Пристальное внимание исследователей приковано к изучению социально значимых многофакторных заболеваний и синдромов с наследственной предрасположенностью, к которым относится и хроническая сердечная недостаточность (СН), сформировавшаяся вследствие атеросклероза (АС) коронарных артерий. Перспективность геномных исследований при АС и СН связывают с возможностью определения генетического риска развития и прогноза нежелательных сердечно-сосудистых событий до появления клинических признаков/симптомов. С позиции понимания патогенеза АС как варианта неспецифического воспаления, имеющего волнообразный характер, предполагается влияние на патологический процесс генов, кодирующих провоспалительные цитокины. Целью обзора был анализ результатов исследований, имеющихся в доступных публикациях, полиморфизма rs1800629 гена фактора некроза опухоли (tumor necrosis factor – TNF) у пациентов с атеросклеротическими сердечно-сосудистыми заболеваниями. Большинство данных свидетельствуют о наличии повышенного сердечно-сосудистого риска у носителей аллеля А полиморфизма rs1800629 гена TNF. Определено, что носительство генотипа АА ассоциировано с эссенциальной артериальной гипертензией и ремоделированием миокарда левого желудочка. У пациентов с хронической СН с сохраненной и умеренно-сниженной фракцией выброса левого желудочка АА-генотипа отмечены низкие показатели артериального давления и частая встречаемость фибрилляции предсердий. В ряде работ приведены результаты исследований полиморфизма rs1800629 гена TNF, продемонстрирована его прогностическая значимость при СН.
The close attention of researchers is riveted to the study of socially significant multifactorial diseases and syndromes with a hereditary predisposition, which include chronic heart failure, formed as a result of atherosclerosis of the coronary arteries. The promise of genomic studies in atherosclerosis and heart failure is associated with the possibility of determining the genetic risk of developing and predicting adverse cardiovascular events before the onset of clinical signs/symptoms. From the standpoint of understanding the pathogenesis of atherosclerosis as a variant of nonspecific inflammation, which has a wave-like character, it is assumed that genes encoding pro-inflammatory cytokines influence the pathological process. The aim of the review was to analyze the results of studies available in available publications on the rs1800629 polymorphism of the tumor necrosis factor (TNF) gene in patients with atherosclerotic cardiovascular diseases. Most data indicate the presence of an increased cardiovascular risk in carriers of the A allele of the rs1800629 polymorphism of the TNF gene. It was determined that carriage of the AA genotype is associated with essential arterial hypertension and remodeling of the left ventricular myocardium. In patients with chronic heart failure with preserved and moderately reduced left ventricular ejection fraction of the AA genotype, low blood pressure and frequent occurrence of atrial fibrillation were noted. A number of papers present the results of studies of the rs1800629 polymorphism of the TNF gene and the prognostic significance of the rs1800629 polymorphism of the TNF gene in heart failure.
1. Guo M, Guo G, Ji X. Genetic polymorphisms associated with heart failure: A literature review. J Int Med Res. 2016;44(1):15-29. DOI:10.1177/0300060515604755
2. Хазова Е.В., Булашова О.В., Ослопов В.Н., и др. Фактор некроза опухоли α – маркер системного воспаления у пациентов с сердечной недостаточностью. Практическая медицина. 2017;2(103):24-7 [Khazova EV, Bulashova OV, Oslopov VN, et al. Tumor necrosis factor α – a marker of systemic inflammation in patients with heart failure. Practical Medicine. 2017;2(103):24-7 (in Russian)].
