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Перспективы терапии ринитов и риносинуситов: обзор применения препарата Эуфорбиум композитум
Перспективы терапии ринитов и риносинуситов: обзор применения препарата Эуфорбиум композитум
Марьяновский А.А. Перспективы терапии ринитов и риносинуситов: обзор применения препарата Эуфорбиум композитум. Consilium Medicum. 2016; 18 (3): 104–106. DOI: 10.26442/2075-1753_2016.3.104-106
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Аннотация
В статье представлен обзор клинических исследований эффективности и безопасности интраназального спрея Эуфорбиум композитум. Спрей для назального применения представляет собой альтернативу традиционным препаратам, используемым для лечения ринитов и синуситов, не имеющую характерных для этих препаратов побочных эффектов и ограничений. Лучшая переносимость по сравнению с ксилометазолином позволяет рекомендовать Эуфорбиум композитум в качестве средства для длительной терапии хронических синуситов. Комплексный механизм действия препарата обеспечивает его противовирусную и противовоспалительную активность.
Ключевые слова: ринит, синусит, натуральные компоненты, спрей.
Ключевые слова: ринит, синусит, натуральные компоненты, спрей.
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The article presents a review of clinical studies on the efficacy and safety of an intranasal spray Euphorbium compositum. Spray for nasal application is an alternative to conventional drugs used for the treatment of rhinitis and sinusitis, which has no characteristic of these drugs side effects and limitations. The better tolerability compared with xylometazoline can recommend Euphorbium compositum as a means for long-term treatment of chronic sinusitis. The complex mechanism of action of the drug provides its antiviral and anti-inflammatory activity.
Key words: rhinitis, sinusitis, natural ingredients, spray.
Key words: rhinitis, sinusitis, natural ingredients, spray.
Полный текст
Список литературы
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2. Zenner S, Metelmann H. Therapeutic Experiences with a Homeopathic Nasal Spray. Hufeland Journal 1992;3:67–74.
3. Gottwald R, Weiser M. Antihomotoxic treatment of chronic sinusitis: results of a drug monitoring study with Euphorbium compositum S Drops. Translated from Medicina Biológica 2000; 13 (3): 84–7.
4. Sprenger F. A study with Euphorbium compositum nasal drops (metered dose spray without propellant gas). J General Practice 1984; 60 (27): 1164–8.
5. Connert WD, Maiwald J. Therapie chronisch-medikamentös und vasormotorisch bedingter rhinopathien. Erfahrungen mit einem biotherapeutischen nasenspray. Therapiewoche 1987; 37: 1179–86. English translation available in: Connert WD, Maiwald J. The therapy of rhinopathy: results of application of a biotherapeutic nasal spray. Biol Therapy 1991; 9 (4): 182–92.
6. Weiser M, Gottwald R. Homöopathische Nasentropfen lassen bei Kindern Rhinitis und Sinusitis schneller abklingen. Therapeutische Mitteilungen. Gesundes Leben 1999; 6: 63.
7. Ammerschläger H, Klein P, Weiser M, Oberbaum M. Treatment of infl ammatory diseases of the upper respiratory tract – comparison of a homeopathic complex remedy with xylometazoline. Forsch Komplementärmed Klass Naturheilkd 2005; 12: 24–31.
8. Urlea-Schön MI. Effectiveness and tolerability of Euphorbium comp SN for the symptomatic treatment of rhinitis in children aged 2–6 years. Eur J Int Med 2009; 1: 236 (Abstract PO-023).
9. Raab V. Practice report. Further therapeutic experience with Euphorbium compositum nasal drops (metered dose spray without propellant gas) in ENT practice. Biologische Medizin 1982; 4: 176–9.
10. Glatthaar-Saalmüller B, Fallier-Becker P. Antiviral action of Euphorbium compositum and its components. Forsch Komplementärmed Klass Naturheilkd 2001; 4: 207–12.
11. Glatthaar-Saalmüller B et al. Euphorbium compositum: viruses of the upper respiratory tract inhibited. Biologische Medizin 2002; 4: 194–5.
