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Тройные комбинации в лечении артериальной гипертензии – реальный путь улучшения контроля артериального давления
Тройные комбинации в лечении артериальной гипертензии – реальный путь улучшения контроля артериального давления
Морозова Т.Е., Юдина И.Ю. Тройные комбинации в лечении артериальной гипертензии – реальный путь улучшения контроля артериального давления. Consilium Medicum. 2017; 19 (1): 8–12.
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Аннотация
Неэффективный контроль уровня артериального давления у больных эссенциальной артериальной гипертензией у российских пациентов (менее 30% у женщин, менее 20% у мужчин) продемонстрирован в эпидемиологических исследованиях. В статье приводится обзор современных возможностей по повышению эффективности лечения артериальной гипертензии с помощью трехкомпонентной комбинированной антигипертензивной терапии и применения фиксированных комбинаций. Обсуждаются преимущества комбинированной антигипертензивной терапии, включающей длительно действующий дигидропиридиновый антагонист кальция амлодипин, тиазидоподобный диуретик индапамид и ингибитор ангиотензинпревращающего фермента периндоприл в различных клинических ситуациях. Приводится обзор исследований, свидетельствующих об эффективности и безопасности фиксированной комбинации амлодипин/индапамид/периндоприл.
Ключевые слова: артериальная гипертензия, антигипертензивная терапия, фармакотерапия, комбинированная фармакотерапия, фиксированные комбинации, ингибиторы ангиотензинпревращающего фермента, антагонисты кальция, тиазидоподобные диуретики, индапамид, периндоприл, амлодипин.
Ключевые слова: артериальная гипертензия, антигипертензивная терапия, фармакотерапия, комбинированная фармакотерапия, фиксированные комбинации, ингибиторы ангиотензинпревращающего фермента, антагонисты кальция, тиазидоподобные диуретики, индапамид, периндоприл, амлодипин.
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Ineffective control of blood pressure in patients with essential arterial hypertension in Russian patients (less than 30% women, 20% less than men) demonstrated in epidemiological studies. The article provides an overview of current capabilities to enhance the effectiveness of the treatment of hypertension using a triple combination antihypertensive therapy and the use of fixed combinations. The advantages of combination antihypertensive therapy, including long-acting dihydropyridine calcium channel blocker amlodipine, thiazide diuretic indapamide, and angiotensin-converting enzyme inhibitors perindopril in various clinical situations. A review of research evidence on the effectiveness and safety of a fixed combination of amlodipine/indapamide/perindopril.
Key words: arterial hypertension, antihypertensive therapy, pharmacotherapy, combined pharmacotherapy, a fixed combination of angiotensin-converting enzyme inhibitors, calcium channel blockers, thiazide diuretics, indapamide, perindopril, amlodipine.
Key words: arterial hypertension, antihypertensive therapy, pharmacotherapy, combined pharmacotherapy, a fixed combination of angiotensin-converting enzyme inhibitors, calcium channel blockers, thiazide diuretics, indapamide, perindopril, amlodipine.
Полный текст
Список литературы
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11. Thoenes M, Neuberger H-R, Volpe M et al. Antihypertensive drug therapy and blood pressure control in men and women: an international perspective. J Hum Hypertens 2010; 24, 336–44.
12. Osterberg L, Blaschke T. Adherence to Medication. N Engl J Med 2005; 353: 487–97.
13. Egan BM, Bandyopadhyay D, Shaftman SR et al. Initial monotherapy and combination therapy and hypertension control the first year. Hypertension 2012; 59 (6): 1124–31.
14. Gupta AK, Arshad S, Poulter N.R. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents, a meta-analysis. Hypertension 2010; 55: 399–407.
15. Burnier et al. Antihypertensive Combination Treatment: State of the Art. Curr Hypertens Rep 2015; 17: 51.
16. Toth K. PIANIST Investigators. Antihypertensive efficacy of triple combination plus amlodipine in risk hypertensive patients. Am J Cardiovasc Drugs 2014; 14 (2): 137–45.
17. Páll D, Szántó I, Szabó Z. Triple combination therapy in hypertension: the antihypertensive efficacy of treatment with perindopril, amlodipine, and indapamide SR. Clin Drug Investig 2014; 34: 701–8.
18. Efficiency of the combined treatment of arterial hypertension in Ukraine: results of the TRIUMF multicenter study M.I.Lutay, on behalf of the TRIUMF multicenter study group. Український кардіологічний журнал 2016; 4: 17–28.
2. Chazova I.E. i dr. Rasprostranennost' faktorov riska serdechno-sosudistykh zabolevanii v rossiiskoi populiatsii bol'nykh arterial'noi gipertoniei. Kardiologiia. 2014; 10: 4–12. [in Russian]
3. Oganov R.G. i dr. Epidemiologiia arterial'noi gipertonii v Rossii. Rezul'taty federal'nogo monitoringa 2003–2010 gg. Kardiovaskuliarnaia terapiia i profilaktika. 2011; 10 (1): 9–13. [in Russian]
4. Ezzati M, Lopez A, Rodgers A et al. Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors. Geneva: World Health Organization, 2004.
