nim zabolevaniia. Pod obshch. red. GA Mel'nichenko, EA Troshinoi. Moscow: GEOTAR-Media, 2024 (in Russian)].
41. Vargas-Uricoechea H. Molecular mechanisms in autoimmune thyroid disease. Cells. 2023;12(6):918. DOI:10.3390/cells12060918
42. Дедов И.И., Платонова Н.М., Трошина Е.А., и др. Профилактика йододефицитных заболеваний: в фокусе региональные целевые программы. Проблемы эндокринологии. 2022;68(3):16-20 [Dedov II, Platonova NM, Troshina EA, et al. Prevention of iodine deficiency diseases: regional target programs are in focus. Problems of Endocrinology.
2022;68(3):16-20 (in Russian)]. DOI:10.14341/probl13119
43. Герасимов Г.А. Программа устранения ЙДЗ в России нуждается в законодательной поддержке. Финансы, право, менеджмент. 2004;9:30-2 [Gerasimov GA. The program for the elimination of IDZ in Russia needs legislative support. Finance, Law, Management. 2004;9:30-2 (in Russian)].
________________________________________________
2. Betterle C, Furmaniak J, Sabbadin C, et al. Type 3 autoimmune polyglandular syndrome (APS-3) or type 3 multiple autoimmune syndrome (MAS-3): An expanding galaxy. J Endocrinol Invest. 2023;46(4):643-65. DOI:10.1007/s40618-022-01994-1
3. Tomer Y, Huber A. The etiology of autoimmune thyroid disease: A story of genes and environment. J Autoimmun. 2009;32(3-4):231-9. DOI:10.1016/j.jaut.2009.02.007
4. Tańska K, Gietka-Czernel M, Glinicki P, Kozakowski J. Thyroid autoimmunity and its negative impact on female fertility and maternal pregnancy outcomes. Front Endocrinol (Lausanne). 2023;13:1049665. DOI:10.3389/fendo.2022.1049665
5. Chiovato L, Magri F, Carlé A. Hypothyroidism in context: Where we’ve been and where we’re going. Adv Ther. 2019;36(Suppl. 2):47-58. DOI:0.1007/s12325-019-01080-8
6. Dos Santos Valsecchi VA, Betoni FR, Ward LS, et al. Clinical and molecular impact of concurrent thyroid autoimmune disease and thyroid cancer: From the bench to bedside. Rev Endocr Metab Disord. 2024;25(1):5-17. DOI:10.1007/s11154-023-09846-w
7. Eschler DC, Hasham A, Tomer Y. Cutting edge: The etiology of autoimmune thyroid diseases. Clin Rev Allergy Immunol. 2011;41(2):190-7. DOI:10.1007/s12016-010-8245-8
8. Sterenborg RBTM, Steinbrenner I, Li Y, et al. Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications. Nat Commun. 2024;15(1):888. DOI:10.1038/s41467-024-44701-9
9. Lee HJ, Stefan-Lifshitz M, Li CW, Tomer Y. Genetics and epigenetics of autoimmune thyroid diseases: Translational implications. Best Pract Res Clin Endocrinol Metab. 2023;37(2):101661. DOI:10.1016/j.beem.2022.101661
10. Troshina EA, Nikonova TV, Svitich OA, Iukina MIu. Autoimmunnyi poliglianduliarnyi sindrom vzroslykh. Pod red. II Dedova, EA Troshinoi. Moscow: GEOTAR-Media, 2019 (in Russian).