12. Metelmann H, Glatthaar-Saalmüller B. Antiviral action of a homeopathic medication. Biomed Ther 2000; 18 (1): 160–4.
13. Schmolz M, Metelmann H. Modulation of cytokine synthesis in human leukocytes by individual components of a combination homeopathic nasal spray. Biol Therapy 1999; 17 (2): 61–3; 75.
14. Dykewicz MS, Hamilos DL. Rhinitis and sinusitis. J Allergy Clin Immunol 2010; 125 (2; Suppl. 2): S103–15.
15. Fokkens WJ, Lund VJ, Mullol J et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. Rhinology 2012; 50 (Suppl. 23): 1–298.
16. Wallace DV, Dykewicz MS, Bernstein DI et al. Joint Task Force on Practice; American Academy of Allergy; Asthma & Immunology; American College of Allergy; Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 2008; 122 (2; Suppl): S1–84.
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18. Settipane RA, Charnock DR. Epidemiology of rhinitis: allergic and nonallergic. Clin Allergy Immunol 2007; 19: 23–34.
19. Hamilos DL. Chronic rhinosinusitis patterns of illness. Clin Allergy Immunol 2007; 20: 1–13.
20. Mattos JL, Woodard CR, Payne SC. Trends in common rhinologic illnesses: analysis of U.S. healthcare surveys 1995–2007. Int Forum Allergy Rhinol 2011; 1 (1): 3–12.
21. Punekar YS, Sheikh A. Establishing the incidence and prevalence of clinician-diagnosed allergic conditions in children and adolescents using routinely collected data from general practices. Clin Exp Allergy 2009; 39 (8): 1209–16.
22. Ghouri N, Hippisley-Cox J, Newton J, Sheikh A. Trends in the epidemiology and prescribing of medication for allergic rhinitis in England. J R Soc Med 2008; 101 (9): 466–72.
23. Klossek JM, Annesi-Maesano I, Pribil C, Didier A. [INSTANT: national survey of allergic rhinitis in a French adult population based-sample]. Presse Med 2009; 38 (9): 1220–9.
24. Quercia O, Incorvaia C, Puccinelli P et al. Prevalence of allergic disorders in Italy: the Cotignola population study. Eur Ann Allergy Clin Immunol 2012; 44 (1): 5–11.
25. Bhattacharyya N. Functional limitations and workdays lost associated with chronic rhinosinusitis and allergic rhinitis. Am J Rhinol Allergy 2012; 26 (2): 120–2.
26. Hastan D, Fokkens WJ, Bachert C et al. Chronic rhinosinusitis in Europe – an underestimated disease. A GA(2)LEN study. Allergy 2011; 66 (9): 1216–23.
27. Jarvis D, Newson R, Lotvall J et al. Asthma in adults and its association with chronic rhinosinusitis: the GA(2)LEN survey in Europe. Allergy 2012; 67 (1): 91–8.
28. Skoner DP. Complications of allergic rhinitis. J Allergy Clin Immunol 2000; 105 (6; Pt 2): S605–609.
29. Cruz AA, Popov T, Pawankar R et al. ARIA Initiative Scientifi c Committee. Common characteristics of upper and lower airways in rhinitis and asthma: ARIA update, in collaboration with GA(2)LEN. Allergy 2007; 62 (Suppl. 84): 1–41.
30. De Groot EP, Nijkamp A, Duiverman EJ, Brand PL. Allergic rhinitis is associated with poor asthma control in children with asthma. Thorax 2012; Jan 2. [Epub ahead of print]
31. Dixon AE. Rhinosinusitis and asthma: the missing link. Curr Opin Pulm Med 2009; 15 (1): 19–24.
32. Lunn M, Craig T. Rhinitis and sleep. Sleep Med Rev 2011; 15 (5): 293–9.
33. Meltzer EO, Nathan R, Derebery J et al. Sleep, quality of life, and productivity impact of nasal symptoms in the United States: findings from the Burden of Rhinitis in America survey. Allergy Asthma Proc 2009; 30 (3): 244–54.
34. Craig TJ, Ferguson BJ, Krouse JH. Sleep impairment in allergic rhinitis, rhinosinusitis, and nasal polyposis. Am J Otolaryngol 2008; 29 (3): 209–17.
