Расстройства, связанные с глютеном: обзор литературы. Часть 1
Расстройства, связанные с глютеном: обзор литературы. Часть 1
Камилова А.Т., Азимова Н.Д., Захарова И.Н. Расстройства, связанные с глютеном: обзор литературы. Часть 1. Педиатрия. Consilium Medicum. 2023;3:173–178. DOI: 10.26442/26586630.2023.3.202389
Kamilova AT, Azimova ND, Zakharova IN. Gluten related disorders: a review of the literature. Pediatrics. Consilium Medicum. 2023;3:173–178.DOI: 10.26442/26586630.2023.3.202389
Расстройства, связанные с глютеном: обзор литературы. Часть 1
Камилова А.Т., Азимова Н.Д., Захарова И.Н. Расстройства, связанные с глютеном: обзор литературы. Часть 1. Педиатрия. Consilium Medicum. 2023;3:173–178. DOI: 10.26442/26586630.2023.3.202389
Kamilova AT, Azimova ND, Zakharova IN. Gluten related disorders: a review of the literature. Pediatrics. Consilium Medicum. 2023;3:173–178.DOI: 10.26442/26586630.2023.3.202389
Расстройства, связанные с глютеном, стали эпидемиологически значимым явлением, распространенность которого в мире оценивается около 5%. Современная классификация глютензависимых заболеваний (ГЗЗ) базируется, в основном, на их патофизиологии, и можно выделить следующие категории: иммуноопосредованные нарушения, которые включают целиакию, аллергические реакции, такие как аллергия на пшеницу, и нецелиакийная чувствительность к глютену – состояние, характеризующееся как желудочно-кишечными, так и внекишечными симптомами, что в последнее время выявляется все чаще. Ошибки в диагностике ГЗЗ все еще остаются актуальной клинической проблемой. Основываясь на литературных данных, мы предлагаем практический методологический подход, чтобы подсказать врачам, как их распознать и избежать ошибок. В первой части обзора представлены данные литературы по истории, о причинных факторах развития ГЗЗ, целиакии, аутоиммунной непереносимости глютена.
Ключевые слова: глютен, пшеница, целиакия, диагностика, дети
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Gluten-related disorders have become an epidemiologically significant phenomenon, with an estimated prevalence of about 5% worldwide. The current classification of gluten-related disorders is based mainly on their pathophysiology, and the following categories can be distinguished: Immune-mediated disorders, which include celiac disease, allergic reactions, such as wheat allerg, and non-celiac gluten sensitivity, a condition characterized by both gastrointestinal and extraintestinal symptoms, which has recently gained popularity. Diagnostic errors in gluten-associated diseases are still a pressing clinical problem. Based on the literature, we propose a practical methodological approach to guide clinicians on how to recognize them and avoid errors. The first part of the review presents literature data on the history, causal factors in the development of gluten-related diseases, and autoimmune gluten intolerance – celiac disease.
Keywords: gluten, wheat, celiac disease, diagnosis, children
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4. Tovoli F, Masi C, Guidetti E, et al. Clinical and diagnostic aspects of gluten related disorders. World J Clin Cases. 2015;3(3):275-84. DOI:10.12998/wjcc.v3.i3.275
5. Leonard MM, Vasagar B. US perspective on gluten-related diseases. Clin Exp Gastroenterol. 2014;7:25-37.
6. Salvatori N, Reccardini F, Convento M, et al. Asthma induced by inhalation of flour in adults with food allergy to wheat. Clin Exp Allergy. 2008;38:1349-56.
7. Taraghikhah N, Ashtari S, Asri N, et al. An updated overview of spectrum of gluten-related disorders: clinical and diagnostic aspects. BMC Gastroenterol. 2020;20(1):258. DOI:10.1186/s12876-020-01390-0
8. Colombo F, Di Lorenzo C, Biella S, et al. Ancient and Modern Cereals as Ingredients of the Gluten-Free Diet: Are They Safe Enough for Celiac Consumers? Foods. 2021;10(4):906. DOI:10.3390/foods10040906
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14. Alvey C, Anderson CM, Freeman M. Wheat Gluten and Coeliac Disease. Arch Dis Child. 1957;32:434-7.
15. Cooper B, Holmes G, Ferguson R, et al. Gluten-Sensitive Diarrhea without Evidence of Celiac Disease. Gastroenterology. 1980;79:801-6.
16. Carroccio A, Mansueto P, Iacono G, et al. Non-Celiac Wheat Sensitivity Diagn osed by Double-Blind Placebo-Controlled Challenge: Exploring a New Clinical Entity. Am J Gastroenterol. 2012;107:1898-906.
