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Эффективность и безопасность комбинированной терапии астенического состояния с применением пирацетама и витаминов группы В в общей медицинской сети
Эффективность и безопасность комбинированной терапии астенического состояния с применением пирацетама и витаминов группы В в общей медицинской сети
Добрушина О.Р., Медведев В.Э. Эффективность и безопасность комбинированной терапии астенического состояния с применением пирацетама и витаминов группы В в общей медицинской сети. Consilium Medicum. 2016; 18 (9): 159–163. DOI: 10.26442/2075-1753_2016.9.159-163
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Аннотация
В ходе проведенного сравнительного исследования получены достоверные данные о том, что включение поливитаминного комплекса в комплексную терапию неврастении способствует ускорению редукции психопатологических симптомов.
Ключевые слова: неврастения, астенические состояния, комплексная терапия.
Ключевые слова: неврастения, астенические состояния, комплексная терапия.
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In the course of pilot naturalistic comparative trial, the authentic data were obtained that inclusion of polyvitaminic complex into complex therapy of neurasthenia contributes to reduction of severity of psychopathological symptoms.
Key words: neurasthenia, asthenic states, complex therapy.
Key words: neurasthenia, asthenic states, complex therapy.
Полный текст
Список литературы
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13. Путилина М.В. Особенности терапии астенических расстройств. Consilium Medicum. Неврология и Ревматология (Прил.). 2010; 1. / Putilina M.V. Osobennosti terapii astenicheskikh rasstroistv. Consilium Medicum. Neurology and Rheumatology (Suppl.). 2010; 1. [in Russian]
14. Carroll D, Ring Ch, Suter M, Willemsen G. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology 2000; 150: 220–5.
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16. Institute of Medicine (IOM). Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC, USA: National Academy Press, 1998.
17. Institute of Medicine (IOM). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. Washington, DC, USA: National Academy Press, 2000.
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19. Haskell CF, Robertson B, Jones E et al. Effects of a multi—Vitamin/mineral supplement on cognitive function and fatigue during extended multi—Tasking. Hum Psychopharmacol Clin 2010; 25: 448–61.
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21. Kennedy DO, Veasey R, Watson A et al. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology 2010; 211: 55–68.
22. Kennedy DO, Veasey RC, Watson AW et al. Vitamins and psychological functioning: A mobile phone assessment of the effects of a B vitamin complex, vitamin C and minerals on cognitive performance and subjective mood and energy. Hum Psychopharmacol Clin Exp 2011; 26: 538–47.
23. Mattson MP, Shea TB. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 2003; 26: 137–46.
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26. Popovic IC. Associations neurotropes de vitamines et de sels mineraux dans la therapeutique anti-stress. /Schweizer Zeitschr Ganzheits Med 1993; 3: 140–43.
27. Ranelli PL, Dickerson RN, White KG. Use of vitamin and mineral supplements by pharmacy students. Am J Hosp Pharm 1993; 50: 674–8.
28. Rosenberg IH, Miller JW. Nutritional factors in physical and cognitive functions of elderly people. Am J Clin Nutr 1992; 55: 1237–43.
29. Selishchev GS, Petchot-Bacque J-P, Volkov AK et al. An open non-comparative study on the efficacy of an oral multivitamin combination containing calcium and magnesium on persons permanently exposed to occupational stress-predisposing factors. J Clin Res 1998; 1: 303–15.
30. Scholey A, Bauer I, Neale Ch et al. Acute Effects of Different Multivitamin Mineral Preparations with and without Guaraná on Mood, Cognitive Performance and Functional Brain Activation. Nutrients 2013; 5: 3589–604.
31. Sobal J, Daly MP. Vitamin/mineral supplement use among general practice patients in the United Kingdom. Fam Pract 1990; 7: 181–3.