3. Cho H-Ch, Yu G, Lee M-Yu, et al. TNF-α polymorphism and coronary artery disease; association study in the Korean population. Cytokine. 2013;62(1):104-9. DOI:10.1016/j.cyto.2013.02.008
4. Kumari R, Kumar S, Ahmad MK, et al. Promoter variants of TNF-α rs1800629 and IL-10 rs1800871 are independently associated with the susceptibility of coronary artery disease in north Indian. Cytokine. 2018;110:131-6. DOI:10.1016/j.cyto.2018.04.035
5. Mishra A, Srivastava A, Mittal T, et al. Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease patients. Cytokine. 2013;61(3):856-61. DOI:10.1016/j.cyto.2012.12.020
6. Tian M, Yuan Yu-Ch, Li J-Y, et al. Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review. Chronic Dis Transl Med. 2015;1(1):18-26. DOI:10.1016/j.cdtm.2015.02.002
7. Schumacher SM, Naga Prasad SV. Tumor necrosis factor-α in heart failure: An updated review. Curr Cardiol Rep. 2018;20(11):117. DOI:10.1007/s11886-018-1067-7
8. Flesch M, Höper A, Dell'Italia L, et al. Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor. Circulation. 2003;108(5):598-604. DOI:10.1161/01.CIR.0000081768.13378.BF
9. Tromp J, Khan MA, Klip UT, et al. Biomarker profiles in heart failure patients with preserved and reduced ejection fraction. J Am Heart Assoc. 2017;6(4):e003989. DOI:10.1161/JAHA.116.003989
10. Hua XP, Qian J, Cao CB, et al. Association between the TNF-α rs1800629 polymorphism and the risk of myocardial infarction: A meta-analysis. Genet Mol Res. 2016;15(3):gmr.15037292. DOI:10.4238/gmr.15037292
11. Pulido-Gómez K, Hernández-Díaz Y, Tovilla-Zárate CA, et al. Association of G308A and G238A polymorphisms of the TNF-α gene with risk of coronary heart disease: Systemic review and meta-analysis. Arch Med Res. 2016;47(7):557-72. DOI:10.1016/j. arcmed.2016.11.006
12. rs1800629 SNP. Available at: http://www.ensembl.org/Homo_sapiens/Variation/Population?db=core;v=rs1800629;vdb=variation. Accessed: 25.03.2023.
13. Wilson AG, Symons JA, McDowell TL, et al. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA. 1997;94(7):3195-9. DOI:10.1073/pnas.94.7.3195
14. Li Y, Chunjiang F, Xukai W, Chunyu Z. A meta analysis of the relation between TNF-α G308A gene polymorphism and heart disease. Life Sci J. 2014;11(4):204-6.
15. Kabita S, Garg PR, Newmei MK, et al. Tumor necrosis factor-alpha gene polymorphisms and complex disorders: A study among mendelian population with East Asian Ancestry. J Pract Cardiovasc Sci. 2019;5(1):35-43. DOI:10.4103/jpcs.jpcs_6_19
16. Гараева Л.А., Маянская С.Д. Ассоциация полиморфных локусов генов провоспалительных цитокинов у пациентов с коронарным и периферическим атеросклерозом различной степени тяжести. Международный научно-исследовательский журнал. 2017;1-1(55):102-6 [Garaeva LA, Mayanskaya SD. Association of polymorphic loci of pro-inflammatory cytokine genes in patients with coronary and peripheral atherosclerosis of varying severity. International Research Journal. 2017;1-1(55):102-6 (in Russian)]. DOI:10.23670/IRJ.2017.55.087
17. Шумилов Д.С., Тугуз А.Р., Смольков И.В., и др. Полиморфизмы генов основных про- и противовоспалительных цитокинов: IL-1b (T511C, RS16944), TNF-α (G308A, RS1800629), IL-4 (C589T, RS2243250) при коронарном атеросклерозе. Вестник Адыгейского государственного университета. Серия 4: Естественно-математические и технические науки. 2017;1(196):41-6 [Shumilov DS, Tuguz AR, Smolkov IV, et al. Gene polymorphisms of major pro- and anti-inflammatory cytokines: IL-1b (T511C, RS16944), TNF-α (G308A, RS1800629), IL-4 (C589T, RS2243250) in coronary atherosclerosis. Bulletin of the Adyghe State University. Series 4: Natural-mathematical and Technical Sciences. 2017;1(196):41-6 (in Russian)].
