Распространенность саркопении у пациентов с хроническим панкреатитом: метаанализ
Распространенность саркопении у пациентов с хроническим панкреатитом: метаанализ
Маев И.В., Андреев Д.Н., Кучерявый Ю.А., Левченко А.И. Распространенность саркопении у пациентов с хроническим панкреатитом: метаанализ. Терапевтический архив. 2020; 92 (12): 43–47. DOI: 10.26442/00403660.2020.12.200430
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Аннотация
Цель. Систематизация данных о частоте выявления саркопении у пациентов с хроническим панкреатитом (ХП).
Материалы и методы. Поиск исследований проводился в электронных базах данных MEDLINE/PubMed, EMBASE, Cochrane, Российский индекс научного цитирования (РИНЦ) до июня 2020 г. Дополнительно выполнялся поиск релевантных абстрактов по электронным базам данных конференций Европейского панкреатологического клуба (European Pancreatic Club, EPC), Международной ассоциации панкреатологии (International Association of Pancreatology, IAP) и Европейского конгресса радиологов (European Congress of Radiology, ECR). В финальный анализ отбирались публикации, в которых применялись валидированные тесты оценки мышечной массы с подробной описательной статистикой, позволяющей включить результирующие данные в метаанализ.
Результаты. В итоговый анализ включено 7 исследований с участием 604 пациентов с ХП. Обобщенная частота саркопении у пациентов с ХП составила 42,09% (95% доверительный интервал – ДИ 27,845–57,055). Выявлена значительная гетерогенность между результатами (p<0,0001; I2=90,81%). При исключении из метаанализа исследований с общей выборкой меньше 50 пациентов обобщенная частота саркопении у пациентов с ХП составила 22,24% (95% ДИ 15,475–29,847).
Заключение. Настоящий метаанализ продемонстрировал, что саркопения является достаточно распространенным осложнением ХП и наблюдается примерно у 2 из 5 пациентов с данным воспалительным заболеванием поджелудочной железы. Учитывая высокую частоту неблагоприятных исходов, ассоциированных с саркопенией, необходимо своевременно диагностировать это патологическое состояние у пациентов с ХП.
Ключевые слова: хронический панкреатит, саркопения, мышечная масса, нутритивный статус, заместительная ферментная терапия.
Materials and methods. MEDLINE/PubMed, EMBASE, Cochrane, the Russian Science Citation Index (RSCI) through June 2020 were searched to identify studies evaluating the prevalence of sarcopenia in CP. Additionally, a search for relevant abstracts was carried out in the electronic databases of the conferences of the European Pancreatic Club (EPC), the International Association of Pancreatology (IAP) and the European Congress of Radiology (ECR). For the final analysis, publications were selected that used validated muscle mass assessment tests with detailed descriptive statistics to enable the resulting data to be included in the meta-analysis.
Results. The final analysis included 7 studies involving 604 patients with CP. The pooled prevalence of sarcopenia in patients with CP was 42.09% (95% confidence interval – CI 27.845–57.055). There was significant heterogeneity between the results (p<0.0001; I2=90.81%). When studies with a total sample of less than 50 patients were excluded from the meta-analysis, the overall prevalence of sarcopenia in patients with CP was 22.24% (95% CI 15.475–29.847).
Conclusion. The present meta-analysis demonstrated that sarcopenia is a common complication of CP and is observed in about 2 out of
5 patients with this inflammatory disease of the pancreas. Given the high incidence of adverse outcomes associated with sarcopenia, it is necessary to promptly diagnose this pathological condition in patients with CP.
Keywords: chronic pancreatitis, sarcopenia, muscle mass, nutritional status, enzyme replacement therapy.
Материалы и методы. Поиск исследований проводился в электронных базах данных MEDLINE/PubMed, EMBASE, Cochrane, Российский индекс научного цитирования (РИНЦ) до июня 2020 г. Дополнительно выполнялся поиск релевантных абстрактов по электронным базам данных конференций Европейского панкреатологического клуба (European Pancreatic Club, EPC), Международной ассоциации панкреатологии (International Association of Pancreatology, IAP) и Европейского конгресса радиологов (European Congress of Radiology, ECR). В финальный анализ отбирались публикации, в которых применялись валидированные тесты оценки мышечной массы с подробной описательной статистикой, позволяющей включить результирующие данные в метаанализ.