35. Hartgerink-Lutgens I, Vermeeren A, Vuurman E, Kremer B. Disturbed cognitive functions after nasal provocation in patients with seasonal allergic rhinitis. Clin Exp Allergy 2009; 39 (4): 500–8.
36. Meltzer EO, Gross GN, Katial R, Storms WW. Allergic rhinitis substantially impacts patient quality of life: fi ndings from the Nasal Allergy Survey Assessing Limitations. J Fam Pract 2012; 61 (2; Suppl.): S5–10.
37. Nathan RA. The burden of allergic rhinitis. Allergy Asthma Proc 2007; 28 (1): 3–9.
38. Blaiss MS. Pediatric allergic rhinitis: physical and mental complications. Allergy Asthma Proc 2008; 29 (1): 1–6.
39. Vuurman EF, van Veggel LM, Uiterwijk MM et al. Seasonal allergic rhinitis and antihistamine effects on children’s learning. Ann Allergy 1993; 71 (2): 121–6.
40. Willsie SK. Improved strategies and new treatment options for allergic rhinitis. J Am Osteopath Assoc 2002; 102 (6; Suppl. 2): S7–14.
41. Puchelle E, Zahm JM, Tournier JM, Coraux C. Airway epithelial repair, regeneration, and remodeling after injury in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2006; 3 (8): 726–33.
2. Zenner S, Metelmann H. Therapeutic Experiences with a Homeopathic Nasal Spray. Hufeland Journal 1992;3:67–74.
3. Gottwald R, Weiser M. Antihomotoxic treatment of chronic sinusitis: results of a drug monitoring study with Euphorbium compositum S Drops. Translated from Medicina Biológica 2000; 13 (3): 84–7.
4. Sprenger F. A study with Euphorbium compositum nasal drops (metered dose spray without propellant gas). J General Practice 1984; 60 (27): 1164–8.
5. Connert WD, Maiwald J. Therapie chronisch-medikamentös und vasormotorisch bedingter rhinopathien. Erfahrungen mit einem biotherapeutischen nasenspray. Therapiewoche 1987; 37: 1179–86. English translation available in: Connert WD, Maiwald J. The therapy of rhinopathy: results of application of a biotherapeutic nasal spray. Biol Therapy 1991; 9 (4): 182–92.
6. Weiser M, Gottwald R. Homöopathische Nasentropfen lassen bei Kindern Rhinitis und Sinusitis schneller abklingen. Therapeutische Mitteilungen. Gesundes Leben 1999; 6: 63.
7. Ammerschläger H, Klein P, Weiser M, Oberbaum M. Treatment of infl ammatory diseases of the upper respiratory tract – comparison of a homeopathic complex remedy with xylometazoline. Forsch Komplementärmed Klass Naturheilkd 2005; 12: 24–31.
8. Urlea-Schön MI. Effectiveness and tolerability of Euphorbium comp SN for the symptomatic treatment of rhinitis in children aged 2–6 years. Eur J Int Med 2009; 1: 236 (Abstract PO-023).
9. Raab V. Practice report. Further therapeutic experience with Euphorbium compositum nasal drops (metered dose spray without propellant gas) in ENT practice. Biologische Medizin 1982; 4: 176–9.
10. Glatthaar-Saalmüller B, Fallier-Becker P. Antiviral action of Euphorbium compositum and its components. Forsch Komplementärmed Klass Naturheilkd 2001; 4: 207–12.
11. Glatthaar-Saalmüller B et al. Euphorbium compositum: viruses of the upper respiratory tract inhibited. Biologische Medizin 2002; 4: 194–5.
12. Metelmann H, Glatthaar-Saalmüller B. Antiviral action of a homeopathic medication. Biomed Ther 2000; 18 (1): 160–4.
13. Schmolz M, Metelmann H. Modulation of cytokine synthesis in human leukocytes by individual components of a combination homeopathic nasal spray. Biol Therapy 1999; 17 (2): 61–3; 75.
14. Dykewicz MS, Hamilos DL. Rhinitis and sinusitis. J Allergy Clin Immunol 2010; 125 (2; Suppl. 2): S103–15.
15. Fokkens WJ, Lund VJ, Mullol J et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. Rhinology 2012; 50 (Suppl. 23): 1–298.