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18. Elli L, Branchi F, Tomba C, et al. Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity. World J Gastroenterol. 2015;21(23):7110-9. DOI:10.3748/wjg.v21.i23.7110
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24. Singh P, Arora A, Strand TA, et al. Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2018;16:823‑36.e2. DOI:10.1016/j.cgh.2017.06.037
25. Allardyce RA, Shearman DJ. Leukocyte reactivity to alpha-gliadin in dermatitis herpetiformis and adult coeliac disease. Int Arch Allergy Appl Immunol. 1975;48(3):395-400. DOI:10.1159/000231324
26. Hofmann S, Fischer J, Eriksson C, et al. IgE detection to α/β/γ-gliadin and its clinical relevance in wheat-dependent exercise-induced anaphylaxis. Allergy. 2012;67:1457-60. DOI:10.1111/all.12020
27. Morita E, Matsuo H, Mihara S, et al. Fast ω-gliadin is a major allergen in wheat-dependent exercise-induced anaphylaxis. J Dermatol Sci. 2003;33(2):99-104.
DOI:10.1016/s0923-1811(03)00156-7
28. Palosuo K, Alenius H, Varjonen E, et al. Rye γ-70 and γ-35 secalins and barley γ-3 hordein cross-react with ω-5 gliadin, a major allergen in wheat-dependent, exercise-induced anaphylaxis. Clin Exp Allergy. 2001;31(3):466-73. DOI:10.1046/j.1365-2222.2001.01023.x
29. Sandiford CP, Tatham AS, Fido R, et al. Identification of the major water/salt insoluble wheat proteins involved in cereal hypersensitivity. Clin Exp Allergy. 1997;27(10):1120-9.
30. Wieser H. Chemistry of gluten proteins. Food Microbiol. 2007;24:115-9. DOI:10.1016/j.fm.2006.07.004
31. Liu L, Ikeda TM, Branlard G, et al. Comparison of low molecular weight glutenin subunits identified by SDS-PAGE, 2-DE, MALDI-TOF-MS and PCR in common wheat. BMC Plant Biol. 2010;10:124. DOI:10.1186/1471-2229-10-124
32. Day L, Augustin MA, Batey IL, Wrigley CW. Wheat-Gluten Uses and Industry Needs. Trends Food Sci Technol. 2006;17:82-90.
33. Kagnoff MF. Celiac disease: pathogenesis of a model immunogenetic disease. J Clin Invest. 2007;117(1):41-9.
34. Ludvigsson J, Green P. Clinical management of celiac disease. J Intern Med. 2011;269:560-71.
35. Makharia GK, Catassi C. Celiac Disease in Asia. Gastroenterol Clin North Am. 2019;48(1):101-13. DOI:10.1016/j.gtc.2018.09.007
36. Malekzadeh R, Sachdev A, Ali AF. Coeliac disease in developing countries: middle east, India and North Africa. Best Pract Res Clin Gastroenterol. 2005;19(3):351-8.
37. Silano M, Agostoni C, Guandalini S. Effect of the timing of gluten introduction on the development of celiac disease. World J Gastroenterol. 2010;16(16):1939-42.
38. Rostami Nejad M, Hogg-Kollars S, Ishaq S, Rostami K. Subclinical celiac disease and gluten sensitivity. Gastroenterol Hepatol Bed Bench. 2011;4(3):102-8.
39. Sollid LM, Markussen G, Ek J, et al. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. J Exp Med. 1989;169:345-50.
40. Husby S, Koletzko S, Korponay-Szabó I, et al. European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr. 2020;70(1):141-56. DOI:10.1097/MPG.0000000000002497
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45. Eigner W, Bashir K, Primas C, et al. Dynamics of occurrence of refractory coeliac disease and associated complications over 25 years. Alimen Pharmacol Ther. 2017;45:364-72. DOI:10.1111/apt.13867
46. Volta U, Caio G, Boschetti E, et al. Seronegative celiac disease: Shedding light on an obscure clinical entity. Dig Liver Dis. 2016;48:1018-22.
47. Krauthammer A, Guz-Mark A, Zevit N, et al. Two decades of pediatric celiac disease in a tertiary referral center: What has changed? Dig Liver Dis. 2020;52:457-61.
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________________________________________________
1. OECD and Food and Agriculture Organization of the United Nations. OECD-FAO Agricultural Outlook 2019–2028.
2. Shewry PR, Hey SJ. The Contribution of Wheat to Human Diet and Health. Food Energy Secur. 2015;4:178-202.
3. Al-Toma A, Volta U, Auricchio R, et al. European Society for the Study of Coeliac Disease (ESsCD) Guideline for Coeliac Disease and Other Gluten-Related Disorders. United Eur Gastroenterol J. 2019;7:583-613.
