1. Coradduzza D, Congiargiu A, Chen Z, et al. Ferroptosis and Senescence: A Systematic Review. Int J Mol Sci. 2023;24(4):3658. DOI:10.3390/ijms24043658
2. May M, Barlow D, Ibrahim R, Houseknecht KL. Mechanisms Underlying Antipsychotic-Induced NAFLD and Iron Dysregulation: A Multi-Omic Approach. Biomedicines. 2022;10(6):1225. DOI:10.3390/biomedicines10061225
3. Wang W, Knovich MA, Coffman LG, et al. Serum ferritin: Past, present and future. Biochim Biophys Acta. 2010;1800(8):760-9. DOI:10.1016/j.bbagen.2010.03.011
4. Ruscitti P, Di Benedetto P, Berardicurti O, et al. Pro-inflammatory properties of H-ferritin on human macrophages, ex vivo and in vitro observations. Sci Rep. 2020;10(1):12232. DOI:10.1038/s41598-020-69031-w
5. Каледа М.И., Федоров Е.С. Значение гиперферритинемии как диагностического и прогностического биомаркера. Современная ревматология. 2022;16(2):74-80 [Kaleda MI, Fedorov ES. Significance of hyperferritinemia as a diagnostic and prognostic biomarker. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2022;16(2):74-80 (in Russian)]. DOI:10.14412/1996-7012-2022-2-74-80
6. Fang X, Cai Z, Wang H, et al. Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis. Circ Res.
2020;127(4):486-501. DOI:10.1161/CIRCRESAHA.120.316509
7. Hagström H, Nasr P, Bottai M, et al. Elevated serum ferritin is associated with increased mortality in non-alcoholic fatty liver disease after 16 years of follow-up. Liver Int. 2016;36(11):1688-95. DOI:10.1111/liv.13144
8. Ellervik C, Marott JL, Tybjærg-Hansen A, et al. Total and cause-specific mortality by moderately and markedly increased ferritin concentrations: general population study and metaanalysis. Clin Chem. 2014;60(11):1419-28. DOI:10.1373/clinchem.2014.229013
9. Леонов С.В., Марусич Е.И., Громова О.А., и др. Антивозрастной эффект гидролизата плаценты человека. Доказательный стандарт. Терапия. 2017;4(14):130-8 [Leonov SV, Marusich YeI, Gromova OA, et al. Anti-aging effect of human placenta hydrolysate. Evidence-based standard. Therapy. 2017;4(14):130-8 (in Russian)].
10. Торшин И.Ю., Громова О.А., Тихонова О.В., Чучалин А.Г. О молекулярных механизмах воздействия пептидов стандартизированного гидролизата плаценты на функционирование митохондрий. Терапевтический архив. 2023;95(12):1133-40 [Torshin IY, Gromova OA, Tikhonova OV, Chuchalin AG. Molecular mechanisms of the effect of standardized placental hydrolysate peptides on mitochondria functioning. Terapevticheskii Arkhiv (Ter. Arkh.). 2023;95(12):1133-40 (in Russian)]. DOI:10.26442/00403660.2023.12.202494
11. Торшин И.Ю., Громова О.А., Чучалин А.Г. Профилактика и лечение COVID-19 с позиций постгеномного фармакологического анализа. Систематический компьютерный анализ 290 000 научных статей по COVID-19. Терапевтический архив. 2024;96(3):205-11 [Torshin IY, Gromova OA, Chuchalin AG. Prevention and treatment of COVID-19 based on post-genomic pharmacological analysis: Systematic computer analysis of 290,000 scientific articles on COVID-19. Terapevticheskii Arkhiv (Ter. Arkh.). 2024;96(3):205-11 (in Russian)]. DOI:10.26442/00403660.2024.03.202635
12. Torshin IYu. Sensing the change from molecular genetics to personalized medicine. New York: Nova Biomedical Books, 2009.
13. Vashisht AA, Zumbrennen KB, Huang X, et al. Control of iron homeostasis by an iron-regulated ubiquitin ligase. Science. 2009;326(5953):718-21. DOI:10.1126/science.1176333