16. Wallace DV, Dykewicz MS, Bernstein DI et al. Joint Task Force on Practice; American Academy of Allergy; Asthma & Immunology; American College of Allergy; Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 2008; 122 (2; Suppl): S1–84.
17. Rosenfeld RM, Andes D, Bhattacharyya N et al. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg 2007; 137 (3; Suppl.): S1–31.
18. Settipane RA, Charnock DR. Epidemiology of rhinitis: allergic and nonallergic. Clin Allergy Immunol 2007; 19: 23–34.
19. Hamilos DL. Chronic rhinosinusitis patterns of illness. Clin Allergy Immunol 2007; 20: 1–13.
20. Mattos JL, Woodard CR, Payne SC. Trends in common rhinologic illnesses: analysis of U.S. healthcare surveys 1995–2007. Int Forum Allergy Rhinol 2011; 1 (1): 3–12.
21. Punekar YS, Sheikh A. Establishing the incidence and prevalence of clinician-diagnosed allergic conditions in children and adolescents using routinely collected data from general practices. Clin Exp Allergy 2009; 39 (8): 1209–16.
22. Ghouri N, Hippisley-Cox J, Newton J, Sheikh A. Trends in the epidemiology and prescribing of medication for allergic rhinitis in England. J R Soc Med 2008; 101 (9): 466–72.
23. Klossek JM, Annesi-Maesano I, Pribil C, Didier A. [INSTANT: national survey of allergic rhinitis in a French adult population based-sample]. Presse Med 2009; 38 (9): 1220–9.
24. Quercia O, Incorvaia C, Puccinelli P et al. Prevalence of allergic disorders in Italy: the Cotignola population study. Eur Ann Allergy Clin Immunol 2012; 44 (1): 5–11.
25. Bhattacharyya N. Functional limitations and workdays lost associated with chronic rhinosinusitis and allergic rhinitis. Am J Rhinol Allergy 2012; 26 (2): 120–2.
26. Hastan D, Fokkens WJ, Bachert C et al. Chronic rhinosinusitis in Europe – an underestimated disease. A GA(2)LEN study. Allergy 2011; 66 (9): 1216–23.
27. Jarvis D, Newson R, Lotvall J et al. Asthma in adults and its association with chronic rhinosinusitis: the GA(2)LEN survey in Europe. Allergy 2012; 67 (1): 91–8.
28. Skoner DP. Complications of allergic rhinitis. J Allergy Clin Immunol 2000; 105 (6; Pt 2): S605–609.
29. Cruz AA, Popov T, Pawankar R et al. ARIA Initiative Scientifi c Committee. Common characteristics of upper and lower airways in rhinitis and asthma: ARIA update, in collaboration with GA(2)LEN. Allergy 2007; 62 (Suppl. 84): 1–41.
30. De Groot EP, Nijkamp A, Duiverman EJ, Brand PL. Allergic rhinitis is associated with poor asthma control in children with asthma. Thorax 2012; Jan 2. [Epub ahead of print]
31. Dixon AE. Rhinosinusitis and asthma: the missing link. Curr Opin Pulm Med 2009; 15 (1): 19–24.
32. Lunn M, Craig T. Rhinitis and sleep. Sleep Med Rev 2011; 15 (5): 293–9.
33. Meltzer EO, Nathan R, Derebery J et al. Sleep, quality of life, and productivity impact of nasal symptoms in the United States: findings from the Burden of Rhinitis in America survey. Allergy Asthma Proc 2009; 30 (3): 244–54.
34. Craig TJ, Ferguson BJ, Krouse JH. Sleep impairment in allergic rhinitis, rhinosinusitis, and nasal polyposis. Am J Otolaryngol 2008; 29 (3): 209–17.
35. Hartgerink-Lutgens I, Vermeeren A, Vuurman E, Kremer B. Disturbed cognitive functions after nasal provocation in patients with seasonal allergic rhinitis. Clin Exp Allergy 2009; 39 (4): 500–8.
36. Meltzer EO, Gross GN, Katial R, Storms WW. Allergic rhinitis substantially impacts patient quality of life: fi ndings from the Nasal Allergy Survey Assessing Limitations. J Fam Pract 2012; 61 (2; Suppl.): S5–10.