2. Gusev V.V., L'vova O.A. Sovremennye podkhody k terapii astenicheskogo sindroma. Consilium Medicum. 2013; 15 (1): 60–4. [in Russian]
3. Kardashian R.A., Dobrushina O.R., Medvedev V.E. Kupirovanie simptomov nevrastenii v obshchei meditsinskoi praktike. Lechashchii vrach. 2015; 12: 63–7. [in Russian]
4. Medvedev V.E. Psikhicheskie rasstroistva u patsientov s serdechno-sosudistymi zabolevaniiami: vozmozhnosti profilakticheskoi i kupiruiushchei terapii nootropnymi preparatami. Cardiosomatics. 2012; 3 (1): 22–8. [in Russian]
5. Medvedev V.E., Frolova V.I., Epifanov A.V. Novye vozmozhnosti farmakoterapii psikhicheskikh rasstroistv u patsientov s serdechno-sosudistymi zabolevaniiami. Zhurn. nevrologii i psikhiatrii im. C.C.Korsakova. 2014; 114 (9): 30–7. [in Russian]
6. Medvedev V.E. Novye vozmozhnosti lecheniia astenicheskikh rasstroistv v psikhiatricheskoi, nevrologicheskoi i somaticheskoi praktike. Psychiatry and Psychopharmacotherapy (P.B.Gannushkin Journal). 2013; 15 (4): 53–9. [in Russian]
7. Medvedev V.E. Predposylki ispol'zovaniia vitaminnykh kompleksov v ad"iuvantnoi terapii psikhicheskikh rasstroistv. Lechashchii vrach. 2015; 9. [in Russian]
8. Medvedev V.E. Psikhicheskie rasstroistva u patsientov s serdechno-sosudistymi zabolevaniiami: vozmozhnosti profilakticheskoi i kupiruiushchei terapii nootropnymi preparatami. Cardiosomatics. 2012; 1: 22–8. [in Russian]
9. Medvedev V.E., Zverev K.V., Epifanov A.V. i dr. Vozmozhnosti nootropnoi terapii pogranichnykh psikhicheskikh rasstroistv u patsientov, perenesshikh ostryi koronarnyi sindrom v usloviiakh kardiologicheskogo statsionara. Arkhiv" vnutrennei meditsiny. 2013; 1: 40–8. [in Russian]
10. Medvedev V.E. Nootropnye preparaty i neiroprotektory v lechenii psikhicheskikh rasstroistv (uchebnoe posobie). M., 2015. [in Russian]
11. Pizova N.V. Klinika, diagnostika i lechenie sindroma khronicheskoi ustalosti. Meditsinskii sovet. 2015; 2: 48–52. [in Russian]
12. Pizova N.V. Utomliaemost', asteniia i khronicheskaia ustalost'. Chto eto takoe? Consilium Medicum. 2012; 14 (2): 61–4. [in Russian]
13. Putilina M.V. Osobennosti terapii astenicheskikh rasstroistv. Consilium Medicum. Neurology and Rheumatology (Suppl.). 2010; 1. [in Russian]
14. Carroll D, Ring Ch, Suter M, Willemsen G. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology 2000; 150: 220–5.
15. Durga J, van Boxtel MPJ, Schouten EG et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007; 369: 208–16.
16. Institute of Medicine (IOM). Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC, USA: National Academy Press, 1998.
17. Institute of Medicine (IOM). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. Washington, DC, USA: National Academy Press, 2000.
18. Harris E, Kirk J, Rowsell R et al. The effect of multivitamin supplementation on mood and stress in healthy older men. Hum Psychopharmacol Clin Exp 2011; 26: 560–7.
19. Haskell CF, Robertson B, Jones E et al. Effects of a multi—Vitamin/mineral supplement on cognitive function and fatigue during extended multi—Tasking. Hum Psychopharmacol Clin 2010; 25: 448–61.
20. Kennedy DO, Haskell CF. Vitamins and cognition: What is the evidence? Drugs 2011; 71: 1957–71.
21. Kennedy DO, Veasey R, Watson A et al. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology 2010; 211: 55–68.
22. Kennedy DO, Veasey RC, Watson AW et al. Vitamins and psychological functioning: A mobile phone assessment of the effects of a B vitamin complex, vitamin C and minerals on cognitive performance and subjective mood and energy. Hum Psychopharmacol Clin Exp 2011; 26: 538–47.