5. Diagnostika i lechenie arterial'noi gipertonii. Klinicheskie rekomendatsii, 2013. http://www.cardioweb.ru/klinicheskie-rekomendatsii [in Russian]
6. ESH/ESC Guidelines for the management of arterial hypertension. J Hypertens 2013; 31 (7): 1281–357.
7. Mourad JJ, Waeber B, Zannad F et al. Comparison of different therapeutic strategies in hypertension: a low-dose combination of perindopril/indapamide versus a sequential monotherapy or a stepped-care approach. J Hypertens 2004; 22: 2379–86.
8. Wald Ds, Law M, Morris JK et al. Combination therapy vs. monotherapy in reducing blood pressure: meta-analysis on 11 000 participants from 42 trials. Am J Med 2009; 122: 290–300.
9. Schafer HH, Sudano I, Theus GR et al. Target blood pressure attainment with antihypertensive therapy in Swiss primary care. Blood Press 2012; 21: 211–19.
10. Bronsert MR, Henderson WG, Valuck R et al. Comparative effectiveness of antihypertensive therapeutic classes and treatment strategies in the initiation of therapy in primary care patients: a distributed ambulatory research in therapeutics network (DARTNet) study. J Am Board Fam Med 2013; 26: 529–38.
11. Thoenes M, Neuberger H-R, Volpe M et al. Antihypertensive drug therapy and blood pressure control in men and women: an international perspective. J Hum Hypertens 2010; 24, 336–44.
12. Osterberg L, Blaschke T. Adherence to Medication. N Engl J Med 2005; 353: 487–97.
13. Egan BM, Bandyopadhyay D, Shaftman SR et al. Initial monotherapy and combination therapy and hypertension control the first year. Hypertension 2012; 59 (6): 1124–31.
14. Gupta AK, Arshad S, Poulter N.R. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents, a meta-analysis. Hypertension 2010; 55: 399–407.
15. Burnier et al. Antihypertensive Combination Treatment: State of the Art. Curr Hypertens Rep 2015; 17: 51.
16. Toth K. PIANIST Investigators. Antihypertensive efficacy of triple combination plus amlodipine in risk hypertensive patients. Am J Cardiovasc Drugs 2014; 14 (2): 137–45.
17. Páll D, Szántó I, Szabó Z. Triple combination therapy in hypertension: the antihypertensive efficacy of treatment with perindopril, amlodipine, and indapamide SR. Clin Drug Investig 2014; 34: 701–8.
18. Efficiency of the combined treatment of arterial hypertension in Ukraine: results of the TRIUMF multicenter study M.I.Lutay, on behalf of the TRIUMF multicenter study group. Український кардіологічний журнал 2016; 4: 17–28.
2. Чазова И.Е. и др. Распространенность факторов риска сердечно-сосудистых заболеваний в российской популяции больных артериальной гипертонией. Кардиология. 2014; 10: 4–12. / Chazova I.E. i dr. Rasprostranennost' faktorov riska serdechno-sosudistykh zabolevanii v rossiiskoi populiatsii bol'nykh arterial'noi gipertoniei. Kardiologiia. 2014; 10: 4–12. [in Russian]
3. Оганов Р.Г. и др. Эпидемиология артериальной гипертонии в России. Результаты федерального мониторинга 2003–2010 гг. Кардиоваскулярная терапия и профилактика. 2011; 10 (1): 9–13. / Oganov R.G. i dr. Epidemiologiia arterial'noi gipertonii v Rossii. Rezul'taty federal'nogo monitoringa 2003–2010 gg. Kardiovaskuliarnaia terapiia i profilaktika. 2011; 10 (1): 9–13. [in Russian]
4. Ezzati M, Lopez A, Rodgers A et al. Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors. Geneva: World Health Organization, 2004.
5. Диагностика и лечение артериальной гипертонии. Клинические рекомендации, 2013. http://www.cardioweb.ru/klinicheskie-rekomendatsii / Diagnostika i lechenie arterial'noi gipertonii. Klinicheskie rekomendatsii, 2013. http://www.cardioweb.ru/klinicheskie-rekomendatsii [in Russian]
6. ESH/ESC Guidelines for the management of arterial hypertension. J Hypertens 2013; 31 (7): 1281–357.
7. Mourad JJ, Waeber B, Zannad F et al. Comparison of different therapeutic strategies in hypertension: a low-dose combination of perindopril/indapamide versus a sequential monotherapy or a stepped-care approach. J Hypertens 2004; 22: 2379–86.
8. Wald Ds, Law M, Morris JK et al. Combination therapy vs. monotherapy in reducing blood pressure: meta-analysis on 11 000 participants from 42 trials. Am J Med 2009; 122: 290–300.
9. Schafer HH, Sudano I, Theus GR et al. Target blood pressure attainment with antihypertensive therapy in Swiss primary care. Blood Press 2012; 21: 211–19.
10. Bronsert MR, Henderson WG, Valuck R et al. Comparative effectiveness of antihypertensive therapeutic classes and treatment strategies in the initiation of therapy in primary care patients: a distributed ambulatory research in therapeutics network (DARTNet) study. J Am Board Fam Med 2013; 26: 529–38.