37. Nathan RA. The burden of allergic rhinitis. Allergy Asthma Proc 2007; 28 (1): 3–9.
38. Blaiss MS. Pediatric allergic rhinitis: physical and mental complications. Allergy Asthma Proc 2008; 29 (1): 1–6.
39. Vuurman EF, van Veggel LM, Uiterwijk MM et al. Seasonal allergic rhinitis and antihistamine effects on children’s learning. Ann Allergy 1993; 71 (2): 121–6.
40. Willsie SK. Improved strategies and new treatment options for allergic rhinitis. J Am Osteopath Assoc 2002; 102 (6; Suppl. 2): S7–14.
41. Puchelle E, Zahm JM, Tournier JM, Coraux C. Airway epithelial repair, regeneration, and remodeling after injury in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2006; 3 (8): 726–33.
2. Zenner S, Metelmann H. Therapeutic Experiences with a Homeopathic Nasal Spray. Hufeland Journal 1992;3:67–74.
3. Gottwald R, Weiser M. Antihomotoxic treatment of chronic sinusitis: results of a drug monitoring study with Euphorbium compositum S Drops. Translated from Medicina Biológica 2000; 13 (3): 84–7.
4. Sprenger F. A study with Euphorbium compositum nasal drops (metered dose spray without propellant gas). J General Practice 1984; 60 (27): 1164–8.
5. Connert WD, Maiwald J. Therapie chronisch-medikamentös und vasormotorisch bedingter rhinopathien. Erfahrungen mit einem biotherapeutischen nasenspray. Therapiewoche 1987; 37: 1179–86. English translation available in: Connert WD, Maiwald J. The therapy of rhinopathy: results of application of a biotherapeutic nasal spray. Biol Therapy 1991; 9 (4): 182–92.
6. Weiser M, Gottwald R. Homöopathische Nasentropfen lassen bei Kindern Rhinitis und Sinusitis schneller abklingen. Therapeutische Mitteilungen. Gesundes Leben 1999; 6: 63.
7. Ammerschläger H, Klein P, Weiser M, Oberbaum M. Treatment of infl ammatory diseases of the upper respiratory tract – comparison of a homeopathic complex remedy with xylometazoline. Forsch Komplementärmed Klass Naturheilkd 2005; 12: 24–31.
8. Urlea-Schön MI. Effectiveness and tolerability of Euphorbium comp SN for the symptomatic treatment of rhinitis in children aged 2–6 years. Eur J Int Med 2009; 1: 236 (Abstract PO-023).
9. Raab V. Practice report. Further therapeutic experience with Euphorbium compositum nasal drops (metered dose spray without propellant gas) in ENT practice. Biologische Medizin 1982; 4: 176–9.
10. Glatthaar-Saalmüller B, Fallier-Becker P. Antiviral action of Euphorbium compositum and its components. Forsch Komplementärmed Klass Naturheilkd 2001; 4: 207–12.
11. Glatthaar-Saalmüller B et al. Euphorbium compositum: viruses of the upper respiratory tract inhibited. Biologische Medizin 2002; 4: 194–5.
12. Metelmann H, Glatthaar-Saalmüller B. Antiviral action of a homeopathic medication. Biomed Ther 2000; 18 (1): 160–4.
13. Schmolz M, Metelmann H. Modulation of cytokine synthesis in human leukocytes by individual components of a combination homeopathic nasal spray. Biol Therapy 1999; 17 (2): 61–3; 75.
14. Dykewicz MS, Hamilos DL. Rhinitis and sinusitis. J Allergy Clin Immunol 2010; 125 (2; Suppl. 2): S103–15.
15. Fokkens WJ, Lund VJ, Mullol J et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. Rhinology 2012; 50 (Suppl. 23): 1–298.
16. Wallace DV, Dykewicz MS, Bernstein DI et al. Joint Task Force on Practice; American Academy of Allergy; Asthma & Immunology; American College of Allergy; Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 2008; 122 (2; Suppl): S1–84.
17. Rosenfeld RM, Andes D, Bhattacharyya N et al. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg 2007; 137 (3; Suppl.): S1–31.