Результаты. В итоговый анализ включено 7 исследований с участием 604 пациентов с ХП. Обобщенная частота саркопении у пациентов с ХП составила 42,09% (95% доверительный интервал – ДИ 27,845–57,055). Выявлена значительная гетерогенность между результатами (p<0,0001; I2=90,81%). При исключении из метаанализа исследований с общей выборкой меньше 50 пациентов обобщенная частота саркопении у пациентов с ХП составила 22,24% (95% ДИ 15,475–29,847).
Заключение. Настоящий метаанализ продемонстрировал, что саркопения является достаточно распространенным осложнением ХП и наблюдается примерно у 2 из 5 пациентов с данным воспалительным заболеванием поджелудочной железы. Учитывая высокую частоту неблагоприятных исходов, ассоциированных с саркопенией, необходимо своевременно диагностировать это патологическое состояние у пациентов с ХП.
Ключевые слова: хронический панкреатит, саркопения, мышечная масса, нутритивный статус, заместительная ферментная терапия.
________________________________________________
Materials and methods. MEDLINE/PubMed, EMBASE, Cochrane, the Russian Science Citation Index (RSCI) through June 2020 were searched to identify studies evaluating the prevalence of sarcopenia in CP. Additionally, a search for relevant abstracts was carried out in the electronic databases of the conferences of the European Pancreatic Club (EPC), the International Association of Pancreatology (IAP) and the European Congress of Radiology (ECR). For the final analysis, publications were selected that used validated muscle mass assessment tests with detailed descriptive statistics to enable the resulting data to be included in the meta-analysis.
Results. The final analysis included 7 studies involving 604 patients with CP. The pooled prevalence of sarcopenia in patients with CP was 42.09% (95% confidence interval – CI 27.845–57.055). There was significant heterogeneity between the results (p<0.0001; I2=90.81%). When studies with a total sample of less than 50 patients were excluded from the meta-analysis, the overall prevalence of sarcopenia in patients with CP was 22.24% (95% CI 15.475–29.847).
Conclusion. The present meta-analysis demonstrated that sarcopenia is a common complication of CP and is observed in about 2 out of
5 patients with this inflammatory disease of the pancreas. Given the high incidence of adverse outcomes associated with sarcopenia, it is necessary to promptly diagnose this pathological condition in patients with CP.
Keywords: chronic pancreatitis, sarcopenia, muscle mass, nutritional status, enzyme replacement therapy.
Список литературы
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25. Shen Y, Chen J, Chen X, et al. Prevalence and Associated Factors of Sarcopenia in Nursing Home Residents: A Systematic Review and Meta-analysis. J Am Med Dir Assoc. 2019;20(1):5-13. doi: 10.1016/j.jamda.2018.09.012
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2. Gardner TB, Adler DG, Forsmark CE, et al. ACG Clinical Guideline: Chronic Pancreatitis. Am J Gastroenterol. 2020;115(3):322-39. doi: 10.14309/ajg.0000000000000535
3. Xiao AY, Tan ML, Wu LM, et al. Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies. Lancet Gastroenterol Hepatol. 2016;1(1):45-55. doi: 10.1016/S2468-1253(16)30004-8
4. Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144(6):1252-61. doi: 10.1053/j.gastro.2013.01.068.
5. Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16(3):175-84. doi: 10.1038/s41575-018-0087-5
6. Kucheryavyy YuA, Andreev DN. Nutritional Status in Patients with Chronic Pancreatitis. J Nutritional Therapeutics. 2014;3(3):122-32. doi: 10.6000/1929-5634.2014.03.03.3
7. Dominguez-Muñoz JE. Diagnosis and treatment of pancreatic exocrine insufficiency. Curr Opin Gastroenterol. 2018;34(5):349-54. doi: 10.1097/MOG.0000000000000459
8. Rasmussen HH, Irtun O, Olesen SS, et al. Nutrition in chronic pancreatitis. World J Gastroenterol. 2013;19:7267-75. doi: 10.3748/wjg.v19.i42.7267
9. Duggan SN, Smyth ND, Murphy A, et al. High prevalence of osteoporosis in patients with chronic pancreatitis: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2014;12(2):219-28. doi: 10.1016/j.cgh.2013.06.016
10. Shintakuya R, Uemura K, Murakami Y, et al. Sarcopenia is closely associated with pancreatic exocrine insufficiency in patients with pancreatic disease. Pancreatology. 2017;17(1):70-5. doi: 10.1016/j.pan.2016.10.005
11. Zanker J, Scott D, Reijnierse EM, et al. Establishing an Operational Definition of Sarcopenia in Australia and New Zealand: Delphi Method Based Consensus Statement. J Nutr Health Aging. 2019;23(1):105-10. doi: 10.1007/s12603-018-1113-6. PMID: 30569078.