11. Laboratornaia diagnostika. Pod red. EA Kondrashevoi, AIu Ostrovskogo. Moscow: Medizdat, 2018 (in Russian).
12. Morita S, Arima T, Matsuda M. Prevalence of nonthyroid specific autoantibodies in autoimmune thyroid diseases. J Clin Endocrinol Metab. 1995;80(4):1203-6. DOI:10.1210/jcem.80.4.7714090
13. Troshina EA. Chronic autoimmune thyroiditis is a "signal disease" in the multiorgan autoimmune syndrome. Problems of Endocrinology. 2023;69(4):4-10 (in Russian). DOI:10.14341/probl13361
14. Betterle C, Zanchetta R. Update on autoimmune polyendocrine syndromes (APS). Acta Biomed. 2003;74(1):9-33. PMID:12817789
15. Kahaly JG. Polyglandular autoimmune syndromes. Eur J Endocrinol. 2009;161(1):11-20. DOI:10.1530/EJE-09-0044
16. Betterle C, Dal Pra C, Mantero F, Zanchetta R. Аutoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: Autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev. 2002;23(3):327-64. DOI:10.1210/edrv.23.3.0466
17. Troshina EA, Larina AA, Terekhova MA. Polyglandular autoimmune syndrome in adults: Molecular genetic and clinical characteristics (lecture). Consilium Medicum. 2019;21(4):91-6 (in Russian). DOI:10.26442/20751753.2019.4.190361
18. Savvateeva EN, Yukina MY, Nuralieva NF, et al. Multiplex autoantibody detection in patients with autoimmune polyglandular syndromes. Int J Mol Sci. 2021;22(11):5502. DOI:10.3390/ijms22115502
19. Betterle C, Sabbadin C, Scaroni C, Presotto F. Autoimmune polyendocrine syndromes (APS) or multiple autoimmune syndromes (MAS). In: Colao A, Jaffrain-Rea ML, Beckers A. (eds). Polyendocrine Disorders and Endocrine Neoplastic Syndromes. Endocrinology. Springer, Cham., 2019. DOI:10.1007/978-3-319-73082-0_1-1
20. Larina AA, Troshina EA, Yukina MYu. A clinical case of type 2 familial polyglandular autoimmune syndrome. Doctor.Ru. 2019;10(165):63-5 (in Russian).
DOI:10.31550/1727-2378-2019-165-10-63-65
21. Koizumi S, Kamisawa T, Kuruma S, et al. Organ correlation in IgG4-related diseases. J Korean Med Sci. 2015;30(6):743-8. DOI:10.3346/jkms.2015.30.6.743
22. Takeshima K, Li Y, Kakudo K, et al. Proposal of diagnostic criteria for IgG4-related thyroid disease. Endocr J. 2021;68(1):1-6. DOI:10.1507/endocrj.EJ20-0557
23. Tywanek E, Michalak A, Świrska J, Zwolak A. Autoimmunity, new potential biomarkers and the thyroid gland – The perspective of Hashimoto's thyroiditis and its treatment. Int J Mol Sci. 2024;25(9):4703. DOI:10.3390/ijms25094703
24. Endokrinologiia i sistemnye zabolevaniia. Pod red. P Portinkasy, G Friubek, KhM Natkho; per. s angl. pod red. EA Troshinoi. Moscow: GEOTAR-Media, 2023 (in Russian).
