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Распространенность и риск мальнутриции у пациентов с хроническим панкреатитом: систематический обзор и метаанализ - Журнал Терапевтический архив №2 Вопросы гастроэнтерологии 2025
Распространенность и риск мальнутриции у пациентов с хроническим панкреатитом: систематический обзор и метаанализ
Андреев Д.Н., Хурматуллина А.Р., Кучерявый Ю.А., Маев И.В. Распространенность и риск мальнутриции у пациентов с хроническим панкреатитом: систематический обзор и метаанализ. Терапевтический архив. 2025;97(2):185–192. DOI: 10.26442/00403660.2025.02.203192
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
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Аннотация
Цель. Систематизация данных о распространенности и риске мальнутриции у пациентов, страдающих хроническим панкреатитом (ХП).
Материалы и методы. В MEDLINE/PubMed, EMBASE, Cochrane, Google Scholar, Scopus и Российском индексе научного цитирования проведен поиск исследований, опубликованных в период с 1 января 1985 по 23 октября 2024 г. (включительно), на основе анализа названий и аннотаций статей в этих базах данных. Включали релевантные публикации в периодических рецензируемых изданиях на английском или русском языках; публикации с данными о частоте мальнутриции у пациентов с ХП и лиц контроля (при наличии); исследования на взрослой популяции пациентов с ХП; публикации с подробной описательной статистикой, позволяющей включить результирующие данные в метаанализ.
Результаты. В финальный анализ включено 13 исследований с участием 3812 человек (3401 пациент с ХП, 411 – лица контроля). Суммарная распространенность мальнутриции у пациентов с ХП составила 43,43% (95% доверительный интервал – ДИ 32,419–54,780), тогда как у лиц контроля – 10,843% (95% ДИ 1,360–27,698). При анализе ассоциативной связи в общем пуле исследований показан значительный риск развития мальнутриции у пациентов с ХП по сравнению с лицами контроля (относительный риск – ОР 3,635, 95% ДИ 1,409–9,373; p=0,008). При анализе использовали модель случайных эффектов, так как выявлена высокая гетерогенность между группами (I2=88,09%, 95% ДИ 74,76–94,38). Анализ исследований, в которых использовались только валидированные инструментальные методы диагностики мальнутриции (критерии Global Leadership Initiative on Malnutrition), показал, что суммарная распространенность мальнутриции составила 38,348% (95% ДИ 14,975–65,047) у пациентов с ХП и 12,22% (95% ДИ 5,985–67,238) – у лиц контроля.
Заключение. Настоящий метаанализ продемонстрировал, что мальнутриция является достаточно распространенным осложнением ХП и наблюдается примерно у 40% пациентов с данным воспалительным заболеванием поджелудочной железы. Современному клиницисту необходимо вовремя оценивать маркеры мальнутриции у пациента с ХП, а в случае их выявления обязательно корригировать с применением заместительной ферментной терапии.
Ключевые слова: хронический панкреатит, мальнутриция, трофологическая недостаточность, нутритивная недостаточность, экзокринная недостаточность поджелудочной железы, заместительная ферментная терапия
Materials and methods. MEDLINE/PubMed, EMBASE, Cochrane, Google Scholar, Scopus, and the Russian Science Citation Index were searched for studies published between January 1, 1985, and October 23, 2024 (inclusive) based on an analysis of the titles and abstracts of articles in these databases. The study included relevant publications in peer-reviewed periodicals in English or Russian, publications with data on the prevalence of malnutrition in patients with CP and control subjects (if any), studies on adult patients with CP, and publications with detailed descriptive statistics that allow using the data in the meta-analysis.
Results. The final analysis included 13 studies involving 3,812 subjects (3,401 patients with CP and 411 controls). The overall prevalence of malnutrition in patients with CP was 43.43% (95% confidence interval [CI] 32.419–54.780), whereas in controls, it was 10.843% (95% CI 1.360–27.698). When analyzing the association in the overall pool of studies, a significant risk of malnutrition in CP patients compared to controls was shown (relative risk [RR] 3.635, 95% CI 1.409–9.373; p=0.008). The analysis used a random effect model, as there was high heterogeneity between the groups (I2=88.09%, 95% CI 74.76–94.38). A review of studies that used only validated instrumental methods for the diagnosis of malnutrition (criteria of the Global Leadership Initiative on Malnutrition) showed a total prevalence of malnutrition of 38.348% (95% CI 14.975–65.047) in patients with CP and 12.22% (95% CI 5.985–67.238) in control subjects.
Conclusion. This meta-analysis demonstrated that malnutrition is a common complication of CP and occurs in approximately 40% of CP patients. A modern clinician should promptly assess malnutrition markers in a CP patient and correct them using enzyme replacement therapy if detected.
Keywords: chronic pancreatitis, malnutrition, protein-energy malnutrition, nutritional insufficiency, pancreatic exocrine insufficiency, enzyme replacement therapy
Материалы и методы. В MEDLINE/PubMed, EMBASE, Cochrane, Google Scholar, Scopus и Российском индексе научного цитирования проведен поиск исследований, опубликованных в период с 1 января 1985 по 23 октября 2024 г. (включительно), на основе анализа названий и аннотаций статей в этих базах данных. Включали релевантные публикации в периодических рецензируемых изданиях на английском или русском языках; публикации с данными о частоте мальнутриции у пациентов с ХП и лиц контроля (при наличии); исследования на взрослой популяции пациентов с ХП; публикации с подробной описательной статистикой, позволяющей включить результирующие данные в метаанализ.
Результаты. В финальный анализ включено 13 исследований с участием 3812 человек (3401 пациент с ХП, 411 – лица контроля). Суммарная распространенность мальнутриции у пациентов с ХП составила 43,43% (95% доверительный интервал – ДИ 32,419–54,780), тогда как у лиц контроля – 10,843% (95% ДИ 1,360–27,698). При анализе ассоциативной связи в общем пуле исследований показан значительный риск развития мальнутриции у пациентов с ХП по сравнению с лицами контроля (относительный риск – ОР 3,635, 95% ДИ 1,409–9,373; p=0,008). При анализе использовали модель случайных эффектов, так как выявлена высокая гетерогенность между группами (I2=88,09%, 95% ДИ 74,76–94,38). Анализ исследований, в которых использовались только валидированные инструментальные методы диагностики мальнутриции (критерии Global Leadership Initiative on Malnutrition), показал, что суммарная распространенность мальнутриции составила 38,348% (95% ДИ 14,975–65,047) у пациентов с ХП и 12,22% (95% ДИ 5,985–67,238) – у лиц контроля.
Заключение. Настоящий метаанализ продемонстрировал, что мальнутриция является достаточно распространенным осложнением ХП и наблюдается примерно у 40% пациентов с данным воспалительным заболеванием поджелудочной железы. Современному клиницисту необходимо вовремя оценивать маркеры мальнутриции у пациента с ХП, а в случае их выявления обязательно корригировать с применением заместительной ферментной терапии.
