Роль биомаркеров крови в прогнозировании исхода течения ишемического инсульта
Роль биомаркеров крови в прогнозировании исхода течения ишемического инсульта
Гулиева М.Ш., Багманян С.Д., Чуканова А.С., Чуканова Е.И. Роль биомаркеров крови в прогнозировании исхода течения ишемического инсульта. Consilium Medicum. 2020; 22 (9): 28–32. DOI: 10.26442/20751753.2020.9.200284
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Gulieva M.S., Bagmanian S.D., Chukanova A.S., Chukanova E.I. The role of blood biomarkers in predicting the outcome of ischemic stroke. Consilium Medicum. 2020; 22 (9): 28–32. DOI: 10.26442/20751753.2020.9.200284
Роль биомаркеров крови в прогнозировании исхода течения ишемического инсульта
Гулиева М.Ш., Багманян С.Д., Чуканова А.С., Чуканова Е.И. Роль биомаркеров крови в прогнозировании исхода течения ишемического инсульта. Consilium Medicum. 2020; 22 (9): 28–32. DOI: 10.26442/20751753.2020.9.200284
________________________________________________
Gulieva M.S., Bagmanian S.D., Chukanova A.S., Chukanova E.I. The role of blood biomarkers in predicting the outcome of ischemic stroke. Consilium Medicum. 2020; 22 (9): 28–32. DOI: 10.26442/20751753.2020.9.200284
Инсульт является одним из наиболее распространенных неврологических заболеваний и третьей причиной инвалидизации пациентов. Ежегодно во всем мире от инсульта умирают более 5 млн человек, и каждый 6-й выживший пациент в течение последующих 5 лет переносит повторный инсульт. За последние два десятилетия отмечается снижение уровня смертности от данного заболевания, однако процент инвалидизации остается еще очень высоким. В настоящее время актуальным направлением научных разработок является прогнозирование течения инсульта, которое позволит разрабатывать оптимальные терапевтические подходы и разрабатывать индивидуальные программы реабилитационного лечения. Одним из перспективных направлений для прогнозирования течения ишемии мозга является использование биомаркеров, изучение роли которых находится в стадии разработки, и их дальнейшие исследования актуальны для возможности их применения в клинической практике врача.
Stroke is one of the most common neurological diseases and the third cause of patient disability. More than 5 million people die from stroke worldwide annually, and every 6th patient survived has a second stroke for the next 5 years. Over the past two decades, mortality from this disease has been declining, but the percentage of disability remains very high. Today, predicting the course of stroke is an important field of scientific development, which will allow to elaborate optimal therapeutic approaches and individualized rehabilitation programs. One of the promising directions for predicting the course of cerebral ischemia is the use of biomarkers, the role of which is being studied, and their further research is relevant for the possibility of their use in clinical practice.
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20. Dassan P, Keir G, Brown MM. Criteria for a clinically informative serum biomarker in acute ischaemic stroke: a review of S100B. Cerebrovasc Dis 2009; 27 (3): 295–302. DOI: 10.1159/000199468
21. Hatfield R, McKernan R. CSF neuron-specific enolase as a quantitative marker of neuronal damage in a rat stroke model. Brain Res 1992; 577: 249–52.
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27. Wunderlich MT, Ebert AD, Kratz T et al. Early neurobehavioral outcome after stroke is related to release of neurobiochemical markers of brain damage. Stroke 1999; 30: 1190–5.
28. Hill MD, Jackowski G, Bayer N et al. Biochemical markers in acute ischemic stroke. CMAJ 2000; 162: 1139–40.
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31. Cunningham RT, Young IS, Winder J et al. Serum neurone specific enolase (NSE) levels as an indicator of neuronal damage in patients with cerebral infarction. Eur J Clin Invest 1991; 21 (5): 497–500.
32. Missler U, Wiesmann M, Friedrich C, Kaps M. S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke 1997; 28 (10): 1956–60.
33. Hasan N, McColgan P, Bentley P et al. Towards the identification of blood biomarkers for acute stroke in humans: a comprehensive systematic review. Br J Clin Pharmacol 2012; 74: 230–40.
34. Martinez-Sanchez P, Gutierrez-Fernandez M, Fuentes B et al. Biochemical and inflammatory biomarkers in ischemic stroke: translational study between humans and two experimental rat models. J Transl Med 2014; 12: 220.
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1. Feigin VL, Norrving B, Mensah GA. Global burden of stroke. Circ Res 2017; 120 (3): 439–48. DOI: 10.1161/CIRCRESAHA.116.308413
2. Riabukhin I.A. Neirospetsificheskie belki v otsenke pronitsaemosti gematoentsefalicheskogo bar'era cheloveka i zhivotnykh. Dis. ... d-ra med. nauk. Moscow, 2004 (in Russian).