12. Beaudart C, Zaaria M, Pasleau F, et al. Health Outcomes of Sarcopenia: A Systematic Review and Meta-Analysis. PLoS One. 2017;12(1):e0169548. doi: 10.1371/journal.pone.0169548
13. Olesen SS, Büyükuslu A, Køhler M, et al. Sarcopenia associates with increased hospitalization rates and reduced survival in patients with chronic pancreatitis. Pancreatology. 2019;19(2):245-51. doi: 10.1016/j.pan.2019.01.006
14. Cruz-Jentoft AJ, Bahat G, Bauer J, et al.; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31. doi: 10.1093/ageing/afy169
15. [Lyadov VK, Bulanova EA, Sinitsyn VE. Possibilities of CT in detecting sarcopenia in patients with tumor and inflammatory diseases of the pancreas. Diagnostic and interventional radiology. 2012;6(1):13-8 (In Russ.)].
16. Kasatkina E, Lyadov VK, Mershina EA, Sinitsyn V. CT assessment of sarcopenia in patients with pancreatic cancer and chronic pancreatitis. European Congress of Radiology; Vienna, Austria 2012; P: B-0563. doi: 10.1594/ecr2012/B-0563
17. O'Connor D, Kok T, Purcell C, et al. Investigating the prevalence of sarcopenia in chronic pancreatitis in an irish cohort: A CT-scan based pilot study. Pancreatology. 2014;14:S74. doi: 10.1016/j.pan.2014.05.628
18. El Amrani M, Vermersch M, Fulbert M, et al. Impact of sarcopenia on outcomes of patients undergoing pancreatectomy: A retrospective analysis of 107 patients. Medicine (Baltimore). 2018;97(39):e12076. doi: 10.1097/MD.0000000000012076
19. Ozola-Zālīte I, Frøkjær JB, Mark EB, et al. A Clinical Feasible Method for Computed Tomography-Based Assessment of Sarcopenia in Patients With Chronic Pancreatitis. Pancreas. 2019;48(10):1354-9. doi: 10.1097/MPA.0000000000001439
20. Bieliuniene E, Brøndum Frøkjær J, Pockevicius A, et al. CT- and MRI-Based Assessment of Body Composition and Pancreatic Fibrosis Reveals High Incidence of Clinically Significant Metabolic Changes That Affect the Quality of Life and Treatment Outcomes of Patients with Chronic Pancreatitis and Pancreatic Cancer. Medicina (Kaunas). 2019;55(10):649. doi: 10.3390/medicina55100649
21. Gupte AR, Forsmark CE. Chronic pancreatitis. Curr Opin Gastroenterol. 2014;30(5):500-5. doi: 10.1097/MOG.0000000000000094
22. [Maev IV, Kucheryavyi YA, Andreev DN, Bideeva TV. Nutritional status in patients with chronic pancreatitis. Therapeutic Archive. 2016;88(2):81-9 (In Russ.)]. doi: 10.17116/terarkh201688281-89
23. Min M, Patel B, Han S, et al. Exocrine Pancreatic Insufficiency and Malnutrition in Chronic Pancreatitis: Identification, Treatment, and Consequences. Pancreas. 2018;47(8):1015-8. doi: 10.1097/MPA.0000000000001137
24. [Maev IV, Kucheryavyy YuA, Samsonov AA, Andreev DN. Difficulties and errors in the management tactics of patients with chronic pancreatitis. Therapeutic Archive. 2013;85(2):65-72 (In Russ.)].
25. Shen Y, Chen J, Chen X, et al. Prevalence and Associated Factors of Sarcopenia in Nursing Home Residents: A Systematic Review and Meta-analysis. J Am Med Dir Assoc. 2019;20(1):5-13. doi: 10.1016/j.jamda.2018.09.012
26. Layer P, Yamamoto H, Kalthoff L, et al. The different courses of early- and late-onset idiopathic and alcoholic chronic pancreatitis. Gastroenterology. 1994;107(5):1481-7. doi: 10.1016/0016-5085(94)90553-3
27. [Maev IV, Kucheryavy YuA, Moskaleva AB. Chronic pancreatitis: myths and realities. Farmateka. 2010;12:24-31 (In Russ.)]