23. Mattson MP, Shea TB. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 2003; 26: 137–46.
24. McGarel C, Pentieva K, Strain JJ, McNulty H. Emerging roles for folate and related B-vitamins in brain health across the lifecycle. Proc Nutr Soc 2015; 74 (1): 46–55.
25. Nelson MV, Bailie G. A survey of pharmacists recommendations for food supplements in the U.S.A. and U.K. J Clin Pharm Ther 1990; 15: 131–9.
26. Popovic IC. Associations neurotropes de vitamines et de sels mineraux dans la therapeutique anti-stress. /Schweizer Zeitschr Ganzheits Med 1993; 3: 140–43.
27. Ranelli PL, Dickerson RN, White KG. Use of vitamin and mineral supplements by pharmacy students. Am J Hosp Pharm 1993; 50: 674–8.
28. Rosenberg IH, Miller JW. Nutritional factors in physical and cognitive functions of elderly people. Am J Clin Nutr 1992; 55: 1237–43.
29. Selishchev GS, Petchot-Bacque J-P, Volkov AK et al. An open non-comparative study on the efficacy of an oral multivitamin combination containing calcium and magnesium on persons permanently exposed to occupational stress-predisposing factors. J Clin Res 1998; 1: 303–15.
30. Scholey A, Bauer I, Neale Ch et al. Acute Effects of Different Multivitamin Mineral Preparations with and without Guaraná on Mood, Cognitive Performance and Functional Brain Activation. Nutrients 2013; 5: 3589–604.
31. Sobal J, Daly MP. Vitamin/mineral supplement use among general practice patients in the United Kingdom. Fam Pract 1990; 7: 181–3.
2. Гусев В.В., Львова О.А. Современные подходы к терапии астенического синдрома. Consilium Medicum. 2013; 15 (1): 60–4. / Gusev V.V., L'vova O.A. Sovremennye podkhody k terapii astenicheskogo sindroma. Consilium Medicum. 2013; 15 (1): 60–4. [in Russian]
3. Кардашян Р.А., Добрушина О.Р., Медведев В.Э. Купирование симптомов неврастении в общей медицинской практике. Лечащий врач. 2015; 12: 63–7. / Kardashian R.A., Dobrushina O.R., Medvedev V.E. Kupirovanie simptomov nevrastenii v obshchei meditsinskoi praktike. Lechashchii vrach. 2015; 12: 63–7. [in Russian]
4. Медведев В.Э. Психические расстройства у пациентов с сердечно-сосудистыми заболеваниями: возможности профилактической и купирующей терапии ноотропными препаратами. CardioСоматика. 2012; 3 (1): 22–8. / Medvedev V.E. Psikhicheskie rasstroistva u patsientov s serdechno-sosudistymi zabolevaniiami: vozmozhnosti profilakticheskoi i kupiruiushchei terapii nootropnymi preparatami. Cardiosomatics. 2012; 3 (1): 22–8. [in Russian]
5. Медведев В.Э., Фролова В.И., Епифанов А.В. Новые возможности фармакотерапии психических расстройств у пациентов с сердечно-сосудистыми заболеваниями. Журн. неврологии и психиатрии им. C.C.Корсакова. 2014; 114 (9): 30–7. / Medvedev V.E., Frolova V.I., Epifanov A.V. Novye vozmozhnosti farmakoterapii psikhicheskikh rasstroistv u patsientov s serdechno-sosudistymi zabolevaniiami. Zhurn. nevrologii i psikhiatrii im. C.C.Korsakova. 2014; 114 (9): 30–7. [in Russian]
6. Медведев В.Э. Новые возможности лечения астенических расстройств в психиатрической, неврологической и соматической практике. Психиатрия и психофармакотерапия (Журнал им. П.Б.Ганнушкина). 2013; 15 (4): 53–9. / Medvedev V.E. Novye vozmozhnosti lecheniia astenicheskikh rasstroistv v psikhiatricheskoi, nevrologicheskoi i somaticheskoi praktike. Psychiatry and Psychopharmacotherapy (P.B.Gannushkin Journal). 2013; 15 (4): 53–9. [in Russian]
