Burd S.G., Mironov M.B., Rubleva Yu.V.,
Krasilshikova T.M. Injectable valproate in the treatment of status
epilepticus. Review of literature, clinical observation. Consilium
Medicum. 2018; 20 (2): 124–127. DOI: 10.26442/2075-1753_2018.2.124-127
Инъекционные вальпроаты в лечении эпилептического статуса. Обзор литературы, клиническое наблюдение
Burd S.G., Mironov M.B., Rubleva Yu.V.,
Krasilshikova T.M. Injectable valproate in the treatment of status
epilepticus. Review of literature, clinical observation. Consilium
Medicum. 2018; 20 (2): 124–127. DOI: 10.26442/2075-1753_2018.2.124-127
В статье представлен литературный обзор применения инъекционных форм вальпроатов в лечении эпилептического статуса. Показан клинический случай доброкачественной затылочной эпилепсии со статусным течением приступов, купированных вальпроатом натрия внутривенно.
Наши данные и результаты исследований других авторов показали высокую эффективность и переносимость препаратов вальпроевой кислоты в инъекционной форме в лечении эпилептического статуса.
The article presents a literature review of the use of the injectable forms of valproate in the treatment of epileptic status. A clinical case of benign occipital epilepsy with a statistic course of attacks, stopped with valproic acid derivatives intravenously, is shown.
Our data and the results of other authors' studies showed high efficacy and tolerability of valproic acid preparations in the injectable form in the treatment of epileptic status.
Key words: epilepsy, status epilepticus, valproate, injectable form.
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13. Alldredge BK, Gelb AM, Isaacs SM et al. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med 2001; 345: 631–7.
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15. Silbergleit R, Durkalski V, Lowenstein D et al. NETT Investigators, et al. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med 2012; 366: 591–600. DOI: 10.1056/NEJMoa1107494
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21. Olsen KB, Tauboll E, Gjerstad L. Valproate is an effective, well-tolerated drug for treatment of status epilepticus/serial attacks in adults. Acta Neurol Scand Suppl 2007; 187: 51–4.
22. Chen L, Feng P, Wang J et al. Intravenous sodium valproate in mainland China for the treatment of diazepam refractory convulsive status epilepticus. J Clin Neurosci 2009; 16 (4): 524–6. DOI: 10.1016/j.jocn.2008.06.007
23. Mundlamuri RC, Sinha S, Subbakrishna DK et al. Management of generalised convulsive status epilepticus (SE): A prospective randomised controlled study of combined treatment with intravenous lorazepam with either phenytoin, sodium valproate or levetiracetam Pilot study. Epilepsy Res 2015; 114: 52–8. DOI: 10.1016/j.eplepsyres.2015.04.013
24. Yasiry Z, Shorvon SD. The relative effectiveness of five antiepileptic drugs in treatment of benzodiazepine-resistant convulsive status epilepticus: a meta-analysis of published studies. Seizure 2014; 23: 167–74.
1. Fisher RS, Cross JH, D'Souza C et al. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017; 58: 531–542. DOI:10.1111/epi.13671
2. Karlov V.A. Epilepsiya u detei i vzroslykh zhenshchin i muzhchin. M.: Meditsina, 2010. [in Russian]
3. Lowenstein DH, Bleck T, Macdonald RL. It’s time to revise the definition of status epilepticus. Epilepsia 1999; 40: 120–2.
4. Mukhin K.Yu., Kholin A.A., Petrukhin A.S. i dr. Elektro-klinicheskaia kharakteristika sindroma Landau–Kleffnera. Zhurn. nevrologii i psikhiatrii im. C.C.Korsakova. 2003; 103: 16. [in Russian]
5. Kholin A.A. Epilepticheskii status v mladencheskom i rannem detskom vozraste. Avtoref. dis. ... d-ra med. nauk. M., 2010. [in Russian]
6. Kholin A.A., Ilina E.S., Lemeshko I.D. i dr. Zlokachestvennye migriruiushchie partsial'nye pristupy mladenchestva (nabliudenie 13 klinicheskikh sluchaev). Vestn. nevrologii, psikhiatrii i neirokhirurgii. 2010; 10: 39–54. [in Russian]
8. Rosenow F, Hamer HM, Knake S. The epidemiology of convulsive and nonconvulsive status epilepticus. Epilepsia 2007; 48 (Suppl. 8): S82–4.