18. Settipane RA, Charnock DR. Epidemiology of rhinitis: allergic and nonallergic. Clin Allergy Immunol 2007; 19: 23–34.
19. Hamilos DL. Chronic rhinosinusitis patterns of illness. Clin Allergy Immunol 2007; 20: 1–13.
20. Mattos JL, Woodard CR, Payne SC. Trends in common rhinologic illnesses: analysis of U.S. healthcare surveys 1995–2007. Int Forum Allergy Rhinol 2011; 1 (1): 3–12.
21. Punekar YS, Sheikh A. Establishing the incidence and prevalence of clinician-diagnosed allergic conditions in children and adolescents using routinely collected data from general practices. Clin Exp Allergy 2009; 39 (8): 1209–16.
22. Ghouri N, Hippisley-Cox J, Newton J, Sheikh A. Trends in the epidemiology and prescribing of medication for allergic rhinitis in England. J R Soc Med 2008; 101 (9): 466–72.
23. Klossek JM, Annesi-Maesano I, Pribil C, Didier A. [INSTANT: national survey of allergic rhinitis in a French adult population based-sample]. Presse Med 2009; 38 (9): 1220–9.
24. Quercia O, Incorvaia C, Puccinelli P et al. Prevalence of allergic disorders in Italy: the Cotignola population study. Eur Ann Allergy Clin Immunol 2012; 44 (1): 5–11.
25. Bhattacharyya N. Functional limitations and workdays lost associated with chronic rhinosinusitis and allergic rhinitis. Am J Rhinol Allergy 2012; 26 (2): 120–2.
26. Hastan D, Fokkens WJ, Bachert C et al. Chronic rhinosinusitis in Europe – an underestimated disease. A GA(2)LEN study. Allergy 2011; 66 (9): 1216–23.
27. Jarvis D, Newson R, Lotvall J et al. Asthma in adults and its association with chronic rhinosinusitis: the GA(2)LEN survey in Europe. Allergy 2012; 67 (1): 91–8.
28. Skoner DP. Complications of allergic rhinitis. J Allergy Clin Immunol 2000; 105 (6; Pt 2): S605–609.
29. Cruz AA, Popov T, Pawankar R et al. ARIA Initiative Scientifi c Committee. Common characteristics of upper and lower airways in rhinitis and asthma: ARIA update, in collaboration with GA(2)LEN. Allergy 2007; 62 (Suppl. 84): 1–41.
30. De Groot EP, Nijkamp A, Duiverman EJ, Brand PL. Allergic rhinitis is associated with poor asthma control in children with asthma. Thorax 2012; Jan 2. [Epub ahead of print]
31. Dixon AE. Rhinosinusitis and asthma: the missing link. Curr Opin Pulm Med 2009; 15 (1): 19–24.
32. Lunn M, Craig T. Rhinitis and sleep. Sleep Med Rev 2011; 15 (5): 293–9.
33. Meltzer EO, Nathan R, Derebery J et al. Sleep, quality of life, and productivity impact of nasal symptoms in the United States: findings from the Burden of Rhinitis in America survey. Allergy Asthma Proc 2009; 30 (3): 244–54.
34. Craig TJ, Ferguson BJ, Krouse JH. Sleep impairment in allergic rhinitis, rhinosinusitis, and nasal polyposis. Am J Otolaryngol 2008; 29 (3): 209–17.
35. Hartgerink-Lutgens I, Vermeeren A, Vuurman E, Kremer B. Disturbed cognitive functions after nasal provocation in patients with seasonal allergic rhinitis. Clin Exp Allergy 2009; 39 (4): 500–8.
36. Meltzer EO, Gross GN, Katial R, Storms WW. Allergic rhinitis substantially impacts patient quality of life: fi ndings from the Nasal Allergy Survey Assessing Limitations. J Fam Pract 2012; 61 (2; Suppl.): S5–10.
37. Nathan RA. The burden of allergic rhinitis. Allergy Asthma Proc 2007; 28 (1): 3–9.
38. Blaiss MS. Pediatric allergic rhinitis: physical and mental complications. Allergy Asthma Proc 2008; 29 (1): 1–6.
39. Vuurman EF, van Veggel LM, Uiterwijk MM et al. Seasonal allergic rhinitis and antihistamine effects on children’s learning. Ann Allergy 1993; 71 (2): 121–6.