18. Fawzy RM, Hammad GA, Egila SE, et al. Association of tumor necrosis factor-α (TNF-α) -308A/G (rs1800629) gene polymorphism with carotid artery atherosclerosis in rheumatoid arthritis patients. The Egyptian Rheumatologist. 2020;40(3):177-81. DOI:10.1016/j.ejr.2020.05.004
19. Rodríguez-Rodríguez L, González-Juanatey C, Palomino-Morales R, et al. TNFα-308 (rs1800629) polymorphism is associated with a higher risk of cardiovascular disease in patients with rheumatoid arthritis. Atherosclerosis. 2011;216(1):125-30. DOI:10.1016/j.atherosclerosis.2010.10.052
20. Wang W, Peng WH, Lu L, et al. Polymorphism on chromosome 9p21.3 contributes to early onset and severity of coronary artery disease in non-diabetic and type 2 diabetic patients. Chin Med J (Engl). 2011;124(1):66-71. DOI:10.3901/jme.2011.08.066
21. Chu H, Yang J, Mi S, et al. Tumor necrosis factor-alpha G-308 A polymorphism and risk of coronary heart disease and myocardial infarction: A case-control study and meta-analysis. J Cardiovasc Dis Res. 2012;3(2):84-90. DOI:10.4103/0975-3583.95359
22. Hussain S, Iqbal T, Javed Q. TNF-alpha-308G>A polymorphism and the risk of familial CAD in a Pakistani population. Hum Immunol. 2015;76(1):13-8. DOI:10.1016/j.humimm.2014.12.010
23. Mastana S, Prakash S, Akam EC, et al. Genetic association of proinflammatory cytokine gene polymorphisms with coronary artery disease (CAD) in a North Indian population. Gene. 2017;628:301-7. DOI:10.1016/j.gene.2017.07.050
24. Khan NS, Shaheen N, Sultan AM, et al. Genetic association of tumour necrosis factor alpha, interleukin-18 and Interleukin 1 beta with the risk of coronary artery disease: A case-control study outcome from Kashmir. J Appl Biomed. 2018;16:387-93. DOI:10.1016/j.jab.2018.02.004
25. Parham N, Samaneh N, Aref S, Majid S. Association of tumor necrosis factor-alpha gene promoter polymorphism and its mRNA expression level in coronary artery disease. Meta Gene. 2018;18:122-6. DOI:10.1016/j.mgene.2018.08.009
26. Pan J, Hu J, Qi X, Xu L. Association study of a functional variant of TNF-α gene and serum TNF-α level with the susceptibility of congenital heart disease in a Chinese population. Postgrad Med J. 2019;95(1128):547-51. DOI:10.1136/postgradmedj-2019-136621
27. Abdulfattah SY, Samawi FT. Estimating the role of single-nucleotide polymorphism (rs1800629)-308 G/A of TNF-alpha gene as genetic marker associated with angina pectoris in a sample of Iraqi patients. J Genet Eng Biotechnol. 2023;21(1):2. DOI:10.1186/s43141-022-00454-w
28. Huang R, Zhao SR, Li Y, et al. Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: A systematic review and meta-analysis. BMC Med Genet. 2020;21(1):29. DOI:10.1186/s12881-020-0952-2
29. Zeybek U, Toptas B, Karaali ZE, et al. Effect of TNF-α and IL-1β genetic variants on the development of myocardial infarction in Turkish population. Mol Biol Rep. 2011;38(8):5453-7. DOI:10.1007/s11033-011-0701-x
30. Biswas S, Ghoshal PK, Mandal N. Synergistic effect of anti and pro-inflammatory cytokine genes and their promoter polymorphism with ST-elevation of myocardial infarction. Gene. 2014;544(2):145-51. DOI:10.1016/j.gene.2014.04.065
31. Зыков М.В., Макеева О.А., Голубенко М.В., и др. Исследование полиморфизма rs1800629 (G-308A) гена TNF больных инфарктом миокарда с подъемом сегмента ST. Российский кардиологический журнал. 2014;19(10):13-8 [Zykov MV, Makeeva OA, Golubenko MV, et al. Study of the rs1800629 (G-308A) polymorphism of the TNF gene in patients with ST-segment elevation myocardial infarction. Russian Journal of Cardiology. 2014;19(10):13-8 (in Russian)]. DOI:10.15829/1560-4071-2014-10-13-18
32. Аймагамбетова А.О., Каражанова Л.К., Котляр А. Полиморфизм генов цитокинов при инфаркте миокарда с подъемом сегмента ST у лиц казахской национальности. Вестник Казахского национального медицинского университета. 2017;4:417-21 [Aimagambetova AO, Karazhanova LK, Kotlyar A. Cytokine gene polymorphism with myocardial infarction with elevated ST-segment in subjects of Kazakh nationality. Bulletin of the Kazakh National Medical University. 2017;4:417-21 (in Russian)].