28. [Kucheryavyy YuA, Moskaleva AB, Sviridova AV, et al. Nutritional status as a risk factor for complications of chronic pancreatitis and the development of pancreatic insufficiency. Experimental and clinical gastroenterology. 2012;7:10-6 (In Russ.)]
29. [Bideeva TV, Maev IV, Kucheryavyy YuA, et al. The effectiveness of pancreatic enzyme replacement therapy using microencapsulated pancreatin preparations in the correction of nutritional status in patients with chronic pancreatitis: a prospective observational study. Therapeutic Archive. 2020;92(1):30-5 (In Russ.)]. doi: 10.26442/00403660.2020.01.000488
30. [Kucheryavyy YuA, Kiryukova MA, Dubtsova EA, Bordin DS. ACG-2020 clinical guidelines for the diagnosis and treatment of chronic pancreatitis: a review of key points in practical refraction. Effective pharmacotherapy. 2020;16(15):60-73 (In Russ.)]. doi: 10.33978/2307-3586-2020-16-15-60-72
2. Gardner TB, Adler DG, Forsmark CE, et al. ACG Clinical Guideline: Chronic Pancreatitis. Am J Gastroenterol. 2020;115(3):322-39. doi: 10.14309/ajg.0000000000000535
3. Xiao AY, Tan ML, Wu LM, et al. Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies. Lancet Gastroenterol Hepatol. 2016;1(1):45-55. doi: 10.1016/S2468-1253(16)30004-8
4. Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144(6):1252-61. doi: 10.1053/j.gastro.2013.01.068.
5. Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16(3):175-84. doi: 10.1038/s41575-018-0087-5
6. Kucheryavyy YuA, Andreev DN. Nutritional Status in Patients with Chronic Pancreatitis. J Nutritional Therapeutics. 2014;3(3):122-32. doi: 10.6000/1929-5634.2014.03.03.3
7. Dominguez-Muñoz JE. Diagnosis and treatment of pancreatic exocrine insufficiency. Curr Opin Gastroenterol. 2018;34(5):349-54. doi: 10.1097/MOG.0000000000000459
8. Rasmussen HH, Irtun O, Olesen SS, et al. Nutrition in chronic pancreatitis. World J Gastroenterol. 2013;19:7267-75. doi: 10.3748/wjg.v19.i42.7267
9. Duggan SN, Smyth ND, Murphy A, et al. High prevalence of osteoporosis in patients with chronic pancreatitis: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2014;12(2):219-28. doi: 10.1016/j.cgh.2013.06.016
10. Shintakuya R, Uemura K, Murakami Y, et al. Sarcopenia is closely associated with pancreatic exocrine insufficiency in patients with pancreatic disease. Pancreatology. 2017;17(1):70-5. doi: 10.1016/j.pan.2016.10.005
11. Zanker J, Scott D, Reijnierse EM, et al. Establishing an Operational Definition of Sarcopenia in Australia and New Zealand: Delphi Method Based Consensus Statement. J Nutr Health Aging. 2019;23(1):105-10. doi: 10.1007/s12603-018-1113-6. PMID: 30569078.
12. Beaudart C, Zaaria M, Pasleau F, et al. Health Outcomes of Sarcopenia: A Systematic Review and Meta-Analysis. PLoS One. 2017;12(1):e0169548. doi: 10.1371/journal.pone.0169548
13. Olesen SS, Büyükuslu A, Køhler M, et al. Sarcopenia associates with increased hospitalization rates and reduced survival in patients with chronic pancreatitis. Pancreatology. 2019;19(2):245-51. doi: 10.1016/j.pan.2019.01.006
14. Cruz-Jentoft AJ, Bahat G, Bauer J, et al.; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31. doi: 10.1093/ageing/afy169
15. Лядов В.К., Буланова Е.А., Синицын В.Е. Возможности КТ при выявлении саркопении у больных с опухолевыми и воспалительными заболеваниями поджелудочной железы. Диагностическая и интервенционная радиология. 2012;6(1):13-8 [Lyadov VK, Bulanova EA, Sinitsyn VE. Possibilities of CT in detecting sarcopenia in patients with tumor and inflammatory diseases of the pancreas. Diagnostic and interventional radiology. 2012;6(1):13-8 (In Russ.)].