3. Blinov D.V. Sovremennye predstavleniia o roli narusheniia rezistentnosti gematoentsefalicheskogo bar'era v patogeneze zabolevanii TsNS. Chast' 2: funktsii i mekhanizmy povrezhdeniia gematoentsefalicheskogo bar'era. Epilepsiia i paroksizmal'nye sostoianiia. 2014; 6 (1): 70–84 (in Russian).
4. Fischer S, Clauss M, Wiesnet M et al. Hypoxia induces permeability in brain microvessel endothelial cells via VEGF and NO. Am J Physiol 1999; 276: 812–20.
5. Schaarschmidt H, Prange HW, Reiber H. Neuron-specific enolase concentrations in blood as a prognostic parameter in cerebrovascular diseases. Stroke 1994; 25: 558–65.
6. Barone FC, Clerk RK, Price W. Neuron-specific enolase increases in cerebral and systemic circulation following focal ischemia. Brain Res 1993; 1: 71–82.
7. Herrmann M, Jost S, Kutz S et al. Temporal profile of release of neurobiochemical markers of brain damage after traumatic brain injury is associated with intracranial pathology as demonstrated in cranial computerized tomography. J Neurotrauma 2000; 17: 113–22.
8. Herrmann M, Elirenreich H. Brain derived proteins as markers of acute stroke: their relation to pathophysiology, outcome prediction and neuroprotective drug monitoring. Restor Neurol Neurosci 2003; 21: 177–90.
9. Chekhonin VP, Zhirkov YA, Belyaeva IA et al. Serum time course of two brain-specific proteins, alpha(l) brain globulin and neuron-specific enolase, in tick-born encephalitis and Lyme disease. Clin Chim Acta 2002; 320: 117–25.
10. Eng LF, Ghirnikar RS, Lee YL. Glial fibrillary acidic protein: GFAP-thirty-one years (1969–2000). Neurochem Res 2000; 25: 1439–51.
11. Engvall E, Perlman P. Enzyme-linked immunoadsorbent assay (ELISA). Quantitative assay of immunoglobulin G. Immunochem 1971; 8: 871–9.
12. Chekhonin V.P., Zhirkov Iu.A., Turina O.I. et al. Kolichestvenno-kineticheskie parametry eliminatsii neirospetsificheskikh antigenov i antitel k nim pri nekotorykh nervno-psikhicheskikh zabolevaniiakh. Ros. psikhiatrich. zhurn. 2000; 3: 4–8 (in Russian).
13. Perry LA, Lucarelli T, Penny-Dimri JC et al. Glial fibrillary acidic protein for the early diagnosis of intracerebral hemorrhage: Systematic review and meta-analysis of diagnostic test accuracy. Int J Stroke 2019; 14 (4): 390–9. DOI: 10.1177/1747493018806167
14. Nylén K, Csajbok LZ, Ost M et al. Serum glial fibrillary acidic protein is related to focal brain injury and outcome after aneurysmal subarachnoid hemorrhage. Stroke 2007; 38 (5): 1489–94.
15. Moore BW. A soluble protein characteristic of the nervous system. Biochem Biophys Res Commun 1965; 19: 739–44.
16. Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 2001; 33: 637–68.
17. Saengen AK, Christenson RN. Stroke Biomarkers: Progress and Challenges for Diagnosis, Prognosis, Differentiation and Treatment. Clin Chem 2010; 56 (1): 21–33.
18. Harish Kumar, Manoj Lakhotia, Hansraj Pahadiya, Jagdish Singh. To study the correlation of serum S-100 protein level with the severity of stroke and its prognostic implication. J Neurosci Rural Pract 2015; 6 (3): 326–30. DOI: 10.4103/0976-3147.158751
19. Foerch C, Singer OC, Neumann-Haefelin T et al. Evaluation of serum S100B as a surrogate marker for long-term outcome and infarct volume in acute middle cerebral artery infarction. Arch Neurol 2005; 62 (7): 1130–4.
20. Dassan P, Keir G, Brown MM. Criteria for a clinically informative serum biomarker in acute ischaemic stroke: a review of S100B. Cerebrovasc Dis 2009; 27 (3): 295–302. DOI: 10.1159/000199468
21. Hatfield R, McKernan R. CSF neuron-specific enolase as a quantitative marker of neuronal damage in a rat stroke model. Brain Res 1992; 577: 249–52.
22. Woertgen C, Rothoerl RD, Brawanski A. Neuron-specific enolase serum levels after controlled cortical impact injury in the rat. J Neurotrauma 2001; 18: 569–73.
23. Haupt WF, Chopan G, Sobesky J et al. Prognostic value of somatosensory evoked potentials, neuron-specific enolase, and S100 for short-term outcome in ischemic stroke. J Neurophysiol 2016; 115: 1273–8.
24. Stevens H, Jakobs C, de Jager AE et al. Neurone-specific enolase and N-acetyl-aspartate as potential peripheral markers of ischaemic stroke. Eur J Clin Invest 1999; 29: 6–11.