33. Маянская С.Д., Гараева Л.А., Тепляков А.Т., и др. Особенности полиморфизма генов FGB, TNFα, IL-1β, LPL, ITGB3 и TGFB1 у пациентов с повторным инфарктом миокарда. Бюллетень сибирской медицины. 2020;19(4):130-7 [Mayanskaya SD, Garaeva LA, Teplyakov AT, et al. FGB, TNFα, IL-1β, LPL, ITGB3, and TGFB1 gene polymorphism features in patients with recurrent myocardial infarction. Bulletin of Siberian Medicine. 2020;19(4):130-7 (in Russian)]. DOI:10.20538/1682-0363-2020-4-130-137
34. Шишкина Е.А., Агафонов А.В., Хлынова О.В., Кривцов А.В. Взаимосвязь полиморфизма G-308A гена TNF с риском развития инфаркта миокарда у больных трудоспособного возраста. Уральский медицинский журнал. 2020;10(193):109-15 [Shishkina EA, Agafonov AV, Khlynova OV, Krivtsov AV. Correlation of G-308A polymorphism of the TNF gene with the risk of myocardial infarction in patients of working age. Ural Medical Journal. 2020;10(193):109-15 (in Russian)]. DOI:10.25694/URMJ.2020.10.42
35. Grira N, Lahidheb D, Lamine O, et al. The association of IL-6, TNFα and CRP gene polymorphisms with coronary artery disease in a Tunisian population: A case-control study. Biochem Genet. 2021;59(3):751-66. DOI:10.1007/s10528-021-10035-0
36. Пушкарева А.Э., Арутюнов Г.П., Хусаинова Р.И., Хуснутдинова Э.К. Исследование полиморфных вариантов генов цитокинов (TNFα, TNFβ) и гена метилентетрагидрофолатредуктазы (MTHFR) при различных типах ремоделирования сердца. Медицинский вестник Башкортостана. 2012;7(4):40-4 [Pushkareva AE, Arutyunov GP, Khusainova RI, Khusnutdinova EK. The analysis of polymorphic variants of cytokines genes (TNFα, TNFβ) and methylentetrahydrofoloatreductase (MTHFR) gene in heart failure patients with different types of heart remodelling. Medical Bulletin of Bashkortostan. 2012;7(4):40-4 (in Russian)].
37. Bielecka-Dabrowa A, Sakowicz A, Pietrucha T, et al. The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction. Sci Rep. 2017;7(1):8974. DOI:10.1038/s41598-017-09564-9
38. Тепляков А.Т., Шилов С.Н., Попова А.А., и др. Роль провоспалительных цитокинов в развитии антрациклин-индуцированной сердечной недостаточности. Сибирский медицинский журнал. 2020;35(2):66-74 [Teplyakov AT, Shilov SN, Popova AA, et al. The role of proinflammatory cytokines in the development of anthracycline-induced heart failure. The Siberian Journal of Clinical and Experimental Medicine. 2020;35(2):66-74 (in Russian)]. DOI:10.29001/2073-8552-2020-35-2-66-74
________________________________________________
1. Guo M, Guo G, Ji X. Genetic polymorphisms associated with heart failure: A literature review. J Int Med Res. 2016;44(1):15-29. DOI:10.1177/0300060515604755
2. Khazova EV, Bulashova OV, Oslopov VN, et al. Tumor necrosis factor α – a marker of systemic inflammation in patients with heart failure. Practical Medicine. 2017;2(103):24-7 (in Russian).
3. Cho H-Ch, Yu G, Lee M-Yu, et al. TNF-α polymorphism and coronary artery disease; association study in the Korean population. Cytokine. 2013;62(1):104-9. DOI:10.1016/j.cyto.2013.02.008
4. Kumari R, Kumar S, Ahmad MK, et al. Promoter variants of TNF-α rs1800629 and IL-10 rs1800871 are independently associated with the susceptibility of coronary artery disease in north Indian. Cytokine. 2018;110:131-6. DOI:10.1016/j.cyto.2018.04.035
5. Mishra A, Srivastava A, Mittal T, et al. Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease patients. Cytokine. 2013;61(3):856-61. DOI:10.1016/j.cyto.2012.12.020
6. Tian M, Yuan Yu-Ch, Li J-Y, et al. Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review. Chronic Dis Transl Med. 2015;1(1):18-26. DOI:10.1016/j.cdtm.2015.02.002
7. Schumacher SM, Naga Prasad SV. Tumor necrosis factor-α in heart failure: An updated review. Curr Cardiol Rep. 2018;20(11):117. DOI:10.1007/s11886-018-1067-7
8. Flesch M, Höper A, Dell'Italia L, et al. Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor. Circulation. 2003;108(5):598-604. DOI:10.1161/01.CIR.0000081768.13378.BF
9. Tromp J, Khan MA, Klip UT, et al. Biomarker profiles in heart failure patients with preserved and reduced ejection fraction. J Am Heart Assoc. 2017;6(4):e003989. DOI:10.1161/JAHA.116.003989
10. Hua XP, Qian J, Cao CB, et al. Association between the TNF-α rs1800629 polymorphism and the risk of myocardial infarction: A meta-analysis. Genet Mol Res. 2016;15(3):gmr.15037292. DOI:10.4238/gmr.15037292
11. Pulido-Gómez K, Hernández-Díaz Y, Tovilla-Zárate CA, et al. Association of G308A and G238A polymorphisms of the TNF-α gene with risk of coronary heart disease: Systemic review and meta-analysis. Arch Med Res. 2016;47(7):557-72. DOI:10.1016/j. arcmed.2016.11.006
12. rs1800629 SNP. Available at: http://www.ensembl.org/Homo_sapiens/Variation/Population?db=core;v=rs1800629;vdb=variation. Accessed: 25.03.2023.