9. Guzeva V.I. Federal'noe rukovodstvo po detskoi nevrologii. Pod red. V.I.Guzevoi. M.: Spetsial'noe izdatel'stvo meditsinskikh knig, 2016. [in Russian]
10. Shorvon S, Baulac M, Cross H et al. The drug treatment of status epilepticus in Europe: consensus document from a workshop at the first London Colloquium on Status Epilepticus. Epilepsia 2008; 49: 1277–85. DOI: 10.1111/j.1528- 1167.2008.01706_3.x
11. Leppik IE, Derivan AT, Homan RW et al. Double-blind study of lorazepam and diazepam in status epilepticus. JAMA 1983; 249: 1452–4.
12. Treiman DM, Meyers PD, Walton NY et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med 1998; 339: 792–8.
13. Alldredge BK, Gelb AM, Isaacs SM et al. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med 2001; 345: 631–7.
14. Silbergleit R, Lowenstein D, Durkalski V, Conwit R. Neurological Emergency Treatment Trials (NETT) Investigators. RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics. Epilepsia 2011; 52 (Suppl. 8): S45–7. DOI: 10.1111/j.1528-1167.2011.03235.x. 15
15. Silbergleit R, Durkalski V, Lowenstein D et al. NETT Investigators, et al. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med 2012; 366: 591–600. DOI: 10.1056/NEJMoa1107494
16. Trinka E. What is the relative value of the standard anticonvulsants: Phenytoin and fosphenytoin, phenobarbital, valproate, and levetiracetam? Epilepsia 2009; 50 (Suppl. 12): S40–3. DOI: 10.1111/j.1528-1167.2009.02368.x
17. Giroud M, Gras D, Escousse A et al. Use of injectable valproic acid in status epilepticus. A pilot study. Drug Investig 1993; 5: 154–9.
18. Czapinski P, Terczynski A. Intravenous valproic acid administration in status epilepticus. Neurol Neurochir Pol 1998; 32 (1): 11–22.
19. Jha S, Jose M, Patel R. Intravenous sodium valproate in status epilepticus. Neurol India 2003 Sep; 51 (3): 421–2.
20. Peters CN, Pohlmann-Eden B. Intravenous valproate as an innovative therapy in seizure emergency situations including status epilepticus--experience in 102 adult patients. Seizure 2005; 14 (3): 164–9.
21. Olsen KB, Tauboll E, Gjerstad L. Valproate is an effective, well-tolerated drug for treatment of status epilepticus/serial attacks in adults. Acta Neurol Scand Suppl 2007; 187: 51–4.
22. Chen L, Feng P, Wang J et al. Intravenous sodium valproate in mainland China for the treatment of diazepam refractory convulsive status epilepticus. J Clin Neurosci 2009; 16 (4): 524–6. DOI: 10.1016/j.jocn.2008.06.007
23. Mundlamuri RC, Sinha S, Subbakrishna DK et al. Management of generalised convulsive status epilepticus (SE): A prospective randomised controlled study of combined treatment with intravenous lorazepam with either phenytoin, sodium valproate or levetiracetam Pilot study. Epilepsy Res 2015; 114: 52–8. DOI: 10.1016/j.eplepsyres.2015.04.013
24. Yasiry Z, Shorvon SD. The relative effectiveness of five antiepileptic drugs in treatment of benzodiazepine-resistant convulsive status epilepticus: a meta-analysis of published studies. Seizure 2014; 23: 167–74.
1 ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1;
2 Медицинский центр детской неврологии и педиатрии. 125371, Россия, Москва, пр-т Андропова, д. 13/32
1 N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovityanova, d. 1;
2 Medical center of pediatric neurology and pediatrics. 125371, Russian Federation, Moscow, prospekt Andropova, d. 13/32