4. Tovoli F, Masi C, Guidetti E, et al. Clinical and diagnostic aspects of gluten related disorders. World J Clin Cases. 2015;3(3):275-84. DOI:10.12998/wjcc.v3.i3.275
5. Leonard MM, Vasagar B. US perspective on gluten-related diseases. Clin Exp Gastroenterol. 2014;7:25-37.
6. Salvatori N, Reccardini F, Convento M, et al. Asthma induced by inhalation of flour in adults with food allergy to wheat. Clin Exp Allergy. 2008;38:1349-56.
7. Taraghikhah N, Ashtari S, Asri N, et al. An updated overview of spectrum of gluten-related disorders: clinical and diagnostic aspects. BMC Gastroenterol. 2020;20(1):258. DOI:10.1186/s12876-020-01390-0
8. Colombo F, Di Lorenzo C, Biella S, et al. Ancient and Modern Cereals as Ingredients of the Gluten-Free Diet: Are They Safe Enough for Celiac Consumers? Foods. 2021;10(4):906. DOI:10.3390/foods10040906
9. Catassi C, Cobellis G. Coeliac disease epidemiology is alive and kicking, especially in the developing world. Dig Liver Dis. 2007;39:908-10.
10. Kamilova AT, Azizova GK, Geller SI. Current state of celiac disease diagnosis in Uzbekistan: problems and solutions. Vopr. det. dietol. (Pediatric Nutrition). 2021;19(4):15-22 (in Russian). DOI:10.20953/1727-5784-2021-4-15-22
11. Ashtari S, Pourhoseingholi MA, Rostami K, et al. Prevalence of gluten-related disorders in Asia-Pacific region: a systematic review. J Gastrointestin Liver Dis. 2019;28(1):95-105. DOI:10.15403/jgld.2014.1121.281.sys
12. Ellis A, Linaker BD. Non-coeliac gluten sensitivity? Lancet. 1978;1:1358-9.
13. Gurova MM. Allergiia k belku pshenitsy i neperenosimost' gliutena (obzor literatury). Meditsina: teoriia i praktika. 2020;(1). Available at: https://cyberleninka.ru/article/n/allergiya-k-belku-pshenitsy-i-neperenosimost-glyutena-obzor-litera.... Accessed: 15.06.2022 (in Russian).
14. Alvey C, Anderson CM, Freeman M. Wheat Gluten and Coeliac Disease. Arch Dis Child. 1957;32:434-7.
15. Cooper B, Holmes G, Ferguson R, et al. Gluten-Sensitive Diarrhea without Evidence of Celiac Disease. Gastroenterology. 1980;79:801-6.
16. Carroccio A, Mansueto P, Iacono G, et al. Non-Celiac Wheat Sensitivity Diagn osed by Double-Blind Placebo-Controlled Challenge: Exploring a New Clinical Entity. Am J Gastroenterol. 2012;107:1898-906.
17. Rubio-Tapia A, Murray JA. Celiac disease. Curr Opin Gastroenterol. 2010;26:116-22.
18. Elli L, Branchi F, Tomba C, et al. Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity. World J Gastroenterol. 2015;21(23):7110-9. DOI:10.3748/wjg.v21.i23.7110
19. Wang D, Li F, Cao S, Zhang K. Genomic and functional genomics analyses of gluten proteins and prospect for simultaneous improvement of end-use and health-related traits in wheat. Theor Appl Genet. 2020;133(5):1521-39. DOI:10.1007/s00122-020-03557-5
20. Asri N, Rostami-Nejad M, Anderson RP, Rostami K. The Gluten Gene: Unlocking the Understanding of Gluten Sensitivity and Intolerance. Appl Clin Genet. 2021;14:37-50. DOI:10.2147/TACG.S276596
21. Iankina GN, Kondrat'eva EI, Loshkova EV, Terent'eva AA. Osobennosti diagnostiki i lecheniia razlichnykh form neperenosimosti belka pshenitsy. Voprosy detskoi dietologii. 2017;15(1):13‑24 (in Russian).
22. Henderson KN, Tye-Din JA, Reid HH, et al. A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease. Immunity. 2007;27(1):23-34. DOI:10.1016/j.immuni.2007.05.015
23. Shan L, Molberg Ø, Parrot I, et al. Structural basis for gluten intolerance in celiac sprue. Science. 2002;297(5590):2275-9. DOI:10.1126/science.1074129
24. Singh P, Arora A, Strand TA, et al. Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2018;16:823‑36.e2. DOI:10.1016/j.cgh.2017.06.037
25. Allardyce RA, Shearman DJ. Leukocyte reactivity to alpha-gliadin in dermatitis herpetiformis and adult coeliac disease. Int Arch Allergy Appl Immunol. 1975;48(3):395-400. DOI:10.1159/000231324
26. Hofmann S, Fischer J, Eriksson C, et al. IgE detection to α/β/γ-gliadin and its clinical relevance in wheat-dependent exercise-induced anaphylaxis. Allergy. 2012;67:1457-60. DOI:10.1111/all.12020
27. Morita E, Matsuo H, Mihara S, et al. Fast ω-gliadin is a major allergen in wheat-dependent exercise-induced anaphylaxis. J Dermatol Sci. 2003;33(2):99-104.