7. Медведев В.Э. Предпосылки использования витаминных комплексов в адъювантной терапии психических расстройств. Лечащий врач. 2015; 9. / Medvedev V.E. Predposylki ispol'zovaniia vitaminnykh kompleksov v ad"iuvantnoi terapii psikhicheskikh rasstroistv. Lechashchii vrach. 2015; 9. [in Russian]
8. Медведев В.Э. Психические расстройства у пациентов с сердечно-сосудистыми заболеваниями: возможности профилактической и купирующей терапии ноотропными препаратами. CardioSomatica. 2012; 1: 22–8. / Medvedev V.E. Psikhicheskie rasstroistva u patsientov s serdechno-sosudistymi zabolevaniiami: vozmozhnosti profilakticheskoi i kupiruiushchei terapii nootropnymi preparatami. Cardiosomatics. 2012; 1: 22–8. [in Russian]
9. Медведев В.Э., Зверев К.В., Епифанов А.В. и др. Возможности ноотропной терапии пограничных психических расстройств у пациентов, перенесших острый коронарный синдром в условиях кардиологического стационара. Архивъ внутренней медицины. 2013; 1: 40–8. / Medvedev V.E., Zverev K.V., Epifanov A.V. i dr. Vozmozhnosti nootropnoi terapii pogranichnykh psikhicheskikh rasstroistv u patsientov, perenesshikh ostryi koronarnyi sindrom v usloviiakh kardiologicheskogo statsionara. Arkhiv" vnutrennei meditsiny. 2013; 1: 40–8. [in Russian]
10. Медведев В.Э. Ноотропные препараты и нейропротекторы в лечении психических расстройств (учебное пособие). М., 2015. / Medvedev V.E. Nootropnye preparaty i neiroprotektory v lechenii psikhicheskikh rasstroistv (uchebnoe posobie). M., 2015. [in Russian]
11. Пизова Н.В. Клиника, диагностика и лечение синдрома хронической усталости. Медицинский совет. 2015; 2: 48–52. / Pizova N.V. Klinika, diagnostika i lechenie sindroma khronicheskoi ustalosti. Meditsinskii sovet. 2015; 2: 48–52. [in Russian]
12. Пизова Н.В. Утомляемость, астения и хроническая усталость. Что это такое? Consilium Medicum. 2012; 14 (2): 61–4. / Pizova N.V. Utomliaemost', asteniia i khronicheskaia ustalost'. Chto eto takoe? Consilium Medicum. 2012; 14 (2): 61–4. [in Russian]
13. Путилина М.В. Особенности терапии астенических расстройств. Consilium Medicum. Неврология и Ревматология (Прил.). 2010; 1. / Putilina M.V. Osobennosti terapii astenicheskikh rasstroistv. Consilium Medicum. Neurology and Rheumatology (Suppl.). 2010; 1. [in Russian]
14. Carroll D, Ring Ch, Suter M, Willemsen G. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology 2000; 150: 220–5.
15. Durga J, van Boxtel MPJ, Schouten EG et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007; 369: 208–16.
16. Institute of Medicine (IOM). Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC, USA: National Academy Press, 1998.
17. Institute of Medicine (IOM). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. Washington, DC, USA: National Academy Press, 2000.
18. Harris E, Kirk J, Rowsell R et al. The effect of multivitamin supplementation on mood and stress in healthy older men. Hum Psychopharmacol Clin Exp 2011; 26: 560–7.