Ключевые слова: хронический панкреатит, мальнутриция, трофологическая недостаточность, нутритивная недостаточность, экзокринная недостаточность поджелудочной железы, заместительная ферментная терапия
________________________________________________
Materials and methods. MEDLINE/PubMed, EMBASE, Cochrane, Google Scholar, Scopus, and the Russian Science Citation Index were searched for studies published between January 1, 1985, and October 23, 2024 (inclusive) based on an analysis of the titles and abstracts of articles in these databases. The study included relevant publications in peer-reviewed periodicals in English or Russian, publications with data on the prevalence of malnutrition in patients with CP and control subjects (if any), studies on adult patients with CP, and publications with detailed descriptive statistics that allow using the data in the meta-analysis.
Results. The final analysis included 13 studies involving 3,812 subjects (3,401 patients with CP and 411 controls). The overall prevalence of malnutrition in patients with CP was 43.43% (95% confidence interval [CI] 32.419–54.780), whereas in controls, it was 10.843% (95% CI 1.360–27.698). When analyzing the association in the overall pool of studies, a significant risk of malnutrition in CP patients compared to controls was shown (relative risk [RR] 3.635, 95% CI 1.409–9.373; p=0.008). The analysis used a random effect model, as there was high heterogeneity between the groups (I2=88.09%, 95% CI 74.76–94.38). A review of studies that used only validated instrumental methods for the diagnosis of malnutrition (criteria of the Global Leadership Initiative on Malnutrition) showed a total prevalence of malnutrition of 38.348% (95% CI 14.975–65.047) in patients with CP and 12.22% (95% CI 5.985–67.238) in control subjects.
Conclusion. This meta-analysis demonstrated that malnutrition is a common complication of CP and occurs in approximately 40% of CP patients. A modern clinician should promptly assess malnutrition markers in a CP patient and correct them using enzyme replacement therapy if detected.
Keywords: chronic pancreatitis, malnutrition, protein-energy malnutrition, nutritional insufficiency, pancreatic exocrine insufficiency, enzyme replacement therapy
Полный текст
Список литературы
1. Löhr JM, Dominguez-Munoz E, Rosendahl J, et al.; HaPanEU/UEG Working Group. United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU). United European Gastroenterol J. 2017;5(2):153-99. DOI:10.1177/2050640616684695
2. Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16(3):175-84. DOI:10.1038/s41575-018-0087-5
3. Machicado JD, Amann ST, Anderson MA, et al. Quality of life in chronic pancreatitis is determined by constant pain, disability/unemployment, current smoking, and associated co-morbidities. Am J Gastroenterol. 2017;112(4):633-42. DOI:10.1038/ajg.2017.42
4. Seicean A, Grigorescu M, Tanţău M, et al. Pain in chronic pancreatitis: Assessment and relief through treatment. Rom J Gastroenterol. 2004;13(1):9-15. PMID:15054520
5. Ghodeif AO, Azer SA. Pancreatic Insufficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2024. Available at: https://www.ncbi.nlm.nih.gov/books/NBK555926/ Accessed: 05.09.2024.
6. Kucheryavyy YuA, Andreev DN. Nutritional status in patients with chronic pancreatitis. J Nutr Ther. 2014;3(3):122-3. DOI:10.6000/1929-5634.2014.03.03.3
7. Keller J, Layer P. Human pancreatic exocrine response to nutrients in health and disease. Gut. 2005;54 (Suppl. 6):vi1-28. DOI:10.1136/gut.2005.065946
8. Маев И.В., Кучерявый Ю.А. Современные подходы к диагностике и лечению хронического панкреатита. Клиническая медицина. 2013;91(9):10-6 [Maev IV, Kucheriavyi IuA. Modern approaches to diagnostics and treatment of chronic pancreatitis. Klinicheskaia Meditsina. 2013;91(9):10-6 (in Russian)].
9. Хатьков И.Е., Маев И.В., Абдулхаков С.Р. Российский консенсус по диагностике и лечению хронического панкреатита. Терапевтический архив. 2017;89(2):105-13 [Khatkov IE, Maev IV, Abdulkhakov SR, et al. The Russian consensus on the diagnosis and treatment of chronic pancreatitis. Terapevticheskii Arkhiv (Ter. Arkh.). 2017;89(2):105-13 (in Russian)]. DOI:10.17116/terarkh2017892105-113
10. Lainscak M, Farkas J, Frantal S, et al. Self-rated health, nutritional intake and mortality in adult hospitalized patients. Eur J Clin Invest. 2014;44(9):813-24. DOI:10.1111/eci.12300
11. Ramai D, Facciorusso A, Maida M, et al. Prevalence of osteopathy in chronic pancreatitis: A systematic review and meta-analysis. Clin Transl Gastroenterol. 2023;14(8):e00623. DOI:10.14309/ctg.0000000000000623
12. Маев И.В., Андреев Д.Н., Кучерявый Ю.А., Левченко А.И. Распространенность саркопении у пациентов с хроническим панкреатитом: метаанализ. Терапевтический архив. 2020;92(12):43-7 [Maev IV, Andreev DN, Kucheryavyy YuA, Levchenko AI. The prevalence of sarcopenia in patients with chronic pancreatitis: A meta-analysis. Terapevticheskii Arkhiv (Ter. Arkh.). 2020;92(12):43-7 (in Russian)]. DOI:10.26442/00403660.2020.12.200430
13. Андреев Д.Н., Маев И.В., Кучерявый Ю.А. Распространенность и риск переломов костей у пациентов с хроническим панкреатитом: метаанализ. Научно-практическая ревматология. 2021;59(1):56-61 [Andreev DN, Maev IV, Kucheryavyi YuA. Prevalence and risk of bone fractures in patients with chronic pancreatitis: Meta-analysis. Nauchno-Prakticheskaya Revmatologiya. 2021;59(1):56-61 (in Russian)]. DOI:10.47360/1995-4484-2021-56-61
14. Midha S, Singh N, Sachdev V, et al. Cause and effect relationship of malnutrition with idiopathic chronic pancreatitis: prospective case-control study. J Gastroenterol Hepatol. 2008;23(9):1378-83. DOI:10.1111/j.1440-1746.2008.05459.x
15. Singh S, Midha S, Singh N, et al. Dietary counseling versus dietary supplements for malnutrition in chronic pancreatitis: A randomized controlled trial. Clin Gastroenterol Hepatol. 2008;6(3):353-9. DOI:10.1016/j.cgh.2007.12.040
16. Sathiaraj E, Gupta S, Chutke M, et al. Malnutrition is not an etiological factor in the development of tropical pancreatitis – A case-control study of southern Indian patients. Trop Gastroenterol. 2010;31(3):169-74. PMID: 21560520
17. Regunath H, Shivakumar BM, Kurien A, et al. Anthropometric measurements of nutritional status in chronic pancreatitis in India: Comparison of tropical and alcoholic pancreatitis. Indian J Gastroenterol. 2011;30(2):78-83. DOI:10.1007/s12664-011-0093-9
18. Кучерявый Ю.А., Москалева А.Б., Свиридова А.В., и др. Нутритивный статус как фактор риска осложнений хронического панкреатита и развития панкреатической недостаточности. Экспериментальная и клиническая гастроэнтерология. 2012;7:10-6 [Kucheryavyy YuA, Moskaleva AB, Sviridova AV, et al. Nutritional status as a risk factor for complications of chronic pancreatitis and the development of pancreatic insufficiency. Experimental and Clinical Gastroenterology. 2012;7:10-6 (in Russian)].