14. D’Angiolella V, Donato V, Vijayakumar S, et al. SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature. 2010;466(7302):138-42. DOI:10.1038/nature09140
15. Rachez C, Gamble M, Chang CP, et al. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. Mol Cell Biol. 2000;20(8):2718-26. DOI:10.1128/MCB.20.8.2718-2726.2000
16. Gorla-Bajszczak A, Juge-Aubry C, Pernin A, et al. Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR. Mol Cell Endocrinol. 1999;147(1-2):37-47. DOI:10.1016/s0303-7207(98)00217-2
17. Sze SCW, Zhang L, Zhang S, et al. Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demonstration of an Intricate Mechanism. Int J Mol Sci. 2022;23(20). DOI:10.3390/ijms232012689
18. Ott C, König J, Höhn A, et al. Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts. Free Radic Biol Med. 2016;101:325-33. DOI:10.1016/j.freeradbiomed.2016.10.492
19. Kurz T, Gustafsson B, Brunk UT. Cell sensitivity to oxidative stress is influenced by ferritin autophagy. Free Radic Biol Med.
2011;50(11):1647-58. DOI:10.1016/j.freeradbiomed.2011.03.014
20. Oda K, Kikuchi E, Kuroda E, et al. Uric acid, ferritin and γ-glutamyltransferase can be informative in prediction of the oxidative stress. J Clin Biochem Nutr. 2019;64(2):124-8. DOI:10.3164/jcbn.18-23
21. Zhang J, Stanton DM, Nguyen XV, et al. Intrapallidal lipopolysaccharide injection increases iron and ferritin levels in glia of the rat substantia nigra and induces locomotor deficits. Neuroscience. 2005;135(3):829-38. DOI:10.1016/j.neuroscience.2005.06.049
22. Галкин К.А. Новые тренды в исследованиях возраста и старения в постпандемийный период (обзор исследований). Успехи геронтологии. 2023;36(3):284-91 [Galkin KA. New trends in age and aging research in the post-pandemic period (research overview). Advances in Gerontology. 2023;36(3):284-91 (in Russian)]. DOI:10.34922/AE.2023.36.3.001
23. Rasyid H, Sangkereng A, Harjianti T, Soetjipto AS. Impact of age to ferritin and neutrophil-lymphocyte ratio as biomarkers for intensive care requirement and mortality risk in COVID-19 patients in Makassar, Indonesia. Physiol Rep. 2021;9(10):e14876. DOI:10.14814/phy2.14876
24. Максимов В.А., Торшин И.Ю., Чучалин А.Г., и др. Эффективность и безопасность полипептидного препарата (Лаеннек) в терапии COVID-19. Экспериментальная и клиническая гастроэнтерология. 2020;(6):55-63 [Maksimov VA, Torshin IYu, Chuchalin AG, et al. The effectiveness and safety of a polypeptide drug (Laennec) for the treatment of COVID-19. Experimental and Clinical Gastroenterology. 2020;(6):55-63 (in Russian)]. DOI:10.31146/1682-8658-ecg-178-6-55-63
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48. Громова О.А., Торшин И.Ю., Максимов В.А., и др. Пептиды в составе препарата Лаеннек®, способствующие устранению гиперферритинемии и перегрузки железом. Фармакоэкономика. Современная фармакоэкономика и фармакоэпидемиология. 2020;13(4):413-25 [Gromova OA, Torshin IYu, Maksimov VA, et al. Peptides contained in the composition of Laennec that contribute to the treatment of hyperferritinemia and iron overload disorders. Farmakoekonomika. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(4):413-25 (in Russian)]. DOI:10.17749/2070-4909/farmakoekonomika.2020.070
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________________________________________________