19. Haskell CF, Robertson B, Jones E et al. Effects of a multi—Vitamin/mineral supplement on cognitive function and fatigue during extended multi—Tasking. Hum Psychopharmacol Clin 2010; 25: 448–61.
20. Kennedy DO, Haskell CF. Vitamins and cognition: What is the evidence? Drugs 2011; 71: 1957–71.
21. Kennedy DO, Veasey R, Watson A et al. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology 2010; 211: 55–68.
22. Kennedy DO, Veasey RC, Watson AW et al. Vitamins and psychological functioning: A mobile phone assessment of the effects of a B vitamin complex, vitamin C and minerals on cognitive performance and subjective mood and energy. Hum Psychopharmacol Clin Exp 2011; 26: 538–47.
23. Mattson MP, Shea TB. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 2003; 26: 137–46.
24. McGarel C, Pentieva K, Strain JJ, McNulty H. Emerging roles for folate and related B-vitamins in brain health across the lifecycle. Proc Nutr Soc 2015; 74 (1): 46–55.
25. Nelson MV, Bailie G. A survey of pharmacists recommendations for food supplements in the U.S.A. and U.K. J Clin Pharm Ther 1990; 15: 131–9.
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25. Nelson MV, Bailie G. A survey of pharmacists recommendations for food supplements in the U.S.A. and U.K. J Clin Pharm Ther 1990; 15: 131–9.
26. Popovic IC. Associations neurotropes de vitamines et de sels mineraux dans la therapeutique anti-stress. /Schweizer Zeitschr Ganzheits Med 1993; 3: 140–43.
27. Ranelli PL, Dickerson RN, White KG. Use of vitamin and mineral supplements by pharmacy students. Am J Hosp Pharm 1993; 50: 674–8.
28. Rosenberg IH, Miller JW. Nutritional factors in physical and cognitive functions of elderly people. Am J Clin Nutr 1992; 55: 1237–43.
29. Selishchev GS, Petchot-Bacque J-P, Volkov AK et al. An open non-comparative study on the efficacy of an oral multivitamin combination containing calcium and magnesium on persons permanently exposed to occupational stress-predisposing factors. J Clin Res 1998; 1: 303–15.
30. Scholey A, Bauer I, Neale Ch et al. Acute Effects of Different Multivitamin Mineral Preparations with and without Guaraná on Mood, Cognitive Performance and Functional Brain Activation. Nutrients 2013; 5: 3589–604.
31. Sobal J, Daly MP. Vitamin/mineral supplement use among general practice patients in the United Kingdom. Fam Pract 1990; 7: 181–3.
Авторы
О.Р.Добрушина1, В.Э.Медведев*2
1 ООО Международный институт психосоматического здоровья. 107031, Россия, Москва, ул. Неглинная, д. 14, стр. 1а, под. 7;
2 ФГАОУ ВО Российский университет дружбы народов. 117198, Россия, Москва, ул. Миклухо-Маклая, д. 6
*medvedev_ve@pfur.ru
1 ООО Международный институт психосоматического здоровья. 107031, Россия, Москва, ул. Неглинная, д. 14, стр. 1а, под. 7;
2 ФГАОУ ВО Российский университет дружбы народов. 117198, Россия, Москва, ул. Миклухо-Маклая, д. 6
*medvedev_ve@pfur.ru
________________________________________________
O.R.Dobrushina1, V.E.Medvedev*2
1 International Institute of Psychosomatic Health. 107031, Russian Federation, Moscow, ul. Neglinnaia, d. 14, str. 1a, pod. 7;
2 People’s Friendship University of Russia. 117198, Russian Federation, Moscow, ul. Miklukho-Maklaya, d. 6
*medvedev_ve@pfur.ru
1 International Institute of Psychosomatic Health. 107031, Russian Federation, Moscow, ul. Neglinnaia, d. 14, str. 1a, pod. 7;
2 People’s Friendship University of Russia. 117198, Russian Federation, Moscow, ul. Miklukho-Maklaya, d. 6
*medvedev_ve@pfur.ru
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