19. Ильченко Л.Ю., Гаврилина Н.С., Никитин И.Г. Клинические варианты трофологического статуса у пациентов с хроническим панкреатитом. Альманах клинической медицины. 2019;47(6):518-24 [Ilchenko LYu, Gavrilina NS, Nikitin IG. Clinical types of nutritional status in patients with chronic pancreatitis. Almanac of Clinical Medicine. 2019;47(6):518-24 (in Russian)]. DOI:10.18786/2072-0505-2019-47-065
20. Bourne DM, White H, French JJ, Leeds JS. A retrospective cohort study of nutritional status, nutritional interventions and hospital admissions in patients with chronic pancreatitis managed at a tertiary referral centre. Clin Nutr ESPEN. 2021;43:290-5. DOI:10.1016/j.clnesp.2021.03.038
21. Casares CU, Zamalloa IG, Concejo FB, et al. Pancreatic exocrine insufficiency, diabetes mellitus and malnutrition in chronic pancreatitis: Data from the Basque-Navarrese registry of chronic pancreatitis (PAN-EUS). Pancreatology. 2022;22(3):e3. DOI:10.1016/j.pan.2022.02.012
22. Gopi S, Qamar S, Singh N, et al. Malnutrition by GLIM criteria in chronic pancreatitis: Prevalence, predictors, and its impact on quality of life. Pancreatology. 2022;22(3):367-73. DOI:10.1016/j.pan.2022.02.004
23. Thantry AN, Urooj A, Halumathigatta Nagappa D. Screening of malnutrition using Patient-Generated Subjective Global Assessment tool and hand muscle strength in subjects with pancreatitis. Chronic Dis Transl Med. 2022;8(4):314-21. DOI:10.1002/cdt3.48
24. Bannert K, Sautter LF, Wiese ML, et al. Analysis of ESPEN and GLIM algorithms reveals specific drivers for the diagnosis of malnutrition in patients with chronic gastrointestinal diseases. Nutrition. 2023;106:111887. DOI:10.1016/j.nut.2022.111887
25. Hettige C, Senavirathne A, Jayatissa R, Pathirana A. Nutritional assessment of patients with chronic pancreatitis: A single-center study. Clin Nutr ESPEN. 2023;54:514. DOI:10.1016/j.clnesp.2022.09.166
26. Bruns N, Meyer F, Rischmüller K, et al. Nutritional status in patients with chronic pancreatitis and liver cirrhosis is related to disease conditions and not dietary habits. Sci Rep. 2024;14(1):4700. DOI:10.1038/s41598-024-54998-7
27. Cederholm T, Jensen GL, Correia MITD, et al.; GLIM Core Leadership Committee, GLIM Working Group. GLIM criteria for the diagnosis of malnutrition – A consensus report from the global clinical nutrition community. J Cachexia Sarcopenia Muscle. 2019;10(1):207-17. DOI:10.1002/jcsm.12383
28. Jensen GL, Mirtallo J, Compher C, et al.; International Consensus Guideline Committee. Adult starvation and disease-related malnutrition: A proposal for etiology-based diagnosis in the clinical practice setting from the International Consensus Guideline Committee. JPEN J Parenter Enteral Nutr. 2010;34(2):156-9. DOI:10.1177/0148607110361910
29. Cederholm T, Barazzoni R, Austin P, et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr. 2017;36(1):49-64. DOI:10.1016/j.clnu.2016.09.004
30. Bhullar FA, Faghih M, Akshintala VS, et al.; P-QST Consortium. Prevalence of primary painless chronic pancreatitis: A systematic review and meta-analysis. Pancreatology. 2022;22(1):20-9. DOI:10.1016/j.pan.2021.11.006. Erratum in: Pancreatology. 2022;22(3):448. DOI:10.1016/j.pan.2022.03.003
31. Duggan SN, Conlon KC. A practical guide to the nutritional management of chronic pancreatitis. Pract Gastroenterol. 2013;118:24-32.
32. Chiavarini M, Ricciotti GM, Genga A, et al. Malnutrition-related health outcomes in older adults with hip fractures: A systematic review and meta-analysis. Nutrients. 2024;16(7):1069. DOI:10.3390/nu16071069
33. Bansal A, Gupta P, Singh H, et al. Gastrointestinal complications in acute and chronic pancreatitis. JGH Open. 2019;3(6):450-5. DOI:10.1002/jgh3.12185
34. Olesen SS, Büyükuslu A, Køhler M, et al. Sarcopenia associates with increased hospitalization rates and reduced survival in patients with chronic pancreatitis. Pancreatology. 2019;19(2):245-51. DOI:10.1016/j.pan.2019.01.006
35. Бидеева Т.В., Маев И.В., Кучерявый Ю.А., и др. Эффективность заместительной ферментной терапии с использованием микрокапсулированных препаратов панкреатина при коррекции нутритивного статуса у пациентов с хроническим панкреатитом: проспективное наблюдательное исследование. Терапевтический архив. 2020;92(1):30-5 [Bideeva TV, Maev IV, Kucheryavyy YA, et al. The effectiveness of pancreatic enzyme replacement therapy using microencapsulated pancreatin preparations in the correction of nutritional status in patients with chronic pancreatitis: a prospective observational study. Terapevticheskii Arkhiv (Ter. Arkh.). 2020;92(1):30-5 (in Russian)]. DOI:10.26442/00403660.2020.01.000488
36. Whitcomb DC, Buchner AM, Forsmark CE. AGA Clinical practice update on the epidemiology, evaluation, and management of exocrine pancreatic insufficiency: Expert review. Gastroenterology. 2023;165(5):1292-301. DOI:10.1053/j.gastro.2023.07.007
37. Gan C, Chen YH, Liu L, et al. Efficacy and safety of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: A meta-analysis. Oncotarget. 2017;8(55):94920-31. DOI:10.18632/oncotarget.21659
38. de la Iglesia-García D, Huang W, Szatmary P, et al.; NIHR Pancreas Biomedical Research Unit Patient Advisory Group. Efficacy of pancreatic enzyme replacement therapy in chronic pancreatitis: Systematic review and meta-analysis. Gut. 2017;66(8):1354-5. DOI:10.1136/gutjnl-2016-312529
39. Iglesia D, Avci B, Kiriukova M, et al. Pancreatic exocrine insufficiency and pancreatic enzyme replacement therapy in patients with advanced pancreatic cancer: A systematic review and meta-analysis. United European Gastroenterol J. 2020;8(9):1115-25. DOI:10.1177/2050640620938987
40. Хронический панкреатит. Клинические рекомендации. 2024. Режим доступа: https://cr.minzdrav.gov.ru/view-cr/273_4. Ссылка активна на 05.09.2024 [Khronicheskii pankreatit. Klinicheskie rekomendatsii. Available at: https://cr.minzdrav.gov.ru/view-cr/273_4. Accessed: 05.09.2024 (in Russian)].