16. Kasatkina E, Lyadov VK, Mershina EA, Sinitsyn V. CT assessment of sarcopenia in patients with pancreatic cancer and chronic pancreatitis. European Congress of Radiology; Vienna, Austria 2012; P: B-0563. doi: 10.1594/ecr2012/B-0563
17. O'Connor D, Kok T, Purcell C, et al. Investigating the prevalence of sarcopenia in chronic pancreatitis in an irish cohort: A CT-scan based pilot study. Pancreatology. 2014;14:S74. doi: 10.1016/j.pan.2014.05.628
18. El Amrani M, Vermersch M, Fulbert M, et al. Impact of sarcopenia on outcomes of patients undergoing pancreatectomy: A retrospective analysis of 107 patients. Medicine (Baltimore). 2018;97(39):e12076. doi: 10.1097/MD.0000000000012076
19. Ozola-Zālīte I, Frøkjær JB, Mark EB, et al. A Clinical Feasible Method for Computed Tomography-Based Assessment of Sarcopenia in Patients With Chronic Pancreatitis. Pancreas. 2019;48(10):1354-9. doi: 10.1097/MPA.0000000000001439
20. Bieliuniene E, Brøndum Frøkjær J, Pockevicius A, et al. CT- and MRI-Based Assessment of Body Composition and Pancreatic Fibrosis Reveals High Incidence of Clinically Significant Metabolic Changes That Affect the Quality of Life and Treatment Outcomes of Patients with Chronic Pancreatitis and Pancreatic Cancer. Medicina (Kaunas). 2019;55(10):649. doi: 10.3390/medicina55100649
21. Gupte AR, Forsmark CE. Chronic pancreatitis. Curr Opin Gastroenterol. 2014;30(5):500-5. doi: 10.1097/MOG.0000000000000094
22. Маев И.В., Кучерявый Ю.А., Андреев Д.Н., Бидеева Т.В. Статус питания больных хроническим панкреатитом. Терапевтический архив. 2016;88(2):81-9 [Maev IV, Kucheryavyi YA, Andreev DN, Bideeva TV. Nutritional status in patients with chronic pancreatitis. Therapeutic Archive. 2016;88(2):81-9 (In Russ.)]. doi: 10.17116/terarkh201688281-89
23. Min M, Patel B, Han S, et al. Exocrine Pancreatic Insufficiency and Malnutrition in Chronic Pancreatitis: Identification, Treatment, and Consequences. Pancreas. 2018;47(8):1015-8. doi: 10.1097/MPA.0000000000001137
24. Маев И.В., Кучерявый Ю.А., Самсонов А.А., Андреев Д.Н. Трудности и ошибки в тактике ведения больных хроническим панкреатитом. Терапевтический архив. 2013;85(2):65-72 [Maev IV, Kucheryavyy YuA, Samsonov AA, Andreev DN. Difficulties and errors in the management tactics of patients with chronic pancreatitis. Therapeutic Archive. 2013;85(2):65-72 (In Russ.)].
25. Shen Y, Chen J, Chen X, et al. Prevalence and Associated Factors of Sarcopenia in Nursing Home Residents: A Systematic Review and Meta-analysis. J Am Med Dir Assoc. 2019;20(1):5-13. doi: 10.1016/j.jamda.2018.09.012
26. Layer P, Yamamoto H, Kalthoff L, et al. The different courses of early- and late-onset idiopathic and alcoholic chronic pancreatitis. Gastroenterology. 1994;107(5):1481-7. doi: 10.1016/0016-5085(94)90553-3
27. Маев И.В., Кучерявый Ю.А., Москалева А.Б. Хронический панкреатит: мифы и реалии. Фарматека. 2010;12:24-31 [Maev IV, Kucheryavy YuA, Moskaleva AB. Chronic pancreatitis: myths and realities. Farmateka. 2010;12:24-31 (In Russ.)]
28. Кучерявый Ю.А., Москалева А.Б., Свиридова А.В. и др. Нутритивный статус как фактор риска осложнений хронического панкреатита и развития панкреатической недостаточности. Экспер. и клин. гастроэнтерология. 2012;7:10-6 [Kucheryavyy YuA, Moskaleva AB, Sviridova AV, et al. Nutritional status as a risk factor for complications of chronic pancreatitis and the development of pancreatic insufficiency. Experimental and clinical gastroenterology. 2012;7:10-6 (In Russ.)]
