Сердечно-сосудистые заболевания, индуцированные лучевой терапией

Барсуков А.В., Борисова Е.В., Глуховской Д.В., Глебова С.А., Рудь С.Д., Ахметшин И.М., Свёклина Т.С., Чумак Б.А. Сердечно-сосудистые заболевания, индуцированные лучевой терапией. CardioСоматика. 2022;13(1):17–22. DOI: 10.17816/22217185.2022.1.201470

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Barsukov AV, Borisova EV, Glukhovskoi DV, Glebova SA, Rud SD, Akhmetshin IM, Sveklina TS, Chumak BA. Cardiovascular diseases induced by radiotherapy. Case report. Cardiosomatics. 2022;13(1):17–22.
DOI: 10.17816/22217185.2022.1.201470

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Аннотация

В статье обобщены современные представления о проблеме индуцированных лучевой терапией (ЛТ) заболеваний сердца. Основу статьи составляет клинический случай, посвященный рестриктивной кардиомиопатии у женщины, ранее излеченной от лимфомы Ходжкина посредством ЛТ. Отражена важность применения современных визуализирующих технологий, направленных на верификацию патоморфологических изменений в миокарде, обусловливающих развитие сердечной недостаточности c сохраненной фракцией выброса левого желудочка. На клиническом примере показан сочетанный характер висцеральных осложнений, возникающих в отдаленные сроки после ЛТ у онкогематологических пациентов.

Ключевые слова: лимфома Ходжкина, лучевая терапия, рестриктивная кардиомиопатия, коморбидность, кардиовизуализирующие технологии

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The article presents the current understanding of the problem of radiation therapy (RT)-induced heart diseases. The paper is based on a clinical case of restrictive cardiomyopathy in a female previously cured of Hodgkin's lymphoma with RT. The importance of using modern imaging technologies aimed at verifying pathomorphological changes in the myocardium that cause the development of heart failure with preserved left ventricular ejection fraction is reflected. The given clinical case shows the combination of visceral complications arising in the long term after RT in oncohematological patients.

Keywords: Hodgkin's lymphoma, radiation therapy, restrictive cardiomyopathy, comorbidity, cardio-imaging technologies

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Список литературы

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4. Aleman BMP, van den Belt-Dusebout AW, De Bruin ML, et al. Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood. 2007;109(5):1878-86.
DOI:10.1182/blood-2006-07-034405
5. Heidenreich PA, Schnittger I, Strauss HW, et al. Screening for coronary artery disease after mediastinal irradiation for Hodgkin's disease. J Clin Oncol. 2007;25(1):43-9. DOI:10.1200/JCO.2006.07.0805
6. Heidenreich PA, Hancock SL, Vagelos RH, et al. Diastolic dysfunction after mediastinal irradiation. Am Heart J. 2005;150(5):977-82. DOI:10.1016/j.ahj.2004.12.026
7. Redfield MM. Heart failure with preserved ejection fraction. N Engl J Med. 2016;375(19):1868-77. DOI:10.1056/NEJMcp1511175
8. McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599-726. DOI:10.1093/eurheartj/ehab368
9. Michaelson EM, Chen YH, Silver B, et al. Thyroid malignancies in survivors of Hodgkin’s lymphoma. Int J Radiation Oncol Biol Phys. 2014;88(3):636-41. DOI:10.1016/j.ijrobp.2013.11.237
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11. Maron BJ, Towbin J, Thiene G, et al. Contemporary definitions and classification of the cardiomyopathies. Circulation. 2006;113(14):1807-16. DOI:10.1161/CIRCULATIONAHA.106.174287
12. Elliott P, Andersson B, Arbustini E, et al. Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2008;29(2):270-6. DOI:10.1093/eurheartj/ehm342
13. Constine L, Schwartz R, Savage D, et al. Cardiac function, perfusion, and morbidity in irradiated long-term survivors of Hodgkin’s disease. Int J Radiat Oncol Biol Phys. 1997;39(4):897-906. DOI:10.1016/s0360-3016(97)00467-7
14. Nagueh S, Smiseth O, Appleton C, et al. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016;29(4):277-314. DOI:10.1016/j.echo.2016.01.011
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19. Никифоров В.С., Никищенкова Ю.В. Cовременные возможности speckle tracking эхокардиографии в клинической практике. Рациональная фармакотерапия в кардиологии. 2017;13(2):248-55 [Nikiforov VS, Nikishchenkova IV. Modern possibilities of speckle tracking echocardiography in clinical practice. Rational Pharmacotherapy in Cardiology. 2017;13(2):248-55 (in Russian)]. DOI:10.20996/1819-6446-2017-13-2-248-255