41. Krishnamurty DM, Rabiee A, Jagannath SB, Andersen DK. Delayed release pancrelipase for treatment of pancreatic exocrine insufficiency associated with chronic pancreatitis. Ther Clin Risk Manag. 2009;5(3):507-20. DOI:10.2147/tcrm.s3196
42. Dominguez-Muñoz JE, Vujasinovic M, de la Iglesia D, et al.; European PEI Multidisciplinary Group. European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations. United European Gastroenterol J. 2025;13(1):125-72. DOI:10.1002/ueg2.12674
43. Maev IV, Kucheryavyy YA, Gubergrits NB, et al. Differences in in vitro properties of pancreatin preparations for pancreatic exocrine insufficiency as marketed in Russia and CIS. Drugs R D. 2020;20(4):369-76. DOI:10.1007/s40268-020-00326-z
2. Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16(3):175-84. DOI:10.1038/s41575-018-0087-5
3. Machicado JD, Amann ST, Anderson MA, et al. Quality of life in chronic pancreatitis is determined by constant pain, disability/unemployment, current smoking, and associated co-morbidities. Am J Gastroenterol. 2017;112(4):633-42. DOI:10.1038/ajg.2017.42
4. Seicean A, Grigorescu M, Tanţău M, et al. Pain in chronic pancreatitis: Assessment and relief through treatment. Rom J Gastroenterol. 2004;13(1):9-15. PMID:15054520
5. Ghodeif AO, Azer SA. Pancreatic Insufficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2024. Available at: https://www.ncbi.nlm.nih.gov/books/NBK555926/ Accessed: 05.09.2024.
6. Kucheryavyy YuA, Andreev DN. Nutritional status in patients with chronic pancreatitis. J Nutr Ther. 2014;3(3):122-3. DOI:10.6000/1929-5634.2014.03.03.3
7. Keller J, Layer P. Human pancreatic exocrine response to nutrients in health and disease. Gut. 2005;54 (Suppl. 6):vi1-28. DOI:10.1136/gut.2005.065946
8. Maev IV, Kucheriavyi IuA. Modern approaches to diagnostics and treatment of chronic pancreatitis. Klinicheskaia Meditsina. 2013;91(9):10-6 (in Russian).
9. Khatkov IE, Maev IV, Abdulkhakov SR, et al. The Russian consensus on the diagnosis and treatment of chronic pancreatitis. Terapevticheskii Arkhiv (Ter. Arkh.). 2017;89(2):105-13 (in Russian). DOI:10.17116/terarkh2017892105-113
10. Lainscak M, Farkas J, Frantal S, et al. Self-rated health, nutritional intake and mortality in adult hospitalized patients. Eur J Clin Invest. 2014;44(9):813-24. DOI:10.1111/eci.12300
11. Ramai D, Facciorusso A, Maida M, et al. Prevalence of osteopathy in chronic pancreatitis: A systematic review and meta-analysis. Clin Transl Gastroenterol. 2023;14(8):e00623. DOI:10.14309/ctg.0000000000000623
12. Maev IV, Andreev DN, Kucheryavyy YuA, Levchenko AI. The prevalence of sarcopenia in patients with chronic pancreatitis: A meta-analysis. Terapevticheskii Arkhiv (Ter. Arkh.). 2020;92(12):43-7 (in Russian). DOI:10.26442/00403660.2020.12.200430
13. Andreev DN, Maev IV, Kucheryavyi YuA. Prevalence and risk of bone fractures in patients with chronic pancreatitis: Meta-analysis. Nauchno-Prakticheskaya Revmatologiya. 2021;59(1):56-61 (in Russian). DOI:10.47360/1995-4484-2021-56-61
14. Midha S, Singh N, Sachdev V, et al. Cause and effect relationship of malnutrition with idiopathic chronic pancreatitis: prospective case-control study. J Gastroenterol Hepatol. 2008;23(9):1378-83. DOI:10.1111/j.1440-1746.2008.05459.x
15. Singh S, Midha S, Singh N, et al. Dietary counseling versus dietary supplements for malnutrition in chronic pancreatitis: A randomized controlled trial. Clin Gastroenterol Hepatol. 2008;6(3):353-9. DOI:10.1016/j.cgh.2007.12.040
16. Sathiaraj E, Gupta S, Chutke M, et al. Malnutrition is not an etiological factor in the development of tropical pancreatitis – A case-control study of southern Indian patients. Trop Gastroenterol. 2010;31(3):169-74. PMID: 21560520
17. Regunath H, Shivakumar BM, Kurien A, et al. Anthropometric measurements of nutritional status in chronic pancreatitis in India: Comparison of tropical and alcoholic pancreatitis. Indian J Gastroenterol. 2011;30(2):78-83. DOI:10.1007/s12664-011-0093-9
18. Kucheryavyy YuA, Moskaleva AB, Sviridova AV, et al. Nutritional status as a risk factor for complications of chronic pancreatitis and the development of pancreatic insufficiency. Experimental and Clinical Gastroenterology. 2012;7:10-6 (in Russian).
19. Ilchenko LYu, Gavrilina NS, Nikitin IG. Clinical types of nutritional status in patients with chronic pancreatitis. Almanac of Clinical Medicine. 2019;47(6):518-24 (in Russian). DOI:10.18786/2072-0505-2019-47-065
20. Bourne DM, White H, French JJ, Leeds JS. A retrospective cohort study of nutritional status, nutritional interventions and hospital admissions in patients with chronic pancreatitis managed at a tertiary referral centre. Clin Nutr ESPEN. 2021;43:290-5. DOI:10.1016/j.clnesp.2021.03.038
21. Casares CU, Zamalloa IG, Concejo FB, et al. Pancreatic exocrine insufficiency, diabetes mellitus and malnutrition in chronic pancreatitis: Data from the Basque-Navarrese registry of chronic pancreatitis (PAN-EUS). Pancreatology. 2022;22(3):e3. DOI:10.1016/j.pan.2022.02.012
22. Gopi S, Qamar S, Singh N, et al. Malnutrition by GLIM criteria in chronic pancreatitis: Prevalence, predictors, and its impact on quality of life. Pancreatology. 2022;22(3):367-73. DOI:10.1016/j.pan.2022.02.004
23. Thantry AN, Urooj A, Halumathigatta Nagappa D. Screening of malnutrition using Patient-Generated Subjective Global Assessment tool and hand muscle strength in subjects with pancreatitis. Chronic Dis Transl Med. 2022;8(4):314-21. DOI:10.1002/cdt3.48
24. Bannert K, Sautter LF, Wiese ML, et al. Analysis of ESPEN and GLIM algorithms reveals specific drivers for the diagnosis of malnutrition in patients with chronic gastrointestinal diseases. Nutrition. 2023;106:111887. DOI:10.1016/j.nut.2022.111887
25. Hettige C, Senavirathne A, Jayatissa R, Pathirana A. Nutritional assessment of patients with chronic pancreatitis: A single-center study. Clin Nutr ESPEN. 2023;54:514. DOI:10.1016/j.clnesp.2022.09.166
26. Bruns N, Meyer F, Rischmüller K, et al. Nutritional status in patients with chronic pancreatitis and liver cirrhosis is related to disease conditions and not dietary habits. Sci Rep. 2024;14(1):4700. DOI:10.1038/s41598-024-54998-7
27. Cederholm T, Jensen GL, Correia MITD, et al.; GLIM Core Leadership Committee, GLIM Working Group. GLIM criteria for the diagnosis of malnutrition – A consensus report from the global clinical nutrition community. J Cachexia Sarcopenia Muscle. 2019;10(1):207-17. DOI:10.1002/jcsm.12383
28. Jensen GL, Mirtallo J, Compher C, et al.; International Consensus Guideline Committee. Adult starvation and disease-related malnutrition: A proposal for etiology-based diagnosis in the clinical practice setting from the International Consensus Guideline Committee. JPEN J Parenter Enteral Nutr. 2010;34(2):156-9. DOI:10.1177/0148607110361910
29. Cederholm T, Barazzoni R, Austin P, et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr. 2017;36(1):49-64. DOI:10.1016/j.clnu.2016.09.004
30. Bhullar FA, Faghih M, Akshintala VS, et al.; P-QST Consortium. Prevalence of primary painless chronic pancreatitis: A systematic review and meta-analysis. Pancreatology. 2022;22(1):20-9. DOI:10.1016/j.pan.2021.11.006. Erratum in: Pancreatology. 2022;22(3):448. DOI:10.1016/j.pan.2022.03.003
31. Duggan SN, Conlon KC. A practical guide to the nutritional management of chronic pancreatitis. Pract Gastroenterol. 2013;118:24-32.