29. Бидеева Т.В., Маев И.В., Кучерявый Ю.А. и др. Эффективность заместительной ферментной терапии с использованием микрокапсулированных препаратов панкреатина при коррекции нутритивного статуса у пациентов с хроническим панкреатитом: проспективное наблюдательное исследование. Терапевтический архив. 2020;92(1):30-5 [Bideeva TV, Maev IV, Kucheryavyy YuA, et al. The effectiveness of pancreatic enzyme replacement therapy using microencapsulated pancreatin preparations in the correction of nutritional status in patients with chronic pancreatitis: a prospective observational study. Therapeutic Archive. 2020;92(1):30-5 (In Russ.)]. doi: 10.26442/00403660.2020.01.000488
30. Кучерявый Ю.А., Кирюкова М.А., Дубцова Е.А., Бордин Д.С. Клинические рекомендации ACG-2020 по диагностике и лечению хронического панкреатита: обзор ключевых положений в практическом преломлении. Эффективная фармакотерапия. 2020;16(15):60-73 [Kucheryavyy YuA, Kiryukova MA, Dubtsova EA, Bordin DS. ACG-2020 clinical guidelines for the diagnosis and treatment of chronic pancreatitis: a review of key points in practical refraction. Effective pharmacotherapy. 2020;16(15):60-73 (In Russ.)]. doi: 10.33978/2307-3586-2020-16-15-60-72
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2. Gardner TB, Adler DG, Forsmark CE, et al. ACG Clinical Guideline: Chronic Pancreatitis. Am J Gastroenterol. 2020;115(3):322-39. doi: 10.14309/ajg.0000000000000535
3. Xiao AY, Tan ML, Wu LM, et al. Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies. Lancet Gastroenterol Hepatol. 2016;1(1):45-55. doi: 10.1016/S2468-1253(16)30004-8
4. Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144(6):1252-61. doi: 10.1053/j.gastro.2013.01.068.
5. Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16(3):175-84. doi: 10.1038/s41575-018-0087-5
6. Kucheryavyy YuA, Andreev DN. Nutritional Status in Patients with Chronic Pancreatitis. J Nutritional Therapeutics. 2014;3(3):122-32. doi: 10.6000/1929-5634.2014.03.03.3
7. Dominguez-Muñoz JE. Diagnosis and treatment of pancreatic exocrine insufficiency. Curr Opin Gastroenterol. 2018;34(5):349-54. doi: 10.1097/MOG.0000000000000459
8. Rasmussen HH, Irtun O, Olesen SS, et al. Nutrition in chronic pancreatitis. World J Gastroenterol. 2013;19:7267-75. doi: 10.3748/wjg.v19.i42.7267
9. Duggan SN, Smyth ND, Murphy A, et al. High prevalence of osteoporosis in patients with chronic pancreatitis: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2014;12(2):219-28. doi: 10.1016/j.cgh.2013.06.016
10. Shintakuya R, Uemura K, Murakami Y, et al. Sarcopenia is closely associated with pancreatic exocrine insufficiency in patients with pancreatic disease. Pancreatology. 2017;17(1):70-5. doi: 10.1016/j.pan.2016.10.005
11. Zanker J, Scott D, Reijnierse EM, et al. Establishing an Operational Definition of Sarcopenia in Australia and New Zealand: Delphi Method Based Consensus Statement. J Nutr Health Aging. 2019;23(1):105-10. doi: 10.1007/s12603-018-1113-6. PMID: 30569078.
12. Beaudart C, Zaaria M, Pasleau F, et al. Health Outcomes of Sarcopenia: A Systematic Review and Meta-Analysis. PLoS One. 2017;12(1):e0169548. doi: 10.1371/journal.pone.0169548
13. Olesen SS, Büyükuslu A, Køhler M, et al. Sarcopenia associates with increased hospitalization rates and reduced survival in patients with chronic pancreatitis. Pancreatology. 2019;19(2):245-51. doi: 10.1016/j.pan.2019.01.006
14. Cruz-Jentoft AJ, Bahat G, Bauer J, et al.; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31. doi: 10.1093/ageing/afy169
15. [Lyadov VK, Bulanova EA, Sinitsyn VE. Possibilities of CT in detecting sarcopenia in patients with tumor and inflammatory diseases of the pancreas. Diagnostic and interventional radiology. 2012;6(1):13-8 (In Russ.)].