13. Wilson AG, Symons JA, McDowell TL, et al. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA. 1997;94(7):3195-9. DOI:10.1073/pnas.94.7.3195
14. Li Y, Chunjiang F, Xukai W, Chunyu Z. A meta analysis of the relation between TNF-α G308A gene polymorphism and heart disease. Life Sci J. 2014;11(4):204-6.
15. Kabita S, Garg PR, Newmei MK, et al. Tumor necrosis factor-alpha gene polymorphisms and complex disorders: A study among mendelian population with East Asian Ancestry. J Pract Cardiovasc Sci. 2019;5(1):35-43. DOI:10.4103/jpcs.jpcs_6_19
16. Garaeva LA, Mayanskaya SD. Association of polymorphic loci of pro-inflammatory cytokine genes in patients with coronary and peripheral atherosclerosis of varying severity. International Research Journal. 2017;1-1(55):102-6 (in Russian). DOI:10.23670/IRJ.2017.55.087
17. Shumilov DS, Tuguz AR, Smolkov IV, et al. Gene polymorphisms of major pro- and anti-inflammatory cytokines: IL-1b (T511C, RS16944), TNF-α (G308A, RS1800629), IL-4 (C589T, RS2243250) in coronary atherosclerosis. Bulletin of the Adyghe State University. Series 4: Natural-mathematical and Technical Sciences. 2017;1(196):41-6 (in Russian).
18. Fawzy RM, Hammad GA, Egila SE, et al. Association of tumor necrosis factor-α (TNF-α) -308A/G (rs1800629) gene polymorphism with carotid artery atherosclerosis in rheumatoid arthritis patients. The Egyptian Rheumatologist. 2020;40(3):177-81. DOI:10.1016/j.ejr.2020.05.004
19. Rodríguez-Rodríguez L, González-Juanatey C, Palomino-Morales R, et al. TNFα-308 (rs1800629) polymorphism is associated with a higher risk of cardiovascular disease in patients with rheumatoid arthritis. Atherosclerosis. 2011;216(1):125-30. DOI:10.1016/j.atherosclerosis.2010.10.052
20. Wang W, Peng WH, Lu L, et al. Polymorphism on chromosome 9p21.3 contributes to early onset and severity of coronary artery disease in non-diabetic and type 2 diabetic patients. Chin Med J (Engl). 2011;124(1):66-71. DOI:10.3901/jme.2011.08.066
21. Chu H, Yang J, Mi S, et al. Tumor necrosis factor-alpha G-308 A polymorphism and risk of coronary heart disease and myocardial infarction: A case-control study and meta-analysis. J Cardiovasc Dis Res. 2012;3(2):84-90. DOI:10.4103/0975-3583.95359
22. Hussain S, Iqbal T, Javed Q. TNF-alpha-308G>A polymorphism and the risk of familial CAD in a Pakistani population. Hum Immunol. 2015;76(1):13-8. DOI:10.1016/j.humimm.2014.12.010
23. Mastana S, Prakash S, Akam EC, et al. Genetic association of proinflammatory cytokine gene polymorphisms with coronary artery disease (CAD) in a North Indian population. Gene. 2017;628:301-7. DOI:10.1016/j.gene.2017.07.050
24. Khan NS, Shaheen N, Sultan AM, et al. Genetic association of tumour necrosis factor alpha, interleukin-18 and Interleukin 1 beta with the risk of coronary artery disease: A case-control study outcome from Kashmir. J Appl Biomed. 2018;16:387-93. DOI:10.1016/j.jab.2018.02.004
25. Parham N, Samaneh N, Aref S, Majid S. Association of tumor necrosis factor-alpha gene promoter polymorphism and its mRNA expression level in coronary artery disease. Meta Gene. 2018;18:122-6. DOI:10.1016/j.mgene.2018.08.009
26. Pan J, Hu J, Qi X, Xu L. Association study of a functional variant of TNF-α gene and serum TNF-α level with the susceptibility of congenital heart disease in a Chinese population. Postgrad Med J. 2019;95(1128):547-51. DOI:10.1136/postgradmedj-2019-136621