11. Thoenes M, Neuberger H-R, Volpe M et al. Antihypertensive drug therapy and blood pressure control in men and women: an international perspective. J Hum Hypertens 2010; 24, 336–44.
12. Osterberg L, Blaschke T. Adherence to Medication. N Engl J Med 2005; 353: 487–97.
13. Egan BM, Bandyopadhyay D, Shaftman SR et al. Initial monotherapy and combination therapy and hypertension control the first year. Hypertension 2012; 59 (6): 1124–31.
14. Gupta AK, Arshad S, Poulter N.R. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents, a meta-analysis. Hypertension 2010; 55: 399–407.
15. Burnier et al. Antihypertensive Combination Treatment: State of the Art. Curr Hypertens Rep 2015; 17: 51.
16. Toth K. PIANIST Investigators. Antihypertensive efficacy of triple combination plus amlodipine in risk hypertensive patients. Am J Cardiovasc Drugs 2014; 14 (2): 137–45.
17. Páll D, Szántó I, Szabó Z. Triple combination therapy in hypertension: the antihypertensive efficacy of treatment with perindopril, amlodipine, and indapamide SR. Clin Drug Investig 2014; 34: 701–8.
18. Efficiency of the combined treatment of arterial hypertension in Ukraine: results of the TRIUMF multicenter study M.I.Lutay, on behalf of the TRIUMF multicenter study group. Український кардіологічний журнал 2016; 4: 17–28.
________________________________________________
2. Chazova I.E. i dr. Rasprostranennost' faktorov riska serdechno-sosudistykh zabolevanii v rossiiskoi populiatsii bol'nykh arterial'noi gipertoniei. Kardiologiia. 2014; 10: 4–12. [in Russian]
3. Oganov R.G. i dr. Epidemiologiia arterial'noi gipertonii v Rossii. Rezul'taty federal'nogo monitoringa 2003–2010 gg. Kardiovaskuliarnaia terapiia i profilaktika. 2011; 10 (1): 9–13. [in Russian]
4. Ezzati M, Lopez A, Rodgers A et al. Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors. Geneva: World Health Organization, 2004.
5. Diagnostika i lechenie arterial'noi gipertonii. Klinicheskie rekomendatsii, 2013. http://www.cardioweb.ru/klinicheskie-rekomendatsii [in Russian]
6. ESH/ESC Guidelines for the management of arterial hypertension. J Hypertens 2013; 31 (7): 1281–357.
7. Mourad JJ, Waeber B, Zannad F et al. Comparison of different therapeutic strategies in hypertension: a low-dose combination of perindopril/indapamide versus a sequential monotherapy or a stepped-care approach. J Hypertens 2004; 22: 2379–86.
8. Wald Ds, Law M, Morris JK et al. Combination therapy vs. monotherapy in reducing blood pressure: meta-analysis on 11 000 participants from 42 trials. Am J Med 2009; 122: 290–300.
9. Schafer HH, Sudano I, Theus GR et al. Target blood pressure attainment with antihypertensive therapy in Swiss primary care. Blood Press 2012; 21: 211–19.
10. Bronsert MR, Henderson WG, Valuck R et al. Comparative effectiveness of antihypertensive therapeutic classes and treatment strategies in the initiation of therapy in primary care patients: a distributed ambulatory research in therapeutics network (DARTNet) study. J Am Board Fam Med 2013; 26: 529–38.
11. Thoenes M, Neuberger H-R, Volpe M et al. Antihypertensive drug therapy and blood pressure control in men and women: an international perspective. J Hum Hypertens 2010; 24, 336–44.
12. Osterberg L, Blaschke T. Adherence to Medication. N Engl J Med 2005; 353: 487–97.
13. Egan BM, Bandyopadhyay D, Shaftman SR et al. Initial monotherapy and combination therapy and hypertension control the first year. Hypertension 2012; 59 (6): 1124–31.
14. Gupta AK, Arshad S, Poulter N.R. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents, a meta-analysis. Hypertension 2010; 55: 399–407.
15. Burnier et al. Antihypertensive Combination Treatment: State of the Art. Curr Hypertens Rep 2015; 17: 51.
16. Toth K. PIANIST Investigators. Antihypertensive efficacy of triple combination plus amlodipine in risk hypertensive patients. Am J Cardiovasc Drugs 2014; 14 (2): 137–45.
17. Páll D, Szántó I, Szabó Z. Triple combination therapy in hypertension: the antihypertensive efficacy of treatment with perindopril, amlodipine, and indapamide SR. Clin Drug Investig 2014; 34: 701–8.
18. Efficiency of the combined treatment of arterial hypertension in Ukraine: results of the TRIUMF multicenter study M.I.Lutay, on behalf of the TRIUMF multicenter study group. Український кардіологічний журнал 2016; 4: 17–28.
Авторы
Т.Е.Морозова*, И.Ю.Юдина
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2
*temorozova@gmail.com
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2
*temorozova@gmail.com
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T. E.Morozova*, I.Yu. Yudina
I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2
*temorozova@gmail.com
I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2
*temorozova@gmail.com
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