32. Chiavarini M, Ricciotti GM, Genga A, et al. Malnutrition-related health outcomes in older adults with hip fractures: A systematic review and meta-analysis. Nutrients. 2024;16(7):1069. DOI:10.3390/nu16071069
33. Bansal A, Gupta P, Singh H, et al. Gastrointestinal complications in acute and chronic pancreatitis. JGH Open. 2019;3(6):450-5. DOI:10.1002/jgh3.12185
34. Olesen SS, Büyükuslu A, Køhler M, et al. Sarcopenia associates with increased hospitalization rates and reduced survival in patients with chronic pancreatitis. Pancreatology. 2019;19(2):245-51. DOI:10.1016/j.pan.2019.01.006
35. Bideeva TV, Maev IV, Kucheryavyy YA, et al. The effectiveness of pancreatic enzyme replacement therapy using microencapsulated pancreatin preparations in the correction of nutritional status in patients with chronic pancreatitis: a prospective observational study. Terapevticheskii Arkhiv (Ter. Arkh.). 2020;92(1):30-5 (in Russian). DOI:10.26442/00403660.2020.01.000488
36. Whitcomb DC, Buchner AM, Forsmark CE. AGA Clinical practice update on the epidemiology, evaluation, and management of exocrine pancreatic insufficiency: Expert review. Gastroenterology. 2023;165(5):1292-301. DOI:10.1053/j.gastro.2023.07.007
37. Gan C, Chen YH, Liu L, et al. Efficacy and safety of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: A meta-analysis. Oncotarget. 2017;8(55):94920-31. DOI:10.18632/oncotarget.21659
38. de la Iglesia-García D, Huang W, Szatmary P, et al.; NIHR Pancreas Biomedical Research Unit Patient Advisory Group. Efficacy of pancreatic enzyme replacement therapy in chronic pancreatitis: Systematic review and meta-analysis. Gut. 2017;66(8):1354-5. DOI:10.1136/gutjnl-2016-312529
39. Iglesia D, Avci B, Kiriukova M, et al. Pancreatic exocrine insufficiency and pancreatic enzyme replacement therapy in patients with advanced pancreatic cancer: A systematic review and meta-analysis. United European Gastroenterol J. 2020;8(9):1115-25. DOI:10.1177/2050640620938987
40. Khronicheskii pankreatit. Klinicheskie rekomendatsii. Available at: https://cr.minzdrav.gov.ru/view-cr/273_4. Accessed: 05.09.2024 (in Russian).
41. Krishnamurty DM, Rabiee A, Jagannath SB, Andersen DK. Delayed release pancrelipase for treatment of pancreatic exocrine insufficiency associated with chronic pancreatitis. Ther Clin Risk Manag. 2009;5(3):507-20. DOI:10.2147/tcrm.s3196
42. Dominguez-Muñoz JE, Vujasinovic M, de la Iglesia D, et al.; European PEI Multidisciplinary Group. European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations. United European Gastroenterol J. 2025;13(1):125-72. DOI:10.1002/ueg2.12674
43. Maev IV, Kucheryavyy YA, Gubergrits NB, et al. Differences in in vitro properties of pancreatin preparations for pancreatic exocrine insufficiency as marketed in Russia and CIS. Drugs R D. 2020;20(4):369-76. DOI:10.1007/s40268-020-00326-z
2. Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16(3):175-84. DOI:10.1038/s41575-018-0087-5
3. Machicado JD, Amann ST, Anderson MA, et al. Quality of life in chronic pancreatitis is determined by constant pain, disability/unemployment, current smoking, and associated co-morbidities. Am J Gastroenterol. 2017;112(4):633-42. DOI:10.1038/ajg.2017.42
4. Seicean A, Grigorescu M, Tanţău M, et al. Pain in chronic pancreatitis: Assessment and relief through treatment. Rom J Gastroenterol. 2004;13(1):9-15. PMID:15054520
5. Ghodeif AO, Azer SA. Pancreatic Insufficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2024. Available at: https://www.ncbi.nlm.nih.gov/books/NBK555926/ Accessed: 05.09.2024.
6. Kucheryavyy YuA, Andreev DN. Nutritional status in patients with chronic pancreatitis. J Nutr Ther. 2014;3(3):122-3. DOI:10.6000/1929-5634.2014.03.03.3
7. Keller J, Layer P. Human pancreatic exocrine response to nutrients in health and disease. Gut. 2005;54 (Suppl. 6):vi1-28. DOI:10.1136/gut.2005.065946
8. Маев И.В., Кучерявый Ю.А. Современные подходы к диагностике и лечению хронического панкреатита. Клиническая медицина. 2013;91(9):10-6 [Maev IV, Kucheriavyi IuA. Modern approaches to diagnostics and treatment of chronic pancreatitis. Klinicheskaia Meditsina. 2013;91(9):10-6 (in Russian)].