27. Abdulfattah SY, Samawi FT. Estimating the role of single-nucleotide polymorphism (rs1800629)-308 G/A of TNF-alpha gene as genetic marker associated with angina pectoris in a sample of Iraqi patients. J Genet Eng Biotechnol. 2023;21(1):2. DOI:10.1186/s43141-022-00454-w
28. Huang R, Zhao SR, Li Y, et al. Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: A systematic review and meta-analysis. BMC Med Genet. 2020;21(1):29. DOI:10.1186/s12881-020-0952-2
29. Zeybek U, Toptas B, Karaali ZE, et al. Effect of TNF-α and IL-1β genetic variants on the development of myocardial infarction in Turkish population. Mol Biol Rep. 2011;38(8):5453-7. DOI:10.1007/s11033-011-0701-x
30. Biswas S, Ghoshal PK, Mandal N. Synergistic effect of anti and pro-inflammatory cytokine genes and their promoter polymorphism with ST-elevation of myocardial infarction. Gene. 2014;544(2):145-51. DOI:10.1016/j.gene.2014.04.065
31. Zykov MV, Makeeva OA, Golubenko MV, et al. Study of the rs1800629 (G-308A) polymorphism of the TNF gene in patients with ST-segment elevation myocardial infarction. Russian Journal of Cardiology. 2014;19(10):13-8 (in Russian). DOI:10.15829/1560-4071-2014-10-13-18
32. Aimagambetova AO, Karazhanova LK, Kotlyar A. Cytokine gene polymorphism with myocardial infarction with elevated ST-segment in subjects of Kazakh nationality. Bulletin of the Kazakh National Medical University. 2017;4:417-21 (in Russian).
33. Mayanskaya SD, Garaeva LA, Teplyakov AT, et al. FGB, TNFα, IL-1β, LPL, ITGB3, and TGFB1 gene polymorphism features in patients with recurrent myocardial infarction. Bulletin of Siberian Medicine. 2020;19(4):130-7 (in Russian). DOI:10.20538/1682-0363-2020-4-130-137
34. Shishkina EA, Agafonov AV, Khlynova OV, Krivtsov AV. Correlation of G-308A polymorphism of the TNF gene with the risk of myocardial infarction in patients of working age. Ural Medical Journal. 2020;10(193):109-15 (in Russian). DOI:10.25694/URMJ.2020.10.42
35. Grira N, Lahidheb D, Lamine O, et al. The association of IL-6, TNFα and CRP gene polymorphisms with coronary artery disease in a Tunisian population: A case-control study. Biochem Genet. 2021;59(3):751-66. DOI:10.1007/s10528-021-10035-0
36. Pushkareva AE, Arutyunov GP, Khusainova RI, Khusnutdinova EK. The analysis of polymorphic variants of cytokines genes (TNFα, TNFβ) and methylentetrahydrofoloatreductase (MTHFR) gene in heart failure patients with different types of heart remodelling. Medical Bulletin of Bashkortostan. 2012;7(4):40-4 (in Russian).
37. Bielecka-Dabrowa A, Sakowicz A, Pietrucha T, et al. The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction. Sci Rep. 2017;7(1):8974. DOI:10.1038/s41598-017-09564-9
38. Teplyakov AT, Shilov SN, Popova AA, et al. The role of proinflammatory cytokines in the development of anthracycline-induced heart failure. The Siberian Journal of Clinical and Experimental Medicine. 2020;35(2):66-74 (in Russian). DOI:10.29001/2073-8552-2020-35-2-66-74
Авторы
Е.В. Хазова*, О.В. Булашова, Е.В. Валеева
ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России, Казань, Россия
*hazova_elena@mail.ru
________________________________________________
Elena V. Khazova*, Olga V. Bulashova, Elena V. Valeeva