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Возможности применения амбазона (Фарингосепт) при инфекционно-воспалительных заболеваниях ротоглотки
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
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Zakharova IN, Berezhnaya IV, Kuznetsova IS, Dubovets NF. Possibilities of using ambazone (Faringosept) in infectious and inflammatory diseases of oropharynx. A review. Pediatrics. Consilium Medicum. 2024;1:37–42.
DOI: 10.26442/26586630.2024.1.202596
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Ключевые слова: мукозальный иммунитет, острые респираторные инфекции, боль в горле, острый тонзиллофарингит, амбазон, дети
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The incidence of acute respiratory infections has remained the same for decades. About 70–80 thousand cases per 100 thousand children are registered annually in the Russian Federation, which is 3.3 times higher than in adults. For the last reporting year, 2022, the incidence of acute respiratory viral infections (ARVI) was almost twice the long-term average. Influenza is a highly contagious severe respiratory infection, the incidence of which peaked in December 2022. At the beginning of the epidemic season, influenza A(H1N1) pdm09 viruses prevailed, and then they were joined by influenza B viruses with more severe disease than in previous years. Compared to 2021, the number of reported cases is 4 times higher, twice the long-term average. Most respiratory viral infections, having their specific features, involve the nasal mucosa and oropharynx and manifest with sore throat, rhinitis, cough, and fever. The study of the oral and pharyngeal microbiota by 16S rRNA gene sequencing showed that in patients with ARVI, there is a significant decrease in the α-diversity of bacteria and the loss of a healthy basic microbiota, in particular anaerobes and Prevotella spp. At the same time, eight respiratory pathogens were identified, including Staphylococcus aureus, Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis, lichen pigmentosa and Corynebacterium propinquum/pseudodiphtheriticum, which commonly cause bacterial complications, especially in children with frequent respiratory infections. The article addresses the treatment of ARVI and tonsillopharyngitis in children following clinical guidelines and the prospects of using topical agents for inflammation of the oropharynx in children.
Keywords: mucosal immunity, acute respiratory infections, sore throat, acute tonsillopharyngitis, ambazone, children
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1. Baranov AA, Albitsky VYu, Ivanova AA, et al. Trends and the health status of the child population of the Russian Federation. The Russian Pediatric Journal. 2012;(6):4‑9 (in Russian).
2. Kliuchnikov SO, Zaitseva OV, Osmanov IM, et al. Ostrye respiratornye zabolevaniia u detei. Posobie dlia vrachei. Moscow: Medkniga, 2008. (Rossiiskii vestnik perinatologii i pediatrii. Prilozhenie 3.2008) (in Russian).
3. Roux S, Hallam SJ, Woyke T, Sullivan MB. Viral dark matter and virus-host interactions resolved from publicly available microbial genomes. Elife. 2015;4:e08490. DOI:10.7554/eLife.08490
4. Ryabichenko TI, Skosyreva GA, Obukhova OO, et al. Etiological structure of acute respiratory viral infections in children hospitalized in 2015‑2018. Infectious Diseases: News, Opinions, Training. 2021;10(2):47‑53 (in Russian). DOI:10.33029/2305‑3496‑2021‑10‑2–47‑53
5. Correia W, Dorta-Guerra R, Sanches M, et al. Study of the Etiology of Acute Respiratory Infections in Children Under 5 Years at the Dr. Agostinho Neto Hospital, Praia, Santiago Island, Cabo Verde. Front Pediatr. 2021;9:716351. DOI:10.3389/fped.2021.716351
6. O sostoianii sanitarno-epidemiologicheskogo blagopoluchiia naseleniia v Rossiiskoi Federatsii v 2022 godu: Gosudarstvennyi doklad. Moscow: Federal’naia sluzhba po nadzoru v sfere zashchity prav potrebitelei i blagopoluchiia cheloveka, 2023 (in Russian).
7. Savenkova MS. Influenza and other acute respiratory viral infections in children. Aspects of antiviral therapy. Consilium Medicum. Pediatrics (Suppl.). 2016;3:73‑8 (in Russian).