25. Schaarschmidt H, Prange HW, Reiber H. Neuron-specific enolase concentrations in blood as a prognostic parameter in cerebrovascular diseases. Stroke 1994; 25: 558–65.
26. Bharosay A, Bharosay VV, Varma M et al. Correlation of brain biomarker Neuron specific enolase (NSE) with degree of disability and neurological worsening in cerebrovascular stroke. Indian J Clin Biochem 2012; 27 (2): 186–90.
27. Wunderlich MT, Ebert AD, Kratz T et al. Early neurobehavioral outcome after stroke is related to release of neurobiochemical markers of brain damage. Stroke 1999; 30: 1190–5.
28. Hill MD, Jackowski G, Bayer N et al. Biochemical markers in acute ischemic stroke. CMAJ 2000; 162: 1139–40.
29. Fassbender K, Schmidt R, Schreiner A et al. Leakage of brain-originated proteins in peripheral blood: temporal profile and diagnostic value in early ischemic stroke. J Neurol Sci 1997; 148 (1): 101–5.
30. Cunningham RT, Watt M, Winder J et al. Serum neurone-specific enolase as an indicator of stroke volume. Eur J Clin Invest 1996; 26 (4): 298–303.
31. Cunningham RT, Young IS, Winder J et al. Serum neurone specific enolase (NSE) levels as an indicator of neuronal damage in patients with cerebral infarction. Eur J Clin Invest 1991; 21 (5): 497–500.
32. Missler U, Wiesmann M, Friedrich C, Kaps M. S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke 1997; 28 (10): 1956–60.
33. Hasan N, McColgan P, Bentley P et al. Towards the identification of blood biomarkers for acute stroke in humans: a comprehensive systematic review. Br J Clin Pharmacol 2012; 74: 230–40.
34. Martinez-Sanchez P, Gutierrez-Fernandez M, Fuentes B et al. Biochemical and inflammatory biomarkers in ischemic stroke: translational study between humans and two experimental rat models. J Transl Med 2014; 12: 220.
35. Mehta SL, Manhas N, Raghubir R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Rev 2007; 4: 34–66. https://doi.org/10.1016/j.brainresrev.2006.11.003
36. Niu FN, Zhang X, Hu XM et al. Targeted mutation of Fas ligand gene attenuates brain inflammation in experimental stroke. Brain Behavior Immunity 2012; 26 (1): 61–71. DOI: 10.1016/j.bbi.2011.07.235
37. Mahovic D, Zurak N, Lakusic N et al. The dynamics of soluble Fas/APO 1 apoptotic biochemical marker in acute ischemic stroke patients. Adv Med Sci 2013; 58 (2): 298–303. DOI: 10.2478/ams-2013-0014
38. Sergeeva S.P., Savin A.A., Arkhipov V.V. et al. Prognozirovanie iskhoda ostrogo perioda ishemicheskogo insul'ta: rol' markerov apoptoza. Klinicheskaia nevrologiia. 2017; 11 (1): 21–7 (in Russian).
39. Chumakov P.M. Belok r53 i ego universal'nye funktsii v mnogokletochnom organizme. Uspekhi biologicheskoi khimii. 2007; 47: 3–52 (in Russian).
40. Stanne TM, Aberg ND, Nilsson S et al. Low circulating acute brain-derived neurotrophic factor levels are associated with poor long-term functional outcome after ischemic stroke. Stroke 2016; 47 (7): 1943–5.
41. Filichia E, Shen H, Zhou X et al. Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model. J Neuroscience 2015; 295: 1–10.
42. Kol'tsova K.V. Rol' polimorfnykh variantov genov, uchastvuiushchikh v retseptornom puti induktsii apoptoza (FADD, Fas i kaspazy-8) v patogeneze ishemicheskogo insul'ta. Dis. … kand. med. nauk. Moscow, 2007 (in Russian).
43. Chernysheva E.N., Panova T.N. Induktor apoptoza – belok r53 i insulinorezistentnost' pri metabolicheskom sindrome. Kubanskii nauch. med. vestn. 2012; 131 (2): 186–90 (in Russian).
44. Matsuo R, Ago T, Kamouchi M et al. Clinical significance of plasma VEGF value in ischemic stroke – Research for biomarkers in ischemic stroke (rebios) study. BMC Neurol 2013; 13: 32.
45. Lee SC, Lee KY, Kim YJ et al. Serum VEGF levels in acute ischaemic strokes are correlated with long-term prognosis. Eur J Neurol 2010; 17: 45–51.
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ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия
*m.gulieva2014@yandex.ru
________________________________________________
Maiia S. Gulieva*, Sona D. Bagmanian, Anna S. Chukanova, Elena I. Chukanova
Pirogov Russian National Research Medical University, Moscow, Russia
*m.gulieva2014@yandex.ru