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1. Cuomo JR, Sharma GK, Conger PD, Weintraub NL. Novel concepts in radiation-induced cardiovascular disease. World J Cardiol. 2016;8(9):504‑19. DOI:10.4330/wjc.v8.i9.504
2. Donnellan E, Phelan D, McCarthy CP, et al. Radiation-induced heart disease: A practical guide to diagnosis and management. Cleve Clin J Med. 2016;83(12):914-22. DOI:10.3949/ccjm.83a.15104
3. Wang H, Wei J, Zheng Q, et al. Radiation-induced heart disease: a review of classification, mechanism and prevention. Int J Biol Sci. 2019;15(10):2128‑38. DOI:10.7150/ijbs.35460
4. Aleman BMP, van den Belt-Dusebout AW, De Bruin ML, et al. Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood. 2007;109(5):1878-86.
DOI:10.1182/blood-2006-07-034405
5. Heidenreich PA, Schnittger I, Strauss HW, et al. Screening for coronary artery disease after mediastinal irradiation for Hodgkin's disease. J Clin Oncol. 2007;25(1):43-9. DOI:10.1200/JCO.2006.07.0805
6. Heidenreich PA, Hancock SL, Vagelos RH, et al. Diastolic dysfunction after mediastinal irradiation. Am Heart J. 2005;150(5):977-82. DOI:10.1016/j.ahj.2004.12.026
7. Redfield MM. Heart failure with preserved ejection fraction. N Engl J Med. 2016;375(19):1868-77. DOI:10.1056/NEJMcp1511175
8. McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599-726. DOI:10.1093/eurheartj/ehab368
9. Michaelson EM, Chen YH, Silver B, et al. Thyroid malignancies in survivors of Hodgkin’s lymphoma. Int J Radiation Oncol Biol Phys. 2014;88(3):636-41. DOI:10.1016/j.ijrobp.2013.11.237
10. Richardson P, McKenna W, Bristow M, et al. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies. Circulation. 1996;93(5):841-2. DOI:10.1161/01.cir.93.5.841
11. Maron BJ, Towbin J, Thiene G, et al. Contemporary definitions and classification of the cardiomyopathies. Circulation. 2006;113(14):1807-16. DOI:10.1161/CIRCULATIONAHA.106.174287
12. Elliott P, Andersson B, Arbustini E, et al. Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2008;29(2):270-6. DOI:10.1093/eurheartj/ehm342
13. Constine L, Schwartz R, Savage D, et al. Cardiac function, perfusion, and morbidity in irradiated long-term survivors of Hodgkin’s disease. Int J Radiat Oncol Biol Phys. 1997;39(4):897-906. DOI:10.1016/s0360-3016(97)00467-7
14. Nagueh S, Smiseth O, Appleton C, et al. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016;29(4):277-314. DOI:10.1016/j.echo.2016.01.011
15. Habib G, Bucciarelli-Ducci C, Caforio ALP, et al. Multimodality Imaging in Restrictive Cardiomyopathies: An EACVI expert consensus document In collaboration with the «Working Group on myocardial and pericardial diseases» of the European Society of Cardiology Endorsed by The Indian Academy of Echocardiography. Eur Heart J Cardiovasc Imaging. 2017;18(10):1090-1. DOI:10.1093/ehjci/jex034
16. Rammos A, Meladinis V, Vovas G, Patsouras D. Restrictive cardiomyopathies: the importance of noninvasive cardiac imaging modalities in diagnosis and treatment-a systematic review. Radiol Res Pract. 2017;2017:e2874902. DOI:10.1155/2017/2874902
17. Luis SA, Pellikka PA. Is speckle tracking imaging ready for prime time in current echo clinical practice? Prog Cardiovasc Dis. 2018;61(5-6):437-45. DOI:10.1016/j.pcad.2018.11.001
18. Gritsenko OV, Chumakova GA, Trubina EV. Features of speckle tracking echocardiography for diagnosis of myocardial dysfunction. CardioSomatics. 2021;12(1):5-10 (in Russian). DOI:10.26442/22217185.2021.1.200756
19. Nikiforov VS, Nikishchenkova IV. Modern possibilities of speckle tracking echocardiography in clinical practice. Rational Pharmacotherapy in Cardiology. 2017;13(2):248-55 (in Russian). DOI:10.20996/1819-6446-2017-13-2-248-255

Авторы

А.В. Барсуков*1,2, Е.В. Борисова1, Д.В. Глуховской2, С.А. Глебова1, С.Д. Рудь2, И.М. Ахметшин2, Т.С. Свёклина2, Б.А. Чумак2

1 АО «КардиоКлиника», Санкт-Петербург, Россия;
2 ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Минобороны России, Санкт-Петербург, Россия
*avbarsukov@yandex.ru

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Anton V. Barsukov*1,2, Ekaterina V. Borisova1, Dmitrii V. Glukhovskoi2, Svetlana A. Glebova1, Sergey D. Rud2, Ilgam M. Akhmetshin2, Tatiana S. Sveklina2, Boris A. Chumak2

1 CardioClinic, Saint Petersburg, Russia;
2 Kirov Military Medical Academy, Saint Petersburg, Russia
*avbarsukov@yandex.ru

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