9. Хатьков И.Е., Маев И.В., Абдулхаков С.Р. Российский консенсус по диагностике и лечению хронического панкреатита. Терапевтический архив. 2017;89(2):105-13 [Khatkov IE, Maev IV, Abdulkhakov SR, et al. The Russian consensus on the diagnosis and treatment of chronic pancreatitis. Terapevticheskii Arkhiv (Ter. Arkh.). 2017;89(2):105-13 (in Russian)]. DOI:10.17116/terarkh2017892105-113
10. Lainscak M, Farkas J, Frantal S, et al. Self-rated health, nutritional intake and mortality in adult hospitalized patients. Eur J Clin Invest. 2014;44(9):813-24. DOI:10.1111/eci.12300
11. Ramai D, Facciorusso A, Maida M, et al. Prevalence of osteopathy in chronic pancreatitis: A systematic review and meta-analysis. Clin Transl Gastroenterol. 2023;14(8):e00623. DOI:10.14309/ctg.0000000000000623
12. Маев И.В., Андреев Д.Н., Кучерявый Ю.А., Левченко А.И. Распространенность саркопении у пациентов с хроническим панкреатитом: метаанализ. Терапевтический архив. 2020;92(12):43-7 [Maev IV, Andreev DN, Kucheryavyy YuA, Levchenko AI. The prevalence of sarcopenia in patients with chronic pancreatitis: A meta-analysis. Terapevticheskii Arkhiv (Ter. Arkh.). 2020;92(12):43-7 (in Russian)]. DOI:10.26442/00403660.2020.12.200430
13. Андреев Д.Н., Маев И.В., Кучерявый Ю.А. Распространенность и риск переломов костей у пациентов с хроническим панкреатитом: метаанализ. Научно-практическая ревматология. 2021;59(1):56-61 [Andreev DN, Maev IV, Kucheryavyi YuA. Prevalence and risk of bone fractures in patients with chronic pancreatitis: Meta-analysis. Nauchno-Prakticheskaya Revmatologiya. 2021;59(1):56-61 (in Russian)]. DOI:10.47360/1995-4484-2021-56-61
14. Midha S, Singh N, Sachdev V, et al. Cause and effect relationship of malnutrition with idiopathic chronic pancreatitis: prospective case-control study. J Gastroenterol Hepatol. 2008;23(9):1378-83. DOI:10.1111/j.1440-1746.2008.05459.x
15. Singh S, Midha S, Singh N, et al. Dietary counseling versus dietary supplements for malnutrition in chronic pancreatitis: A randomized controlled trial. Clin Gastroenterol Hepatol. 2008;6(3):353-9. DOI:10.1016/j.cgh.2007.12.040
16. Sathiaraj E, Gupta S, Chutke M, et al. Malnutrition is not an etiological factor in the development of tropical pancreatitis – A case-control study of southern Indian patients. Trop Gastroenterol. 2010;31(3):169-74. PMID: 21560520
17. Regunath H, Shivakumar BM, Kurien A, et al. Anthropometric measurements of nutritional status in chronic pancreatitis in India: Comparison of tropical and alcoholic pancreatitis. Indian J Gastroenterol. 2011;30(2):78-83. DOI:10.1007/s12664-011-0093-9
18. Кучерявый Ю.А., Москалева А.Б., Свиридова А.В., и др. Нутритивный статус как фактор риска осложнений хронического панкреатита и развития панкреатической недостаточности. Экспериментальная и клиническая гастроэнтерология. 2012;7:10-6 [Kucheryavyy YuA, Moskaleva AB, Sviridova AV, et al. Nutritional status as a risk factor for complications of chronic pancreatitis and the development of pancreatic insufficiency. Experimental and Clinical Gastroenterology. 2012;7:10-6 (in Russian)].
19. Ильченко Л.Ю., Гаврилина Н.С., Никитин И.Г. Клинические варианты трофологического статуса у пациентов с хроническим панкреатитом. Альманах клинической медицины. 2019;47(6):518-24 [Ilchenko LYu, Gavrilina NS, Nikitin IG. Clinical types of nutritional status in patients with chronic pancreatitis. Almanac of Clinical Medicine. 2019;47(6):518-24 (in Russian)]. DOI:10.18786/2072-0505-2019-47-065
20. Bourne DM, White H, French JJ, Leeds JS. A retrospective cohort study of nutritional status, nutritional interventions and hospital admissions in patients with chronic pancreatitis managed at a tertiary referral centre. Clin Nutr ESPEN. 2021;43:290-5. DOI:10.1016/j.clnesp.2021.03.038
21. Casares CU, Zamalloa IG, Concejo FB, et al. Pancreatic exocrine insufficiency, diabetes mellitus and malnutrition in chronic pancreatitis: Data from the Basque-Navarrese registry of chronic pancreatitis (PAN-EUS). Pancreatology. 2022;22(3):e3. DOI:10.1016/j.pan.2022.02.012
22. Gopi S, Qamar S, Singh N, et al. Malnutrition by GLIM criteria in chronic pancreatitis: Prevalence, predictors, and its impact on quality of life. Pancreatology. 2022;22(3):367-73. DOI:10.1016/j.pan.2022.02.004
23. Thantry AN, Urooj A, Halumathigatta Nagappa D. Screening of malnutrition using Patient-Generated Subjective Global Assessment tool and hand muscle strength in subjects with pancreatitis. Chronic Dis Transl Med. 2022;8(4):314-21. DOI:10.1002/cdt3.48
24. Bannert K, Sautter LF, Wiese ML, et al. Analysis of ESPEN and GLIM algorithms reveals specific drivers for the diagnosis of malnutrition in patients with chronic gastrointestinal diseases. Nutrition. 2023;106:111887. DOI:10.1016/j.nut.2022.111887
25. Hettige C, Senavirathne A, Jayatissa R, Pathirana A. Nutritional assessment of patients with chronic pancreatitis: A single-center study. Clin Nutr ESPEN. 2023;54:514. DOI:10.1016/j.clnesp.2022.09.166
26. Bruns N, Meyer F, Rischmüller K, et al. Nutritional status in patients with chronic pancreatitis and liver cirrhosis is related to disease conditions and not dietary habits. Sci Rep. 2024;14(1):4700. DOI:10.1038/s41598-024-54998-7
27. Cederholm T, Jensen GL, Correia MITD, et al.; GLIM Core Leadership Committee, GLIM Working Group. GLIM criteria for the diagnosis of malnutrition – A consensus report from the global clinical nutrition community. J Cachexia Sarcopenia Muscle. 2019;10(1):207-17. DOI:10.1002/jcsm.12383
28. Jensen GL, Mirtallo J, Compher C, et al.; International Consensus Guideline Committee. Adult starvation and disease-related malnutrition: A proposal for etiology-based diagnosis in the clinical practice setting from the International Consensus Guideline Committee. JPEN J Parenter Enteral Nutr. 2010;34(2):156-9. DOI:10.1177/0148607110361910
29. Cederholm T, Barazzoni R, Austin P, et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr. 2017;36(1):49-64. DOI:10.1016/j.clnu.2016.09.004
30. Bhullar FA, Faghih M, Akshintala VS, et al.; P-QST Consortium. Prevalence of primary painless chronic pancreatitis: A systematic review and meta-analysis. Pancreatology. 2022;22(1):20-9. DOI:10.1016/j.pan.2021.11.006. Erratum in: Pancreatology. 2022;22(3):448. DOI:10.1016/j.pan.2022.03.003
31. Duggan SN, Conlon KC. A practical guide to the nutritional management of chronic pancreatitis. Pract Gastroenterol. 2013;118:24-32.