16. Kasatkina E, Lyadov VK, Mershina EA, Sinitsyn V. CT assessment of sarcopenia in patients with pancreatic cancer and chronic pancreatitis. European Congress of Radiology; Vienna, Austria 2012; P: B-0563. doi: 10.1594/ecr2012/B-0563
17. O'Connor D, Kok T, Purcell C, et al. Investigating the prevalence of sarcopenia in chronic pancreatitis in an irish cohort: A CT-scan based pilot study. Pancreatology. 2014;14:S74. doi: 10.1016/j.pan.2014.05.628
18. El Amrani M, Vermersch M, Fulbert M, et al. Impact of sarcopenia on outcomes of patients undergoing pancreatectomy: A retrospective analysis of 107 patients. Medicine (Baltimore). 2018;97(39):e12076. doi: 10.1097/MD.0000000000012076
19. Ozola-Zālīte I, Frøkjær JB, Mark EB, et al. A Clinical Feasible Method for Computed Tomography-Based Assessment of Sarcopenia in Patients With Chronic Pancreatitis. Pancreas. 2019;48(10):1354-9. doi: 10.1097/MPA.0000000000001439
20. Bieliuniene E, Brøndum Frøkjær J, Pockevicius A, et al. CT- and MRI-Based Assessment of Body Composition and Pancreatic Fibrosis Reveals High Incidence of Clinically Significant Metabolic Changes That Affect the Quality of Life and Treatment Outcomes of Patients with Chronic Pancreatitis and Pancreatic Cancer. Medicina (Kaunas). 2019;55(10):649. doi: 10.3390/medicina55100649
21. Gupte AR, Forsmark CE. Chronic pancreatitis. Curr Opin Gastroenterol. 2014;30(5):500-5. doi: 10.1097/MOG.0000000000000094
22. [Maev IV, Kucheryavyi YA, Andreev DN, Bideeva TV. Nutritional status in patients with chronic pancreatitis. Therapeutic Archive. 2016;88(2):81-9 (In Russ.)]. doi: 10.17116/terarkh201688281-89
23. Min M, Patel B, Han S, et al. Exocrine Pancreatic Insufficiency and Malnutrition in Chronic Pancreatitis: Identification, Treatment, and Consequences. Pancreas. 2018;47(8):1015-8. doi: 10.1097/MPA.0000000000001137
24. [Maev IV, Kucheryavyy YuA, Samsonov AA, Andreev DN. Difficulties and errors in the management tactics of patients with chronic pancreatitis. Therapeutic Archive. 2013;85(2):65-72 (In Russ.)].
25. Shen Y, Chen J, Chen X, et al. Prevalence and Associated Factors of Sarcopenia in Nursing Home Residents: A Systematic Review and Meta-analysis. J Am Med Dir Assoc. 2019;20(1):5-13. doi: 10.1016/j.jamda.2018.09.012
26. Layer P, Yamamoto H, Kalthoff L, et al. The different courses of early- and late-onset idiopathic and alcoholic chronic pancreatitis. Gastroenterology. 1994;107(5):1481-7. doi: 10.1016/0016-5085(94)90553-3
27. [Maev IV, Kucheryavy YuA, Moskaleva AB. Chronic pancreatitis: myths and realities. Farmateka. 2010;12:24-31 (In Russ.)]
28. [Kucheryavyy YuA, Moskaleva AB, Sviridova AV, et al. Nutritional status as a risk factor for complications of chronic pancreatitis and the development of pancreatic insufficiency. Experimental and clinical gastroenterology. 2012;7:10-6 (In Russ.)]
29. [Bideeva TV, Maev IV, Kucheryavyy YuA, et al. The effectiveness of pancreatic enzyme replacement therapy using microencapsulated pancreatin preparations in the correction of nutritional status in patients with chronic pancreatitis: a prospective observational study. Therapeutic Archive. 2020;92(1):30-5 (In Russ.)]. doi: 10.26442/00403660.2020.01.000488
30. [Kucheryavyy YuA, Kiryukova MA, Dubtsova EA, Bordin DS. ACG-2020 clinical guidelines for the diagnosis and treatment of chronic pancreatitis: a review of key points in practical refraction. Effective pharmacotherapy. 2020;16(15):60-73 (In Russ.)]. doi: 10.33978/2307-3586-2020-16-15-60-72
Авторы
И.В. Маев, Д.Н. Андреев, Ю.А. Кучерявый, А.И. Левченко
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России,
Москва, Россия
Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России,
Москва, Россия
________________________________________________
Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
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