40. Willsie SK. Improved strategies and new treatment options for allergic rhinitis. J Am Osteopath Assoc 2002; 102 (6; Suppl. 2): S7–14.
41. Puchelle E, Zahm JM, Tournier JM, Coraux C. Airway epithelial repair, regeneration, and remodeling after injury in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2006; 3 (8): 726–33.
________________________________________________
2. Zenner S, Metelmann H. Therapeutic Experiences with a Homeopathic Nasal Spray. Hufeland Journal 1992;3:67–74.
3. Gottwald R, Weiser M. Antihomotoxic treatment of chronic sinusitis: results of a drug monitoring study with Euphorbium compositum S Drops. Translated from Medicina Biológica 2000; 13 (3): 84–7.
4. Sprenger F. A study with Euphorbium compositum nasal drops (metered dose spray without propellant gas). J General Practice 1984; 60 (27): 1164–8.
5. Connert WD, Maiwald J. Therapie chronisch-medikamentös und vasormotorisch bedingter rhinopathien. Erfahrungen mit einem biotherapeutischen nasenspray. Therapiewoche 1987; 37: 1179–86. English translation available in: Connert WD, Maiwald J. The therapy of rhinopathy: results of application of a biotherapeutic nasal spray. Biol Therapy 1991; 9 (4): 182–92.
6. Weiser M, Gottwald R. Homöopathische Nasentropfen lassen bei Kindern Rhinitis und Sinusitis schneller abklingen. Therapeutische Mitteilungen. Gesundes Leben 1999; 6: 63.
7. Ammerschläger H, Klein P, Weiser M, Oberbaum M. Treatment of infl ammatory diseases of the upper respiratory tract – comparison of a homeopathic complex remedy with xylometazoline. Forsch Komplementärmed Klass Naturheilkd 2005; 12: 24–31.
8. Urlea-Schön MI. Effectiveness and tolerability of Euphorbium comp SN for the symptomatic treatment of rhinitis in children aged 2–6 years. Eur J Int Med 2009; 1: 236 (Abstract PO-023).
9. Raab V. Practice report. Further therapeutic experience with Euphorbium compositum nasal drops (metered dose spray without propellant gas) in ENT practice. Biologische Medizin 1982; 4: 176–9.
10. Glatthaar-Saalmüller B, Fallier-Becker P. Antiviral action of Euphorbium compositum and its components. Forsch Komplementärmed Klass Naturheilkd 2001; 4: 207–12.
11. Glatthaar-Saalmüller B et al. Euphorbium compositum: viruses of the upper respiratory tract inhibited. Biologische Medizin 2002; 4: 194–5.
12. Metelmann H, Glatthaar-Saalmüller B. Antiviral action of a homeopathic medication. Biomed Ther 2000; 18 (1): 160–4.
13. Schmolz M, Metelmann H. Modulation of cytokine synthesis in human leukocytes by individual components of a combination homeopathic nasal spray. Biol Therapy 1999; 17 (2): 61–3; 75.
14. Dykewicz MS, Hamilos DL. Rhinitis and sinusitis. J Allergy Clin Immunol 2010; 125 (2; Suppl. 2): S103–15.
15. Fokkens WJ, Lund VJ, Mullol J et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. Rhinology 2012; 50 (Suppl. 23): 1–298.
16. Wallace DV, Dykewicz MS, Bernstein DI et al. Joint Task Force on Practice; American Academy of Allergy; Asthma & Immunology; American College of Allergy; Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 2008; 122 (2; Suppl): S1–84.
17. Rosenfeld RM, Andes D, Bhattacharyya N et al. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg 2007; 137 (3; Suppl.): S1–31.
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Авторы
А.А.Марьяновский
ГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н.И.Пирогова Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
Marjanovsky@arnebia.ru
ГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н.И.Пирогова Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
Marjanovsky@arnebia.ru
________________________________________________
A.A.Marianovskii
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
Marjanovsky@arnebia.ru
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
Marjanovsky@arnebia.ru
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