32. Chiavarini M, Ricciotti GM, Genga A, et al. Malnutrition-related health outcomes in older adults with hip fractures: A systematic review and meta-analysis. Nutrients. 2024;16(7):1069. DOI:10.3390/nu16071069
33. Bansal A, Gupta P, Singh H, et al. Gastrointestinal complications in acute and chronic pancreatitis. JGH Open. 2019;3(6):450-5. DOI:10.1002/jgh3.12185
34. Olesen SS, Büyükuslu A, Køhler M, et al. Sarcopenia associates with increased hospitalization rates and reduced survival in patients with chronic pancreatitis. Pancreatology. 2019;19(2):245-51. DOI:10.1016/j.pan.2019.01.006
35. Бидеева Т.В., Маев И.В., Кучерявый Ю.А., и др. Эффективность заместительной ферментной терапии с использованием микрокапсулированных препаратов панкреатина при коррекции нутритивного статуса у пациентов с хроническим панкреатитом: проспективное наблюдательное исследование. Терапевтический архив. 2020;92(1):30-5 [Bideeva TV, Maev IV, Kucheryavyy YA, et al. The effectiveness of pancreatic enzyme replacement therapy using microencapsulated pancreatin preparations in the correction of nutritional status in patients with chronic pancreatitis: a prospective observational study. Terapevticheskii Arkhiv (Ter. Arkh.). 2020;92(1):30-5 (in Russian)]. DOI:10.26442/00403660.2020.01.000488
36. Whitcomb DC, Buchner AM, Forsmark CE. AGA Clinical practice update on the epidemiology, evaluation, and management of exocrine pancreatic insufficiency: Expert review. Gastroenterology. 2023;165(5):1292-301. DOI:10.1053/j.gastro.2023.07.007
37. Gan C, Chen YH, Liu L, et al. Efficacy and safety of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: A meta-analysis. Oncotarget. 2017;8(55):94920-31. DOI:10.18632/oncotarget.21659
38. de la Iglesia-García D, Huang W, Szatmary P, et al.; NIHR Pancreas Biomedical Research Unit Patient Advisory Group. Efficacy of pancreatic enzyme replacement therapy in chronic pancreatitis: Systematic review and meta-analysis. Gut. 2017;66(8):1354-5. DOI:10.1136/gutjnl-2016-312529
39. Iglesia D, Avci B, Kiriukova M, et al. Pancreatic exocrine insufficiency and pancreatic enzyme replacement therapy in patients with advanced pancreatic cancer: A systematic review and meta-analysis. United European Gastroenterol J. 2020;8(9):1115-25. DOI:10.1177/2050640620938987
40. Хронический панкреатит. Клинические рекомендации. 2024. Режим доступа: https://cr.minzdrav.gov.ru/view-cr/273_4. Ссылка активна на 05.09.2024 [Khronicheskii pankreatit. Klinicheskie rekomendatsii. Available at: https://cr.minzdrav.gov.ru/view-cr/273_4. Accessed: 05.09.2024 (in Russian)].
41. Krishnamurty DM, Rabiee A, Jagannath SB, Andersen DK. Delayed release pancrelipase for treatment of pancreatic exocrine insufficiency associated with chronic pancreatitis. Ther Clin Risk Manag. 2009;5(3):507-20. DOI:10.2147/tcrm.s3196
42. Dominguez-Muñoz JE, Vujasinovic M, de la Iglesia D, et al.; European PEI Multidisciplinary Group. European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations. United European Gastroenterol J. 2025;13(1):125-72. DOI:10.1002/ueg2.12674
43. Maev IV, Kucheryavyy YA, Gubergrits NB, et al. Differences in in vitro properties of pancreatin preparations for pancreatic exocrine insufficiency as marketed in Russia and CIS. Drugs R D. 2020;20(4):369-76. DOI:10.1007/s40268-020-00326-z
________________________________________________
2. Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16(3):175-84. DOI:10.1038/s41575-018-0087-5
3. Machicado JD, Amann ST, Anderson MA, et al. Quality of life in chronic pancreatitis is determined by constant pain, disability/unemployment, current smoking, and associated co-morbidities. Am J Gastroenterol. 2017;112(4):633-42. DOI:10.1038/ajg.2017.42
4. Seicean A, Grigorescu M, Tanţău M, et al. Pain in chronic pancreatitis: Assessment and relief through treatment. Rom J Gastroenterol. 2004;13(1):9-15. PMID:15054520
5. Ghodeif AO, Azer SA. Pancreatic Insufficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2024. Available at: https://www.ncbi.nlm.nih.gov/books/NBK555926/ Accessed: 05.09.2024.
6. Kucheryavyy YuA, Andreev DN. Nutritional status in patients with chronic pancreatitis. J Nutr Ther. 2014;3(3):122-3. DOI:10.6000/1929-5634.2014.03.03.3
7. Keller J, Layer P. Human pancreatic exocrine response to nutrients in health and disease. Gut. 2005;54 (Suppl. 6):vi1-28. DOI:10.1136/gut.2005.065946
8. Maev IV, Kucheriavyi IuA. Modern approaches to diagnostics and treatment of chronic pancreatitis. Klinicheskaia Meditsina. 2013;91(9):10-6 (in Russian).
9. Khatkov IE, Maev IV, Abdulkhakov SR, et al. The Russian consensus on the diagnosis and treatment of chronic pancreatitis. Terapevticheskii Arkhiv (Ter. Arkh.). 2017;89(2):105-13 (in Russian). DOI:10.17116/terarkh2017892105-113
10. Lainscak M, Farkas J, Frantal S, et al. Self-rated health, nutritional intake and mortality in adult hospitalized patients. Eur J Clin Invest. 2014;44(9):813-24. DOI:10.1111/eci.12300
11. Ramai D, Facciorusso A, Maida M, et al. Prevalence of osteopathy in chronic pancreatitis: A systematic review and meta-analysis. Clin Transl Gastroenterol. 2023;14(8):e00623. DOI:10.14309/ctg.0000000000000623
12. Maev IV, Andreev DN, Kucheryavyy YuA, Levchenko AI. The prevalence of sarcopenia in patients with chronic pancreatitis: A meta-analysis. Terapevticheskii Arkhiv (Ter. Arkh.). 2020;92(12):43-7 (in Russian). DOI:10.26442/00403660.2020.12.200430
13. Andreev DN, Maev IV, Kucheryavyi YuA. Prevalence and risk of bone fractures in patients with chronic pancreatitis: Meta-analysis. Nauchno-Prakticheskaya Revmatologiya. 2021;59(1):56-61 (in Russian). DOI:10.47360/1995-4484-2021-56-61
14. Midha S, Singh N, Sachdev V, et al. Cause and effect relationship of malnutrition with idiopathic chronic pancreatitis: prospective case-control study. J Gastroenterol Hepatol. 2008;23(9):1378-83. DOI:10.1111/j.1440-1746.2008.05459.x
15. Singh S, Midha S, Singh N, et al. Dietary counseling versus dietary supplements for malnutrition in chronic pancreatitis: A randomized controlled trial. Clin Gastroenterol Hepatol. 2008;6(3):353-9. DOI:10.1016/j.cgh.2007.12.040
16. Sathiaraj E, Gupta S, Chutke M, et al. Malnutrition is not an etiological factor in the development of tropical pancreatitis – A case-control study of southern Indian patients. Trop Gastroenterol. 2010;31(3):169-74. PMID: 21560520
17. Regunath H, Shivakumar BM, Kurien A, et al. Anthropometric measurements of nutritional status in chronic pancreatitis in India: Comparison of tropical and alcoholic pancreatitis. Indian J Gastroenterol. 2011;30(2):78-83. DOI:10.1007/s12664-011-0093-9
18. Kucheryavyy YuA, Moskaleva AB, Sviridova AV, et al. Nutritional status as a risk factor for complications of chronic pancreatitis and the development of pancreatic insufficiency. Experimental and Clinical Gastroenterology. 2012;7:10-6 (in Russian).