DOI:10.1016/s0923-1811(03)00156-7
28. Palosuo K, Alenius H, Varjonen E, et al. Rye γ-70 and γ-35 secalins and barley γ-3 hordein cross-react with ω-5 gliadin, a major allergen in wheat-dependent, exercise-induced anaphylaxis. Clin Exp Allergy. 2001;31(3):466-73. DOI:10.1046/j.1365-2222.2001.01023.x
29. Sandiford CP, Tatham AS, Fido R, et al. Identification of the major water/salt insoluble wheat proteins involved in cereal hypersensitivity. Clin Exp Allergy. 1997;27(10):1120-9.
30. Wieser H. Chemistry of gluten proteins. Food Microbiol. 2007;24:115-9. DOI:10.1016/j.fm.2006.07.004
31. Liu L, Ikeda TM, Branlard G, et al. Comparison of low molecular weight glutenin subunits identified by SDS-PAGE, 2-DE, MALDI-TOF-MS and PCR in common wheat. BMC Plant Biol. 2010;10:124. DOI:10.1186/1471-2229-10-124
32. Day L, Augustin MA, Batey IL, Wrigley CW. Wheat-Gluten Uses and Industry Needs. Trends Food Sci Technol. 2006;17:82-90.
33. Kagnoff MF. Celiac disease: pathogenesis of a model immunogenetic disease. J Clin Invest. 2007;117(1):41-9.
34. Ludvigsson J, Green P. Clinical management of celiac disease. J Intern Med. 2011;269:560-71.
35. Makharia GK, Catassi C. Celiac Disease in Asia. Gastroenterol Clin North Am. 2019;48(1):101-13. DOI:10.1016/j.gtc.2018.09.007
36. Malekzadeh R, Sachdev A, Ali AF. Coeliac disease in developing countries: middle east, India and North Africa. Best Pract Res Clin Gastroenterol. 2005;19(3):351-8.
37. Silano M, Agostoni C, Guandalini S. Effect of the timing of gluten introduction on the development of celiac disease. World J Gastroenterol. 2010;16(16):1939-42.
38. Rostami Nejad M, Hogg-Kollars S, Ishaq S, Rostami K. Subclinical celiac disease and gluten sensitivity. Gastroenterol Hepatol Bed Bench. 2011;4(3):102-8.
39. Sollid LM, Markussen G, Ek J, et al. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. J Exp Med. 1989;169:345-50.
40. Husby S, Koletzko S, Korponay-Szabó I, et al. European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr. 2020;70(1):141-56. DOI:10.1097/MPG.0000000000002497
41. Gujral N, Freeman HJ, Thomson ABR. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol. 2012;18(42):6036-59.
42. Nelson Textbook Of Pediatrics, 20th ed. 2016.
43. Rubio-Tapia A, Murray JA. Classification and management of refractory coeliac disease. Gut. 2010;59(4):547-57. DOI:10.1136/gut.2009.195131
44. Rubio-Tapia A, Kelly DG, Lahr BD, et al. Clinical staging and survival in refractory celiac disease: a single center experience. Gastroenterology. 2009;136:99-107. DOI:10.1053/j.gastro.2008.10.013
45. Eigner W, Bashir K, Primas C, et al. Dynamics of occurrence of refractory coeliac disease and associated complications over 25 years. Alimen Pharmacol Ther. 2017;45:364-72. DOI:10.1111/apt.13867
46. Volta U, Caio G, Boschetti E, et al. Seronegative celiac disease: Shedding light on an obscure clinical entity. Dig Liver Dis. 2016;48:1018-22.
47. Krauthammer A, Guz-Mark A, Zevit N, et al. Two decades of pediatric celiac disease in a tertiary referral center: What has changed? Dig Liver Dis. 2020;52:457-61.
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Авторы
А.Т. Камилова*1, Н.Д. Азимова1, И.Н. Захарова2
1Республиканский специализированный научно-практический медицинский центр педиатрии Минздрава Республики Узбекистан, Ташкент, Узбекистан; 2ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*okamilova@mail.ru
________________________________________________
Altinoy T. Kamilova*1, Noiba D. Azimova1, Irina N. Zakharova2
1Republican Specialized Scientific-Practical Medical Center of Pediatrics, Tashkent, Uzbekistan; 2Russian Medical Academy of Continuous Professional Education, Moscow, Russia
*okamilova@mail.ru