25. Bai MF, Gao CY, Yang CK, et al. Effects of thyroid dysfunction on the severity of coronary artery lesions and its prognosis. J Cardiol. 2014;64(6):496-500. DOI:10.1016/j.jjcc.2014.03.009
26. Panevin TS, Zotkin EG, Troshina EA. Autoimmune polyendocrine syndrome in adults. Focus on rheumatological aspects of the problem: A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2023;95(10):881-7 (in Russian). DOI:10.26442/00403660.2023.10.202484
27. Girón-Pïllado M, Cruz-Bautista I, Saavedra-González V, et al. Autoimmune thyroid disease in primary Sjögren's syndrome: Real-life screening practice and clinical outcomes. Curr Rheumatol Rev. 2022;18(3):272-7. DOI:10.2174/1573397118666220127105546
28. Luo W, Mao P, Zhang L, Yang Z. Association between systemic lupus erythematosus and thyroid dysfunction: A meta-analysis. Lupus. 2018;27(13):2120-8. DOI:10.1177/0961203318805849
29. Gordon T, Isenberg D. The endocrinologic associations of the autoimmune rheumatic diseases. Semin Arthritis Rheum. 1987;17(1):58-70. DOI:10.1016/0049-0172(87)90016-3
30. Posselt RT, Coelho VN, Pigozzo DC, et al. Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study. Sao Paulo Med J. 2017;135(6):535-40. DOI:10.1590/1516-3180.2017.0089110617
31. Husebye ES, Anderson MS, Kämpe O. Autoimmune polyendocrine syndromes. N Engl J Med. 2018;378(12):1132-41. DOI:10.1056/NEJMra1713301
32. Nagayama Y. Thyroid autoimmunity and thyroid cancer – The pathogenic connection: A 2018 update. Horm Metab Res. 2018;50(12):922-31. DOI:10.1055/a-0648-4593
33. Ferrari SM, Fallahi P, Galdiero MR, et al. Immune and inflammatory cells in thyroid cancer microenvironment. Int J Mol Sci. 2019;20(18):4413. DOI:10.3390/ijms20184413
34. Bergdorf K, Ferguson DC, Mehrad M, et al. Papillary thyroid carcinoma beh * avior: Clues in the tumor microenvironment. Endocr Relat Cancer. 2019;26(6):601-14.
DOI:10.1530/ERC-19-0074
35. Kim M, Kim TH, Shin DY, et al.; Korean Thyroid Cancer Study Group (KTCSG). Tertiary care experience of Sorafenib in the treatment of progressive radioiodine-refractory differentiated thyroid carcinoma: A Korean multicenter study. Thyroid. 2018;28(3):340-8. DOI:10.1089/thy.2017.0356 [Correction to: Thyroid. 2018;28(5):686. DOI:10.1089/thy.2017.0356.correx].
36. Na KJ, Choi H. Immune landscape of papillary thyroidcancer and immunotherapeutic implications. Endocr Relat Cancer. 2018;25(5):523-31. DOI:10.1530/ERC-17-0532
37. Troshina EA, Platonova NM, Abdulkhabirova FM, Gerasimov GA. Iododefitsitnye zabolevaniia v Rossiiskoi Federatsii: vremia priniatiia reshenii. Pod red. II Dedova, GA Mel'nichenko. Moscow: Konti-Print, 2012 (in Russian).
38. Troshina EA, Platonova NM, Panfilova EA. Dynamics of epidemiological indicators of thyroid pathology in the population of the Russian Federation: analytical report for the period 2009–2018. Problems of Endocrinology. 2021;67(2):10-9 (in Russian). DOI:10.14341/probl12433
39. Yilmaz D, Baykan O, Baykan H. The frequency of thyroid dysfunction in patients with a diagnosis of depressive disorder. Niger J Clin Pract. 2023;26(10):1575-8. DOI:10.4103/njcp.njcp_72_23
40. Troshina EA, Platonova NM, Suplotova LA, et al. Defitsit ioda i assotsiirovannye s nim zabolevaniia. Pod obshch. red. GA Mel'nichenko, EA Troshinoi. Moscow: GEOTAR-Media, 2024 (in Russian).
41. Vargas-Uricoechea H. Molecular mechanisms in autoimmune thyroid disease. Cells. 2023;12(6):918. DOI:10.3390/cells12060918
42. Dedov II, Platonova NM, Troshina EA, et al. Prevention of iodine deficiency diseases: regional target programs are in focus. Problems of Endocrinology. 2022;68(3):16-20 (in Russian). DOI:10.14341/probl13119
43. Gerasimov GA. The program for the elimination of IDZ in Russia needs legislative support. Finance, Law, Management. 2004;9:30-2 (in Russian).
Авторы
Е.А. Трошина*
ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России, Москва, Россия
*troshina@inbox.ru
Endocrinology Research Center, Moscow, Russia
*troshina@inbox.ru
ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России, Москва, Россия
*troshina@inbox.ru
________________________________________________
Endocrinology Research Center, Moscow, Russia
*troshina@inbox.ru
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