8. Pavia AT. Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis. Clin Infect Dis. 2011;52(Suppl. 4):S284‑9. DOI:10.1093/cid/cir043
9. Mizernitskiy YuL, Melnikova IM. Modern therapy of acute respiratory viral infections and influenza in children: how to resist polypharmacy? Pediatrics (Suppl. Consilium Medicum). 2018;3:69‑73 (in Russian). DOI:10.26442/2413‑8460_2018.3.69‑73
10. Gripp u detei. Klinicheskie rekomendatsii. ID: KR249. 2017 (in Russian).
11. Radtsig EYu, Gurov AV. Sore throat. Crossing problems and finding solutions. Russian Journal of Woman and Child Health. 2022;5(3):228‑36 (in Russian). DOI:10.32364/2618‑8430‑2022‑5–3‑228‑236
12. Edouard S, Million M, Bachar D, et al. The nasopharyngeal microbiota in patients with viral respiratory tract infections is enriched in bacterial pathogens. Eur J Clin Microbiol Infect Dis. 2018;37(9):1725‑33. DOI:10.1007/s10096‑018‑3305‑8
13. DeMuri GP, Gern JE, Eickhoff JC, et al. Dynamics of Bacterial Colonization With Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis During Symptomatic and Asymptomatic Viral Upper Respiratory Tract Infection. Clin Infect Dis. 2018;66(7):1045‑53. DOI:10.1093/cid/cix941
14. Pearce S, Bowen AC, Engel ME, et al. The incidence of sore throat and group A streptococcal pharyngitis in children at high risk of developing acute rheumatic fever: A systematic review and meta-analysis. PLoS One. 2020;15(11):e0242107. DOI:10.1371/journal.pone.0242107
15. Ostryi tonzillit i faringit (Ostryi tonzillofaringit). Klinicheskie rekomendatsii. 2021 (in Russian).
16. Claassen-Weitz S, Lim KYL, Mullally C, et al. The association between bacteria colonizing the upper respiratory tract and lower respiratory tract infection in young children: a systematic review and meta-analysis. Clin Microbiol Infect. 2021;27(9):1262‑70. DOI:10.1016/j.cmi.2021.05.034
17. Price R, MacLennan G, Glen J; SuDDICU Collaboration. Selective digestive or oropharyngeal decontamination and topical oropharyngeal chlorhexidine for prevention of death in general intensive care: systematic review and network meta-analysis. BMJ. 2014;348: g2197. DOI:10.1136/bmj.g2197
18. Kladova OV, Shamsheva OV. Klinicheski dokazannaia effektivnost’ antisepticheskogo sredstva Faringosept® (Ambazon) za mnogoletnii period ego primeneniia v meditsinskoi praktike. Praktika pediatra. 2017;(4):66‑70 (in Russian).
19. Kacso I, Racz CP, Santa S, et al. Ambazone-lipoic acid salt: Structural and thermal characterization. Thermochimica Acta. 2012;550:13‑8. DOI:10.1016/j.tca.2012.09.026
20. Löber G, Hoffmann H. Ambazone as a membrane active antitumor drug. Biophys Chem. 1990;35(2‑3):287‑300. DOI:10.1016/0301‑4622(90)80016‑z
21. Kiviranta UK, Maekitalo R. Tonsillitis acuta. Ubersicht ueber mikrobiologie und behandlung [Acute tonsillitis. Survey of microbiology and therapy]. Pract Oto-Rhino-Laryngol (Basel). 1964;26(Suppl. 1):1‑30 [Article in German]. DOI:10.1159/000274619
22. Fulga I, Neguţ M, Năşcuţiu AM, et al. Studiu privind sensibilitatea la ambazonă (Faringosept) a microbilor din izolate faringiene de la bolnavii cu infecţii acute ale căilor aeriene superioare [Microbial sensitivity to ambazone (Faringosept) in pharyngeal samples from patients with acute infections of the upper respiratory tract]. Bacteriol Virusol Parazitol Epidemiol. 2007;52(1‑2):19‑27 [Article in Romanian].
23. Timofeev AA. Use Faringosept for the prevention of postextraction inflammatory complications in patients with aggravated chronic periodontitis. Dentist-practitioner. 2011;2:48‑51 (in Russian).
1ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия;
2ГБУЗ г. Москвы «Детская городская клиническая больница им. З.А. Башляевой Департамента здравоохранения г. Москвы», Москва, Россия
*zakharova-rmapo@yandex.ru
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Irina N. Zakharova*1, Irina V. Berezhnaya1,2, Irina S. Kuznetsova1, Natalia F. Dubovets2
1Russian Medical Academy of Continuous Professional Education, Moscow, Russia;
2Bashlyaeva Children’s City Clinical Hospital of the Moscow City Health Care Department, Moscow, Russia
*zakharova-rmapo@yandex.ru