19. Ilchenko LYu, Gavrilina NS, Nikitin IG. Clinical types of nutritional status in patients with chronic pancreatitis. Almanac of Clinical Medicine. 2019;47(6):518-24 (in Russian). DOI:10.18786/2072-0505-2019-47-065
20. Bourne DM, White H, French JJ, Leeds JS. A retrospective cohort study of nutritional status, nutritional interventions and hospital admissions in patients with chronic pancreatitis managed at a tertiary referral centre. Clin Nutr ESPEN. 2021;43:290-5. DOI:10.1016/j.clnesp.2021.03.038
21. Casares CU, Zamalloa IG, Concejo FB, et al. Pancreatic exocrine insufficiency, diabetes mellitus and malnutrition in chronic pancreatitis: Data from the Basque-Navarrese registry of chronic pancreatitis (PAN-EUS). Pancreatology. 2022;22(3):e3. DOI:10.1016/j.pan.2022.02.012
22. Gopi S, Qamar S, Singh N, et al. Malnutrition by GLIM criteria in chronic pancreatitis: Prevalence, predictors, and its impact on quality of life. Pancreatology. 2022;22(3):367-73. DOI:10.1016/j.pan.2022.02.004
23. Thantry AN, Urooj A, Halumathigatta Nagappa D. Screening of malnutrition using Patient-Generated Subjective Global Assessment tool and hand muscle strength in subjects with pancreatitis. Chronic Dis Transl Med. 2022;8(4):314-21. DOI:10.1002/cdt3.48
24. Bannert K, Sautter LF, Wiese ML, et al. Analysis of ESPEN and GLIM algorithms reveals specific drivers for the diagnosis of malnutrition in patients with chronic gastrointestinal diseases. Nutrition. 2023;106:111887. DOI:10.1016/j.nut.2022.111887
25. Hettige C, Senavirathne A, Jayatissa R, Pathirana A. Nutritional assessment of patients with chronic pancreatitis: A single-center study. Clin Nutr ESPEN. 2023;54:514. DOI:10.1016/j.clnesp.2022.09.166
26. Bruns N, Meyer F, Rischmüller K, et al. Nutritional status in patients with chronic pancreatitis and liver cirrhosis is related to disease conditions and not dietary habits. Sci Rep. 2024;14(1):4700. DOI:10.1038/s41598-024-54998-7
27. Cederholm T, Jensen GL, Correia MITD, et al.; GLIM Core Leadership Committee, GLIM Working Group. GLIM criteria for the diagnosis of malnutrition – A consensus report from the global clinical nutrition community. J Cachexia Sarcopenia Muscle. 2019;10(1):207-17. DOI:10.1002/jcsm.12383
28. Jensen GL, Mirtallo J, Compher C, et al.; International Consensus Guideline Committee. Adult starvation and disease-related malnutrition: A proposal for etiology-based diagnosis in the clinical practice setting from the International Consensus Guideline Committee. JPEN J Parenter Enteral Nutr. 2010;34(2):156-9. DOI:10.1177/0148607110361910
29. Cederholm T, Barazzoni R, Austin P, et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr. 2017;36(1):49-64. DOI:10.1016/j.clnu.2016.09.004
30. Bhullar FA, Faghih M, Akshintala VS, et al.; P-QST Consortium. Prevalence of primary painless chronic pancreatitis: A systematic review and meta-analysis. Pancreatology. 2022;22(1):20-9. DOI:10.1016/j.pan.2021.11.006. Erratum in: Pancreatology. 2022;22(3):448. DOI:10.1016/j.pan.2022.03.003
31. Duggan SN, Conlon KC. A practical guide to the nutritional management of chronic pancreatitis. Pract Gastroenterol. 2013;118:24-32.
32. Chiavarini M, Ricciotti GM, Genga A, et al. Malnutrition-related health outcomes in older adults with hip fractures: A systematic review and meta-analysis. Nutrients. 2024;16(7):1069. DOI:10.3390/nu16071069
33. Bansal A, Gupta P, Singh H, et al. Gastrointestinal complications in acute and chronic pancreatitis. JGH Open. 2019;3(6):450-5. DOI:10.1002/jgh3.12185
34. Olesen SS, Büyükuslu A, Køhler M, et al. Sarcopenia associates with increased hospitalization rates and reduced survival in patients with chronic pancreatitis. Pancreatology. 2019;19(2):245-51. DOI:10.1016/j.pan.2019.01.006
35. Bideeva TV, Maev IV, Kucheryavyy YA, et al. The effectiveness of pancreatic enzyme replacement therapy using microencapsulated pancreatin preparations in the correction of nutritional status in patients with chronic pancreatitis: a prospective observational study. Terapevticheskii Arkhiv (Ter. Arkh.). 2020;92(1):30-5 (in Russian). DOI:10.26442/00403660.2020.01.000488
36. Whitcomb DC, Buchner AM, Forsmark CE. AGA Clinical practice update on the epidemiology, evaluation, and management of exocrine pancreatic insufficiency: Expert review. Gastroenterology. 2023;165(5):1292-301. DOI:10.1053/j.gastro.2023.07.007
37. Gan C, Chen YH, Liu L, et al. Efficacy and safety of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: A meta-analysis. Oncotarget. 2017;8(55):94920-31. DOI:10.18632/oncotarget.21659
38. de la Iglesia-García D, Huang W, Szatmary P, et al.; NIHR Pancreas Biomedical Research Unit Patient Advisory Group. Efficacy of pancreatic enzyme replacement therapy in chronic pancreatitis: Systematic review and meta-analysis. Gut. 2017;66(8):1354-5. DOI:10.1136/gutjnl-2016-312529
39. Iglesia D, Avci B, Kiriukova M, et al. Pancreatic exocrine insufficiency and pancreatic enzyme replacement therapy in patients with advanced pancreatic cancer: A systematic review and meta-analysis. United European Gastroenterol J. 2020;8(9):1115-25. DOI:10.1177/2050640620938987
40. Khronicheskii pankreatit. Klinicheskie rekomendatsii. Available at: https://cr.minzdrav.gov.ru/view-cr/273_4. Accessed: 05.09.2024 (in Russian).
41. Krishnamurty DM, Rabiee A, Jagannath SB, Andersen DK. Delayed release pancrelipase for treatment of pancreatic exocrine insufficiency associated with chronic pancreatitis. Ther Clin Risk Manag. 2009;5(3):507-20. DOI:10.2147/tcrm.s3196
42. Dominguez-Muñoz JE, Vujasinovic M, de la Iglesia D, et al.; European PEI Multidisciplinary Group. European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations. United European Gastroenterol J. 2025;13(1):125-72. DOI:10.1002/ueg2.12674
43. Maev IV, Kucheryavyy YA, Gubergrits NB, et al. Differences in in vitro properties of pancreatin preparations for pancreatic exocrine insufficiency as marketed in Russia and CIS. Drugs R D. 2020;20(4):369-76. DOI:10.1007/s40268-020-00326-z
Авторы
Д.Н. Андреев*1, А.Р. Хурматуллина2, Ю.А. Кучерявый3, И.В. Маев1
1ФГБОУ ВО «Российский университет медицины» Минздрава России, Москва, Россия;
2ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
3АО «Ильинская больница», г.о. Красногорск, Россия
*dna-mit8@mail.ru
1Russian University of Medicine, Moscow, Russia;
2Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
3Ilyinsky Hospital JSC, Krasnogorsk, Russia
*dna-mit8@mail.ru
1ФГБОУ ВО «Российский университет медицины» Минздрава России, Москва, Россия;
2ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
3АО «Ильинская больница», г.о. Красногорск, Россия
*dna-mit8@mail.ru
________________________________________________
1Russian University of Medicine, Moscow, Russia;
2Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
3Ilyinsky Hospital JSC, Krasnogorsk, Russia
*dna-mit8@mail.ru
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