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Факторы риска развития СРК: что необходимо учитывать? - Журнал Терапевтический архив №2 Вопросы гастроэнтерологии 2024
Факторы риска развития СРК: что необходимо учитывать?
Гаус О.В., Ливзан М.А., Гавриленко Д.А. Факторы риска развития СРК: что необходимо учитывать? Терапевтический архив. 2024;96(2):159–167. DOI: 10.26442/00403660.2024.02.202597
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
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Аннотация
Синдром раздраженного кишечника (СРК) относится к числу самых распространенных заболеваний пищеварительного тракта из группы расстройств взаимодействия по оси «кишечник–мозг». Общепризнано негативное влияние СРК на качество жизни пациентов и значимое социально-экономическое бремя заболевания, обусловленное низкой эффективностью существующих лечебных стратегий, которые носят исключительно симптоматический характер без учета факторов и механизмов формирования нарушений функции кишечника. С этих позиций крайне актуальным представляется вопрос изучения факторов, способствующих развитию и персистенции симптомов СРК, для улучшения ранней диагностики заболевания и реализации технологии таргетной профилактики в группах риска. Цель публикации – систематизация данных об основных факторах риска СРК, включая наследственную предрасположенность, стресс и психоэмоциональное состояние, диету и пищевые привычки, перенесенные острые кишечные инфекции.
Ключевые слова: синдром раздраженного кишечника, факторы риска, наследственная предрасположенность, пищевые привычки, психологические факторы, острые кишечные инфекции, постинфекционный синдром раздраженного кишечника
Keywords: irritable bowel syndrome, risk factors, hereditary predisposition, eating habits, psychological factors, acute intestinal infections, post-infection irritable bowel syndrome
Ключевые слова: синдром раздраженного кишечника, факторы риска, наследственная предрасположенность, пищевые привычки, психологические факторы, острые кишечные инфекции, постинфекционный синдром раздраженного кишечника
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Keywords: irritable bowel syndrome, risk factors, hereditary predisposition, eating habits, psychological factors, acute intestinal infections, post-infection irritable bowel syndrome
Полный текст
Список литературы
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82. Bertz RJ, Granneman GR. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Clin Pharmacokinet. 1997;32(3):210-58. DOI:10.2165/00003088-199732030-00004
83. Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013;138(1):103-41. DOI:10.1016/j.pharmthera.2012.12.007
2. Oka P, Parr H, Barberio B, et al. Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2020;5(10):908-17. DOI:10.1016/S2468-1253(20)30217-X
3. Goodoory VC, Ng CE, Black CJ, Ford AC. Direct healthcare costs of Rome IV or Rome III-defined irritable bowel syndrome in the United Kingdom. Aliment Pharmacol Ther. 2022;56(1):110-20. DOI:10.1111/apt.16939
4. Маев И.В., Охлобыстина О.З., Халиф И.Л., Андреев Д.Н. Синдром раздраженного кишечника в Российской Федерации – результаты многоцентрового наблюдательного исследования ROMERUS. Терапевтический архив. 2023;95(1):38-51 [Maev IV, Okhlobystina OZ, Khalif IL, Andreev DN. Irritable bowel syndrome in the Russian Federation: results of the ROMERUS multicenter observational study. Terapevticheskii Arkhiv (Ter. Arkh.). 2023;95(1):38-51 (in Russian)]. DOI:10.26442/00403660.2023.01.202043
5. Гаус О.В., Ливзан М.А. Фенотипы синдрома раздраженного кишечника и стратегии пациентоориентированной курации больного. Лечащий Врач. 2023;7-8(26):36-44 [Gaus OV, Livzan MA. Phenotypes of irritable bowel syndrome and strategies for patient-oriented curation of patient. Lechaschi Vrach. 2023;7-8(26):36-44 (in Russian)]. DOI:10.51793/OS.2023.26.8.006
6. Saito YA, Petersen GM, Larson JJ, et al. Familial aggregation of irritable bowel syndrome: a family case-control study. Am J Gastroenterol. 2010;105(4):833-41. DOI:10.1038/ajg.2010.116
7. Waehrens R, Ohlsson H, Sundquist J, et al. Risk of irritable bowel syndrome in first-degree, second-degree and third-degree relatives of affected individuals: a nationwide family study in Sweden. Gut. 2015;64(2):215-21. DOI:10.1136/gutjnl-2013-305705
8. Bengtson MB, Rønning T, Vatn MH, Harris JR. Irritable bowel syndrome in twins: genes and environment. Gut. 2006;55(12):1754-9. DOI:10.1136/gut.2006.097287
9. Mohammed I, Cherkas LF, Riley SA, et al. Genetic influences in irritable bowel syndrome: a twin study. Am J Gastroenterol. 2005;100(6):1340-4. DOI:10.1111/j.1572-0241.2005.41700.x
10. Park JM, Choi MG, Park JA, et al. Serotonin transporter gene polymorphism and irritable bowel syndrome. Neurogastroenterol Motil. 2006;18(11):995-1000.
DOI:10.1111/j.1365-2982.2006.00829.x
11. Kumar S, Ranjan P, Mittal B, Ghoshal UC. Serotonin transporter gene (SLC6A4) polymorphism in patients with irritable bowel syndrome and healthy controls. J Gastrointestin Liver Dis. 2012;21(1):31-8.
12. Гаус О.В., Ливзан М.А. Генетические факторы и течение синдрома раздраженного кишечника: ассоциации и взаимосвязи. РМЖ. Медицинское обозрение.
2023;7(5):237-48 [Gaus OV, Livzan MA. Genetic factors and the course of irritable bowel syndrome: associations and interactions. Russian Medical Inquiry. 2023;7(5):237-48 (in Russian)]. DOI:10.32364/2587-6821-2023-7-5-1
13. Pata C, Erdal E, Yazc K, et al. Association of the -1438 G/A and 102 T/C polymorphism of the 5-Ht2A receptor gene with irritable bowel syndrome 5-Ht2A gene polymorphism in irritable bowel syndrome. J Clin Gastroenterol. 2004;38(7):561-6. DOI:10.1097/00004836-200408000-00005
14. Wang Y, Wu Z, Qiao H, Zhang Y. A genetic association study of single nucleotide polymorphisms in GNβ3 and COMT in elderly patients with irritable bowel syndrome. Med Sci Monit. 2014;20:1246-54. DOI:10.12659/MSM.890315
15. Karling P, Danielsson Å, Wikgren M, et al. The relationship between the val158met catechol-O-methyltransferase (COMT) polymorphism and irritable bowel syndrome. PLoS One. 2011;6(3):e18035. DOI:10.1371/journal.pone.0018035
16. Xiao QY, Fang XC, Li XQ, Fei GJ. Ethnic differences in genetic polymorphism associated with irritable bowel syndrome. World J Gastroenterol. 2020;26(17):2049-63. DOI:10.3748/wjg.v26.i17.2049
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Авторы
О.В. Гаус*, М.А. Ливзан, Д.А. Гавриленко
ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России, Омск, Россия
*gaus_olga@bk.ru
Omsk State Medical University, Omsk, Russia
*gaus_olga@bk.ru
ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России, Омск, Россия
*gaus_olga@bk.ru
________________________________________________
Omsk State Medical University, Omsk, Russia
*gaus_olga@bk.ru
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