1. Coradduzza D, Congiargiu A, Chen Z, et al. Ferroptosis and Senescence: A Systematic Review. Int J Mol Sci. 2023;24(4):3658. DOI:10.3390/ijms24043658
2. May M, Barlow D, Ibrahim R, Houseknecht KL. Mechanisms Underlying Antipsychotic-Induced NAFLD and Iron Dysregulation: A Multi-Omic Approach. Biomedicines. 2022;10(6):1225. DOI:10.3390/biomedicines10061225
3. Wang W, Knovich MA, Coffman LG, et al. Serum ferritin: Past, present and future. Biochim Biophys Acta. 2010;1800(8):760-9. DOI:10.1016/j.bbagen.2010.03.011
4. Ruscitti P, Di Benedetto P, Berardicurti O, et al. Pro-inflammatory properties of H-ferritin on human macrophages, ex vivo and in vitro observations. Sci Rep. 2020;10(1):12232. DOI:10.1038/s41598-020-69031-w
5. Kaleda MI, Fedorov ES. Significance of hyperferritinemia as a diagnostic and prognostic biomarker. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2022;16(2):74-80 (in Russian). DOI:10.14412/1996-7012-2022-2-74-80
6. Fang X, Cai Z, Wang H, et al. Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis. Circ Res.
2020;127(4):486-501. DOI:10.1161/CIRCRESAHA.120.316509
7. Hagström H, Nasr P, Bottai M, et al. Elevated serum ferritin is associated with increased mortality in non-alcoholic fatty liver disease after 16 years of follow-up. Liver Int. 2016;36(11):1688-95. DOI:10.1111/liv.13144
8. Ellervik C, Marott JL, Tybjærg-Hansen A, et al. Total and cause-specific mortality by moderately and markedly increased ferritin concentrations: general population study and metaanalysis. Clin Chem. 2014;60(11):1419-28. DOI:10.1373/clinchem.2014.229013
9. Leonov SV, Marusich YeI, Gromova OA, et al. Anti-aging effect of human placenta hydrolysate. Evidence-based standard. Therapy. 2017;4(14):130-8 (in Russian)]
10. Torshin IY, Gromova OA, Tikhonova OV, Chuchalin AG. Molecular mechanisms of the effect of standardized placental hydrolysate peptides on mitochondria functioning. Terapevticheskii Arkhiv (Ter. Arkh.). 2023;95(12):1133-40 (in Russian). DOI:10.26442/00403660.2023.12.202494
11. Torshin IY, Gromova OA, Chuchalin AG. Prevention and treatment of COVID-19 based on post-genomic pharmacological analysis: Systematic computer analysis of 290,000 scientific articles on COVID-19. Terapevticheskii Arkhiv (Ter. Arkh.). 2024;96(3):205-11 (in Russian). DOI:10.26442/00403660.2024.03.202635
12. Torshin IYu. Sensing the change from molecular genetics to personalized medicine. New York: Nova Biomedical Books, 2009.
13. Vashisht AA, Zumbrennen KB, Huang X, et al. Control of iron homeostasis by an iron-regulated ubiquitin ligase. Science. 2009;326(5953):718-21. DOI:10.1126/science.1176333
14. D’Angiolella V, Donato V, Vijayakumar S, et al. SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature. 2010;466(7302):138-42. DOI:10.1038/nature09140
15. Rachez C, Gamble M, Chang CP, et al. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. Mol Cell Biol. 2000;20(8):2718-26. DOI:10.1128/MCB.20.8.2718-2726.2000
16. Gorla-Bajszczak A, Juge-Aubry C, Pernin A, et al. Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR. Mol Cell Endocrinol. 1999;147(1-2):37-47. DOI:10.1016/s0303-7207(98)00217-2
17. Sze SCW, Zhang L, Zhang S, et al. Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demonstration of an Intricate Mechanism. Int J Mol Sci. 2022;23(20). DOI:10.3390/ijms232012689
18. Ott C, König J, Höhn A, et al. Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts. Free Radic Biol Med. 2016;101:325-33. DOI:10.1016/j.freeradbiomed.2016.10.492
19. Kurz T, Gustafsson B, Brunk UT. Cell sensitivity to oxidative stress is influenced by ferritin autophagy. Free Radic Biol Med.
2011;50(11):1647-58. DOI:10.1016/j.freeradbiomed.2011.03.014
20. Oda K, Kikuchi E, Kuroda E, et al. Uric acid, ferritin and γ-glutamyltransferase can be informative in prediction of the oxidative stress. J Clin Biochem Nutr. 2019;64(2):124-8. DOI:10.3164/jcbn.18-23
21. Zhang J, Stanton DM, Nguyen XV, et al. Intrapallidal lipopolysaccharide injection increases iron and ferritin levels in glia of the rat substantia nigra and induces locomotor deficits. Neuroscience. 2005;135(3):829-38. DOI:10.1016/j.neuroscience.2005.06.049
22. Galkin KA. New trends in age and aging research in the post-pandemic period (research overview). Advances in Gerontology. 2023;36(3):284-91 (in Russian). DOI:10.34922/AE.2023.36.3.001
23. Rasyid H, Sangkereng A, Harjianti T, Soetjipto AS. Impact of age to ferritin and neutrophil-lymphocyte ratio as biomarkers for intensive care requirement and mortality risk in COVID-19 patients in Makassar, Indonesia. Physiol Rep. 2021;9(10):e14876. DOI:10.14814/phy2.14876
24. Maksimov VA, Torshin IYu, Chuchalin AG, et al. The effectiveness and safety of a polypeptide drug (Laennec) for the treatment of COVID-19. Experimental and Clinical Gastroenterology. 2020;(6):55-63 (in Russian). DOI:10.31146/1682-8658-ecg-178-6-55-63
25. Torshin IYu, Gromova OA, Dibrova EA, et al. Peptides in the composition of Laennec that show antiviral effects in the therapy of atopic dermatitis and herpes infection. Russian Journal of Allergy. 2018;1:82-90 (in Russian).
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О.А. Громова*¹, И.Ю. Торшин¹, А.Г. Чучалин<sup>2

1</sup>Федеральный исследовательский центр «Информатика и управление» РАН, Москва, Россия;
²ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия
*unesco.gromova@gmail.com

________________________________________________

Olga A. Gromova*¹, Ivan Iu. Torshin¹, Alexander G. Chuchalin<sup>2

1</sup>Federal Research Center “Informatics and Control”, Moscow, Russia;
²Pirogov Russian National Research Medical University, Moscow, Russia
*unesco.gromova@gmail.com